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. 1973 Jan;132(1):125–128. doi: 10.1042/bj1320125

Glucose metabolism in the rat small intestine: the effect of glucose analogues on hexokinase activity (Short Communication)

Gwyneth M Jones 1, R John Mayer 1,*
PMCID: PMC1177568  PMID: 4722895

Abstract

The effect of intubation of starved rats with solutions of glucose, 3-O-methylglucose, mannose, 2-deoxyglucose and sorbitol on the subcellular location of hexokinase in the mucosa of the small intestine was studied. Glucose, 3-O-methylglucose and mannose caused the soluble hexokinase activity to rise to a value similar to that found in fed animals, whereas sorbitol and 2-deoxyglucose caused smaller increases.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. CRANE R. K., SOLS A. The association of hexokinase with particulate fractions of brain and other tissue homogenates. J Biol Chem. 1953 Jul;203(1):273–292. [PubMed] [Google Scholar]
  2. Campbell P. N., Davson H. Absorption of 3-methylglucose from the small intestine of the rat and the cat. Biochem J. 1948;43(3):426–429. doi: 10.1042/bj0430426. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Elsas L. J., 2nd, Macdonell R. C., Jr Hexose transport and phosphorylation by hamster kidney cortex slices and averted jejunal rings. Biochim Biophys Acta. 1972 Mar 17;255(3):948–959. doi: 10.1016/0005-2736(72)90405-1. [DOI] [PubMed] [Google Scholar]
  4. Grossbard L., Schimke R. T. Multiple hexokinases of rat tissues. Purification and comparison of soluble forms. J Biol Chem. 1966 Aug 10;241(15):3546–3560. [PubMed] [Google Scholar]
  5. Hübscher G., West G. R., Brindley D. N. Studies on the fractionation of mucosal homogenates from the small intestine. Biochem J. 1965 Dec;97(3):629–642. doi: 10.1042/bj0970629. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Mayer R. J., Shakespeare P., Hübscher G. Glucose metabolism in the mucosa of the small intestine. Changes of hexokinase activity during perfusion of the proximal half of rat small intestine. Biochem J. 1970 Jan;116(1):43–48. doi: 10.1042/bj1160043. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Rose I. A., Warms J. V. Mitochondrial hexokinase. Release, rebinding, and location. J Biol Chem. 1967 Apr 10;242(7):1635–1645. [PubMed] [Google Scholar]
  8. SOLS A., CRANE R. K. Substrate specificity of brain hexokinase. J Biol Chem. 1954 Oct;210(2):581–595. [PubMed] [Google Scholar]
  9. SOLS A. The hexokinase activity of the intestinal mucosa. Biochim Biophys Acta. 1956 Jan;19(1):144–152. doi: 10.1016/0006-3002(56)90396-1. [DOI] [PubMed] [Google Scholar]
  10. Shakespeare P., Srivastava L. M., Hübscher G. Glucose metabolism in the mucosa of the small intestine. The effect of glucose on hexokinase activity. Biochem J. 1969 Jan;111(1):63–67. doi: 10.1042/bj1110063. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Srivastava L. M., Hübscher G. Glucose metabolism in the mucosa of the small intestine. Glycolysis in subcellular preparations from the cat and rat. Biochem J. 1966 Aug;100(2):458–466. doi: 10.1042/bj1000458. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Srivastava L. M., Shakespeare P., Hübscher G. Glucose metabolism in the mucosa of the small intestine. A study of hexokinase activity. Biochem J. 1968 Aug;109(1):35–42. doi: 10.1042/bj1090035. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. WILSON T. H., LANDAU B. R. Specificity of sugar transport by the intestine of the hamster. Am J Physiol. 1960 Jan;198:99–102. doi: 10.1152/ajplegacy.1960.198.1.99. [DOI] [PubMed] [Google Scholar]
  14. WILSON T. H., LIN E. C., LANDAU B. R., JORGENSEN C. R. Intestinal transport of sugars and amino acids. Fed Proc. 1960 Dec;19:870–875. [PubMed] [Google Scholar]
  15. Wilson J. E. Brain hexokinase. A proposed relation between soluble-particulate distribution and activity in vivo. J Biol Chem. 1968 Jul 10;243(13):3640–3647. [PubMed] [Google Scholar]

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