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. 1971 Apr;122(2):135–138. doi: 10.1042/bj1220135

Incorporation of label from d-β-hydroxy-[14C]butyrate and [3-14C]acetoacetate into amino acids in rat brain in vivo

Jill E Cremer 1
PMCID: PMC1176756  PMID: 5117566

Abstract

The metabolism of ketone bodies by rat brain was studied in vivo. Rats starved for 48h were given either d-β-hydroxy[3-14C]butyrate or [3-14C]acetoacetate by intravenous injection and killed after 3 or 10min. Total radioactivity in the acid-soluble material of the brain and the specific radioactivities of the brain amino acids glutamate, glutamine, aspartate and γ-aminobutyrate were determined. A group of fed animals were also given d-β-hydroxy[3-14C]butyrate. In the brains of all animals 14C was present in the acid-soluble material and the specific radioactivity of glutamate was greater than that of glutamine.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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