Skip to main content
PMC home page
Biophysical Journal logoLink to Biophysical Journal
. 1997 Dec;73(6):2965–2971. doi: 10.1016/S0006-3495(97)78325-5

Current noise spectrum and capacitance due to the membrane motor of the outer hair cell: theory.

K H Iwasa 1
PMCID: PMC1181202  PMID: 9414211

Abstract

The voltage-dependent motility of the outer hair cell is based on a membrane motor densely distributed in the lateral membrane. The gating charge of the membrane motor is manifested as a bell-shaped membrane potential dependence of the membrane capacitance. In this paper it is shown that movements of the gating charge should produce a high-pass current noise described by an inverse Lorentzian similar to the one shown by Kolb and Läuger for ion carriers. The frequency dependence of the voltage-dependent capacitance is also derived. These derivations are based on membrane motor models with two or three states. These two models lead to similar predictions on the capacitance and current noise. It is expected that the examination of the spectral properties of these quantities would be a useful means of determining the relaxation time for conformational transitions of the membrane motor.

Full text

PDF
2965

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ashmore J. F. Forward and reverse transduction in the mammalian cochlea. Neurosci Res Suppl. 1990;12:S39–S50. doi: 10.1016/0921-8696(90)90007-p. [DOI] [PubMed] [Google Scholar]
  2. Benz R., Kolb H. A., Läuger P., Stark G. Ion carriers in planar bilayers: relaxation techniques and noise analysis. Methods Enzymol. 1989;171:274–286. doi: 10.1016/s0076-6879(89)71017-x. [DOI] [PubMed] [Google Scholar]
  3. Brownell W. E., Bader C. R., Bertrand D., de Ribaupierre Y. Evoked mechanical responses of isolated cochlear outer hair cells. Science. 1985 Jan 11;227(4683):194–196. doi: 10.1126/science.3966153. [DOI] [PubMed] [Google Scholar]
  4. Conti F., Stühmer W. Quantal charge redistributions accompanying the structural transitions of sodium channels. Eur Biophys J. 1989;17(2):53–59. doi: 10.1007/BF00257102. [DOI] [PubMed] [Google Scholar]
  5. Dallos P., Evans B. N. High-frequency motility of outer hair cells and the cochlear amplifier. Science. 1995 Mar 31;267(5206):2006–2009. doi: 10.1126/science.7701325. [DOI] [PubMed] [Google Scholar]
  6. Fernández J. M., Taylor R. E., Bezanilla F. Induced capacitance in the squid giant axon. Lipophilic ion displacement currents. J Gen Physiol. 1983 Sep;82(3):331–346. doi: 10.1085/jgp.82.3.331. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Gale J. E., Ashmore J. F. Charge displacement induced by rapid stretch in the basolateral membrane of the guinea-pig outer hair cell. Proc Biol Sci. 1994 Mar 22;255(1344):243–249. doi: 10.1098/rspb.1994.0035. [DOI] [PubMed] [Google Scholar]
  8. Heinemann S. H., Conti F. Nonstationary noise analysis and application to patch clamp recordings. Methods Enzymol. 1992;207:131–148. doi: 10.1016/0076-6879(92)07009-d. [DOI] [PubMed] [Google Scholar]
  9. Holley M. C., Ashmore J. F. On the mechanism of a high-frequency force generator in outer hair cells isolated from the guinea pig cochlea. Proc R Soc Lond B Biol Sci. 1988 Jan 22;232(1269):413–429. doi: 10.1098/rspb.1988.0004. [DOI] [PubMed] [Google Scholar]
  10. Housley G. D., Ashmore J. F. Ionic currents of outer hair cells isolated from the guinea-pig cochlea. J Physiol. 1992 Mar;448:73–98. doi: 10.1113/jphysiol.1992.sp019030. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Iwasa K. H. A membrane motor model for the fast motility of the outer hair cell. J Acoust Soc Am. 1994 Oct;96(4):2216–2224. doi: 10.1121/1.410094. [DOI] [PubMed] [Google Scholar]
  12. Iwasa K. H., Adachi M. Force generation in the outer hair cell of the cochlea. Biophys J. 1997 Jul;73(1):546–555. doi: 10.1016/S0006-3495(97)78092-5. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Iwasa K. H. Effect of stress on the membrane capacitance of the auditory outer hair cell. Biophys J. 1993 Jul;65(1):492–498. doi: 10.1016/S0006-3495(93)81053-1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Iwasa K. H., Li M., Jia M. Can membrane proteins drive a cell? Biophys J. 1995 Apr;68(4 Suppl):214S–214S. [PMC free article] [PubMed] [Google Scholar]
  15. Kakehata S., Santos-Sacchi J. Membrane tension directly shifts voltage dependence of outer hair cell motility and associated gating charge. Biophys J. 1995 May;68(5):2190–2197. doi: 10.1016/S0006-3495(95)80401-7. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Kolb H. A., Läuger P. Electrical noise from lipid bilayer membranes in the presence of hydrophobic ions. J Membr Biol. 1977 Dec 15;37(3-4):321–345. doi: 10.1007/BF01940938. [DOI] [PubMed] [Google Scholar]
  17. Santos-Sacchi J. Reversible inhibition of voltage-dependent outer hair cell motility and capacitance. J Neurosci. 1991 Oct;11(10):3096–3110. doi: 10.1523/JNEUROSCI.11-10-03096.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Szabo G. Electrical characteristics of ion transport in lipid bilayer membranes. Ann N Y Acad Sci. 1977 Dec 30;303:266–280. [PubMed] [Google Scholar]

Articles from Biophysical Journal are provided here courtesy of The Biophysical Society

RESOURCES