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. 1971 Mar;122(1):1–4. doi: 10.1042/bj1220001

Metabolic studies on retinoic acid in the rat

P R Sundaresan 1, H N Bhagavan 1
PMCID: PMC1176680  PMID: 4330965

Abstract

The nature of metabolites in the urine arising from differentially labelled retinoic acid was investigated after injection of physiological doses into retinol-deficient rats. Distribution of radioactivity after partition of urine into ether-soluble, acidic and water-soluble fractions revealed that there were at least six metabolites in urine. Of these, the major metabolite(s) was one lacking both C-14 and C-15 of retinoic acid. Enzymic or alkaline hydrolysis of acidic and water-soluble fractions did not release any retinoic acid, thus indicating that retinoyl β-glucuronide was not present in urine in significant amounts.

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Selected References

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