Fig. 4.

Lifetime risk of developing a second tumor in R337H and non-R337H males and females. A) Ages of male and female individuals at second tumor diagnosis (Wilcoxon tests); B) Kaplan–Meier curves showing the cumulative risks of male and female individuals (R337H and non-R337H carriers) of developing a second tumor (pairwise log-rank tests; FDR adjusted p-values); C) and D) Proportions of additional tumors diagnosed in R337H and non-R337H C) female and D) male carriers (from second to last diagnosis). P-value representation: “∗”: p < 0.05; “∗∗”: p < 0.01; ns: not significant.