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. 1971 Oct;124(4):809–813. doi: 10.1042/bj1240809

Tentative identification of a vasopressin–neurophysin and an oxytocin–neurophysin in the rat

G D Burford 1, C W Jones 1, B T Pickering 1
PMCID: PMC1177259  PMID: 5131737

Abstract

1. Rat neurohypophysial extracts have been examined by polyacrylamide-gel electrophoresis. 2. Three of the proteins were tentatively identified as neurophysins by their acidic nature and their disappearance after dehydration of the animals. 3. These proteins were radioactive 24h after intracisternal injection of [35S]cysteine. 4. Two of the proteins were present in much greater quantities than the third, and these two were present in the gland in the same ratio as the hormones vasopressin and oxytocin. 5. One of these proteins was absent from glands of rats homozygous for diabetes insipidus but present in heterozygous animals. 6. It is suggested that these two proteins are the vasopressin–neurophysin and oxytocin–neurophysin of the rat.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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