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. 1972 Apr;127(3):553–559. doi: 10.1042/bj1270553

The relationship between δ-aminolaevulinate synthetase induction and the concentrations of cytochrome P-450 and catalase in rat liver

M R Satyanarayana Rao 1, K Malathi 1, G Padmanaban 1
PMCID: PMC1178697  PMID: 5076198

Abstract

The porphyrinogenic drug 2-allyl-2-isopropylacetamide causes the degradation of microsomal cytochrome P-450 and inhibits the synthesis of catalase in rat liver. The inhibition of catalase synthesis follows the induction of δ-aminolaevulinate synthetase and the consequent overproduction of haem. The allylisopropylacetamide-mediated breakdown of cytochrome P-450 is a rapid event and has a reciprocal relationship to the pattern of δ-aminolaevulinate synthetase induction. Breakdown of cytochrome P-450 appears to be one of the conditions leading to the `derepression' of δ-aminolaevulinate synthetase.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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