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. 1992 Apr;449:429–440. doi: 10.1113/jphysiol.1992.sp019094

Evidence that a long latency stretch reflex in humans is transcortical.

E Palmer 1, P Ashby 1
PMCID: PMC1176087  PMID: 1522516

Abstract

1. The hypothesis that the long latency reflex response to muscle stretch in humans uses a transcortical pathway was tested by looking for convergence onto cortical neurones in eleven normal subjects. 2. Postsynaptic events in single flexor pollicis longus (FPL) motoneurones were derived from changes in the firing probability of individual FPL motor units. 3. Extension of the terminal phalynx of the thumb resulted in both short latency and long latency facilitations of individual FPL motoneurones. These were not reproduced by electrical stimulation of afferents in the terminal phalynx. Magnetic stimulation over the contralateral motor cortex produced strong, short latency facilitation of FPL motoneurones. 4. When the facilitation produced by stimulation over the cortex was superimposed on the long latency facilitation produced by extension of the thumb, the facilitation produced by both stimuli was greater than the sum of the individual facilitations produced by either stimulus given alone. This was not the case when the superimposition occurred on the short latency response to stretch. 5. We conclude that afferent systems excited by the stretch of FPL converge onto cortical neurones which are known to facilitate motoneurones. Thus the cortex is likely to contribute to the long latency stretch reflex in humans.

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Selected References

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  1. Ashby P., Zilm D. Relationship between EPSP shape and cross-correlation profile explored by computer simulation for studies on human motoneurons. Exp Brain Res. 1982;47(1):33–40. doi: 10.1007/BF00235883. [DOI] [PubMed] [Google Scholar]
  2. BERNHARD C. G., BOHM E. Cortical representation and functional significance of the corticomotoneuronal system. AMA Arch Neurol Psychiatry. 1954 Oct;72(4):473–502. doi: 10.1001/archneurpsyc.1954.02330040075006. [DOI] [PubMed] [Google Scholar]
  3. Cope T. C., Fetz E. E., Matsumura M. Cross-correlation assessment of synaptic strength of single Ia fibre connections with triceps surae motoneurones in cats. J Physiol. 1987 Sep;390:161–188. doi: 10.1113/jphysiol.1987.sp016692. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Day B. L., Dressler D., Maertens de Noordhout A., Marsden C. D., Nakashima K., Rothwell J. C., Thompson P. D. Electric and magnetic stimulation of human motor cortex: surface EMG and single motor unit responses. J Physiol. 1989 May;412:449–473. doi: 10.1113/jphysiol.1989.sp017626. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Day B. L., Riescher H., Struppler A., Rothwell J. C., Marsden C. D. Changes in the response to magnetic and electrical stimulation of the motor cortex following muscle stretch in man. J Physiol. 1991 Feb;433:41–57. doi: 10.1113/jphysiol.1991.sp018413. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Edgley S. A., Eyre J. A., Lemon R. N., Miller S. Excitation of the corticospinal tract by electromagnetic and electrical stimulation of the scalp in the macaque monkey. J Physiol. 1990 Jun;425:301–320. doi: 10.1113/jphysiol.1990.sp018104. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Fetz E. E., Gustafsson B. Relation between shapes of post-synaptic potentials and changes in firing probability of cat motoneurones. J Physiol. 1983 Aug;341:387–410. doi: 10.1113/jphysiol.1983.sp014812. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. HAMMOND P. H. The influence of prior instruction to the subject on an apparently involuntary neuro-muscular response. J Physiol. 1956 Apr 27;132(1):17–8P. [PubMed] [Google Scholar]
  9. Hess C. W., Mills K. R., Murray N. M. Responses in small hand muscles from magnetic stimulation of the human brain. J Physiol. 1987 Jul;388:397–419. doi: 10.1113/jphysiol.1987.sp016621. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Illert M., Lundberg A., Tanaka R. Integration in descending motor pathways controlling the forelimb in the cat. 3. Convergence on propriospinal neurones transmitting disynaptic excitation from the corticospinal tract and other descending tracts. Exp Brain Res. 1977 Sep 28;29(3-4):323–346. doi: 10.1007/BF00236174. [DOI] [PubMed] [Google Scholar]
  11. Lawrence D. G., Porter R., Redman S. J. Corticomotoneuronal synapses in the monkey: light microscopic localization upon motoneurons of intrinsic muscles of the hand. J Comp Neurol. 1985 Feb 22;232(4):499–510. doi: 10.1002/cne.902320407. [DOI] [PubMed] [Google Scholar]
  12. Marsden C. D., Merton P. A., Morton H. B., Adam J. The effect of lesions of the sensorimotor cortex and the capsular pathways on servo responses from the human long thumb flexor. Brain. 1977 Sep;100(3):503–526. doi: 10.1093/brain/100.3.503. [DOI] [PubMed] [Google Scholar]
  13. Marsden C. D., Merton P. A., Morton H. B., Adam J. The effect of posterior column lesions on servo responses from the human long thumb flexor. Brain. 1977 Mar;100(Pt 1):185–200. doi: 10.1093/brain/100.1.185. [DOI] [PubMed] [Google Scholar]
  14. Marsden C. D., Merton P. A., Morton H. B. Is the human stretch reflex cortical rather than spinal? Lancet. 1973 Apr 7;1(7806):759–761. doi: 10.1016/s0140-6736(73)92141-7. [DOI] [PubMed] [Google Scholar]
  15. Marsden C. D., Merton P. A., Morton H. B. Stretch reflex and servo action in a variety of human muscles. J Physiol. 1976 Jul;259(2):531–560. doi: 10.1113/jphysiol.1976.sp011481. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Matthews P. B. Evidence from the use of vibration that the human long-latency stretch reflex depends upon spindle secondary afferents. J Physiol. 1984 Mar;348:383–415. doi: 10.1113/jphysiol.1984.sp015116. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Midroni G., Ashby P. How synaptic noise may affect cross-correlations. J Neurosci Methods. 1989 Feb;27(1):1–12. doi: 10.1016/0165-0270(89)90048-4. [DOI] [PubMed] [Google Scholar]
  18. PHILLIPS C. G., PORTER R. THE PYRAMIDAL PROJECTION TO MOTONEURONES OF SOME MUSCLE GROUPS OF THE BABOON'S FORELIMB. Prog Brain Res. 1964;12:222–245. doi: 10.1016/s0079-6123(08)60625-1. [DOI] [PubMed] [Google Scholar]
  19. Palmer E., Ashby P. Corticospinal projections to upper limb motoneurones in humans. J Physiol. 1992 Mar;448:397–412. doi: 10.1113/jphysiol.1992.sp019048. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Phillips C. G. The Ferrier lecture, 1968. Motor apparatus of the baboon's hand. Proc R Soc Lond B Biol Sci. 1969 May 20;173(1031):141–174. doi: 10.1098/rspb.1969.0044. [DOI] [PubMed] [Google Scholar]
  21. Pierrot-Deseilligny E. Peripheral and descending control of neurones mediating non-monosynaptic Ia excitation to motoneurones: a presumed propriospinal system in man. Prog Brain Res. 1989;80:305–297. doi: 10.1016/s0079-6123(08)62225-6. [DOI] [PubMed] [Google Scholar]
  22. Tatton W. G., Forner S. D., Gerstein G. L., Chambers W. W., Liu C. N. The effect of postcentral cortical lesions on motor responses to sudden upper limb displacements in monkeys. Brain Res. 1975 Oct 10;96(1):108–113. doi: 10.1016/0006-8993(75)90580-6. [DOI] [PubMed] [Google Scholar]
  23. Zarola F., Caramia M. D., Paradiso C., Mariorenzi R., Martino G., Traversa R., Rossini P. M. Single fibre motor evoked potentials to brain, spinal roots and nerve stimulation. Comparisons of the 'central' and 'peripheral' response jitter to magnetic and electric stimuli. Brain Res. 1989 Aug 28;495(2):217–224. doi: 10.1016/0006-8993(89)90215-1. [DOI] [PubMed] [Google Scholar]

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