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. 1970 Apr;117(3):539–542. doi: 10.1042/bj1170539

The stereochemistry of hydrogen elimination from C-7 in cholesterol and ergosterol biosynthesis

M Akhtar 1, A D Rahimtula 1, D C Wilton 1
PMCID: PMC1178958  PMID: 5419748

Abstract

The synthesis of [7α-3H]lanosterol is described. It is shown that in the conversion of [7α-3H,26,27-14C2]lanosterol into cholesterol by a rat liver system, it is the 7β-hydrogen atom that is predominantly removed. On the other hand, the conversion of doubly labelled lanosterol into ergosterol by whole yeast cells results in the loss of the 7α-hydrogen atom. These results therefore suggest that the C-7 hydrogen atoms with opposite stereochemistry are labilized by the rat liver and the yeast Δ8–Δ7 steroid isomerases.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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