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. 1973 Jun;134(2):629–635. doi: 10.1042/bj1340629

Determination and significance of l-tyrosine O-sulphate and its deaminated metabolites in normal human and mouse urine

Paul M Hext 1, Susan Thomas 1, Frederick A Rose 1, Kenneth S Dodgson 1
PMCID: PMC1177851  PMID: 16742825

Abstract

Methods were developed for the determination of the O-sulphate esters of l-tyrosine, p-hydroxyphenylpyruvate, p-hydroxyphenylacetate and p-hydroxybenzaldehyde in human urine. The amounts of these esters normally present in human female urine were determined. The quantities and specific radioactivities of l-tyrosine O-sulphate and p-hydroxyphenylpyruvate O-sulphate in mouse urine after labelled tyrosine had been fed were determined and were consistent with the hypothesis that the sole source of p-hydroxyphenylpyruvate O-sulphate was l-tyrosine O-sulphate. It is suggested that the turnover of known polypeptides containing l-tyrosine O-sulphate residues can account for only a portion of the quantities of the ester and its metabolite(s) that are present in normal female human urine.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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