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. 1973 Jun;134(2):671–672. doi: 10.1042/bj1340671

Acceleration of gluconeogenesis from lactate by lysine (Short Communication)

Neal W Cornell 1, Patricia Lund 1, Reginald Hems 1, Hans A Krebs 1
PMCID: PMC1177859  PMID: 16742833

Abstract

l-Lysine (2mm) causes an increase (mean 60%) in the rate of gluconeogenesis from lactate in isolated liver cells. The effect is of a catalytic nature. No other amino acid has the same effect, though ornithine is slightly active. The effect is additional to the stimulatory effects of oleate and of dibutyryl cyclic AMP.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Berry M. N., Friend D. S. High-yield preparation of isolated rat liver parenchymal cells: a biochemical and fine structural study. J Cell Biol. 1969 Dec;43(3):506–520. doi: 10.1083/jcb.43.3.506. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Exton J. H., Park C. R. Control of gluconeogenesis in liver. II. Effects of glucagon, catecholamines, and adenosine 3',5'-monophosphate on gluconeogenesis in the perfused rat liver. J Biol Chem. 1968 Aug 25;243(16):4189–4196. [PubMed] [Google Scholar]
  3. Hems R., Ross B. D., Berry M. N., Krebs H. A. Gluconeogenesis in the perfused rat liver. Biochem J. 1966 Nov;101(2):284–292. doi: 10.1042/bj1010284. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Krebs H. A. Rate control of the tricarboxylic acid cycle. Adv Enzyme Regul. 1970;8:335–353. doi: 10.1016/0065-2571(70)90028-2. [DOI] [PubMed] [Google Scholar]
  5. Ross B. D., Hems R., Freedland R. A., Krebs H. A. Carbohydrate metabolism of the perfused rat liver. Biochem J. 1967 Nov;105(2):869–875. doi: 10.1042/bj1050869. [DOI] [PMC free article] [PubMed] [Google Scholar]

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