Correction: CD2AP deficiency aggravates Alzheimer’s disease phenotypes and pathology through p38 MAPK activation

Correction: Translational Neurodegeneration (2024) 13:64 10.1186/s40035-024-00454-5

Following publication of the original article [1], the authors reported an error in the Fig. 3h, which presented incorrect lane image of p-tau 396. The Fig. 3 is corrected from:

Fig. 3.

Neuronal Cd2ap deletion aggravated cognitive function and pathological features in APP/PS1 mice. a Scheme of the experimental mouse timeline. Briefly, a series of behavioral tests were performed in 4-month-old mice, and subsequent pathological analyses were conducted in 4.5-month-old mice. b No significant difference in time spent in the center area was observed in the open field test. n = 13 (WT, female n = 5, male n = 8), n = 8 (APP/PS1, female n = 3, male n = 5), n = 10 (CKO, female n = 5, male n = 5), n = 7 (CKO × APP/PS1, female n = 4, male n = 3). c CKO × APP/PS1 mice spent less time in the novel arm in the Y-maze novel arm preference test compared to WT mice. n = 13 (WT, female n = 5, male n = 8), n = 8 (APP/PS1, female n = 3, male n = 5), n = 10 (CKO, female n = 5, male n = 5), n = 7 (CKO × APP/PS1, female n = 4, male n = 3). d, e CKO × APP/PS1 mice showed significantly decreased contextual and cue-related freezing compared to WT mice. n = 13 (WT, female n = 5, male n = 8), n = 8 (APP/PS1, female n = 3, male n = 5), n = 9 (CKO, female n = 5, male n = 4), n = 7 (CKO × APP/PS1, female n = 4, male n = 3). f ELISA analysis of Aβ showed that neuronal Cd2ap deletion had no obvious influence on human Aβ level. n = 3 (APP/PS1, female n = 1, male n = 2), n = 5 (CKO × APP/PS1, female n = 3, male n = 2). g ELISA analysis of Aβ showed that neuronal Cd2ap deletion had no obvious influence on murine Aβ level. n = 6 (WT, female n = 2, male n = 4), n = 6 (APP/PS1, female n = 3, male n = 3), n = 4 (CKO, female n = 3, male n = 1), n = 6 (CKO × APP/PS1, female n = 4, male n = 2). h-j In 4.5-month-old mice, Immunoblots revealed that neuronal Cd2ap deletion had no obvious influence on the full-length APP (APP-FL) and APP-CTF proteins. n = 6 (WT, female n = 3, male n = 3), n = 6 (APP/PS1, female n = 3, male n = 3), n = 6 (CKO, female n = 3, male n = 3), n = 6 (CKO × APP/PS1, female n = 3, male n = 3). k, l In 4.5-month-old mice, Immunoblots revealed that neuronal Cd2ap deletion led to significantly increased ptau202/205 (AT8) and p-tau396 level, especially in the CKO × APP/PS1 mice. n = 7 (WT, female n = 3, male n = 4), n = 7 (APP/PS1, female n = 3, male n = 4), n = 7 (CKO, female n = 4, male n = 3), n = 7 (CKO × APP/PS1, female n = 4, male n = 3). All data are presented as mean ± SEM. Unpaired t-test with two-tailed analysis (f), one-way ANOVA with Turkey’s multiple comparison tests for multiple comparisons (b-e, g, i, j, k), Kruskal–Wallis tests with Dunn’s multiple comparison tests (l). *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001

Fig. 3.

Neuronal Cd2ap deletion aggravated cognitive function and pathological features in APP/PS1 mice. a Scheme of the experimental mouse timeline. Briefly, a series of behavioral tests were performed in 4-month-old mice, and subsequent pathological analyses were conducted in 4.5-month-old mice. b No significant difference in time spent in the center area was observed in the open field test. n = 13 (WT, female n = 5, male n = 8), n = 8 (APP/PS1, female n = 3, male n = 5), n = 10 (CKO, female n = 5, male n = 5), n = 7 (CKO × APP/PS1, female n = 4, male n = 3). c CKO × APP/PS1 mice spent less time in the novel arm in the Y-maze novel arm preference test compared to WT mice. n = 13 (WT, female n = 5, male n = 8), n = 8 (APP/PS1, female n = 3, male n = 5), n = 10 (CKO, female n = 5, male n = 5), n = 7 (CKO × APP/PS1, female n = 4, male n = 3). d, e CKO × APP/PS1 mice showed significantly decreased contextual and cue-related freezing compared to WT mice. n = 13 (WT, female n = 5, male n = 8), n = 8 (APP/PS1, female n = 3, male n = 5), n = 9 (CKO, female n = 5, male n = 4), n = 7 (CKO × APP/PS1, female n = 4, male n = 3). f ELISA analysis of Aβ showed that neuronal Cd2ap deletion had no obvious influence on human Aβ level. n = 3 (APP/PS1, female n = 1, male n = 2), n = 5 (CKO × APP/PS1, female n = 3, male n = 2). g ELISA analysis of Aβ showed that neuronal Cd2ap deletion had no obvious influence on murine Aβ level. n = 6 (WT, female n = 2, male n = 4), n = 6 (APP/PS1, female n = 3, male n = 3), n = 4 (CKO, female n = 3, male n = 1), n = 6 (CKO × APP/PS1, female n = 4, male n = 2). h-j In 4.5-month-old mice, Immunoblots revealed that neuronal Cd2ap deletion had no obvious influence on the full-length APP (APP-FL) and APP-CTF proteins. n = 6 (WT, female n = 3, male n = 3), n = 6 (APP/PS1, female n = 3, male n = 3), n = 6 (CKO, female n = 3, male n = 3), n = 6 (CKO × APP/PS1, female n = 3, male n = 3). k, l In 4.5-month-old mice, Immunoblots revealed that neuronal Cd2ap deletion led to significantly increased ptau202/205 (AT8) and p-tau396 level, especially in the CKO × APP/PS1 mice. n = 7 (WT, female n = 3, male n = 4), n = 7 (APP/PS1, female n = 3, male n = 4), n = 7 (CKO, female n = 4, male n = 3), n = 7 (CKO × APP/PS1, female n = 4, male n = 3). All data are presented as mean ± SEM. Unpaired t-test with two-tailed analysis (f), one-way ANOVA with Turkey’s multiple comparison tests for multiple comparisons (b-e, g, i, j, k), Kruskal–Wallis tests with Dunn’s multiple comparison tests (l). *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001

To:

This correction does not affect the description of the results or the conclusion of this work.

The original article [1] has been updated.