Abstract
1. In cardiac strips of the monkey ventricle which included a section of coronary artery (cardiac preparation), a depolarizing response, which appeared to be an excitatory junction potential (EJP), and a hyperpolarizing response were observed from the coronary artery smooth muscles when an action potential was generated in cardiac muscle by the application of electrical stimulation to the cardiac muscle alone. 2. In an isolated preparation of the coronary artery dissected from the ventricle (arterial preparation), similar responses, an EJP and a hyperpolarizing response, could be evoked by electrical stimulation. 3. In the cardiac preparation, the threshold of electrical stimulation for generation of the cardiac action potential and for production of an electrical response in the vascular smooth muscle were the same. 4. The EJP and the hyperpolarizing responses of the smooth muscle of the coronary artery ceased or were weakened by elimination of the adventitial connective tissues and endothelium, respectively, in both the cardiac preparation and the coronary artery preparation. 5. These results indicate that the action potential of cardiac muscle generated by electrical stimulation activates the nerves and the vascular endothelium, which, in turn, produce an EJP and a hyperpolarizing response of the coronary artery smooth muscle, respectively.
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Selected References
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- Busse R., Fichtner H., Lückhoff A., Kohlhardt M. Hyperpolarization and increased free calcium in acetylcholine-stimulated endothelial cells. Am J Physiol. 1988 Oct;255(4 Pt 2):H965–H969. doi: 10.1152/ajpheart.1988.255.4.H965. [DOI] [PubMed] [Google Scholar]
- Bény J. L., Brunet P. C. Electrophysiological and mechanical effects of substance P and acetylcholine on rabbit aorta. J Physiol. 1988 Apr;398:277–289. doi: 10.1113/jphysiol.1988.sp017042. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Casteels R., Kitamura K., Kuriyama H., Suzuki H. Excitation-contraction coupling in the smooth muscle cells of the rabbit main pulmonary artery. J Physiol. 1977 Sep;271(1):63–79. doi: 10.1113/jphysiol.1977.sp011990. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Feigl E. O. Coronary physiology. Physiol Rev. 1983 Jan;63(1):1–205. doi: 10.1152/physrev.1983.63.1.1. [DOI] [PubMed] [Google Scholar]
- Komori K., Lorenz R. R., Vanhoutte P. M. Nitric oxide, ACh, and electrical and mechanical properties of canine arterial smooth muscle. Am J Physiol. 1988 Jul;255(1 Pt 2):H207–H212. doi: 10.1152/ajpheart.1988.255.1.H207. [DOI] [PubMed] [Google Scholar]
- Komori K., Suzuki H. Electrical responses of smooth muscle cells during cholinergic vasodilation in the rabbit saphenous artery. Circ Res. 1987 Oct;61(4):586–593. doi: 10.1161/01.res.61.4.586. [DOI] [PubMed] [Google Scholar]
- Mekata F. Current spread in the smooth muscle of the rabbit aorta. J Physiol. 1974 Oct;242(1):143–155. doi: 10.1113/jphysiol.1974.sp010698. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Mekata F. Different electrical responses of outer and inner muscle of rabbit carotid artery to noradrenaline and nerves. J Physiol. 1984 Jan;346:589–598. doi: 10.1113/jphysiol.1984.sp015043. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Mekata F. Electrical current-induced contraction in the smooth muscle of the rabbit aorta. J Physiol. 1981 Aug;317:149–161. doi: 10.1113/jphysiol.1981.sp013818. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Mekata F. Electrophysiological studies of the smooth muscle cell membrane of the rabbit common carotid artery. J Gen Physiol. 1971 Jun;57(6):738–751. doi: 10.1085/jgp.57.6.738. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Mekata F. The role of hyperpolarization in the relaxation of smooth muscle of monkey coronary artery. J Physiol. 1986 Feb;371:257–265. doi: 10.1113/jphysiol.1986.sp015972. [DOI] [PMC free article] [PubMed] [Google Scholar]