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. 1992 Mar;448:225–235. doi: 10.1113/jphysiol.1992.sp019038

Effects of sympathetic activity and galanin on cardiac vagal action in anaesthetized cats.

L G Ulman 1, E K Potter 1, D I McCloskey 1
PMCID: PMC1176196  PMID: 1375635

Abstract

1. Stimulation of the right cardiac sympathetic nerve for 3 or 5 min at 16 Hz in the presence of effective beta-adrenoceptor blockade evoked prolonged attenuation of subsequent cardiac vagal action in anaesthetized cats. Concurrent sympathetic and vagal stimulation, both at 16 Hz for the same period of time as sympathetic stimulation alone, reduced or abolished the inhibition of vagal action which followed when sympathetic stimulation was given alone. 2. A series of three successive intravenous injections of galanin all caused attenuation of vagally induced slowing of the heart, but the effect of each injection was less than that of the previous one. A fourth injection of galanin given after a 45 or 60 min rest period showed return of sensitivity. 3. Sympathetic stimulation at 16 Hz for 5 min was less efficient in causing attenuation of vagal slowing when applied following the administration of exogenous galanin. This is consistent with galanin being the mediator of vagal attenuation following sympathetic stimulation.

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Selected References

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  1. Allen J. M., Gjörstrup P., Björkman J. A., Ek L., Abrahamsson T., Bloom S. R. Studies on cardiac distribution and function of neuropeptide Y. Acta Physiol Scand. 1986 Mar;126(3):405–411. doi: 10.1111/j.1748-1716.1986.tb07834.x. [DOI] [PubMed] [Google Scholar]
  2. Darvesh S., Nance D. M., Hopkins D. A., Armour J. A. Distribution of neuropeptide-like immunoreactivity in intact and chronically decentralized middle cervical and stellate ganglia of dogs. J Auton Nerv Syst. 1987 Dec;21(2-3):167–180. doi: 10.1016/0165-1838(87)90019-1. [DOI] [PubMed] [Google Scholar]
  3. Ehinger B., Falck B., Sporrong B. Possible axo-axonal synapses between peripheral adrenergic and cholinergic nerve terminals. Z Zellforsch Mikrosk Anat. 1970;107(4):508–521. doi: 10.1007/BF00335438. [DOI] [PubMed] [Google Scholar]
  4. Ekblad E., Edvinsson L., Wahlestedt C., Uddman R., Håkanson R., Sundler F. Neuropeptide Y co-exists and co-operates with noradrenaline in perivascular nerve fibers. Regul Pept. 1984 Apr;8(3):225–235. doi: 10.1016/0167-0115(84)90064-8. [DOI] [PubMed] [Google Scholar]
  5. Furness J. B., Costa M., Papka R. E., Della N. G., Murphy R. Neuropeptides contained in peripheral cardiovascular nerves. Clin Exp Hypertens A. 1984;6(1-2):91–106. doi: 10.3109/10641968409062553. [DOI] [PubMed] [Google Scholar]
  6. Gardner T. D., Potter E. K. Dependence of non-adrenergic inhibition of cardiac vagal action on peak frequency of sympathetic stimulation in the dog. J Physiol. 1988 Nov;405:115–122. doi: 10.1113/jphysiol.1988.sp017324. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Gu J., Polak J. M., Adrian T. E., Allen J. M., Tatemoto K., Bloom S. R. Neuropeptide tyrosine (NPY)--a major cardiac neuropeptide. Lancet. 1983 May 7;1(8332):1008–1010. doi: 10.1016/s0140-6736(83)92642-9. [DOI] [PubMed] [Google Scholar]
  8. Hall G. T., Gardner T. D., Potter E. K. Attenuation of long-lasting effects of sympathetic stimulation after repeated stimulation. Circ Res. 1990 Jul;67(1):193–198. doi: 10.1161/01.res.67.1.193. [DOI] [PubMed] [Google Scholar]
  9. Jacobowitz D., Cooper T., Barner H. B. Histochemical and chemical studies of the localization of adrenergic and cholinergic nerves in normal and denervated cat hearts. Circ Res. 1967 Mar;20(3):289–298. doi: 10.1161/01.res.20.3.289. [DOI] [PubMed] [Google Scholar]
  10. Katona P. G., Poitras J. W., Barnett G. O., Terry B. S. Cardiac vagal efferent activity and heart period in the carotid sinus reflex. Am J Physiol. 1970 Apr;218(4):1030–1037. doi: 10.1152/ajplegacy.1970.218.4.1030. [DOI] [PubMed] [Google Scholar]
  11. Kilborn M. J., Potter E. K., McCloskey D. I. Effects of periods of conditioning stimulation and of neuropeptides on vagal action at the heart. J Auton Nerv Syst. 1986 Oct;17(2):131–142. doi: 10.1016/0165-1838(86)90088-3. [DOI] [PubMed] [Google Scholar]
  12. Kilborn M. J., Potter E. K., McCloskey D. I. Neuromodulation of the cardiac vagus: comparison of neuropeptide Y and related peptides. Regul Pept. 1985 Oct;12(2):155–161. doi: 10.1016/0167-0115(85)90196-x. [DOI] [PubMed] [Google Scholar]
  13. Kummer W. Galanin- and neuropeptide Y-like immunoreactivities coexist in paravertebral sympathetic neurones of the cat. Neurosci Lett. 1987 Jul 22;78(2):127–131. doi: 10.1016/0304-3940(87)90620-3. [DOI] [PubMed] [Google Scholar]
  14. Kötter V., Pontzen W., Kruckenberg P. Posttetanische Potenzierung der Acetylcholinfreisetzung im Herzen unter Vagusreizung. Pflugers Arch. 1969;306(2):176–190. doi: 10.1007/BF00586884. [DOI] [PubMed] [Google Scholar]
  15. Parker P., Celler B. G., Potter E. K., McCloskey D. I. Vagal stimulation and cardiac slowing. J Auton Nerv Syst. 1984 Sep;11(2):226–231. doi: 10.1016/0165-1838(84)90080-8. [DOI] [PubMed] [Google Scholar]
  16. Potter E. K. Cardiac vagal action and plasma levels of neuropeptide Y following intravenous injection in the dog. Neurosci Lett. 1987 Jun 15;77(2):243–247. doi: 10.1016/0304-3940(87)90594-5. [DOI] [PubMed] [Google Scholar]
  17. Potter E. K. Guanethidine blocks neuropeptide-Y-like inhibitory action of sympathetic nerves on cardiac vagus. J Auton Nerv Syst. 1987 Nov;21(1):87–90. doi: 10.1016/0165-1838(87)90095-6. [DOI] [PubMed] [Google Scholar]
  18. Potter E. K. Neuropeptide Y as an autonomic neurotransmitter. Pharmacol Ther. 1988;37(2):251–273. doi: 10.1016/0163-7258(88)90028-9. [DOI] [PubMed] [Google Scholar]
  19. Potter E. K. Prolonged non-adrenergic inhibition of cardiac vagal action following sympathetic stimulation: neuromodulation by neuropeptide Y? Neurosci Lett. 1985 Mar 15;54(2-3):117–121. doi: 10.1016/s0304-3940(85)80065-3. [DOI] [PubMed] [Google Scholar]
  20. Revington M. L., McCloskey D. I. Sympathetic-parasympathetic interactions at the heart, possibly involving neuropeptide Y, in anaesthetized dogs. J Physiol. 1990 Sep;428:359–370. doi: 10.1113/jphysiol.1990.sp018216. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Revington M., Potter E. K., McCloskey D. I. Prolonged inhibition of cardiac vagal action following sympathetic stimulation and galanin in anaesthetized cats. J Physiol. 1990 Dec;431:495–503. doi: 10.1113/jphysiol.1990.sp018342. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Rudehill A., Sollevi A., Franco-Cereceda A., Lundberg J. M. Neuropeptide Y (NPY) and the pig heart: release and coronary vasoconstrictor effects. Peptides. 1986 Sep-Oct;7(5):821–826. doi: 10.1016/0196-9781(86)90101-4. [DOI] [PubMed] [Google Scholar]
  23. Sternini C., Brecha N. Distribution and colocalization of neuropeptide Y- and tyrosine hydroxylase-like immunoreactivity in the guinea-pig heart. Cell Tissue Res. 1985;241(1):93–102. doi: 10.1007/BF00214630. [DOI] [PubMed] [Google Scholar]
  24. Waris T., Lähteenmäki T., Hukki J., von Smitten K., Kyösola K. Congruence of adrenergic and cholinergic intrinsic innervation of human and rat atria. Basic Res Cardiol. 1987 Sep-Oct;82(5):445–453. doi: 10.1007/BF01907092. [DOI] [PubMed] [Google Scholar]
  25. Warner M. R., Levy M. N. Neuropeptide Y as a putative modulator of the vagal effects on heart rate. Circ Res. 1989 May;64(5):882–889. doi: 10.1161/01.res.64.5.882. [DOI] [PubMed] [Google Scholar]

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