Abstract
1. We investigated the central role of corticotrophin-releasing factor (CRF-41) in psychological stress-induced responses, including cardiovascular, thermoregulatory and locomotive activity in free-moving rats. 2. Psychological stress was induced by cage-switch stress. After rats were placed in the novel environment, blood pressure, heart rate, body temperature and locomotive activity significantly increased. The intracerebroventricular (I.C.V.) injection of alpha-helical CRF(9-41), a CRF-41 receptor antagonist, significantly attenuated the stress-induced hypertension, tachycardia, hyperthermia and increase in locomotive activity. However, in unstressed rats, the I.C.V. injection of alpha-helical CRF(9-41) had no effect on physiological parameters measured in this study. 3. In unstressed rats, the I.C.V. injection of CRF-41 (1 microgram and 10 micrograms) increased blood pressure, heart rate, body temperature and locomotive activity in a dose-dependent manner. The changes in these responses were quite similar to those observed during cage-switch stress. 4. The results suggest that central CRF-41 plays an important role in psychological stress-induced hypertension, hyperthermia, tachycardia and increase in locomotive activity. However, it is likely that central CRF-41 does not contribute to normal cardiovascular and body temperature regulation when rats are free from stress.
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Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Brown M. R., Fisher L. A. Corticotropin-releasing factor: effects on the autonomic nervous system and visceral systems. Fed Proc. 1985 Jan;44(1 Pt 2):243–248. [PubMed] [Google Scholar]
- Brown M. R., Fisher L. A., Webb V., Vale W. W., Rivier J. E. Corticotropin-releasing factor: a physiologic regulator of adrenal epinephrine secretion. Brain Res. 1985 Mar 4;328(2):355–357. doi: 10.1016/0006-8993(85)91048-0. [DOI] [PubMed] [Google Scholar]
- Brown M. R., Gray T. S., Fisher L. A. Corticotropin-releasing factor receptor antagonist: effects on the autonomic nervous system and cardiovascular function. Regul Pept. 1986 Dec 30;16(3-4):321–329. doi: 10.1016/0167-0115(86)90032-7. [DOI] [PubMed] [Google Scholar]
- Diamant M., de Wied D. Autonomic and behavioral effects of centrally administered corticotropin-releasing factor in rats. Endocrinology. 1991 Jul;129(1):446–454. doi: 10.1210/endo-129-1-446. [DOI] [PubMed] [Google Scholar]
- Fisher L. A. Corticotropin-releasing factor: endocrine and autonomic integration of responses to stress. Trends Pharmacol Sci. 1989 May;10(5):189–193. doi: 10.1016/0165-6147(89)90236-8. [DOI] [PubMed] [Google Scholar]
- Gruber K. A., Klein M. C., Hutchins P. M., Buckalew V. M., Jr, Lymangrover J. R. Natriuretic and hypertensive activities reside in a fragment of ACTH. Hypertension. 1984 Jul-Aug;6(4):468–474. doi: 10.1161/01.hyp.6.4.468. [DOI] [PubMed] [Google Scholar]
- Haas D. A., George S. R. Single or repeated mild stress increases synthesis and release of hypothalamic corticotropin-releasing factor. Brain Res. 1988 Oct 4;461(2):230–237. doi: 10.1016/0006-8993(88)90254-5. [DOI] [PubMed] [Google Scholar]
- Kregel K. C., Overton J. M., Seals D. R., Tipton C. M., Fisher L. A. Cardiovascular responses to exercise in the rat: role of corticotropin-releasing factor. J Appl Physiol (1985) 1990 Feb;68(2):561–567. doi: 10.1152/jappl.1990.68.2.561. [DOI] [PubMed] [Google Scholar]
- LeFeuvre R. A., Rothwell N. J., Stock M. J. Activation of brown fat thermogenesis in response to central injection of corticotropin releasing hormone in the rat. Neuropharmacology. 1987 Aug;26(8):1217–1221. doi: 10.1016/0028-3908(87)90272-3. [DOI] [PubMed] [Google Scholar]
- Lebrun C., Rohmeiss P., Demmert G., Rettig R., Unger T. Central cardiovascular actions of vasopressin in the rat. Can J Physiol Pharmacol. 1987 Aug;65(8):1712–1716. doi: 10.1139/y87-269. [DOI] [PubMed] [Google Scholar]
- Lenz H. J. Extrapituitary effects of corticotropin-releasing factor. Horm Metab Res Suppl. 1987;16:17–23. [PubMed] [Google Scholar]
- Morimoto A., Watanabe T., Morimoto K., Nakamori T., Murakami N. Possible involvement of prostaglandins in psychological stress-induced responses in rats. J Physiol. 1991 Nov;443:421–429. doi: 10.1113/jphysiol.1991.sp018841. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Murakami K., Akana S., Dallman M. F., Ganong W. F. Correlation between the stress-induced transient increase in corticotropin-releasing hormone content of the median eminence of the hypothalamus and adrenocorticotropic hormone secretion. Neuroendocrinology. 1989 Mar;49(3):233–241. doi: 10.1159/000125122. [DOI] [PubMed] [Google Scholar]
- Rothwell N. J. Central effects of CRF on metabolism and energy balance. Neurosci Biobehav Rev. 1990 Fall;14(3):263–271. doi: 10.1016/s0149-7634(05)80037-5. [DOI] [PubMed] [Google Scholar]
- Schönbaum E., Johnson G. E., Sellers E. A., Gill M. J. Adrenergic beta-receptors and non-shivering thermogenesis. Nature. 1966 Apr 23;210(5034):426–426. doi: 10.1038/210426a0. [DOI] [PubMed] [Google Scholar]
- Suemaru S., Hashimoto K., Hattori T., Inoue H., Kageyama J., Ota Z. Starvation-induced changes in rat brain corticotropin-releasing factor (CRF) and pituitary-adrenocortical response. Life Sci. 1986 Sep 29;39(13):1161–1166. doi: 10.1016/0024-3205(86)90347-4. [DOI] [PubMed] [Google Scholar]