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. 1971 Feb;121(3):531–535. doi: 10.1042/bj1210531

Haem synthesis during mitochondrogenesis in yeast

J Jayaraman 1, G Padmanaban 2, K Malathi 2, P S Sarma 2,*
PMCID: PMC1176602  PMID: 5119790

Abstract

The activities of δ-aminolaevulate synthetase and δ-aminolaevulate dehydratase have been assayed in Saccharomyces cerevisiae during glucose repression and de-repression. δ-Aminolaevulate dehydratase increased concomitantly with the increase in oxygen uptake during the de-repression phase caused by the depletion of glucose in the medium. δ-Aminolaevulate synthetase showed an oscillatory behaviour and a spurt in its activity always preceded the increase in oxygen uptake. The activity of both the enzymes was lowered if the cells were incubated with glucose or cycloheximide, but not with chloramphenicol.

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Selected References

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  1. BURNHAM B. F., PIERCE W. S., WILLIAMS K. R., BOYER M. H., KIRBY C. K. delta-aminolaevulate dehydratase from Rhodopseudomonas spheroides. Biochem J. 1963 Jun;87:462–472. doi: 10.1042/bj0870462. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. De Barreiro O. L. 5-aminolaevulinate hydro-lyase from yeast. Isolation and purification. Biochim Biophys Acta. 1967 Jul 11;139(2):479–486. doi: 10.1016/0005-2744(67)90051-4. [DOI] [PubMed] [Google Scholar]
  3. Ebbon J. G., Tait G. H. Studies on S-adenosylmethionine-magnesium protoporphyrin methyltransferase in Euglena gracilis strain Z. Biochem J. 1969 Feb;111(4):573–582. doi: 10.1042/bj1110573. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. GRANICK S., MAUZERALL D. Pbrphyrin biosynthesis in erythrocytes. II. Enzymes converting gamma-aminolevulinic acid to coproporphyrinogen. J Biol Chem. 1958 Jun;232(2):1119–1140. [PubMed] [Google Scholar]
  5. Granick S. The induction in vitro of the synthesis of delta-aminolevulinic acid synthetase in chemical porphyria: a response to certain drugs, sex hormones, and foreign chemicals. J Biol Chem. 1966 Mar 25;241(6):1359–1375. [PubMed] [Google Scholar]
  6. Hayashi N., Yoda B., Kikuchi G. Mechanism of allylisopropylacetamide-induced increase of delta-aminolevulinate synthetase in liver mitochondria. IV. Accumulation of the enzyme in the soluble fraction of rat liver. Arch Biochem Biophys. 1969 Apr;131(1):83–91. doi: 10.1016/0003-9861(69)90107-6. [DOI] [PubMed] [Google Scholar]
  7. Huang M., Biggs D. R., Clark-Walker G. D., Linnane A. W. Chloramphenicol inhibition of the formation of particulate mitochondrial enzymes of Saccharomyces cerevisiae. Biochim Biophys Acta. 1966 Feb 21;114(2):434–436. doi: 10.1016/0005-2787(66)90330-3. [DOI] [PubMed] [Google Scholar]
  8. Jayaraman J., Cotman C., Mahler H. R., Sharp C. W. Biochemical correlates of respiratory deficiency. VII. Glucose repression. Arch Biochem Biophys. 1966 Sep 26;116(1):224–251. doi: 10.1016/0003-9861(66)90029-4. [DOI] [PubMed] [Google Scholar]
  9. Kraml J., Mahler H. R. Biochemical correlates of respiratory deficiency. 8. A precipitating antiserum against cytochrome oxidase of yeast and its use in the study of respiratory deficiency. Immunochemistry. 1967 Jul;4(4):213–226. doi: 10.1016/0019-2791(67)90182-6. [DOI] [PubMed] [Google Scholar]
  10. LOWRY O. H., ROSEBROUGH N. J., FARR A. L., RANDALL R. J. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951 Nov;193(1):265–275. [PubMed] [Google Scholar]
  11. Linnane A. W., Stewart P. R. The inhibition of chlorophyll formation in Euglena by antibiotics which inhibit bacterial and mitochondrial protein synthesis. Biochem Biophys Res Commun. 1967 Jun 9;27(5):511–516. doi: 10.1016/s0006-291x(67)80016-0. [DOI] [PubMed] [Google Scholar]
  12. MAHLER H. R., MACKLER B., SLONIMSKI P. P., GRANDCHAMP S. BIOCHEMICAL CORRELATES OF RESPIRATORY DEFICIENCY. II. ANTIGENIC PROPERTIES OF RESPIRATORY PARTICLES. Biochemistry. 1964 May;3:677–682. doi: 10.1021/bi00893a013. [DOI] [PubMed] [Google Scholar]
  13. Menon I. A., Shemin D. Concurrent decrease of enzymic activities concerned with the synthesis of coenzyme B 12 and of propionic acid in propionibacteria. Arch Biochem Biophys. 1967 Aug;121(2):304–310. doi: 10.1016/0003-9861(67)90080-x. [DOI] [PubMed] [Google Scholar]
  14. Muthukrishnan S., Padmanaban G., Sarma P. S. Regulation of heme biosynthesis in Neurspora crassa. J Biol Chem. 1969 Aug 10;244(15):4241–4246. [PubMed] [Google Scholar]
  15. Polakis E. S., Bartley W. Changes in the enzyme activities of Saccharomyces cerevisiae during aerobic growth on different carbon sources. Biochem J. 1965 Oct;97(1):284–297. doi: 10.1042/bj0970284. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Porra R. J., Irving E. A. Tetrapyrrole biosynthesis in plant and yeast organelles. Biochem J. 1970 Feb;116(4):42P–42P. doi: 10.1042/bj1160042pa. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Tschudy D. P., Waxman A., Collins A. Oscillations of hepatic delta-aminolevulinic acid synthetase produced by estrogen: a possible role of "rebound induction" in biological clock mechanisms. Proc Natl Acad Sci U S A. 1967 Nov;58(5):1944–1948. doi: 10.1073/pnas.58.5.1944. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Tuppy H., Birkmayer G. D. Cytochrome oxidase apoprotein in "petite" mutant yeast mitochondria. Reconstitution of cytochrome oxidase by combining apoprotein with cytohemin. Eur J Biochem. 1969 Mar;8(2):237–243. doi: 10.1111/j.1432-1033.1969.tb00520.x. [DOI] [PubMed] [Google Scholar]
  19. YOTSUYANAGI Y. [Study of yeast mitochondria. I. Variations in mitochondrial ultrastructure during the aerobic growth cycle]. J Ultrastruct Res. 1962 Aug;7:121–140. doi: 10.1016/s0022-5320(62)80031-8. [DOI] [PubMed] [Google Scholar]

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