Abstract
The concentration and composition of phospholipids and mitotic activity in regenerating rat liver were studied. (1) The total amount of liver phospholipid increased approximately linearly during 48h after operation but without change in the relative concentrations of individual phospholipids. (2) The appearance of mitoses 30h after operation was accompanied by an increased incorporation of 32P into the liver phospholipids. (3) The regenerating livers incorporated a higher percentage of the label into the phosphatidylserine+phosphatidylinositol fraction than those of control rats. The percentage of the label incorporated into phosphatidylethanolamine in these livers increased but decreased in the phosphatidylcholine.
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Selected References
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- Arvidson G. A. Structural and metabolic heterogeneity of rat liver glycerophosphatides. Eur J Biochem. 1968 May;4(4):478–486. doi: 10.1111/j.1432-1033.1968.tb00237.x. [DOI] [PubMed] [Google Scholar]
- CATER D. B., HOLMES B. E., MEE L. K. Cell division and nucleic acid synthesis in the regenerating liver of the rat. Acta radiol. 1956 Nov;46(5):655–667. doi: 10.3109/00016925609171460. [DOI] [PubMed] [Google Scholar]
- Daniels M. J. Lipid synthesis in relation to the cell cycle of Bacillus megaterium KM and Escherichia coli. Biochem J. 1969 Dec;115(4):697–701. doi: 10.1042/bj1150697. [DOI] [PMC free article] [PubMed] [Google Scholar]
- FOLCH J., LEES M., SLOANE STANLEY G. H. A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem. 1957 May;226(1):497–509. [PubMed] [Google Scholar]
- Fex G. The metabolism of liver and plasma lipids after partial hepatectomy in the rat. Biochim Biophys Acta. 1970 May 5;202(3):415–425. doi: 10.1016/0005-2760(70)90112-8. [DOI] [PubMed] [Google Scholar]
- Glende E. A., Jr, Morgan W. S. Alteration in liver lipid and lipid fatty acid composition after partial hepatectomy in the rat. Exp Mol Pathol. 1968 Apr;8(2):190–200. doi: 10.1016/0014-4800(68)90015-4. [DOI] [PubMed] [Google Scholar]
- Gurr M. I., Prottey C., Hawthorne J. N. The phospholipids of liver-cell fractions. II. Incorporation of [32P]orthophosphate in vivo in normal and regenerating rat liver. Biochim Biophys Acta. 1965 Oct 4;106(2):357–370. [PubMed] [Google Scholar]
- JOHNSON R. M., ALBERT S. The uptake of radioactive phosphorus by rat liver following partial hepatectomy. Arch Biochem Biophys. 1952 Feb;35(2):340–345. doi: 10.1016/s0003-9861(52)80014-1. [DOI] [PubMed] [Google Scholar]
- McMurray W. C., Dawson R. M. Phospholipid exchange reactions within the liver cell. Biochem J. 1969 Mar;112(1):91–108. doi: 10.1042/bj1120091. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Menyhárt J., Simon L. Circulatory events accompanying liver regeneration following partial hepatectomy. Acta Physiol Acad Sci Hung. 1966;30(2):169–174. [PubMed] [Google Scholar]
- OLIVECRONA T. The metabolism of 1-C-14-palmitic acid in the rat. Acta Physiol Scand. 1962 Mar-Apr;54:295–305. doi: 10.1111/j.1748-1716.1962.tb02353.x. [DOI] [PubMed] [Google Scholar]
- Skipski V. P., Peterson R. F., Barclay M. Quantitative analysis of phospholipids by thin-layer chromatography. Biochem J. 1964 Feb;90(2):374–378. doi: 10.1042/bj0900374. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Tata J. R. Co-ordination between membrane phospholipid synthesis and accelerated biosynthesis of cytoplasmic ribonucleic acid and protein. Biochem J. 1970 Feb;116(4):617–630. doi: 10.1042/bj1160617. [DOI] [PMC free article] [PubMed] [Google Scholar]
- WEINBREN K. Regeneration of the liver. Gastroenterology. 1959 Nov;37:657–678. [PubMed] [Google Scholar]