Abstract
1. Oral administration of trans- and cis-2-methyldecalin to rabbits increased the urinary glucuronide content. 2. The metabolite of the trans isomer was isolated and shown to be either trans-cis-6- or -7-methyl-2-decalol. The metabolite of the cis isomer was shown to be a 1:1 mixture of cis-6-methyl-2-decalol and cis-7-methyl-2-decalols, but the conformations of the hydroxyl groups were not determined. 3. It was concluded that a specific hydroxylase was responsible for the oxidations observed, and that this hydroxylase could be responsible for the metabolic oxidation of other simple alicyclic compounds.
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Selected References
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