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. 1971 Nov;125(1):235–240. doi: 10.1042/bj1250235

Biosynthesis of the carbohydrate portions of immunoglobulin M

R M E Parkhouse 1,2, Fritz Melchers 1,2,*
PMCID: PMC1178045  PMID: 5158908

Abstract

Incorporations of radioactive mannose, galactose and fucose into MOPC 104E mouse plasma-cell tumour suspensions suggest a stepwise addition of carbohydrate residues to immunoglobulin M (IgM) during the process of secretion. Mannose and glucosamine residues are added at an early stage, whereas galactose and fucose are added just before, or at the time that, IgM leaves the cell. Free light chains secreted in excess by the same tumour cells incubated with mannose, galactose or fucose contained barely detectable amounts of radioactivity.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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