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. 1970 May;117(5):921–927. doi: 10.1042/bj1170921

Aspects of the stereochemistry of torularhodin biosynthesis

R E Tefft 1,*, T W Goodwin 1,†, K L Simpson 1,*
PMCID: PMC1179051  PMID: 5465554

Abstract

1. The incorporation of [2-14C]acetate, [2-14C]mevalonic acid and [2-14C,2-3H2]-mevalonic acid into torulene and torularhodin by Rhodotorula rubra and Rhodotorula glutinis was studied. 2. A recovery of 14.3% of the label was obtained on decarboxylation of the torularhodin biosynthesized from [2-14C]mevalonic acid. 3. An analysis of the 3H/14C ratio in torularhodin gave a value of 9.44:8. 4. These results, obtained by different experimental techniques, show that the reactions in the conversion of the dimethyl group of isopentenyl pyrophosphate into the 16′,17′-position of torularhodin must be free from randomization. A mechanism for the isomerization of isopentenyl pyrophosphate to dimethylallyl pyrophosphate is suggested.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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