Skip to main content
NCBI home page
The Journal of Physiology logoLink to The Journal of Physiology
. 1991 Nov;443:421–429. doi: 10.1113/jphysiol.1991.sp018841

Possible involvement of prostaglandins in psychological stress-induced responses in rats.

A Morimoto 1, T Watanabe 1, K Morimoto 1, T Nakamori 1, N Murakami 1
PMCID: PMC1179849  PMID: 1668342

Abstract

1. We investigated the effect of pre-treatment with intraperitoneal (I.P.) injection of indomethacin, an inhibitor of prostaglandin synthesis, on psychological stress-induced responses including cardiovascular, thermoregulatory and hormonal responses in free-moving rats. 2. Psychological stress was induced by cage-switch stress. After the rats were placed in the novel environment, blood pressure, heart rate and body temperature significantly increased. Plasma levels of adrenocorticotrophic hormone (ACTH) and prostaglandin E2 were significantly higher 30 min after exposure to stress, in comparison to normal levels. 3. Pre-treatment with I.P. indomethacin significantly suppressed the increases in body temperature induced by cage-switch stress, but had no effect on increases in blood pressure and heart rate induced by this stress. Indomethacin also significantly suppressed the increases in the plasma levels of ACTH and prostaglandin E2 induced by cage-switch stress. 4. The present results suggest that prostaglandins are involved in the development of hyperthermia and the ACTH response induced by psychological stress.

Full text

PDF
421

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ATKINS E. Pathogenesis of fever. Physiol Rev. 1960 Jul;40:580–646. doi: 10.1152/physrev.1960.40.3.580. [DOI] [PubMed] [Google Scholar]
  2. Breder C. D., Dinarello C. A., Saper C. B. Interleukin-1 immunoreactive innervation of the human hypothalamus. Science. 1988 Apr 15;240(4850):321–324. doi: 10.1126/science.3258444. [DOI] [PubMed] [Google Scholar]
  3. Busija D. W., Leffler C. W. Eicosanoid synthesis elicited by norepinephrine in piglet parietal cortex. Brain Res. 1987 Feb 17;403(2):243–248. doi: 10.1016/0006-8993(87)90061-8. [DOI] [PubMed] [Google Scholar]
  4. Cannon J. G., Kluger M. J. Endogenous pyrogen activity in human plasma after exercise. Science. 1983 May 6;220(4597):617–619. doi: 10.1126/science.6836306. [DOI] [PubMed] [Google Scholar]
  5. Dinarello C. A. Interleukin-1. Rev Infect Dis. 1984 Jan-Feb;6(1):51–95. doi: 10.1093/clinids/6.1.51. [DOI] [PubMed] [Google Scholar]
  6. Eguchi N., Hayashi H., Urade Y., Ito S., Hayaishi O. Central action of prostaglandin E2 and its methyl ester in the induction of hyperthermia after their systemic administration in urethane-anesthetized rats. J Pharmacol Exp Ther. 1988 Nov;247(2):671–679. [PubMed] [Google Scholar]
  7. Fontana A., Kristensen F., Dubs R., Gemsa D., Weber E. Production of prostaglandin E and an interleukin-1 like factor by cultured astrocytes and C6 glioma cells. J Immunol. 1982 Dec;129(6):2413–2419. [PubMed] [Google Scholar]
  8. Hedqvist P. Basic mechanisms of prostaglandin action on autonomic neurotransmission. Annu Rev Pharmacol Toxicol. 1977;17:259–279. doi: 10.1146/annurev.pa.17.040177.001355. [DOI] [PubMed] [Google Scholar]
  9. Kluger M. J., O'Reilly B., Shope T. R., Vander A. J. Further evidence that stress hyperthermia is a fever. Physiol Behav. 1987;39(6):763–766. doi: 10.1016/0031-9384(87)90263-0. [DOI] [PubMed] [Google Scholar]
  10. Milton A. S., Wendlandt S. Effects on body temperature of prostaglandins of the A, E and F series on injection into the third ventricle of unanaesthetized cats and rabbits. J Physiol. 1971 Oct;218(2):325–336. doi: 10.1113/jphysiol.1971.sp009620. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Moberg G. P. Site of action of endotoxins on hypothalamic-pituitary-adrenal axis. Am J Physiol. 1971 Feb;220(2):397–400. doi: 10.1152/ajplegacy.1971.220.2.397. [DOI] [PubMed] [Google Scholar]
  12. Morimoto A., Murakami N., Nakamori T., Sakata Y., Watanabe T. Possible involvement of prostaglandin E in development of ACTH response in rats induced by human recombinant interleukin-1. J Physiol. 1989 Apr;411:245–256. doi: 10.1113/jphysiol.1989.sp017571. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Morimoto A., Murakami N., Nakamori T., Watanabe T. Evidence for separate mechanisms of induction of biphasic fever inside and outside the blood-brain barrier in rabbits. J Physiol. 1987 Feb;383:629–637. doi: 10.1113/jphysiol.1987.sp016433. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Morimoto A., Murakami N., Nakamori T., Watanabe T. Multiple control of fever production in the central nervous system of rabbits. J Physiol. 1988 Mar;397:269–280. doi: 10.1113/jphysiol.1988.sp017000. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Morimoto A., Watanabe T., Myogin T., Murakami N. Restraint induced stress elicits acute-phase response in rabbits. Pflugers Arch. 1987 Nov;410(4-5):554–556. doi: 10.1007/BF00586538. [DOI] [PubMed] [Google Scholar]
  16. Singer R., Harker C. T., Vander A. J., Kluger M. J. Hyperthermia induced by open-field stress is blocked by salicylate. Physiol Behav. 1986;36(6):1179–1182. doi: 10.1016/0031-9384(86)90497-x. [DOI] [PubMed] [Google Scholar]
  17. Watanabe T., Morimoto A., Morimoto K., Nakamori T., Murakami N. ACTH release induced in rats by noradrenaline is mediated by prostaglandin E2. J Physiol. 1991 Nov;443:431–439. doi: 10.1113/jphysiol.1991.sp018842. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Watanabe T., Morimoto A., Sakata Y., Long N. C., Murakami N. Prostaglandin E2 is involved in adrenocorticotrophic hormone release during swimming exercise in rats. J Physiol. 1991 Feb;433:719–725. doi: 10.1113/jphysiol.1991.sp018452. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Watanabe T., Morimoto A., Sakata Y., Murakami N. ACTH response induced by interleukin-1 is mediated by CRF secretion stimulated by hypothalamic PGE. Experientia. 1990 May 15;46(5):481–484. doi: 10.1007/BF01954238. [DOI] [PubMed] [Google Scholar]
  20. al-Damluji S. Adrenergic mechanisms in the control of corticotrophin secretion. J Endocrinol. 1988 Oct;119(1):5–14. doi: 10.1677/joe.0.1190005. [DOI] [PubMed] [Google Scholar]

Articles from The Journal of Physiology are provided here courtesy of The Physiological Society

RESOURCES