Abstract
1. A single glucose meal stimulated the incorporation of acetate into fatty acids in liver slices. If the glucose was added in vitro, it had no effect. Fructose and glycerol in vitro markedly stimulated fatty acid synthesis from acetate. Fructose and glycerol probably by-passed a rate-controlling reaction between glucose and triose phosphate. This reaction may have been stimulated by glucose administered in vivo. 2. The stimulation of fatty acid synthesis caused by fructose did not require the synthesis of enzyme, thus indicating that fatty acid-synthesizing enzymes were present in a latent form in the livers from unfed chicks.
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Selected References
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- Eberhagen D., Mrosek H., Pranzelt N., Seitz W. Uber das Syntheseprodukt der Fettsäure-Synthetase aus den Lebern verschiedener Wirbeltiere. Hoppe Seylers Z Physiol Chem. 1969 Apr;350(4):407–410. [PubMed] [Google Scholar]
- GOLDFINE H., BLOCH K. On the origin of unsaturated fatty acids in clostridia. J Biol Chem. 1961 Oct;236:2596–2601. [PubMed] [Google Scholar]
- Goodridge A. G. Conversion of[U-14C]glucose into carbon dioxide, glycogen, cholesterol and fatty acids in liver slices from embryonic and growing chicks. Biochem J. 1968 Jul;108(4):655–661. doi: 10.1042/bj1080655. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Heman R. H., Zakim D. Fructose metabolism. I. The fructose metabolic pathway. Am J Clin Nutr. 1968 Mar;21(3):245–249. doi: 10.1093/ajcn/21.3.245. [DOI] [PubMed] [Google Scholar]
- TIETZ A. Studies on the mechanism of fatty acid synthesis. IV. Biosynthesis of long-chain fatty acids in a reconstructed system of soluble enzymes from chicken liver. Biochim Biophys Acta. 1957 Aug;25(2):303–310. doi: 10.1016/0006-3002(57)90473-0. [DOI] [PubMed] [Google Scholar]
- WOOL I. G., MOYER A. N. EFFECT OF ACTINOMYCIN AND INSULIN ON THE METABOLISM OF ISOLATED RAT DIAPHRAGM. Biochim Biophys Acta. 1964 Oct 16;91:248–256. doi: 10.1016/0926-6550(64)90248-8. [DOI] [PubMed] [Google Scholar]