ARO’s 48th Annual MidWinter Meeting in Orlando 2025: podium and poster titles

Saturday, February 22, 2025

PS1. Presidential Symposium - Innovations, Challenges, and Personalization in Hearing Aids - Part 1

8:00 a.m. – 10:00 a.m.

Ocean Ballroom

Chair: Sunil Puria, Harvard Medical School

Listening through Hearing Aids with Thomas Edison

Mara Mills

New York University

Hearing Aids: What Works Well and What Can Be Improved

Brian Moore

University of Cambridge

Acoustic Scene-Aware and Auditory Model-Based Compensation Strategies

Torsten Dau

Technical University of Denmark

PS2. Presidential Symposium: Innovations, Challenges, and Personalization in Hearing Aids - Part 2

10:30 a.m. – 12:00 p.m.

Ocean Ballroom

Chair: Sunil Puria, Harvard Medical School

Personalized Hearing Loss Compensation for the Next-Generation Hearables and Hearing Aids

Sarah Verhulst

Ghent University

The Potential and Limitations of Applying DNN Based Algorithms for Speech Enhancement in Hearing Aids

Stefan Launer

Phonak

A Future of Hearing Aids

Jaipreet Virdi

University of Delaware

POSTER SESSION I

1:00 p.m. – 2:30 p.m.

Peninsula Ballroom

1. Hearing Aid Use and Speech Recognition in Older Adults: Preliminary Findings from a Six-Month Follow-Up

Liat Shechter-Shvartzman¹, Limor Lavie¹, Karen Banai^*1

¹ University of Haifa

2. Prosthesis Stimulation and the Flocculus Activity for Compensatory Saccade During the Head Impulse Test in the Vestibular Impaired Monkey

Yoshiko Kojima^*1, Leo Ling², James Phillips³

¹University of Washington, ²University of Washington, Oto-HNS, ³University of Washington, Oto-HNS Dept.

3. Complement Component C3 Accumulates in the Cochlea of CBA/CaJ Mice with Noise-Induced Hearing Loss

Zixu Guo^*1, Benjamin Seicol², Katy Garrity¹, Mina Shenouda¹, Shengyin Lin¹, Ruili Xie¹

¹The Ohio State University, ²Johns Hopkins Medicine

4. Optical Coherence Tomography Vibrometry in Low Signal-to-Noise Ratio Regime

Anes Macić^*1, Jong-Hoon Nam¹

¹ University of Rochester

5. Behavioral and Electrophysiological Measurements of Vowel Integration

Hanna Dolhopiatenko^*1, Yang-Soo Yoon², Waldo Nogueira³

¹Hannover Medical School anCluster of Excellence “Hearing4all”, ²Baylor University, ³Medical University Hannover and Cluster of Excellence “Hearing4all”

6. Towards Extracochlear Electric-Acoustic Stimulation of the Auditory System

Waldo Nogueira^*1, Aenne Grosskopf², Yixuan Zhang³, Daniel Kipping³, Benjamin Krueger³

¹Medical University of Hannover, ²Medical University Hannover, ³Hannover Medical School (MHH)

7. Frequency-Following Responses and Auditory Brainstem Responses in Individuals with a Vestibular Schwannoma

Laura Jacxsens^*1, Lana Biot¹, Emilie Cardon¹, Vincent Van Rompaey¹, Willem De Hertogh², Carles Escera³, Marc J.W. Lammers¹

¹Antwerp University Hospital, ²University of Antwerp, ³University of Barcelona

8. Protective Effects of Non-Invasive Mild Therapeutic Hypothermia in Preclinical Models of Blast-induced Hearing and Vestibular Loss

Federica M. Raciti^*1, Maria Fernanda Yepes², Suhrud Rajguru³

¹University of Miami, ²University of Miami Miller School of Medicine, ³University of Miami, Restor-Ear Devices LLC

9. Towards a Vestibular Epithelium Model: Modeling Quantal and Nonquantal Transmission in Dimorphic Afferent Neurons

Aravind Chenrayan Govindaraju^*1, Hannah Martin², Anna Lysakowski³, Ruth Anne Eatock², Robert Raphael¹

¹Rice University, ²University of Chicago, ³University of Illinois at Chicago

10. Refined Auditory-Visual Spatial Integration in Musicians is Accounted for by a Bayesian Prior Rather Than by Differences in Sensory Precision

Matthew O'Donohue^*1, Philippe Lacherez², Naohide Yamamoto²

¹Macquarie University, ²School of Psychology and Counselling, Queensland University of Technology

11. Vestibular Speed Advantage: New Insights into Ultrafast Nonquantal Synaptic Transmission in Vivo

Christopher Pastras^*1, Ian Curthoys², Mohsen Asadnia¹, David McAlpine³, Richard Rabbitt⁴, Daniel Brown⁵

¹Macquarie University, ²The University of Sydney, ³Macquarie University, ⁴University of Utah, ⁵Curtin University

12. The Wonder of Evolution: Optimization of Bone Layer Thickness between Turns to Minimize Cochlear Volume

Shota Toyoda¹, Akari IDE¹, Yasushi Horii^*1

¹ Kansai University

13. An Advanced Rule-Based Mobile Classifier for the Automated Diagnosis of Vestibular Disorders

Jung Sook Joo^*1, Cecilia A. Callejas Pastor², Hyun Tae Ryu¹, Yunseo Ku², Myung-Whan Suh¹

¹Seoul National University Hospital, ²Chungnam National University

14. Beta-band Brain Activity in the EEG Associated with the McGurk Effect: A Comparison of Normal-Hearing and CI Users

Hiroshi Yamazaki^*1, Yota Tobe², Masao Matsuhashi², Koichi Omori²

¹Kyoto University, ²Kyoto University Graduate School of Medicine

15. One Year Integrity and Biocompatibility Data of an Alginate Hydrogel Cochlear Implant Coating Under Simulated Inner Ear Conditions

Verena Scheper^*1, Thomas Rau¹, Thomas Lenarz¹, Jana Schwieger¹

¹ Hannover Medical School

16. Unlocking Regeneration of Auditory Neuroprogenitors Using the Phoenix Platform

Francis Rousset^*1, Stéphanie Sgroi², Lucie Oberhauser², Dimitrios Daskalou², Rebecca Sipione², Vincent Jaquet³, Pascal Senn²

¹University of Geneva, ²The inner ear and olfaction lab, University of Geneva, Faculty of Medicine, ³University of Geneva, Faculty of Medicine

17. An Auditory Cortex Network Represents Both Vocal Categories and Family Dialects

Estelle in \'t Zandt^*1, Dan Sanes²

¹NYU Center for Neural Science, ²New York University

18. Layer 6 is a Hub for Cholinergic Modulation in the Mouse Primary Auditory Cortex

Lucas Vattino^*1, Kameron Clayton², Troy Hackett³, Anne Takesian⁴, Daniel Polley¹

¹Eaton-Peabody Laboratories, Massachusetts Eye and Ear, Harvard Medical School, ²Eaton-Peabody Laboratories, Massachusetts Eye and Ear, ³Vanderbilt School of Medicine, ⁴Eaton-Peabody Laboratories, Massachusetts Eye and Ear - Harvard Medical School

19. Cochlear Health Assessments in Cochlear Implant Users Using Electrically Evoked Compound Action Potentials and Electrocochleography

Huib Versnel^*1, Dyan Ramekers², Ralf Boerboom¹, Alexander Hoetink¹, Hans Thomeer¹, Robert Stokroos¹

¹University Medical Center Utrecht, ²University Hospital Antwerp

20. Confidence in Sound Localization Reflects Calibrated Uncertainty Estimation

Lakshmi Narasimhan Govindarajan^*1, Sagarika Alavilli², Josh McDermott¹

¹Massachusetts Institute of Technology, ²Harvard University

21. Cochlear Neural Degeneration in Ménière’s Disease: A Temporal Bone Study

Charanjeet Kaur^*1, Peizhe Wu², Jennifer O\'Malley³, Charles Liberman³

¹Eaton-Peabody Laboratories, Massachusetts Eye and Ear, Harvard Medical School, ²Mass Eye and Ear, ³Massachusetts Eye and Ear

22. Evaluating the Impact of COVID-19 Vaccination on Sudden Sensorineural Hearing Loss Prognosis

Jacquelyn Golden^*1, Devin Kennedy¹, Matthew Wiefels¹, Addison Lana¹, Madeline Pyle¹, Michael Hoffer¹, Erin Williams¹

¹ Miller School of Medicine, University of Miami

23. Changes in Cochlear Microphonics and Electrode Impedances in Cochlear Implant Recipients in the First Year after Implantation

Imogen van Beurden¹, Frank Hartong¹, Ilse Haan¹, Saad Jwair¹, Dyan Ramekers², Robert Stokroos¹, Hans Thomeer¹, Huib Versnel^*1

¹University Medical Center Utrecht, ²University Hospital Antwerp

24. Oscillatory Activity Changes in Executive Attentional Networks Following Neurofeedback Training of Talker- And Space-Based Selective Attention

Hwan Shim^*1, Jusung Ham², Akira Takeuchi¹, Jinhee Kim³, Inyong Choi², Sungyoung Kim¹

¹Rochester Institute of Technology, ²University of Iowa, ³Carnegie Mellon University

25. Functional Consequences of Selective Ablation of Type I Hair Cells in the Striolae and Central Zones of the Vestibular System

Hyun Jae Lee^*1, Kazuya Ono², Talah Wafa³, Tracy Fitzgerald³, Doris K. Wu⁴

¹National Institute on Deafness and Other Communication Disorders, National Institutes of Health, ²Division of Glocal Pharmacology, Graduate School of Medicine, Osaka University, ³Mouse Auditory Testing Core Facility, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, ⁴Section on Sensory Cell Regeneration and Development, Laboratory of Molecular Biology, National Institute on Deafness and Other Communication Disorders, National Institutes of Health

26. Tracing Inner Ear Progenitor Cells in Cochlear Organoids

Farideh Moeinvaziri^*1, Mary Pressé¹, Dunia Abdul-Aziz¹, Albert Edge¹

¹ Mass Eye and Ear, Harvard Medical School

27. Predicting Hearing Performance With eCAP-Based Cochlear Health Measures in Cochlear Implant Users

Dyan Ramekers^*1, Tinne Vandenbroeke¹, Vincent Van Rompaey¹, Marc J.W. Lammers¹

¹ Antwerp University Hospital

28. The Sound of a Cochlear Implant Longitudinally Investigated in Single-Sided Deaf Subjects

Anne Wendrich¹, Ruben van Eijl¹, Jeroen Peters¹, Jan van Heteren¹, Imogen van Beurden¹, Robert Stokroos¹, Koenraad Rhebergen¹, Huib Versnel^*1

¹ University Medical Center Utrecht

29. A Differentiable Model of Speech Processing Combining Neuroscience Models and Deep Learning

Ruolan Famularo^*1, Dmitry Zotkin¹, Shihab Shamma¹, Ramani Duraiswami¹

¹ University of Maryland - College Park

30. Onset-Driven Dynamic Range Compression Resolves the Audibility/Sound-Quality Trade-Off

Olaf Strelcyk^*1, Dylan Pearson², Ralph Peter Derleth³, Pavel Zahorik²

¹Sonova US Corporate Services LLC, ²University of Central Florida, ³Sonova AG

31. Kinematic Behavioral Differences Provide a Video-Based Method for Sorting SLC and LLC Startle Responses in Larval Zebrafish

Xinlan Chen^*1, Haoran Tong¹, Stacey Beganny¹, Josef Trapani¹

¹ Amherst College

32. Computational Modeling of the Electrode-Neuron Interface to Estimate the Electrode-modiolus Distance and Neuronal Density

Julie Arenberg^*1, Christopher Giardina², Joshua Goldwyn³, David Perkel⁴

¹Massachusettes Eye and Ear Infirmary, Eaton Peabody Laboratory, ²Harvard Medical School, Massachusetts Eye and Ear Infirmary, ³jgoldwy1@swarthmore.edu, ⁴University of Washington

33. Effects of Repeated Exposures to Low-Intensity Blast Overexposure via the Ear Canal on Vestibular Function in Rats

Jena' Mazique¹, Leo Mei², Raven Riley², Raymond Huang², Zelma Iriarte-Oporto², Youguo Xu², David Huang², Bryan Rivers², Ian Mcneill², Jake Harthcock², Yi Pang³, Wu Zhou², Hong Zhu^*3

¹Program in Neuroscience, University of Mississippi Medical Center, ²University of Mississippi Medical Center, ³University of Mississippi Medical Center

34. Musicianship Modulates Cortical (but Not Brainstem) Effects of Attention on Processing Musical Triads

Jessica MacLean^*1, Elizabeth Drobny¹, Rose Rizzi¹, Gavin Bidelman¹

¹ Indiana University

35. Predictable and Periodic Rhythmic Cues Facilitate Concurrent Speech Perception at Nominal Speech Rate

Jessica MacLean^*1, Mengyuan Zhou¹, Gavin Bidelman¹

¹ Indiana University

36. The Effect of Neural Health on Azbio Sentence Scores Measured in Quiet and Noise in Postlingually Deafened Adult Cochlear Implant Users

Shuman He^*1, Yi Yuan², Christopher Mueller¹, Zi Gao¹

¹The Ohio State University, ²San José State University

37. Time Course of Attention During Word-In-Noise Recognition in Cochlear Implants

Francis Smith^*1, Nour Alsabbagh¹, Joel Berger¹, Phillip Gander¹, Timothy Griffiths², Bob McMurray¹, Inyong Choi¹

¹University of Iowa, ²Newcastle University

38. Lgr5+ Endogenous Progenitor Cells in the Adult Human and (Deafened) Mouse Cochlea

Georgina Fenton^*1, Natalia Smith-Cortinez¹, Fabio Holtappels¹, Tobias Pieper¹, Huib Versnel¹, Hans G.X.M. Thomeer¹, Louise Straatman¹

¹ University Medical Center Utrecht

39. Inferior Colliculus Responses to Synthetic and Instrumental Timbre

Johanna Fritzinger^*1, Laurel H. Carney²

¹University of Rochester Medical and Dental School, ²University of Rochester

40. Histopathologic Assessment of Archival Temporal Bone Specimens with Pediatric Rickets

Eleftheria Slika^*1, Srijita Paul¹, Julie Winston¹, Bryan Ward¹, Amanda Lauer¹

¹ Johns Hopkins University Otolaryngology Department

41. Mechanical Influence of Acute Versus Chronic Cochlear Implantation in a Guinea Pig Model

Wenxuan He¹, Rubing Xing¹, Jordan Hill¹, Lina Reiss¹, George Burwood^*1

¹ Oregon Health and Science University

42. The Impact of Musical Expertise on Disentangled and Contextual Neural Encoding of Music Revealed by Generative Music Models

Yinghao Li¹, Gavin Mischler¹, Stephan Bickel², Ashesh Mehta², Nima Mesgarani^*1

¹Columbia University, ²The Feinstein Institute for Medical Research

43. Success of Targeted Sequencing in the Search for Genetic Causes of Usher Syndrome Type 2

Dominika Oziębło^*1, Natalia Bałdyga², Janine Reurink³, Henryk Skarzynski⁴, Hannie Kremer⁵, Monika Ołdak²

¹Institute of Physiology and Pathology of Hearing, ²Institute of Physiology and Pathology of Hearing, ³Radboud University Medical Center, Nijmegen, The Netherlands, ⁴Oto-Rhino-Laryngology Surgery Clinic, Institute of Physiology and Pathology of Hearing, ⁵Radboud University Medical Center, Nijmegen, The Netherlands; Radboud University Medical Center, Nijmegen, The Netherlands

44. Evaluating the Utility of Virtual-Channel-Based Sound Coding for Future Optogenetic Cochlear Implants

Antonia Klobe¹, Lakshay Khurana², Tobias Moser², Gerwald Lichtenberg³, Lukasz Jablonski^*4

¹Junior Research Group "Computational Neuroscience and Neuroengineering", Institute for Auditory Neuroscience, University Medical Center Göttingen, Germany, ²Institute for Auditory Neuroscience, University Medical Center Göttingen, Germany, ³Faculty of Life Sciences, Hamburg University of Applied Sciences Hamburg, ⁴Institute for Auditory Neuroscience, University Medical Center

45. Hair Cell Dysfunction Promotes Cochlear Inflammation Independent of Trauma

Weintari Sese^*1, Andrew O'Connor², Samuel Webb², Aubrey Hornak¹, Janith Halpage¹, Walter Marcotti², Dwayne Simmons¹

¹Baylor University, ²University of Sheffield

46. Determining the Impact of Igf2bp1 Re-Expression on Hair Cell Regeneration in the Mouse Cochlea

Victoria Idowu^*1, Deborah Hamilton¹, Luyi Zhou¹, Brandon Cox¹, Victoria Idowu²

¹Southern Illinois University School of Medicine, ²Southern Illinois University School of Medicine

47. Hypoxia and Radiation Reduce Viability of Normal Schwann Cells but Not NF2-Mutant Schwann Cells

Lucienna Wolf^*1, Olena Bracho², Fred Telischi², Cristina Fernandez-Valle³, Christine Dinh²

¹University of Miami Miller School of Medicine, ²Department of Otolaryngology, University of Miami Miller School of Medicine, ³Burnett School Biomedical Sciences, College of Medicine, University of Central Florida

48. Role of LRP2 in Cellular Uptake and Efflux of Aminoglycosides in Vitro

Vignesh RA^*1, Kylee Sutton², Peter Steyger²

¹Creighton University, ²Bellucci Translational Hearing Center, Creighton University

49. Effects of Noise Exposure on Vestibular Function in Tmc2KO Mice

Caroline Sit^*1, Zelma Iriarte Oporto², Tianwen Chen², David Huang¹, Youguo Xu², Douglas E. Vetter², Jeffrey R. Holt³, Gwenaëlle S.G. Géléoc³, Wu Zhou², Hong Zhu²

¹School of Medicine, University of Mississippi Medical Center, ²University of Mississippi Medical Center, ³Boston Children's Hospital, Harvard Medical School

50. Cumulative Vestibular Dysfunction and Changes in Walking Speed Associated with Repeated Noise Exposure

David Bauer¹, Marie Anderson¹, Ariane Kanicki¹, W. Michael King¹, Richard Altschuler¹, Courtney Stewart^*2

¹Kresge Hearing Research Institute, University of Michigan, ²VA Ann Arbor Healthcare System

51. Three-Dimensional Vibration of the Human Tympanic Membrane Under Pathologic Conditions

Bastian Baselt¹, Nicole Brodhag², Merlin Schär¹, Thomsa Karasinski², Alexander Huber¹, Jae Hoon Sim^*3

¹Head and Neck Surgery, University Hospital Zurich, University of Zurich, ²Polytec GmbH, ³University Hospital Zurich, University of Zurich

52. Analysing a Large Clinical Dataset Using Linear and Non-Linear Data-Reduction Algorithms

Gerard Encina-Llamas^*1, Erik Kjærbøl², Abigail Anne Kressner²

¹University of Vic - Central University of Catalonia, ²Copenhagen Hearing and Balance Center. Rigshospitalet (Denmark)

53. Relationship between Subcortical Speech Encoding, Sustained Auditory Attention, and the Neural Signal-To-Noise Ratio

Subong Kim^*1, Susan Arzac¹, Natalie Dokic¹, Jenn Donnelly¹, Nicole Genser¹, Amaya Nina¹, Kristen Nortwich¹, Melissa Rafaniello¹, Grace Vericker¹, Alexis Rooney¹

¹ Montclair State University

54. Exploring Geometrical Variations in Middle Ear Models for Conductive Pathology Analysis

Hamid Motallebzadeh^*1

¹ California State University, Sacramento

55. Investigating the Relationship Between Apolipoprotein E (APOE) and Auditory Abilities

Uzma Akhtar^*1, Shinya Tasaki², Jingyung Yang², Sue Leurgans², Valeriy Shafiro¹, Raj Shah²

¹Rush University Medical Center, ²Rush Alzheimer's Disease Center

56. Behavioral Strategies for Spatial Speech Perception under Monauralized Listening

Hillary Snapp^*1, Sandra Prentiss², Kaitlyn Marsh², Sebastián Ausili²

¹University of Miami, ²University of Miami Miller School of Medicine

57. Optical Method of Diagnosing Middle Ear Effusions

Jordan Villa^*1, Joaquin Cury¹, Claus-Peter Richter¹

¹ Feinberg School of Medicine, Northwestern University

58. Spectral Weighting of Interaural Time Differences Near the Low-Frequency “Dominant Region”

G. Christopher Stecker^*1, Brittany Williams¹, Niklas Isserstedt², Kerry Walker³, Matthew Goupell⁴, Mathias Dietz², Daniel Tollin³

¹Boys Town National Research Hospital, ²University of Oldenburg, ³University of Colorado School of Medicine, ⁴University of Maryland-College Park

59. Determining the Contributions of Sound Localization Cues to Spatial Tuning in the Auditory Midbrain Using Individualized Head-Related Transfer Functions

Emili Garretson¹, Joshua Mencsik¹, Mitchell Day^*1

¹ Ohio University

60. Morphological Changes Associated with Aging in the Mammalian Vestibular System

Morgaine Goettl-Meyer^*1, Michelle Perez-Guevara¹, Katie Rennie¹, Anthony Peng¹

¹ University of Colorado Anschutz Medical Campus

61. Artificial Intelligence-Based Genetic Risk Modeling of Acquired Hearing Loss

Ishan Bhatt^*1, Raquel Dias², Ali Torkamani³

¹University of Iowa, ²University of Florida, ³Scripps Research Institute

62. Calcium Channel Expression and Localization in the Inferior Colliculus: Unraveling the Interplay Between Pharmacological Blockade and Noise-Induced Hearing Loss

Selin Yalcinoglu^*1, Rod Braun¹, Avril Genene Holt¹

¹ Wayne State University School of Medicine

63. Neural and Behavioral Changes from Auditory-Cognitive Speech-In-Noise Training in Older Adults

Charlie Fisher^*1, I.M Dushyanthi Karunathilake¹, Michael Johns¹, Allison Vance¹, Stefanie Kuchinsky², Samira Anderson¹, Jonathan Simon¹

¹University of Maryland - College Park, ²Walter Reed National Military Medical Center

64. Improving Speech Intelligibility and Reducing Listening Effort with a Deep Neural Network Based Noise Reduction System

Matthias Keller^*1, Nathan Higgins², Ashley Wright¹, Erol Ozmeral², Jason Galster¹, Matthias Latzel¹, Volker Kühnel¹, Kevin Seitz-Paquette¹

¹Sonova US Corporate Services, ²University of South Florida

65. Cytomegalovirus Infection Effects on Vestibular System

Megna Reddy^*1, Peter Kfoury², Albert Park³, Shi Lang³, Timothy Jones⁴, Pranav Mathur⁵, Ali Almishaal⁶

¹Medical College of Georgia, University of Utah, ²Division of Otolaryngology, University of Utah, ³University of Utah, School of Medicine, ⁴University of Nebraska, ⁵Otonomy, Inc., ⁶University of Utah, University of Hail

66. Neural Processing the Global Properties of Natural Auditory Scenes

Margaret McMullin^*1, Nathan Higgins², Rodica Constantine¹, Joel Snyder¹

¹University of Nevada, Las Vegas, ²University of South Florida

67. Envelope Representations Substantially Enhance the Predictive Power of Spectrotemporal Receptive Models in the Human Auditory Cortex

Guoyang Liao^*1, Dana Boebinger², Jenelle Feather³, Christopher Garcia⁴, Kirill Nourski⁴, Matthew Howard Iii⁴, Thomas Wychowski², Webster Pilcher², Sam Norman-Haignere²

¹University of Rochester, ²University of Rochester Medical Center, ³Flatiron Institute, ⁴The University of Iowa

68. Limited-English Proficiency and Its Impact on the Presentation and Management of Vestibular Schwannomas

Christian Jung^*1, Carly Yang¹, Keshav Shah¹, Tiffany Hwa¹, Christian Jung²

¹University of Pennsylvania Health System, ²Perelman School of Medicine University of Pennsylvania

69. Identification of Conductive Hearing Loss Using a Sweep Frequency Impedance (SFI) Meter

Teruki Toya¹, Di Zhou², Hisashi Sugimoto², Michio Murakoshi^*2

¹Yamanashi University, ²Kanazawa University

70. Study on the Method of Controlling the Vestibular Organ and Cochlea Using Bone Conduction Stimulation

Jongwoo Lim^*1, Namkeun Kim²

¹Korea Advanced Institute of Science and Technology, ²Sogang University

71. Investigation of the Regulation of Innate Immunity via Modulating Cochlin and Lccl Domain Peptide

Hyoyeol Kim^*1, Sia Kim², Seunghyeon Jang¹, Yeji Song¹, Minjin Kang¹, Jinsei Jung¹

¹Yonsei University College of Medicine, ²Yongsan International School

72. Novel Variant in CEP250 Causes Protein Mislocalization and Leads to Nonsyndromic Autosomal Recessive Type of Progressive Hearing Loss

Min Jin Kang^*1, Heon Yung Gee¹, Jae-Young Choi¹, Jinsei Jung¹

¹ Yonsei University College of Medicine

73. Phex Gene Dosage Effect as a Likely Trigger for Meniere Disease in Patients with X-Linked Hypophosphatemia

Paula Robles-Bolivar^*1, Divya Chari², David Bächinger³, Arpan Bose⁴, Kimberly Ramirez⁵, Eva Liu⁶, Steven Rauch⁷, Andreas Eckhard⁸

¹Massachusetts General Hospital, Harvard Medical School, ²Massachusetts Eye and Ear Infirmary, ³University Hospital Zurich, ⁴University of Massachusetts Chan Medical School, ⁵UMASS Medical School, ⁶Brigham and Women's Hospital, ⁷Harvard Medical School, Massachusetts Eye and Ear, ⁸Massachusetts Eye and Ear

74. Novel Small Molecule-Mediated Restoration of the Surface Expression and Anion Exchange Activity of Mutated Pendrin Causing Pendred Syndrome and DFNB4

Min Jin Kang^*1, Jae-Young Choi¹, Wan Namkung², Gyoonhee Han², Min Goo Lee¹, Jinsei Jung¹

¹Yonsei University College of Medicine, ²Yonsei University College of Pharmacy, Incheon, Republic of Korea.

75. Developing a Personalized Hearing Framework with CARFAC v3 and ANN Based on Performance on the Categorical Loudness Scale and Quick-VC Tests

Nima Salimi¹, Jason Mikiel-Hunter^*1, Alan Kan¹, Jorg Buchholz¹, Stephen Neely², Simon Carlile³, Dick Lyon³

¹Macquarie University, ²Boys Town National Research Hospital, ³Google Australia

76. The Exclusive Use of Local Anesthesia as an Alternative to General Anesthesia for Adolescent and Adult Patients Undergoing Cleft Lip Repair or Revision

Amer Mansour^*1, Wassim Najjar², Jose Garcia-Garcia³, Beyhan Annan³, Raj Vyas², Usama Hamdan³

¹State University of New York Upstate Medical University, ²University of California, Irvine, ³Global Smile Foundation

77. Proportional Differences in Alternative Splicing Isoforms of SLC12A2 Across Tissues and Their Role in Disease Phenotypes

Yuzhong Zhang^*1, Wanjin Hu¹, Mingjun Zhong¹, Hela Azaiez², Kevin T. Booth³, Yu Zhao¹, Huijun Yuan¹, Jing Cheng¹

¹West China Hospital of Sichuan University, ²University of Iowa, ³Indiana University School of Medicine

78. Transitioning to Personalized Care for Idiopathic Sudden Hearing Loss with Machine Learning

Yen-Ting Guo¹, Ching-Ting Tan², Chen-Chi Wu³, Chun-Ying Wang⁴, Chein-Yu Huang⁵, Tzu-Hsiang Yang⁵, Ting-Yi Lee⁶, Ting-Hua Yang¹, Tien-Chen Liu¹, Pey-Yu Chen^*7, Pei-Hsuan Lin¹

¹National Taiwan University Hospital, ²National Taiwan University Hospital; National Taiwan University Hospital Hsin-Chu Branch; National Taiwan University College of Medicine, ³National Taiwan University Hospital; National Taiwan University Hospital Hsin-Chu Branch, ⁴National Taiwan University Hospital Hsin-Chu Branch, ⁵Business Unit 12, Quanta Computer Inc., ⁶National Taiwan University Hospital, Yun-Lin Branch, ⁷MacKay Memorial Hospital

79. Comparative Analysis of Temporal Bone Anatomy and Whole-Mount Dissection in the Inner Ear in Mice Vs. Common Marmosets

Hidekane Yoshimura^*1, Shu Yokota¹, Yutaka Takumi¹

¹ Shinshu University School of Medicine

80. Socio-Demographic Barriers to Vestibular Rehabilitation Therapy for Schwannoma Patients in South Florida

Luis Rodriguez-Diaz^*1, Madison Hawthorne², Devin Kennedy², Michael Hoffer³, Erin Williams¹

¹University of Miami Miller School of Medicine, ²Miller School of Medicine, University of Miami, ³University of Miami School of Medicine, University of Miami Ear Institute

81. Modified Tinnitus Relieving Sound Therapy for Chronic Subjective Tinnitus: Results of a Prospective Controlled Study

Dongmei Tang^*1, Yunfeng Wang¹, Shan Sun¹, Huawei Li¹

¹ Eye and ENT Hospital, Fudan University

82. Novel Deep Learning-Based Tools for Inner Ear Research

Abhijeeth Erra¹, Cayla Miller¹, Kenta Ninomiya², Jeffrey Chen³, Elena Chrysostomou¹, Lauren Sullivan¹, Yuzuru Ninoyu¹, Yasmin Kassim¹, Shannon Barrett¹, Federico Ceriani⁴, Rick Friedman¹, Walter Marcotti⁴, Artur Indzhykulian⁵, Cody Carroll³, Alexey Terskikh⁶, Uri Manor^*1

¹University of California, San Diego, ²University of Western Australia, ³University of San Francisco Data Science Institute, ⁴University of Sheffield, ⁵Massachusetts Eye and Ear Institute, ⁶Scintillon Institute, University of Western Australia

83. Cognitive Biases Cause an Overestimation of Vestibular Direction-Recognition Perceptual Thresholds

Elena López-Contreras Gonzalez¹, Torin Clark², Faisal Karmali^*3

¹Massachusetts Eye and Ear, ²University of Colorado Boulder, ³Harvard Medical School

84. Effects of the Middle Ear Muscle Reflex on the Cochlear Microphonic Evoked by Swept Tones

Shawn Goodman¹, Lydia White², Sarah Haysley², Sarah Haysley^*3, Skyler Jennings²

¹Department of Communication Sciences and Disorders, The University of Iowa, ²University of Utah, ³The University of Utah

85. Characterizing Level Growth Functions of Distortion Product Otoacoustic Emissions Evoked by a Fixed L1 Swept L2 Paradigm

Mohammad Ehsan Khalili^*1, Rachael Baiduc², Vinaya Manchaiah³, Sumitrajit Dhar⁴, Jeffery Lichtenhan⁵, Shawn Goodman⁶

¹The University of Iowa, ²University of Colorado Boulder, ³University of Colorado School of Medicine, ⁴Northwestern University, ⁵University of South Florida Morsani College of Medicine, ⁶Department of Communication Sciences and Disorders, The University of Iowa

86. The Calcium and Integrin‐Binding Protein 2 (CIB2) Provides Fast Kinetics to the Met Complex through Localization of BAIAP2L2 to Stereocilia Tips

Isabel Aristizabal^*1, Arnaud Giese², Abigail Dragich¹, K. Sofia Zuluaga-Osorio¹, Shadan Hadi¹, Saima Riazuddin³, Ana I. Lopez-Porras¹, A. Catalina Velez-Ortega¹, Zubair Ahmed³, Gregory Frolenkov¹

¹University of Kentucky, ²Sensorion SA, ³University of Maryland School of Medicine

87. Regeneration of Hair Cells and Restoration of Vestibular Function by Notch Inhibition

Hanae Lahlou^*1, Hong Zhu², Wu Zhou², Albert S. B. Edge³

¹Harvard Medical School, ²University of Mississippi Medical Center, ³Massachusetts Eye and Ear Infirmary/Harvard Medical School

88. Evaluation of a Universal Canalith Repositioning Maneuver to Resolve 3-Canal Ipisilateral BPPV: Physical and Computational Models

Micah Frerck¹, Tanner Frahm², Janet Helminski³, Christopher Smith⁴, Richard Rabbitt^*1

¹University of Utah, ²Mount Sinai Medical Center, ³Rosalind Franklin University, ⁴American Museum of Natural History

89. Predicting the Etiology of Hearing Loss with a Joint (Reflection-Distortion) OAE Profile

Carolina Abdala^*1, Tricia Benjamin¹, Ping Luo¹, Christopher Shera¹

¹ University of Southern California

90. Differential Hearing Restoration in the DFNB9 Mouse Model through Aav Gene Therapy with Human and Mouse Cdna

Mauricio Saenz^*1, Najate Benamer², Yann Nguyen³, Saaid Safieddine⁴

¹Institut Pateur, ²Institut de l'Audition, Institut Pasteur, INSERM, Université de Paris, ³Technologies et Thérapie Génique Pour la Surdité, Institut de l’Audition, Inserm/Institut Pasteur/Université de Paris; Unité Fonctionnelle Implants Auditifs et Explorations Fonctionnelles, Service ORL, GHU Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris (AP-HP)/Sorbonne Université, ⁴CNRS/Institut de l'Audition

91. Application of a Novel Capsid Engineered Vector to Rescue Hearing Loss in TMPRSS3 Mutant Mice

Jennifer Marx¹, Axel Rossi², Serena Sutter³, Athanasia Warnecke⁴, Axel Schambach¹, Hinrich Staecker^*5, Hildegard Buening¹

¹Hannover Medical School, ²Bayer Inc., ³University of Zurich, ⁴Hannover Medical School/Institute of Audioneurotechnology, ⁵Univeristy of Kansas Medical Center

92. Tailoring AAV Vectors for Gene Therapy of Inner Ear Disorders by Directed Evolution

Josephine Macdonald¹, Jennifer Marx¹, Peixin Huang², Nico Jaeschke¹, Lisa Prager¹, Sabrina Just¹, PHilipp John-Neek¹, Lutz Wielmann¹, Christoph Arnoldner³, Anselm Joseph Gadenstaetter³, Matthias Gerlitz³, Erdem Yildiz³, Athanasia Warnecke¹, Odett Kaiser¹, Axel Schambach¹, Hildegard Buening¹, Hinrich Staecker^*4

¹Hannover Medical School, ²University of Kansas Medical Center, ³Medical University of Vienna, ⁴Univeristy of Kansas Medical Center

93. Hoo’s There, a Ghost? Coding of Phantom Sounds in Barn Owls

Shreya Nandi¹, Jordan Fox^*1, Roland Ferger¹, Jose Luis Pena¹

¹ Albert Einstein College of Medicine

94. Myelin Degeneration in the Aging Human Auditory System

Kelly Harris^*1, James Dias¹, Carolyn McClaskey¹

¹ Medical University of South Carolina

95. Functional Roles of Quantal and Non-Quantal Transmission in the Vestibular Periphery

Dyllan Zhou¹, Wesley Schoo¹, Zhou Yu¹, Takashi Kodama², Sascha du Lac¹, Elisabeth Glowatzki¹, Soroush Sadeghi¹

¹Johns Hopkins University, ²Johns Hopkins University, Tokyo Women's Medical University

Dyllan Zhou, Johns Hopkins University

96. Longitudinal Study of Otoacoustic Emissions in a Rat Model of Age-Related Hearing Loss

Mathieu Petremann^*1, Valentina Kaden-Volynets², Karolina Charaziak³, Hubert Loewenheim⁴, Jonas Dyhrfjeld-Johnsen²

¹Translational Hearing Research Center, University of Tübingen, ²Acousia Therapeutics, ³USC Keck School of Medicine, ⁴Translational Hearing Research Center, University of Tübingen

97. Multiomic Analysis Highlights an Aberrant Gut-Metabolome-Proteome Network in Mice with Age-Related Hearing Loss

Ting Yang^*1, Wei Yuan¹

¹ Chongqing General Hospital

98. Interneurons Contribute to the Adaptation to Sound of Corticocollicular Neurons in the Auditory Cortex of Mice

Philip Bender^*1, Mason McCollum¹, Kaitlin Bainer¹, Charles T. Anderson¹

¹ West Virginia University

99. Complex Difference Analysis Provides Insight into Internal Organ of Corti Motion

Lauren Chiriboga^*1, C.Elliott Strimbu², Elizabeth S. Olson¹

¹ Columbia University

100. Investigation of Synaptic Excitation and Inhibition Underpinning Mechanisms Involved in Processing Sound Sequences with Behaviorally Relevant Short Intervals in IC Neurons

Chun-Jen Hsiao^*1, Ashonti Wright¹, Bradley Winters¹, Yong Lu¹, Alexander Galazyuk¹

¹ Northeast Ohio Medical University

101. AI-Driven Automatic Speech Perception Scoring

Rohit Makol^*1, Maya Hatley², Megan Eitel², Mahan Azadpour², Mario A. Svirsky², Ariel Edward Hight²

¹New York University Grossman School of Medicine, ²Department of Otolaryngology, New York University Grossman School of Medicine

102. Organ of Corti Responses to Tones with Low Side-Suppression, and in the Post Mortem Condition

Clark "Elliott" Strimbu^*1, Elizabeth Olson¹

¹ Columbia University

103. Advisor II: Rapid Oculomotor, Vestibular, and Reaction Time Testing for Mild Traumatic Brain Injury (mTBI)

Bernat Miro^*1, Erin Williams², Valerie Yunis², Phillip Desrochers³, Michael Hoffer⁴

¹University of Miami Miller School of Medicine, ²Miller School of Medicine, University of Miami, ³Charles River Analytics, ⁴Miller School of Medicine, University of Miami. Miller School of Medicine, University of Medicine.

104. Genetic Evaluation of a Large Cohort of Pediatric Cochlear Implant Patients: Correlation with Outcomes

Thore Schade-Mann¹, Shelby Redfield², Adrian Pastolero², Tieqi Sun³, Margaret Kenna³, Eliot Shearer^*4

¹University of Tübingen, ²Boston Children’s Hospital, ³Boston Children’s Hospital; Harvard Medical School, ⁴Harvard Medical School

105. Testing the Requirement of Peripheral Type I Vestibular Hair Cells for Motor Behaviors in Adult Mice

Amanda Ciani Berlingeri^*1, Noah Druckenbrod², Joe Burns², Brandon Cox³, James Phillips⁴, Jennifer Stone⁵

¹University of Washington, ²Decibel Therapeutics, ³Southern Illinois University School of Medicine, ⁴The University of Washington, Oto-HNS Dept, Virginia Merrill Bloedel Hearing Resource Center, ⁵The University of Washington, Virginia Merrill Bloedel Hearing Resource Center

106. Salicylate-Induced Changes in Low-Frequency Organ of Corti Vibrations

Sebastiaan Meenderink^*1, Wei Dong¹

¹ VA Loma Linda Healthcare System

107. Developmental Expression of Membrane Bound and Secreted Corticotropin Releasing Factor Receptors in the Cochlea

Sarah Hayek^*1, Douglas Vetter¹, Kathleen Yee¹

¹ University of Mississippi Medical Center

108. Convergence of Bilateral Auditory Tectothalamic Pathways

John Kara^*1, Tolulope Adeyelu², Charles Lee²

¹Louisiana State University Health Science Center, ²Louisiana State University

109. Voltage-Driven Bundle Movements in Mammalian Cochlear Hair Cells Support Common Underlying Mechanisms Across Species and End Organs

Jamis McGrath^*1, Anthony Ricci¹

¹ Stanford University

110. Integrating rTMS, Psychotherapy, and Pharmacotherapy for Tinnitus in Patients with Depression: A Comprehensive Approach

Aynur Aliyeva^*1, Xuraman Namazova²

¹College of Medicine, The Catholic University of Korea, ²Department of Psychiatry, Akdeniz University, Antalya, Turkey

111. Template-Independent Genome Editing for Restoring Inherited Deafness Caused by Frameshift Mutations

Shiwei Qiu¹, Lian Liu², Bin Xiang³, Wei Xiong^*4

¹Tsinghua University, ²Shandong University, ³Chinese Institute for Brain Research, Beijing, ⁴Chinese Institute for Brain Research

112. Exploring the Regulation of Myosin-15 by Whirlin in Mechanosensory Stereocilia

Zane Moreland^*1, Matthew Petrides¹, James Heidings¹, Juan Guan², Linda Bloom¹, Jonathan Bird¹

¹University of Florida, ²University of Texas at Austin

113. Reduced Neural Adaptation for Encoding Complex Sounds in the Auditory Cortex with Aging

HiJee Kang^*1, Patrick Kanold¹

¹ Johns Hopkins University

114. A Mitochondrially Associated Myosin Motor is Necessary for Hearing

Ghazaleh Behnammanesh^*1, Abigail Dragich², Gregory Frolenkov², Jonathan Bird¹

¹University of Florida, ²University of Kentucky

115. Development and Characterization of Blast Apparatus for Preclinical Auditory and Vestibular Research

Yuan Gao^*1, Pavan Krishnan², Megan Barber³, Federica M. Raciti⁴, Curtis King⁵, Michael Hoffer⁶, Suhrud Rajguru⁷

¹University of Miami Miller School of Medicine, ²University of Miami/Jackson Health System, ³University of Miami, ⁴University of Miami Miller School of Medicine, ⁵Restor-Ear Devices LLC, ⁶University of Miami School of Medicine, University of Miami Ear Institute, ⁷University of Miami, Restor-Ear Devices LLC

116. Application and Usefulness of Multimodal Ai for Otological Examinations Including Nystagmus

Yutaka Takumi^*1, Hidekane Yoshimura¹

¹ Shinshu University School of Medicine

117. The Effect of Genetic Background on Balance Behavior in an USH1C Mouse Model

Jennifer Lentz^*1, Reed Smith², Jessica Landry², Bhagwat Alapure²

¹Louisiana State University Health Sciences Center School of Medicine, ²LSU Health-New Orleans

118. Optimizing Antisense Oligonucleotide Chemistry for the Treatment of Hearing Loss and Imbalance in Usher Syndrome

Jennifer Lentz^*1, Reed Smith², Jessica Landry², Bhagwat Alapure²

¹Louisiana State University Health Sciences Center School of Medicine, ²LSU Health-New Orleans

119. Temporal Bone Histopathology of a Malignant Peripheral Nerve Sheath Tumor

Zohar Hovev^*1, Jennifer O\'Malley¹, Andreas Eckhard¹, Ophir Handzel²

¹Massachusetts Eye and Ear, ²Tel Aviv Sourasky Medical Center

120. The Opto-Electrical Cochlear Implant

Joaquin Cury^*1, Xiaodong Tan², Claus-Peter Richter¹

¹Feinberg School of Medicine, Northwestern University, ²Feinberg School of Medicine, Northwestern University, Chicago

121. The Effect of Undamping Feedback Force on Otoacoustic Emissions Derived from a Nonlinear Cochlear Model

Vaclav Vencovsky^*1

¹ Czech Technical University in Prague

122. Human Vs. Machine: Evaluation of a Novel Robotic Device for Electrode Insertion during Cochlear Implantation in a Large Animal Model

Caroline Sesztak^*1, Till Buschhorn¹, Anselm Gadenstaetter¹, Matthias Gerlitz¹, Clemens Honeder¹, Erdem Yildiz¹, Christoph Arnoldner¹

¹ Vienna General Hospital, Medical University of Vienna

123. Optical Detection of Basilar Membrane Damage

Joaquin Cury^*1, Olivia Griffith², Xiaodong Tan², Claus-Peter Richter¹

¹Feinberg School of Medicine, Northwestern University, ²Feinberg School of Medicine, Northwestern University, Chicago

124. Biocompatible 3D Printing Platform with Integrated Miniaturized Optical Systems for Otolaryngology Applications

Joaquin Cury^*1, Xiaodong Tan², Claus-Peter Richter¹

¹Feinberg School of Medicine, Northwestern University, ²Feinberg School of Medicine, Northwestern University, Chicago

125. The Role of Alternative Splicing on the Otoferlin C-Terminal Transmembrane Domain in Auditory Hair Cell Synaptic Transmission

Yohan Bouleau¹, Steven Condamine¹, Hung Thai-Van¹, Didier Dulon^*1

¹ INSERM, Institut Pasteur - Institut de l'Audition

126. Neural Correlates of Spectro-Temporal Modulation Detection: Insights from Cross-Species EEG Studies

Madhurima Patra^*1, Adarsh Mukesh¹, Hari Bharadwaj², Michael Heinz¹

¹Purdue University, ²University of Pittsburgh

127. The Relationship Between Self-Reported and Computer-Based Measures of Music Perception in Adult Cochlear Implant Users

Burcu Deniz¹, Barbara Tillmann², Etienne Gaudrain³, Robert Harris⁴, Bert Maat⁵, Rolien Free⁵, Deniz Başkent⁵, Eleanor Harding^*6

¹İstanbul University-Cerrahpaşa, ²Laboratory for Research on Learning and Development (LEAD), CNRS UMR5022, ³Lyon Neuroscience Research Center, CNRS UMR5292, ⁴Prince Claus Conservatory, Hanze University of Applied Sciences, ⁵University of Groningen, University Medical Center Groningen, ⁶University of Groningen

128. Comparative Micro-Ct Analysis of Inner Ear Anatomy in Adult Mouse, Chicken, and Human: Insights for Surgical Access and Drug Delivery

Jing Wang^*1, Fabian Blanc², Nesrine Benkafadar³, Michel Mondain⁴

¹INM, ²Institute for Neurosciences of Montpellier (INM), University Montpellier, INSERM U1298, Montpellier, France, ³Stanford University School of Medicine Department of Otolaryngology, Head and Neck Surgery, ⁴Montepellier - Hopital St. Charles

129. Macro-Patch Voltage Clamp Evaluation of Sub-Membranous Chloride Levels at the Outer Hair Cell Lateral Membrane

Joseph Santos-Sacchi^*1, Winston Tan², Dhasakumar Navaratnam²

¹Yale University School of Medicine, Section of Otolaryngology, ²Yale University School of Medicine

130. Use of Opm-Meg for Auditory Research

Stephan Wolpert^*1, Rodrigo Donoso-San Martín², Stefan Fink³, Markus Siegel⁴, Paul Delano², Christoph Braun⁴, Marlies Knipper³, Lukas Rüttiger³

¹University of Tübingen, ²Laboratorio Neurobiología de la Audición, Departamento de Neurociencia, Facultad de Medicina, Universidad de Chile, Santiago, Chile, ³Molecular Physiology of Hearing, University of Tübingen, Germany, ⁴MEG-Center, Univ. of Tübingen

131. Contribution of Diotic and Dichotic Speech-In-Noise Test in Hearing Loss Diagnosis

Arnaud Genin¹, Jerôme Courtial², Frédéric Venail³, Jean-Luc Puel⁴, Jean-Charles Ceccato^*2

¹INM, Inserm, Audiocampus, University of Montpellier, SONUP, ²Audiocampus, University of Montpellier, ³INM, Inserm, Otology and Neurotology Unit, Univ Montpellier, CHU Montpellier, France, ⁴INM, Inserm, Audiocampus, University of Montpellier

132. Economic and Social Burden of Tinnitus in France (2021–2022)

Jean-Charles Ceccato^*1, Sebastien Leroy², Frédéric Venail³, Cécile Puel⁴, Jean-Luc Puel⁵

¹Audiocampus, University of Montpellier, ²Association Nationale de l'Audition (ANA), France, ³INM, Inserm, Otology and Neurotology Unit, Univ Montpellier, CHU Montpellier, France, ⁴INM, Inserm, Univ Montpellier, Montpellier Hospital, ⁵Institute for Neurosciences of Montpellier (INM), Audiocampus, University Montpellier, INSERM, France

The Role of Membrane Cholesterol in Cochlear Hair Cell Mechano-Electrical Transduction

Shefin George^*1, Thomas Effertz², Anthony Ricci¹

¹Stanford University, ²InnerEarLab, University of Goettingen

133. Distribution Patterns and Role of BK-Type Calcium-Activated Potassium Channels in the Octopus Cell Area of the Posteroventral Cochlear Nucleus

Aaron Hardman^*1, Shobhana Sivaramakrishnan¹, Nace Golding¹

¹ University of Texas at Austin

134. Investigating the Relationship Between the Ventral Attention Network, Vigilance, and Fatigue Utilizing Listening Effort, Neurophysiological, and Neurostimulation Methods: An Electroencephalogram (EEG) and Transcranial Alternating Current Stimulation (tACS) Study

Corrin Stines-Ringling^*1, Edward Golob¹, Alyssa Randez¹, Juan Fernandez¹, Ricardo Castañeda¹, Jeffrey Mock¹

¹ University of Texas at San Antonio

135. G-A Interacting Protein, C-Terminus 3 (GIPC3) Regulates Intracellular Vesicle Transport in Mammalian Auditory Hair Cells

Abigail Dragich^*1, Savita Sharma¹, Shadan Hadi¹, Craig Vander Kooi², Gregory Frolenkov¹

¹University of Kentucky, ²University of Florida, College of Medicine

136. Regulation of Myosin-Dependent Stereocilia Trafficking by Centrin-2

James Heidings^*1, Zane Moreland¹, Elli Hartig², John Garcia¹, Basile Tarchini², Jonathan Bird¹, James Heidings¹

¹University of Florida, ²The Jackson Laboratory

137. Impact of Cochlear Implants for Single-Sided Deafness on Head Movement and Resulting of Interaural Level and Timing Difference Cues During a Novel Localization Task

Libby Chambers¹, Obada Abdulrazzak¹, Gerilyn Jones¹, Renee Banakis Hartl^*1

¹ University of Michigan

138. Developmental Impacts on Neural and Behavioral Measures of Binaural Acuity in Normal Hearing and Electroacoustic Stimulation (EAS) Listeners

Fan-Yin Cheng¹, Linsey Sunderhaus², Linjie Shi², Olaedochim Obinna¹, Sarah Medina¹, Jonathan Neukam², Spencer Smith^*1, Rene Gifford²

¹University of Texas at Austin, ²Vanderbilt University Medical Center

139. Calcium-Dependent Conductances Shape Firing in Octopus Cells of the Posterior Ventral Cochlear Nucleus: Implications for Temporal Coding

Shobhana Sivaramakrishnan^*1, Aaron Hardman¹, Nace Golding¹

¹ University of Texas at Austin

140. Cell-Type Specific Synaptic Zinc-Signaling in the Auditory Cortex Contributes to the Recovery of Perceptual Hearing After Noise Trauma

Cassandra Linnertz^*1, Aidan Soose¹, Manoj Kumar¹, Thanos Tzounoupoulos²

¹University of Pittsburgh, ²Pittsburgh Hearing Research Center, Department of Otolaryngology, University of Pittsburgh

141. Decoding Speech and Music from Listened and Imagined MEG Recordings

Maryam Maghsoudi Shaghaghi^*1, Sonal Kumar¹, Utkarsh Tyagi¹, Mohsen Rezaeizadeh¹, Guilhem Marion², Jonathan Z. Simon³, Shihab A. Shamma⁴

¹University of Maryland - College Park, ²New York University; Ecole Normale Superieure, ³University of Maryland, ⁴University of Maryland; École Normale Supérieure

142. Calcium Puncta and Dynamics in Hair Bundles of the Mouse Crista Ampullaris

Holly Holman^*1, Richard D. Rabbitt²

¹University of Utah, ²Otolaryngology, Neuroscience Program, University of Utah

143. Impacts of Extended High-Frequency Hearing Loss on Neural Encoding and Perception of Speech

Sajana Aryal¹, Fan-Yin Cheng², Spencer Smith^*2

¹The University of Texas At Austin, ²University of Texas at Austin

144. Central Processing of Optical Hearing in the Anteroventral Cochlear Nucleus

Sabina Nowakowska^*1, Antoine Huet²

¹Institute for Auditory Neuroscience, University Medical Centre Goettingen, ²Institute for Auditory Neuroscience, University Medical Center Göttingen

145. EBF1 is Necessary for Sensory Domain Establishment Within the Organ of Corti

Kathryn Powers^*1, Brent Wilkerson², Kylie Beach³, Sophie Seo⁴, Jose Rodriguez¹, Ashton Baxter², Sarah Hunter², Olivia Bermingham-McDonogh¹

¹Neurobiology and Biophysics, University of Washington, ²Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, Charleston, SC, ³Pathology, University of Utah, Salt Lake City, ⁴Biological Structure, University of Washington

146. PEA3 Transcription Factors Role in Cochlear Epithelial Development

Selena Tian^*1, Mathew Papiernik¹, Hongji Zhang², Michael Ebeid²

¹Midwestern University College of Osteopathic Medicine, ²Midwestern University College of Graduate Studies

147. Alternate Structures of Prestin, the Motor Responsible for the Electromotility of Outer Hair Cells

Richard Mariadasse^*1, Carmen Butan², Qiang Song², Jun-Ping Bai², Joseph Santos-Sacchi³, Dhasakumar Navaratnam⁴

¹Yale Medical School, ²Yale University School of Medicine, ³Yale University School of Medicine, Section of Otolaryngology, ⁴Yale University School of Medicine, Neurology, Surgery, Neuroscience

148. Dendrite-Based Delay Lines in Sound Localization Neurons of the Medial Superior Olive

Jared Casarez^*1, Rebecca Voglewede¹, Bradley Winters¹, Ken Ledford¹, Nace Golding¹

¹ University of Texas at Austin

149. Identifying the Vestibular Pathology in a Chick Model for Congenital Vestibular Disorders

Katherine Phillips^*1, Vanshika Jain², Zoe Shaw², Nina Bell², Brielle Hentz², Elizabeth Bogin², Kathleen Gallagher², June Hirsch², Anastas Popratiloff², Kenna Peusner²

¹George Washington University, School of Medicine and Health Sciences, ²George Washington University School of Medicine

150. Exploring the Contribution of MYO15A Towards Alzheimer's Disease: Is DFNB3 Really Non-Syndromic?

Jinho Park^*1, Sam McDonald¹, Nicole Chambers¹, John Garcia¹, John Howard¹, Jada Lewis¹, Mark Moehle¹, Jonathan Bird¹

¹ University of Florida

151. Spatial and Spectro-Temporal Resolution in Spanish and English-Speaking Populations

Sandra Prentiss^*1, Sebastián Ausili¹, Kaitlyn Marsh¹, Hillary Snapp¹

¹ University of Miami Miller School of Medicine

152. Identifying Disparities in Saccade Testing Among Individuals with Mild Traumatic Brain Injury

Valerie Yunis^*1, Erin Williams¹, Allison Olivia¹, Bernat Miro¹, Jennifer Coto², Phillip Desrochers³, Michael Hoffer⁴

¹Miller School of Medicine, University of Miami, ²University of Miami Miller School of Medicine, ³Charles River Analytics, ⁴University of Miami School of Medicine, University of Miami Ear Institute

153. Differential Age-Related Decline in Central Auditory Function in Adults Living with HIV

Christopher Niemczak^*1, Albert Magohe², Samantha Leigh³, Monika Adhikari³, Shireen Geimer³, Linda Zhang⁴, Odile Clavier⁵, Jiang Gui³, Enica Massawe², Jay Buckey³

¹Dartmouth-Hitchcock, Geisel School of Medicine, ²Muhimbili University of Health and Allied Sciences, ³Geisel School of Medicine at Dartmouth, ⁴Geisel School of Medicine, ⁵Creare LLC

154. Pupil-Indexed Brain State Modulates Activity at Multiple Stations in the Auditory Brainstem

Hemant Kumar Srivastava^*1, Kyunghee Kim¹, Hong Jiang¹, Matthew McGinley¹

¹ Baylor College of Medicine

155. UmboMic: Fabrication, Design, and Fixation of an Implantable Middle Ear Microphone

John Zhang^*1, Emma F. Wawrzynek², Julie G. Arenberg³, D. Bradford Welling⁴, Ioannis Kymissis⁵, Elizabeth S. Olson⁵, Jeffrey H. Lang², Hideko Heidi Nakajima³

¹Massachusetts Institute of Technology, ²MIT, ³Massachusetts Eye and Ear, Harvard Medical School, ⁴Massachusetts Eye and Ear, Harvard Medical School, ⁵Columbia University

156. Noise-Induced Hearing Loss Alters Structure and Function of Inhibitory Cells in the Dorsal Cochlear Nucleus

Reginald Edwards^*1, Michael Kasten¹, Kendall Hutson¹, Paul Manis¹

¹ University of North Carolina, Chapel Hill

157. Expansion and Differentiation of Inner Ear Organoid Progenitors

Liqian Liu¹, R. Keith Duncan^*1

¹ University of Michigan

158. Repopulating Microglia in the Auditory Brainstem Recapitulate Developmental Properties following Cessation of CSF1R Inhibitor Treatment

Sima Chokr^*1, Giedre Milinkeviciute¹, Gisselle Jimenez², Jason Hoang¹, Dylan H. Mai¹, Karina S. Cramer¹

¹University of California, Irvine, ²Oregon Health and Sciences University

159. Impact of FGF8 Secreted by Inner Hair Cells on Supporting Cell Identity and Distribution in the Organ of Corti

Berta Soria-Izquierdo^*1, Ignacio Garcia-Gomez¹, Yingjie Zhou¹, Jaime García-Añoveros¹

¹ Northwestern University

160. Designing a Fluid-Jet Suitable for both Fast and Prolonged Deflections of Stereocilia in Mammalian Auditory Hair Cells

Daniel Acevedo^*1, Abigail Dragich¹, Gregory Frolenkov¹

¹ University of Kentucky

161. Sensitivity to Amplitude and Spectrotemporal Risetimes Predicts Phonological Awareness and Literacy in Children

Sheila Flanagan^*1, Angela Wilson¹, Fiona Gabrielczyk¹, Annabel MacFarlane¹, Kanad Mandke¹, Usha Goswami¹

¹ University of Cambridge

162. Two Waves of Acetylcholine Encode Distinct Aspects of Sensation, Action, and Related Expectations

Chung-Wei Chiang^*1, Hemant Kumar Srivastava¹, Zakir Mridha¹, Siddhartha Joshi², Jan Willem de Gee³, Marina Rodriguez Alonso¹, Hong Jiang¹, Matthew McGinley¹

¹Baylor College of Medicine, ²Stanford University, ³University of Amsterdam

163. Signal and Noise Characteristics in Response Discharge of Semicircular Canal Afferent Neurons.

Ahmed Eladly^*1, Kevin Wright¹, Michael Paulin², Larry Hoffman¹, Ahmed Eladly³

¹Geffen School of Medicine at UCLA, ²University of Otago, ³University of California, Los Angeles

164. Hair Cell Patterning During Zebrafish Utricular Development

Selina Baeza-Loya^*1, David Raible¹

¹ University of Washington

165. Increases in Attentional Intensity Shift Auditory Cortical Responses Towards Object-Oriented Coding

Kunpeng Yu^*1, Hemant Kumar Srivastava¹, Justin Fine¹, Ben Hayden¹, Kit Jaspe¹, Nikolas A. Scarcelli¹, Hong Jiang¹, Matthew J. McGinley¹

¹ Baylor College of Medicine

166. Role of Immune Cell Trafficking via Cochlear Blood Vessels and the Newly Discovered Cochlear Lymphatics in the Foreign Body Response Following Cochlear Implantation

Muhammad Rahman^*1, Md Ibrahim Razu¹, Shakila Mahmuda Fatima¹, Md Fahad Hossain¹, Md Shuaib Akhter¹, Bryce Hunger¹, Alexander Claussen¹, Young-Kwon Hong², Marlan Hansen¹

¹The University of Iowa, ²Keck School of Medicine, University of Southern California

167. Long-Read Sequencing of a STRC Deletion

Maria Wong^*1, Maisie Dantuma², Henry Keen², Hela Azaiez¹, Richard J. H. Smith¹

¹University of Iowa Hospitals and Clinics, Molecular Otolaryngology and Renal Laboratories, ²Iowa Institute of Human Genetics, University of Iowa

168. Calyx-Only Afferents in the Vestibular Nuclear Complex Are Chemically Diverse

Syed Naqvi^*1, Rod Braun¹, Avril Genene Holt¹

¹ Wayne State University School of Medicine

169. Localization of Perineuronal Nets in the Contralesional Cochlea Following Unilateral Cochlear Ablation

Walter Moore^*1, Lauren Kate Storm¹, Douglas Vetter¹, Kathleen Yee¹

¹ University of Mississippi Medical Center

170. Effect of Inhalation Exposure of Mn Fumes on Hearing Loss

Vijaya Muthaiah^*1, Supriya Mahajan², Ignacio Novoa Cornejo², Athika Kandaswamy², Calista-Mehitabel Okine², Sakina Bhapuranwala²

¹State University of New York, Buffalo, ²SUNY Buffalo

171. Is Cognitive Decline Following Hearing Loss Correlated with or Impacted by Visual Training

Samantha Zenteno^*1, Sriram Hemachandran², Anthony Ricci¹

¹Stanford University, ²Stanford Medical School

172. Towards Characterizing the Biophysical Properties of Dimorphic Afferents from Central Zones of Mouse Vestibular Epithelia

Daniel Bronson^*1, Katherine Regalado², Radha Kalluri¹

¹University of Southern California, ²University of Southern California, Keck School of Medicine

173. Comparing Infant and Adult Electrophysiological Responses to Pitch Changes With and Without Variations in Brightness

Bonnie K. Lau^*1, Andrew Oxenham²

¹University of Washington, ²University of Minnesota

174. Probing Vertical Sound Localization, and the Role of Ear Movements, in Head-Fixed Behaving Mice

Katharina Bochtler^*1, J Drew¹, August Pfliger¹, James Webb¹, Kyunghee Kim¹, Hemant Kumar Srivastava¹, Junzhan Jing¹, Xialong Jiang¹, Matthew McGinley¹

¹ Baylor College of Medicine

175. Novel Stimulation Methods for Direct Intraneural Stimulation of the Auditory Nerve in Guinea Pig

Inderbir Sondh^*1, Lei Feng¹, Hubert H. Lim¹

¹ University of Minnesota

176. Memory Encoding for Middle-Age and Older Adults during Word Identification in Noise

Kenneth Vaden^*1, Carolyn McClaskey¹, Judy Dubno¹, Mark Eckert¹

¹ Medical University of South Carolina

177. Quantified Measures of Outer Hair Cell Structure from Fib_sem

Miya Imeda¹, Junping Bai², Song Peng², Shan Sue², Joseph Santos-Sacchi², Dhasakumar Navaratnam^*2

¹Bowdoin College, ²Yale University School of Medicine

178. Characterization of Potential Roles for Glial Precursors during Wiring of the Developing Cochlea

Jessica Dixon^*1, Olubusola Olukoya¹, Lisa Goodrich¹

¹ Harvard Medical School

179. Age-Related Alteration of Neural Correlates of Tone-In-Noise Detection in the Auditory Midbrain

Dimitri Brunelle^*1, Luis Franco-Waite¹, Timothy Fawcett¹, Anders Vargas¹, Joseph P. Walton²

¹University of South Florida, ²Med. Engin., Chem. and Biolog. Engin.,Global Ctr. for Hearing and Speech Res., Univ. of South Florida

180. Cortical Layer-Specific Differences in Auditory Responses between Young and Old Mice

Anjum Hussain¹, Katrina Deane^*1, Khaleel Razak¹

¹ University of California Riverside

181. Effects Tubulin Depolymerization on OHC and Deiter Cell Membrane Tension Measured by Flipper-TR

Crystal Gettman^*1, Krish Agrawal², Jun-Ping Bai³, Jie Yang³, Joseph Santos-Sacchi³, Dhasakumar Navaratnam³

¹University of Minnesota, ²Hopkins School in New Haven, ³Yale University School of Medicine

182. Vestibular-Associated Shape Changes in the Prefrontal Cortex Depend on Cognitive Ability

Dominic Padova^*1, J. Tilak Ratnanather², Andreia Faria¹, Yuri Agrawal³

¹Johns Hopkins School of Medicine, ²Johns Hopkins University, ³University of Colorado

183. Lipid Composition of Outer Hair Cells

Kiera Stankewich^*1, Jun-Ping Bai¹, Michael Stankewich¹, Joseph Santos-Sacchi¹, Dhasakumar Navaratnam¹

¹ Yale University School of Medicine

184. Investigating the Transcriptomic Landscape of the Vestibular Ganglion

Rahilla Tarfa^*1, Sarath Vijayakumar², MI ZHOU², David Raible¹, Litao Tao², Jennifer Stone³

¹University of Washington, ²Creighton University, ³University of Washington, Virginia Merrill Bloedel Hearing Resource Center

185. Characterization of Giant Cells of the Dorsal Cochlear Nucleus

Michael Kasten^*1, Reginald Edwards¹, Kendall Hutson¹, Malcolm Lutz¹, Paul Manis¹

¹ University of North Carolina - Chapel Hill

186. Latency Differences Between Lateral Line and Inner-Ear Evoked Startle Responses in Larval Zebrafish

Alyssa Xu^*1, Andrea Mirow¹, Diego Carias¹, Stacey Beganny¹, Josef Trapani¹

¹ Amherst College

187. Individual Spatial Auditory Cognitive Patterns and Self-Construal

Akira Takeuchi^*1, Hwan Shim¹, Inyong Choi², Sungyoung Kim³

¹Rochester Institute of Technology, ²University of Iowa, ³Rochester Institute of Technology/Graduate School of Culture Technology, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea

188. An Open-Science Cross-Species Data Resource for Standardized Hearing Assessments

Michael Heinz^*1, Ananth Grama¹, Samantha Hauser¹, Andrew Sivaprakasam¹, Hari Bharadwaj², Odile Clavier³

¹Purdue University, ²University of Pittsburgh, ³Creare LLC

189. Biophysically Constrained Acoustic Models of Cochlear Implants Are Reliably Optimized Using Interactive Genetic Algorithms (iGA)

Ariel Hight^*1, Rohit Makol¹, Maya Hatley¹, Noam Zigdon², Nicole Capach¹, Megan Eitel¹, Jonathan Neukam³, Robert C. Froemke¹, Mario A. Svirsky¹

¹New York University Grossman School of Medicine, ²University of Rochester, ³Vanderbilt University Medical Center

190. Hair Bundle Variation in the Squid Lateral Line

Brian McDermott^*1, Haoming Wang¹, Carsten Wolff²

¹Case Western Reserve University, ²Marine Biological Laboratory

191. Passive Mechanics in the Human Cochlea Appears to be Sharply Tuned

Aleksandrs Zosuls^*1, Paul Secchia², Anbuselvan Dharmarajan³, Sunil Puria², Hideko Heidi Nakajima²

¹Mass Eye and Ear, Boston University, ²Harvard Medical School, Mass Eye and Ear, ³Otopathology Laboratory, Massachusetts Eye and Ear

192. Intracranial Electrophysiology of Cortical Responses to Self-Generated Speech in Delirium

Emily Dappen^*1, Mitchell Steinschneider¹, Matthew Banks², Kirill Nourski¹

¹The University of Iowa, ²University of Wisconsin - Madison

193. A Novel Clearing and Analysis Pipeline for Quantitative Cellular Analysis within the Cochlea

Trinh Nguyen^*1, Kevin Yu¹, Dwight Bergles¹

¹ Johns Hopkins School of Medicine

194. Nuclear Translocation Coinciding with the Onset of Hearing in Rat and Mouse Inner Haircells

Radha Kalluri^*1, Karla Sintigo¹, Nathaniel Nowak¹, Megana Iyer¹

¹ University of Southern California

195. Place and Temporal Envelope Cues for Pitch, Music, and Emotion Perception with Cochlear Implants

Clementine McTaggart^*1, Holden Sanders², Nicole Dean³, Qian-Jie Fu⁴, David Landsberger⁵, John Galvin⁶, Monita Chatterjee⁷, Lina Reiss³

¹Oregon Health and Sciences University, ²Oregon Health and Science University, ³Oregon Health and Science University, ⁴UCLA, ⁵New York University, ⁶House Institute Foundation, ⁷Boys Town National Research Hospital

196. Quantifying Binaural Speech Fusion Using a Dichotic Formant, Vowel Identification Task in Children and Adults with Cochlear Implants

Emily Burg^*1, Caroline Paroby², Matthew Fitzgerald³, Duane Watson¹, Rene Gifford¹

¹Vanderbilt University, ²University of North Carolina at Chapel Hill, ³Stanford University

197. Epigenetic Modulation of Cochlear Organoids: Investigating the Role of CHD4 in Sensorineural Hearing Impairment Associated with Sifrim-Hitz-Weiss Syndrome

Ilyas Chohra¹, Subhajit Giri¹, Laurent Nguyen¹, Laurence Delacroix¹, Brigitte Malgrange^*1

¹ University of Liege

198. Speech Perception in Noise for Cochlear Implant Recipients with Forwardfocus

Euyhyun Park^*1, Jiwon Chang¹, Gi Jung Im¹

¹ Korea University Anam Hospital, Korea University College of Medicine

199. POLD3 Haploinsufficiency is Linked to Non-Syndromic Sensorineural Adult-Onset Progressive Hearing and Balance Impairments

Eliane Chouery^*1, Cybel Mehawej¹, Rami Saade¹, Rana Barake¹, Patryk Zarecki², Catherine Gennery², Sandra Corbani¹, Rima Korban¹, Ali Hamam¹, Jade Nasser Eldin¹, Andre Megarbane¹, Mirna Mustapha²

¹Lebanese American University, ²University of Sheffield

SS1. Special Session 1: Deep Neural Networks and AI For Auditory Modeling

2:30 p.m. – 4:30 p.m.

Ocean Ballroom 1–4

Chair: Malcolm Slaney, Stanford University

Co-chair: Sarah Verhulst, Ghent University

Co-chair: Josh McDermott, Massachusetts Institute of Technology

Deep-Neural-Network Models of Peripheral Auditory Processing and Their Applications for Hearing Research

Sarah Verhulst^*1, Chuan Wen², Fotios Drakopoulos², Deepak Baby², Arthur Van Den Broucke², Marjoleen Wouters², Sarineh Keshishzadeh²

¹Ghent University, ²Hearing Technology @ WAVES, Dept. of Information Technology, Ghent University

Modeling the Central Auditory System with Machine Learning

Josh McDermott¹

¹ Massachusetts Institute of Technology

Developing Personalized Hearing Models in Jax to Train Novel Machine Learning Strategies for Cochlear Implant Stimulation and Hearing Aid Processing

Maryam Hosseini^*1, Jason Mikiel-Hunter², Nima Salimi², Alan Kan¹, Jorg Buchholz¹, Rob Schonberger³, Honglin Yu³, Tim Brochier⁴, Zachary Smith⁴, Simon Carlile³, Dick Lyon³

¹Macquarie University, ²Macquarie University, ³Google Australia, ⁴Cochlear Limited

A Neural Network Approximation of Cochlear Filtering and Hair-Cell Transduction for Outer and Inner Hair Cell Hearing Impairments

Anil Nagathil^*1, Ian Bruce²

¹Ruhr-Universität Bochum, ²McMaster University

Deep-Learning Based Hearing-Loss Compensation Using an Auditory-Nerve Model

Peter Leer¹, Lars Bramsløw^*1

¹ Eriksholm Research Centre

Hearing Aid Speech Intelligibility Enhancement Using Speech Foundation Models

Jonathan Barker^*1

¹ University of Sheffield

P1. Podium Session 1: Accessing The Inner Ear: Advances in Cochlear Drug Delivery

2:30 p.m. – 4:30 p.m.

Ocean Ballroom 5–8

Contrast Enhancement of Cochlea after Direct Microneedle Intracochlear Injection of Gadodiamide Through the Round Window Membrane with Minimal Dosage

Chaoqun Zhou^*1, Sharon Feng², Stephen Leong³, Eugénie Breil¹, François Voruz¹, Chris Valentini¹, Daniella Hammer¹, Aykut Aksit¹, Elizabeth S. Olson¹, Jia Guo¹, Jeffrey Kysar¹, Anil Lalwani¹

¹Columbia University, ²College of Physicians and Surgeons, Columbia University, ³Columbia University Vagelos College of Physicians and Surgeons

Porcine Ex-Vivo Chamber for Quantitative Assessment of Drug Permeability Through the Round and Oval Window Membranes

Farimah Moazzam^*1, Adele Moatti¹, Samuel Holdsclaw¹, Alon Greenbaum¹

¹ North Carolina State University

Outer Hair Cells Stir Cochlear Fluids

Choongheon Lee^*1, Mohammad Shokrian¹, Kenneth Henry¹, Laurel Carney¹, Joseph Holt¹, Jong-Hoon Nam¹

¹ University of Rochester

Chemosensory Ciliated Cells of the Round Window Niche: Dual Functions in Sensation and Drug Transport to the Inner Ear

Adele Moatti^*1, Shannon Connard², Anna Vavakou³, Ross Lampe², Mani Rai², Farimah Moazzam², Jorge Piedrahita², Lauren Schanbel², Doug Fitzpatrick⁴, Kendall Hutson⁵, Carlton Zdanski⁵, Frances Ligler⁶, Marcel Van Der Heijden⁷, Kenneth Adler², Alon Greenbaum²

¹University of Pittsburgh, ²North Carolina State University, ³University Medical Center Göttingen, ⁴University of North Carolina, ⁵University of North Carolina at Chapel Hill, ⁶Texas A and M University, ⁷Erasmus Medical Center

New Insights into Drug Distribution in the Cochlea: Translational Studies to Understand and Enhance the Cochlear Response to Implantation

Nathan Creber^*1, Hayden Eastwood², Justin Tan², Kate Brody², Dong Zhang², Stephen O'Leary²

¹The University of Sydney, ²University of Melbourne

Development of Optogenetic Microneedle for Minimally Invasive Neuro-Stimulation of Inner Ear

Subin Kim^*1, So-Young Chang², Keum Jin Yang³, Seong su Won⁴, Jiae Jeon⁴, Jae Yun Jung⁵, Dong-Kee Kim⁴, Min Young Lee⁵

¹Soonchunhyang University College of Medicine, Cheonan, Republic of Korea, ²Beckman Laser Institute Korea, Dankook University, ³Daejeon Mary's Hospital, ⁴College of Medicine, The Catholic University of Korea, ⁵Dankook University Hospital

Perilymph and Tissue Distribution of the Novel Drug AC102 After Intratympanic Drug Delivery in a Large Animal Model

Anselm Gadenstaetter^*1, Michael Nieratschker¹, Matthias Gerlitz¹, Erdem Yildiz¹, Till Buschhorn¹, Caroline Sesztak¹, Reimar Schlingensiepen¹, Clemens Honeder¹, Christoph Arnoldner¹

¹Vienna General Hospital, Medical University of Vienna, ²AudioCure Pharma GmbH

Delivery of CRISPR/Cas9 Using Mesenchymal Stem Cell Derived Extracellular Vesicles

Xiaoshu Pan¹, Peixin Huang², Athanasia Warnecke³, Mei He¹, Hinrich Staecker^*2

¹University of Florida School of Pharmacy, ²University of Kansas Medical Center, ³Hannover Medical School/Institute of Audioneurotechnology

P2. Podium Session 2: Auditory Nerve: Mechanisms, Damage, And Protective Strategies

2:30 p.m. – 4:30 p.m.

Ocean Ballroom 9–12

Live Imaging of Macrophage Response to Excitotoxic Injury in Zebrafish Lateral Line

Prithwijit Roychowdhury^*1, Mark Warchol¹, Lavinia Sheets¹

¹ Washington University School of Medicine in St. Louis

Background Noise Impairs Precise Timing of Consonant Cues by Single Auditory Nerve Fibers

Amarins Heeringa^*1, Christine Koeppl¹

¹ Carl Von Ossietzky University

Estrogen-Related Receptor Gamma (Esrrg) is Required for Auditory Innervation and is Essential for Hearing

Shri Vidhya Seshadri¹, Neil J. Ingham¹, Rhianna R. Mackenzie¹, Anwen Bullen², Darya Alcock¹, Katie E. Smith², Adam J. Carlton³, Stuart L. Johnson³, Walter Marcotti³, Karen P. Steel¹, Lisa S. Nolan^*1

¹King's College London, ²University College London, ³University of Sheffield

ATP-Gated P2x7 Receptor Predominantly Expresses in the Type II Auditory Nerves and is Required for the Auditory Efferent System Function and Noise Protection

Chun Liang^*1, Tian-Ying Zhai¹, Li-Man Liu¹, Jin Chen¹, Ning Yu², Hong-Bo Zhao¹

¹Yale University Medical School, ²University of Kentucky Medical Center

TRC051384 Prevents Noise Induced Hearing Loss through Activation of the Heat Shock Response in Spiral Ganglion Neurons

Jintao Yu^*1, Miguel A Ramirez², Seby Edassery², Maxwell Shramuk², Mary Ann Cheatham³, Leah J Welty², Jeffrey N Savas²

¹Huazhong University of Science and Technology, ²Northwestern University Feinberg School of Medicine, ³Northwestern University

Effects of Cochlear Synaptopathy on Single-Unit Auditory-Nerve Responses in the Budgerigar

Leslie Gonzales^*1, Margaret R. Youngman¹, Kenneth S. Henry¹

¹ University of Rochester Medical Center

Translational and Multidisciplinary Investigation of Age-Related Myelin Degeneration in the Auditory Nerve

Kelly Harris^*1, Hainan Lang¹

¹ Medical University of South Carolina

Evaluation of Auditory Evoked Potential Biomarkers of Cochlear Synaptopathy in Listeners with Self-Reported Hearing Difficulties

Attila Fráter^*1, Iris Arweiler², Matthias Inghels², Frederic Acke³, Ingeborg Dhooge³, Sarah Verhulst²

¹Hearing Technology @ WAVES, Ghent University, ²Hearing Technology @ WAVES, Ghent University, ³Ghent University/Ghent University Hospital

IMS2. In Memoriam Symposium: Memorial Symposium for Eric Young: From the Auditory Nerve to Cochlear Nucleus to Cortex, And Back

4:45 p.m. – 6:45 p.m.

Ocean Ballroom 5–8

Chair: Lina Reiss, Oregon Health and Science University

Co-chair: George Spirou, University of South Florida

Co-chair: Tilak Ratnanather, Johns Hopkins University

Eric Young at Johns Hopkins

Paul Fuchs

Johns Hopkins University School of Medicine

Eric Young’s Contributions to Quantifying and Modeling Neural Representations of Sound

Laurel H. Carney

University of Rochester

Auditory Nerve Encoding with Acoustic Trauma

Ian Bruce^*1, Michael Heinz²

¹McMaster University, ²Purdue University

Dorsal Cochlear Nucleus: Functional Anatomy and Circuitry for Auditory Processing

Israel Nelken^*1, George Spirou²

¹Hebrew University, ²University of South Florida

Beyond the STRF: Random Spectrum Stimuli (RSS) Models

Lina Reiss^*1, Sharba Bandyopadhyay²

¹Oregon Health and Science University, ²Indian Institute of Technology Kharagpur

Multimodal Processing in the (Dorsal) Cochlear Nucleus

Patrick Kanold

Johns Hopkins University

Eric Young’s Impact Internationally and Within the ARO

Alan Palmer¹

¹ Hearing Sciences, University of Nottingham

W1. NIDCD Workshop: Seed Grants: NIH Funding for Small Business Research and Development

7:15 p.m. – 8:15 p.m.

Ocean Ballroom 1–4

Chair: Roger Miller, NIDCD/NIH

W2. NIDCD Workshop: Navigating NIDCD Extramural Clinical Trials

7:15 p.m. – 8:15 p.m.

Ocean Ballroom 5–8

Co-chair: Trinh Ly, National Institute on Deafness and Other Communication Disorders, NIH

Co-chair: Kausik Ray, NIDCD/NIH

W3. NIDCD Workshop: NIDCD Early Stage and New Investigators

7:15 p.m. – 8:15 p.m.

Ocean Ballroom 9–12

Co-chair: Janet Cyr, NIH/NIDCD

Co-chair: Martin Basch, Case Western Reserve University

Sunday, February 23, 2025

S1. Symposium 1: Inter-Areal Contributions to Auditory-Guided Behavior

8:00 a.m. – 10:00 a.m.

Ocean Ballroom 1–4

Chair: Ross Williamson, University of Pittsburgh

Co-chair: Justin Yao, Rutgers University

Interactions Between the Ascending and Descending Flow of Information in the Auditory System

Andrew King¹

¹ University of Oxford

Diverse Cortical Layer 1 Circuits for Context-Dependent Auditory Perception

Anne Takesian^*1, Lucas Vattino², Carolyn Sweeney³, Maryse Thomas³, Cathryn MacGregor⁴

¹Harvard Medical School, ²Eaton-Peabody Laboratories, Massachusetts Eye and Ear, Harvard Medical School, ³Massachusetts Eye and Ear/Harvard Medical School, ⁴Eaton-Peabody Laboratories, Massachusetts Eye and Ear

Deep-Layer Projection Neurons Develop Representations of Perceptual Categories and Behavioral Choice

Nathan A. Schneider¹, Michael Malina², Ross Williamson^*1

¹University of Pittsburgh, ²Carnegie Mellon University

Projection-Specific Cortical Processing of Vocalizations Driving Mouse Maternal Behavior

Amy LeMessurier^*1, Ayat A. Agha², Gurket Kaur², Janaye Stephens², Robert C. Froemke²

¹New York University School of Medicine, ²NYU School of Medicine

Orbitofrontal Cortex Modulates Auditory Cortical Sensitivity and Sound Perception

Matheus Macedo-Lima¹, Lashaka S. Hamlette¹, Melissa Caras^*1

¹ University of Maryland

The Asynchronous Maturation of the Left and Right Auditory Cortex Could Underpin Specialized Sound Processing Development

Demetrious Neophytou¹, Ashlan Reid², Cody Pham³, Hysell Oviedo^*3

¹CUNY Graduate Center, ²New York Medical College, ³Washington University

Contribution of Top-Down and Bottom-Up Processing in Auditory Decision-Making

Corey Roach¹, Lalitta Suriya-Arunroj¹, Sophia Fu¹, Joshua Gold¹, Yale Cohen^*1

¹ University of Pennsylvania School of Medicine

YIS1: Young Investigator Symposium 1: Cochlear Health After Cochlear Implants, Biomarkers, Therapeutics, And Outcomes

8:00 a.m. – 10:00 a.m.

Ocean Ballroom 5–8

Chair: Seba Ausili, University of Miami

Drug-Eluting Cochlear Implants

Stephen O'Leary^*1, Tayla Razmovski¹, Kate Brody¹, Ellie Cho¹

¹ University of Melbourne

A Glimpse into the Implanted Ear: Modeling and Modulating Electrode-Tissue Interface

Federico Di Lella¹, Sebastián Ausili²

¹Hospital Italiano de Buenos Aires, ²University of Miami

Therapeutic Hypothermia for Inner Ear Functional Preservation: Translational Journey from Preclinical Research to Clinical Applications

Maria Fernanda Yepes Restrepo^*1, Rachele Sangaletti¹, Curtis King², Kaelan Grooves², Suhrud Rajguru¹

¹University of Miami, ²Restor-Ear Devices LLC

Using the Panoramic Ecap Method to Characterize Current Spread and Neural Responsiveness in Cochlear Implant Users

Charlotte Garcia^*1, Robert Carlyon²

¹University of Cambridge, ²Cambridge Hearing Group, MRC Cognition and Brain Sciences Unit, University of Cambridge

From Neural Health to Decision-Making and Their Role on Patient Outcomes

Ignacio Calderón^*1, Andy Beynon², John Van Opstal³, Emmanuel A., M. Mylanus², Marc Van Wanrooij³

¹Radboudumc, ²Radboud University Medical Center, Nijmegen, The Netherlands, ³Radboud University Nijmegen

Measures for CI Outcomes Prediction: Deep Learning with Temporal Bone Histology, Advances in Electrophysiology, and Quantification of the Electrode-Neural Interface

Christopher Giardina^*1, Julie Arenberg², Alicia Quesnel³

¹Harvard Medical School, ²Harvard Medical School, Massachusetts Eye and Ear, ³Massachusetts Eye and Ear Infirmary, Harvard Medical School

P3. Podium Session 3: Hair Cell Anatomy and Physiology: Molecular Dynamics, Structural Components, And Pathways to Protection

8:00 a.m. – 10:00 a.m.

Ocean Ballroom 9–12

Lipid Flippase ATP8B1 in the Function and Degeneration of Sensory Hair Cells

Henry De Hoyos^*1, Jun-Sub Im¹, Betsy Szeto¹, Emma Kim¹, Nikhil Amin¹, Jung-Bum Shin¹

¹ University of Virginia

Analyses of MYO7A-Driven Active Cargo Transport in Stereocilia Using Single-Molecule Microscopy in Live Hair Cells

Takushi Miyoshi^*1, Mrudhula Sajeevadathan², Harshad Vishwasrao³, Inna Belyantseva⁴, Yasuko Ishibashi⁵, Samuel Adadey⁶, Narinobu Harada⁷, Hari Shroff⁸, Thomas Friedman⁴

¹Southern Illinois University School of Medicine, ²Southern Illinois University, ³NIBIB/NIH, ⁴NIDCD/NIH, ⁵Inner Ear Gene Therapy Program, National Institute on Deafness and Other Communication Disorders (NIDCD), National Institutes of Health; Laboratory of Molecular Genetics, National Institute on Deafness and Other Communication Disorders (NIDCD), National Institutes of Health, ⁶National Institute on Deafness and Other Communication Disorders, ⁷Harada Ear Institute, ⁸Janelia Research Campus

The Auditory Hair Cell Mechanotransduction Complex Regulates Stereocilia Membrane Mechanics

Shefin George^*1, Anthony Ricci¹

¹ Stanford University

Characterization of the Lipid Scramblase Activity of TMC1 and TMC2: New Perspectives on Mechanotransduction and Disease Mechanisms

Yein Christina Park^*1, Hubert Lee², Jayashree Balaraman², Angela Ballesteros²

¹National Institute of Health, ²Section on Sensory Physiology and Biophysics, National Institute on Deafness and other Communication Disorders

The Mechanotransduction Complex of Inner Hair Cells is the Primary Target of Noise-Induced Hearing Loss

Samuel Webb^*1, Stuart Johnson¹

¹ University of Sheffield

Identification of a Novel Principal Component of Outer Hair Cell Stereocilia – Tectorial Membrane Connectors

Dennis Derstroff¹, Antonia Löhnes¹, Vijay Vijay Renigunta², Boris A. Stuck¹, Nicola Strenzke³, Dominik Oliver², Katrin Reimann^*1

¹University Hospital Marburg, Philipps-University Marburg, ²Institute of Physiology and Pathophysiology, Philipps‐Universität Marburg, ³Institute for Auditory Neuroscience, University Medical Center Göttingen

Sensory Transduction Plays an Essential Role in the Maturation of Inner Hair Cells, Afferent Ribbon Synapses and Auditory Nerve Fibers

Thibault Peineau^*1, John Lee¹, Brikha Shrestha², Wu Zhou³, Hong Zhu³, Jeffrey Holt¹, Gwenaelle Geleoc¹

¹Boston Children's Hospital, Harvard Medical School, ²Mass Eye and Ear/Harvard Medical School, ³University of Mississippi Medical Center

Effects of the Abolition of Salt Bridges on Prestin Voltage-Sensor Charge Movements

Jie Yang^*1, Chenou Zhang², Jun-Ping Bai¹, Richard Mariadasse¹, Joseph Santos-Sacchi¹, Oliver Beckstein², Dhasakumar Navaratnam¹

¹Yale University School of Medicine, ²Arizona State University

S2. Symposium 2: Vestibular Disorders: Breakthroughs in Diagnosis and Management

10:30 a.m. – 12:30 p.m.

Ocean Ballroom 1–4

Chair: John Lee, National Institute on Deafness and Other Communication Disorders

Quantifying Clinical Measures of Vestibular Function and Perception in Children with Vestibular Loss

Kristen Janky^*1, Andrew Wagner², Jessie Patterson¹, Choudhry Bisma¹

¹Boys Town National Research Hospital, ²Creighton University

Are we Underestimating Fall Risk in Balance Disordered Patients?

Christopher Zalewski^*1, Talah Wafa², Carmen Brewer³

¹NIH - NIDCD, ²Audiology Unit, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, ³Audiology Unit, National Institute on Deafness and Other Communication Disorders, National Institutes of Health

Assessment of Vestibular Perception in Persistent Postural Perceptual Dizziness

Megan Kobel^*1, Andrew Wagner², Dan Merfeld³

¹University of Arizona, ²Creighton University, ³Ohio State University

Central Vestibular Processing After Peripheral lesions: Implications for Diagnosis

Amsal Madhani¹, Richard Lewis², Faisal Karmali^*2

¹Massachusetts Eye and Ear Infirmary, Harvard Medical School, ²Harvard Medical School

Novel Kinematic Analyses for Detection of Intravenous Aminoglycoside-Induced Vestibular Loss

Angela Garinis^*1, Timothy Hullar², Laurie King², Robert Peterka², Daniel Putterman¹, Jay Vachhani², Ma Vida Echaluse¹

¹Oregon Health and Science University, ²VA National Center for Rehabilitative Auditory Research

Implementation of an Automated Triage System in Epic for Patients with Dizziness Using Machine Learning

Devin McCaslin

University of Michigan

P4. Podium Session 4: From Hearing Loss to Functional Hearing

10:30 a.m. – 12:30 p.m.

Ocean Ballroom 5–8

Using Large-Scale Brain Recordings and Deep Learning to Engineer Optimal Hearing Aids

Fotios Drakopoulos^*1, Lloyd Pellatt¹, Yiqing Xia¹, Shievanie Sabesan¹, Andreas Fragner², Nicholas Lesica¹

¹University College London, ²Perceptual Technologies

Prophylactic Nimodipine for Hearing Preservation in Vestibular Schwannoma: A Retrospective Cohort Study

Clifford He^*1, Douglas Bennion², Abhishek Bhatt³, Michael Brandel⁴, Joshua Lee⁵, Marc Schwartz⁴, Rick Friedman⁶

¹University of California, San Diego, ²Division of Otolaryngology – Head and Neck Surgery, University of California, San Diego, ³UC San Diego, ⁴University of California San Diego, ⁵New York Medical College, ⁶University of California, San Diego Medical Center

Neurotransmitter Concentration Levels in the Auditory Cortex Correlate with Subjective Hearing Impairment in Age-Related Hearing Loss

Stephanie Rosemann^*1, Christiane M Thiel¹

¹ Carl von Ossietzky Universität Oldenburg

The Effects of Noise-Induced Hearing Loss on Auditory Decision-Making

Madeline Berns^*1, Genesis Nunez¹, Xingeng Zhang¹, Anindita Chavan¹, Klavdia Zemlianova², Marissa Calvano¹, Todd Mowery¹, Justin Yao¹

¹Rutgers University, ²Columbia University

Impact of Hearing Loss and Cochlear Implantation on Attentional Selection in Older Adults

Alex Tu^*1, Gennadiy Gurariy², Shannon Walsh¹, Kristin Kozlowski¹, Samiah Ziadeh³, Sarah Mleziva¹, Adam Greenberg³, Michael Harris¹

¹Medical College of Wisconsin, ²Ohio University, ³Medical College of Wisconsin and Marquette University

Assessing the Cognitive Decline Post Hearing Loss

Sriram Hemachandran^*1, Jesus Maldonado², Anthony Ricci³

¹Stanford Medical School, ²Stanford School of Medicine, ³Stanford University

Behavioral and Neurophysiological Signatures of Functional Hearing Difficulties in Blast Exposed Veterans

Jonathan Venezia^*1

¹ VA Loma Linda Healthcare System

Peripheral and Central Auditory Effects from Continuous Aircraft Carrier Noise Exposure at Moderate Sound Levels

Fernando Aguilera de Alba^*1, Isabella Huddleston¹, Elizabeth Jensen¹, Michael Heinz¹

¹ Purdue University

P5. Podium Session 5: Immunology: Function, Dysfunction, And Treatment

10:30 a.m. – 12:30 p.m.

Ocean Ballroom 9–12

Complement Component C3 Accumulates in the Cochlea of CBA/CaJ Mice with Noise-Induced Hearing Loss

Zixu Guo^*1, Benjamin Seicol², Katy Garrity¹, Mina Shenouda¹, Shengyin Lin¹, Ruili Xie¹

¹The Ohio State University, ²Johns Hopkins Medicine

Dectin-1 Dysregulation: A Potential Contributor to Age-Related Demyelination in the Auditory Nerve

Shelby Payne^*1, Jamie L Barth¹, Hainan Lang¹

¹ Medical University of South Carolina

Endothelial Cells and Iba1-Positive Cells Under the Organ of Corti Constitute the Immunological Unit for Cochlear Hair Cells

Yushi Hayashi^*1

¹ Nippon Medical School

Bulk RNA and ScRNA-Seq Analyses Identify Macrophages as Major Effectors of Fibrosis After Cochlear Implantation in Rat

Frederic Venail^*1, Mélissa Urbain², Jholy de la Cruz Talaverano³, Jerome Bourien⁴, Adrien Caplot⁵, Farida Djouad³, Jean Luc Puel⁶

¹University Hospital of Montpellier, ²Institut for Neurociences of Montpellier, ³Institute for Regenerative Medicine, Montpellier, ⁴Institute for Neurosciences Montpellier, University of Montpellier, Institut National de la Santé et de la Recherche Médicale, ⁵Institut for Neurosciences of Montpellier, ⁶Montpellier University

INO-3107, DNA Immunotherapy for Treatment of Recurrent Respiratory Papillomatosis, Results in a Reduction of Surgeries in Patients With HPV-6 and HPV-11 Genotypes

Jeffrey M Skolnik¹, Matthew P Morrow¹, Chris Welsh¹, Stefani Slog^*1

¹ Inovio Pharmaceuticals

The Time Course of Monocytes Infiltration after Acoustic Overstimulation

Seong Hoon Bae^*1, Seung Ho Shin², HaengRan Park¹, Sung Huhn Kim³, Jinsei Jung³

¹Yonsei University College of Medicine, ²Yonsei University, College of Medicine, ³Yonsei University College of Medicine

Radiation Alters Secretion of Proinflammatory Cytokines from Primary Vestibular Schwannoma Cells

Mikhail Marasigan^*1, Olena Bracho², Bryan Sousa², Michael Ivan³, Fred Telischi², Cristina Fernandez-Valle⁴, Christine Dinh²

¹Miller School of Medicine, University of Miami, ²Miller School of Medicine, University of Miami, ³Miller School of Medicine, University of Miami, ⁴Burnett School Biomedical Sciences, College of Medicine, University of Central Florida

Spatial Organization of Cochlear Lymphatic Vessels in Murine Model

Md Ibrahim Razu^*1, Muhammad Rahman², Shakila Mahmuda Fatima², Md Fahad Hossain², Md Shuaib Akhter², Bryce Hunger², Young-Kwon Hong³, Alexander Claussen², Marlan Hansen²

¹The University of Iowa, ²The University of Iowa, ³Keck School of Medicine, University of Southern California

Poster Session II

1:30 p.m. – 3:00 p.m.

Peninsula Ballroom

1. Perceptual Categorization of and Adaptation to Human Voice and Musical instruments: A Passive-Listening Study

Zi Gao^*1, Andrew J. Oxenham²

¹The Ohio State University, ²University of Minnesota, Department of Psychology

2. Characterization of Supporting Cell Diversity in the Mammalian Utricle

Robin Ruth Kee^*1, Beatrice Mao², Tessa Sanders², Matthew Kelley²

¹National Institutes of Health, National Institute on Aging, National Institute on Deafness and Other Communication Disorders, ²National Institute on Deafness and Other Communication Disorders, NIH

3. Prox1 Regulates Development of the Lateral Compartment of the Organ of Corti

Braulio Peguero^*1, Mhamed Grati², Wade Chien³, Matthew Kelley²

¹National Institute on Deafness and Other Communication Disorders, National Institutes of Health, ²National Institute on Deafness and Other Communication Disorders (NIDCD), National Institutes of Health (NIH), ³National Institute on Deafness and Other Communication Disorders (NIDCD), National Institutes of Health (NIH) and Johns Hopkins School of Medicine

4. Hair Cells Do Not Require Core PCP Proteins or GPR156 Signaling to Correct Their Orientation in Time

Amandine Jarysta^*1, Cesare Orlandi², Michael Deans³, Basile Tarchini¹

¹The Jackson Laboratory, ²University of Rochester Medical Center, ³Emory University School of Medicine

5. Absence of Sall1 Delays the Differentiation of Cochlear Outer Hair Cell

Yunpeng Gu^*1, ZHIYONG LIU²

¹Chinese Academy of Sciences, ²Institute of Neuroscience, Chinese Academy of Sciences

6. Pre- And Post-Hearing Development of Glutamatergic Neurotransmission in the Dorsal Cochlear Nucleus of Mice

Natalia Boaretto^*1, Ricardo Leao¹

¹ University of Sao Paulo

7. Predicting Speech Perception Through Information Processing Rate in a Mild Traumatic Brain Injury Population

Conner Corbett^*1, Karen Garcia¹, Lauren Charney¹, Tess Koerner², Frederick Gallun¹

¹Oregon Health and Sciences University, ²VA RR and D National Center for Rehabilitative Auditory Research

8. Measuring the Performance of Hearing Aid Fitting Algorithms on Hearing in Noise

Ahsan Cheema^*1, Sunil Puria²

¹Harvard Medical School, Massachusetts General Hospital, ²MEE

9. A New Genetic Model to Mark Pure Neonatal Cochlear Outer Hair Cells for Single-Cell Transcriptomic Analysis

Zhenglin Jiang^*1, Minghui Ren², Zhiyong Liu², Hao Wu¹

¹Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine; Ear Institute, Shanghai Jiao Tong University School of Medicine; Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, ²Institute of Neuroscience, Chinese Academy of Sciences

10. Effect of Subclinical Cochlear Damage on Brainstem Encoding of Amplitude Envelope

Anu Sreenivasan Nair^*1, Pedro Andres Alba Diaz¹, Srikanta Mishra¹

¹ University of Texas at Austin

11. Two-Dimensional Organ of Corti Motion in the Mouse Apex

Gabriel Alberts^*1, Wiam Lahlou², Sunil Puria³

¹Harvard University, ²International University of Rabat, ³MEE

12. Not Fishy at All: Hair Cell Damage and Protection in the Zebrafish Model System

Allison Coffin^*1, Khia Min Sabrina Koh², Mariana Lopes Soares Llamas², Isabella Moreno Stedman², Noel Smith², Bella Williams²

¹Creighton University, ²Washington State University - Vancouver

13. Translating a Computational Model of the Human Auditory Periphery to Gerbil and Mouse for Comparative Auditory Research

Morgan Thienpont^*1, Francois Deloche², Sarineh Keshishzadeh¹, Daniil Kiselev³, Jerome Bourien⁴, Jean Luc Puel⁵, Brad Buran⁶, Naomi Bramhall⁷, Sarah Verhulst⁸

¹Ghent University, ²Ghent University, Belgium, ³Institute for Neurosciences Montpellier, University of Montpellier, Institut National de la Santé et de la Recherche Médicale, ⁴Institute for Neurosciences Montpellier, University of Montpellier, Institut National de la Santé et de la Recherche Médicale, ⁵Montpellier University, ⁶Oregon Health and Science University, ⁷VA NCRAR, ⁸Hearing Technology @ WAVES, Ghent University

14. Sensory Inhibition in Central Auditory Processing Disorder

Megan Guidry^*1, Julia Campbell², Lauren Aronowitz², Phoebe Fertig²

¹University of Texas at Austin, ²The University of Texas at Austin

15. A Transient Memory Lapse in Humans Less Than One Hour After Training on a Sound-Localization Task

Allison A. May¹, Hannah R. Rostollan¹, Beverly A. Wright^*1

¹ Northwestern University

16. Sox 10 Haploinsufficiency Increases Hair Cell Reprogramming in Mature Non-Sensory Cells

Alissa Buck^*1, Melissa McGovern¹

¹ University of Pittsburgh

17. Characterization of a Progressive Early Onset Hearing Loss in SIRT3 Knock-Out Mice

Chail Koo^*1, Devin Thomas¹, Robert Fuentes¹, Claus-Peter Richter¹, Xiaodong Tan¹

¹ Northwestern University

18. Harmonic Distortion Products Within the Cochlear Partition in the Basal Turn of Sensitive Gerbil Cochleae

Wenxuan He¹, Tianying Ren^*1

¹ Oregon Health Science University

19. Electrical and Mechanical Basis for Prestin's Role in Mammalian Hearing Adaptation to Loud Sound

Henrik Sahlin Pettersen¹, Anders Fridberger², Pierre Hakizimana^*3

¹Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, NO-7491 Trondheim, Norway; St. Olav’s hospital, Trondheim University Hospital, Trondheim, Norway., ²Linköping University, Sweden, ³Linköping University

20. Abnormal Histopathological Features in the Aging Vestibular System of an Alzheimer’s Mouse Model

Deborah Hamilton^*1, Brandon C. Cox², Bradley J. Walters³

¹Southern Illinois University School of Medicine, ²SIU School of Medicine, ³University of Mississippi Medical Center

21. Otoprotective Effect of Mntbap in Cisplatin-Induced Hearing Loss

Shomaila Mehmood¹, Pankaj Bhatia¹, Nicole Doyon-Reale¹, Samson Jamesdaniel^*1

¹ Wayne State University

22. Simultaneous Encoding of Features of Frequency-Modulated Sweeps in Individual Inferior Colliculus Neurons

Sarah Wajdi^*1, Audrey Drotos¹, Michael Malina², Ross Williamson³, Michael Roberts¹

¹University of Michigan, ²Carnegie-Mellon University, ³University of Pittsburgh

23. Evaluating the Effectiveness of Short Interpulse Interval (SIPI) Stimulation in Multichannel Cochlear Implants

Yibo Fan^*1, Demi Wu¹, Rene Gifford²

¹Vanderbilt University, ²Vanderbilt University Medical Center

24. To Glimpse or Not to Glimpse: Behavioral and Neuroimaging Evidence for Binaural Glimpsing

Jörg Encke^*1, Hamish Innes-Brown², Heivet Hernandez-Perez¹, David McAlpine¹

¹Macquarie University, ²Eriksholm Research Centre

25. Organoid-Derived Otic Neuronal Progenitor Cells for Restoration of the Denervated Cochlea

Merete Hartmann^*1, Angeliki Koufali², Maria-Patapia Zafeiriou², Christian Wrobel¹

¹University Medical Center Goettingen, ²Institute for Pharmacology and Toxicology, University Medical Center Goettingen

26. Deep Neural Network Models of Human Sound Localization Indicate Which Aspects of Localization Are Mediated by Explicit Binaural Processing

Mathias Dietz^*1, Mohammad Dehghani-Habibabadi¹, Mark Saddler², Josh McDermott³

¹University of Oldenburg, ²Technical University of Denmark (DTU), ³MIT

27. CDK1 Regulating Calcium Influx Underlies Susceptibility to Noise-Induced Cochlear Synaptopathy and Riviciclib Protects against NICS

Hongchao Liu^*1, Ruijie Cai², Yunge Gao², huihui liu³, Hao Wu⁴

¹Shanghai Jiaotong University, ²Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, ³Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, ⁴Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine; Ear Institute, Shanghai Jiao Tong University School of Medicine; Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases

28. Cortical Contribution to Task-Relevant Activity in the Inferior Colliculus

Clara Martinez-Voigt^*1, Pierre Apostolides¹, Clara Martinez-Voigt²

¹Kresge Hearing Research Institute, University of Michigan, ²University of Michigan

29. Cross-Culturally Shared Sensitivity to Harmonic Structure Underlies Aspects of Pitch Discrimination

Aidan Seidle^*1, Malinda McPherson¹, Eduardo Undurraga², Josh McDermott³

¹Purdue University, ²Escuela de Gobierno, Pontificia Universidad Católica de Chile, ³MIT

30. L-Ergothioneine Shows Sex-Specific Benefits in Reducing Age-Related Hearing Loss: Improved Signal-in-Noise Detection in Male Mice

Collin Park^*1, Olivia Stanley², Parveen Bazard³, Robert D. Frisina⁴, Joseph P. Walton⁵

¹Global Ctr. Hearing and Speech Res., University of South Florida, ²University of South Florida, ³Medical Engineering Dept., Global Ctr. Hearing and Speech Res., University of South Florida, Missouri University of Science and Technology, ⁴Global Ctr. Hearing and Speech Res., University of South Florida, ⁵Med. Engin., Chem. and Biolog. Engin., Global Ctr. for Hearing and Speech Res., Dept. of Communication Sci. and Disorders.,Univ. of South Florida

31. Language Learning and Musical Activities in Older Adults with Hearing Loss: Cumulative Effects on Cognitive Function and Psychosocial Wellbeing

Eleanor Harding^*1, Deniz Başkent², Merel Keijzer¹

¹University of Groningen, ²University of Groningen, University Medical Center Groningen

32. Genetic Landscape of Hearing Loss in Argentina: Comprehensive Molecular Studies and Preclinical Research Using the Zebrafish Model

Paula Ines Buonfiglio^*1, Carlos David Bruque², Mariela Pace¹, Lucia Salatino³, Vanesa Lotersztein⁴, Sebastián Menazzi⁵, Paola Plazas³, Ana Elgoyhen⁶, Viviana Dalamón¹, Paula Buonfiglio⁷

¹Laboratory of Physiology and Genetics of Hearing, Institute of Genetic Engineering and Molecular Biology “Dr. Héctor N. Torres”—National Council of Scientific and Technology (INGEBI-CONICET), Buenos Aires C1428ADN, Argentina, ²Patagonian Translational Knowledge Unit, El Calafate SAMIC High Complexity Hospital, El Calafate, Argentina, ³Pharmacology Institute, Faculty of Medicine, University of Buenos Aires, Buenos Aires C1121A6B, Argentina, ⁴Genetics Service, National Center for Medical Genetics, Buenos AiresArgentina, ⁵Genetics Division of the Hospital de Clínicas “José de San Martín”.Buenos Aires, Argentina., ⁶Institute for Research in Genetic Engineering, ⁷Instituto de Investigaciones en Ingeniería Genética y Biología Molecular ''Dr. Héctor N. Torres'' (INGEBI), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET)

33. Direct Connectivity Between the Inferior Colliculus and the Lateral Vestibular Nucleus in the Integration of Auditory and Vestibular Systems

Sunghee Kang^*1, Youngrae Ji¹, Gunsoo Kim¹

¹ Korea Brain Research Institute

34. No Evidence for Cochlear Dysfunction in Ageing Barn Owls

Christine Koeppl^*1

¹ Carl Von Ossietzky University

35. The Detection of Biomarkers for the Development of Age-Related Hearing Loss Using Metabolomics in the Japanese General Population

Ryoko Yotsuyanagi^*1, Daichi Kokubu², Akira Sasaki¹, Shinichi Goto¹, Hiroyuki Yamamoto³, Kozue Terai³, Ken Itoh⁴, Atsushi Matsubara¹, Ryoko Yotsuyanagi⁵

¹Hirosaki University Graduate School of Medicine, ²Diet and Well-being Research Institute, KAGOME CO., LTD., ³Human Metabolome Technologies, Inc., ⁴Hirosaki University Graduate School of Medicine, ⁵Hirosaki University

36. Towards a Generalized Deep Neural Network Model of Human Eeg Responses to Sounds

Thomas Stoll^*1, Joseph Casale¹, Ross Maddox¹

¹ University of Michigan

37. Association of Glial Cells in Hearing Loss in the Zebrafish Spen Mutant

Yan Gao^*1, Anna Shipman², Eliot Smith², Peng Sun³, Itallia Pacentine⁴, Timothy Erickson⁵, Alex Nechiporuk⁴, NA ZHANG³, Teresa Nicolson⁶

¹Stanford School of Medicine, ²Stanford School of Medicine - Otolaryngology, ³Stanford University School of Medicine, ⁴Oregon Health and Science University, ⁵East Carolina University, ⁶Stanford School of Medicine - Otololaryngology

38. Memory-Guided Attention in Hearing Loss and Aging

Dominica Pec¹, Negar Salehi¹, Claude Alain², Brandon Paul^*1

¹Toronto Metropolitan University, ²Rotman Research Institute

39. Donut Mitochondria: A ‘Hot and Ready’ Mitochondrial Repair/Defense Mechanism?

Elayna Malak^*1, Josef Trapani¹, Lavinia Sheets²

¹Amherst College, ²Washington University School of Medicine in St. Louis

40. Emergence of Interaural Time Difference Tuning in a Neural Network Trained for Sound Classification

Takuya Koumura^*1, Hiroki Terashima¹, Shigeto Furukawa²

¹NTT Communication Science Laboratories, ²Shizuoka Graduate University of Public Health

41. Repurposing Pravastatin and Metformin for the Treatment and Prevention of Noise-Induced Hidden Hearing Loss in a Mouse Model

Reza Amanipour^*1, Benjamin Shuster², Beatrice Milon³, Ronna Hertzano²

¹National Institute on Deafness and Other Communication Disorders, National Institutes of Health, ²NIH/NIDCD, University of Maryland School of Medicine, ³NIH/NIDCD

42. Exploring the Correlation Between Blast-Induced Hearing Loss and the Progression of Alzheimer’s Disease

Rachele Sangaletti^*1, Winston M. Walters¹, Shinelle Williams¹, Suhrud Rajguru¹, Nadine Kerr¹

¹ University of Miami

43. Peripheral Auditory Impacts of Alzheimer’s Disease in Cochlear-Implanted Transgenic Mice

Logan Flom^*1, Samia Sultana Lira¹, Brian Mostaert¹, Ibrahim Razu¹, Shakila Fatima¹, Muhammed Rahman¹, Rachel Scheperle¹, Marlan Hansen¹

¹ University of Iowa Health Care

44. Influence of Single-Nucleotide Polymorphisms of the NF-E2-Related Factor 2 Gene on Age-Related Hearing Loss in the General Japanese Population from the Iwaki Health Promotion Project

Akira Sasaki^*1, Takashi Kasai¹, Shuya Kasai¹, Shiori Miura¹, Shinichi Goto¹, Ryoko Yotsuyanagi¹, Tatsuya Mikami¹, Yoshinori Tamada¹, Ken Itoh¹, Atsushi Matsubara¹

¹ Hirosaki University Graduate School of Medicine

45. Hearing at Home: The Auditory Environment of Young Children with Hearing Loss

Annerenée Meijer^*1, Michel Benard¹, Aart Woonink², Deniz Başkent³, Evelien Dirks⁴

¹Pento Speech and Hearing Centers, Zwolle, the Netherlands, ²Cauberg-Huygen, Zwolle, the Netherlands, ³University of Groningen, University Medical Center Groningen, the Netherlands, ⁴Dutch Foundation of the Deaf and Hard of Hearing Child (NSDSK), Amsterdam, the Netherlands

46. Rational Design of a Lfng-Enhancer AAV Construct Drives Specific and Efficient Gene Expression in Inner Ear Supporting Cells

Richard Seist^*1, Juwan Copeland¹, Hongyuan Zhang¹, Litao Tao², Andrew K. Groves¹

¹Baylor College of Medicine, ²Creighton University

47. The Effect of Chirp vs Click Stimuli on the ABR Binaural Interaction Component and Behavioral Sensitivity to Interaural Time Difference in Humans

Kerry Walker¹, Carol Sammeth¹, Matthew Mavandi², Nathaniel Greene¹, Daniel Tollin^*1

¹University of Colorado School of Medicine, ²Kansas City University

48. Oligogenic Approaches to Whole Exome Sequence Analysis of a Large, Well-Phenotyped Cohort of Older Adults

Morag Lewis^*1, Jennifer Schulte², Bradley Schulte², Judy Dubno², Karen Steel³

¹King’s College London, ²The Medical University of South Carolina, ³King's College London

49. Candidate Therapeutic Approaches Identified from Transcriptomic Analyses of Mice Carrying Human MIR96 Mutations

Morag Lewis^*1, Maria Lachgar-Ruiz¹, Francesca di Domenico¹, Graham Duddy², Jing Chen¹, Sergio Fernandez³, Matias Morin³, Gareth Williams¹, Miguel Ángel Moreno Pelayo³, Karen Steel¹

¹King’s College London, ²Wellcome Sanger Institute, ³Hospital Universitario Ramón y Cajal and IRYCIS and CIBERER

50. Characterization of Kdm6a Conditional Knockout Mice as a Preclinical Model for Kabuki Syndrome Type 2

Yuichi Shimizu^*1, Mason Palaga², Loryn Smith², Shriya Jhaveri², Amir Etemadi³, Kalley Waldrop², Kevin Wu², Yohei Honkura⁴, Jun Suzuki⁴, Yukio Katori⁴, Shinichi Someya²

¹University of Florida, ²University of Florida, Department of Physiology and Aging, ³Carleton College, ⁴Tohoku University Graduate School of Medicine

51. Texture Streaming in Auditory Scenes

Jarrod Hicks^*1, Josh McDermott²

¹Massachusetts Institute of Technology, ²MIT

52. Hearing Acuity and Musicianship Differentially Affect Mismatch Negativity and Memory Precision

Ricky Chow^*1, Jennifer Bugos², Shimin Mo³, Claude Alain³, R. Shayna Rosenbaum⁴

¹York University and Rotman Research Institute at Baycrest, ²University of Florida, ³University of Toronto, ⁴York University

53. Mitigation of Cochlear Damage with Liraglutide Treatment in Chinchillas Exposed to Repeated Blasts

Qunfeng Cai^*1, Shangyuan Jiang¹, Yijie Jiang¹, Rong Gan¹

¹ University of Oklahoma

54. CHD7 Enriched Silencers Promote Neuronal Differentiation

Jingyun Qiu^*1, Azadeh Jadali², Julie Ni¹, Edward Martinez¹, Zhichao Song³, Kelvin Y. Kwan¹

¹Rutgers University, ²Sampled, ³Sherpa Healthcare Partners

55. CRISPR/Cas9-Mediated Exon Skipping to Restore Premature Translation Termination in a DFNB4 Mouse Model

Yi-Hsiu Tsai^*1, Chun-Ying Huang², Yi-Fen Cheng², Peng-Yu Wu², Yu-Chi Chuang³, Po-Yuan Huang², Jai-Shin Liu⁴, Chen-Chi Wu⁵, Yen-Fu Cheng⁶

¹Institute of Brain Science, National Yang Ming Chiao Tung University, ²Taipei Veterans General Hospital, ³Institute of Brain Science, National Yang Ming Chiao Tung University, ⁴Yuanpei University of Medical Technology, ⁵National Taiwan University Hospital; National Taiwan University Hospital Hsin-Chu Branch, ⁶Taipei Veterans General Hospital, Taipei, Taiwan; Taipei Veteran General Hospital

56. Lentiviral Transduction of the Avian Inner Ear

Austin Huang^*1, Maggie Matern¹, Nesrine Benkafadar¹, Stefan Heller¹

¹ Stanford University School of Medicine

57. Multi-Omics Analysis for Elucidating the Mechanism of Supporting Cell Reprogramming During Chick Cochlear Hair Cell Regeneration

Mami Matsunaga^*1, Marie Takeuchi¹, Koichi Omori¹, Takayuki Nakagawa¹

¹ Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan

58. Rare Missense Variants in Constrained Regions in the Otog Gene Support a Founder Effect in Southern European Population in Familial Meniere Disease

Jose Lopez-Escamez^*1, Alberto M. Parra-Pérez², Alvaro Gallego-Martinez²

¹The University of Sydney, ²University of Granada

59. Ergothioneine Consumption Shows Improvements in Hearing in Older Adults: An Analysis of Nhanes Data

Parveen Bazard¹, Timothy J Fawcett², Anders Vargas², Collin Park³, Mark A. Bauer⁴, Robert Frisina^*2, Joseph P. Walton⁵

¹Medical Engineering Dept., Global Ctr. Hearing and Speech Res., University of South Florida, Missouri University of Science and Technology, ²University of South Florida, ³Global Ctr. Hearing and Speech Res., University of South Florida, ⁴Global Ctr. Hearing and Speech Res., University of South Florida, ⁵Med. Engin., Chem. and Biology. Engin., Global Ctr. for Hearing and Speech Res, Univ. of South Florida

60. Can Hearing Loss in Pex3 Mutants with Synaptic Defects Be Reversed?

Rechal Kumar^*1, Elisa Martelletti¹, Karen P. Steel¹

¹ King's College London

61. Non-Invasive Imaging of the Inner Ear in Animal Models

Parveen Bazard^*1, Mikalai Budzevich², Akil Turner³, Xiaoxia Zhu⁴, Bo Ding⁵, Robert Frisina⁴

¹Missouri University of Science and Technolgy, ²H Lee Moffitt Cancer Center, SAIL, ³University of South Florida, ⁴Global Ctr. Hearing and Speech Res., University of South Florida, ⁵Global Ctr. Hearing and Speech Res., Univ. of South Florida

62. Assessing Auditory Brainstem Response Changes Due to Aging in Macaque Monkeys

Aneesh Batchu^*1, Amy Stahl¹, Swarat Kulkarni¹, Oscar Rausis¹, Troy Hackett², Ramnarayan Ramachandran²

¹Vanderbilt University, ²Vanderbilt University Medical Center

63. An Antioxidative Treatment to Prevent Further Noise-Induced Hearing Loss in Hearing Impaired Mongolian Gerbils

Damian Gulbin-Murphy^*1, Shrivaishnavi Chandrasekar¹, Sean Hong², Eran Peci¹, Aaron Tucker², Matthew Kiel¹, P. Ashley Wackym², Todd Mowery¹

¹Rutgers University, ²Rutgers Robert Wood Johnson Medical School

64. Hair Cell Proteins in Stereocilia Embedded in the Tectorial Membrane: Dysferlin, Annexin A2, FKBP8, Bcl2, and RyR3, Forming a Molecular Pathway to Regulate Ca2+

Marian Drescher^*1, Dennis Drescher¹

¹ Wayne State University School of Medicine

65. Injury-Induced Remodeling of the Actin Cytoskeleton in the Vestibular Maculae of Mice

Mark Warchol^*1

¹ Washington University School of Medicine

66. Protective Effect of an FDA- Approved Drug via Middle Ear Delivery Against Noise Exposure in Swine Model

Wei Wei^*1, Yizhou Quan², Ying Wang³, Yanling Wei³, Tesfaye Teshome³, Irene Gist³, Joseph Long³, Zheng-Yi Chen²

¹Massachusetts Eye and Ear, Harvard Medical School, ²Massachusetts Eye and Ear/Harvard Medical School, ³Blast-Induced Neurotrauma Branch/Center for Military Psychiatry and Neuroscience, WRAIR

67. Measurements in Vivo Show That Active Outer-Hair-Cell Motion Exceeds and Can Drive Basilar-Membrane Motion up to Frequencies of 40 Khz

Sunil Puria^*1, Nam Hyun Cho², John Guinan³

¹Harvard Medical School, ²Harvard Medical School, Mass. Eye and Ear Infirmary, ³Mass Eye and Ear, Harvard Medical School

68. Outer Hair Cells Suppress and Boost the Organ of Corti Vibrations

Mohammad Shokrian^*1, Wei-Ching Lin¹, Anes Macić¹, Jong-Hoon Nam¹

¹ University of Rochester

69. Perceptual Anchoring to Auditory Textures in Neurotypical and Neurodivergent Listeners

Heivet Hernandez Perez^*1, Divya Mehta¹, Kurt Shulver¹, Rebecca Poulsen¹, David McAlpine²

¹Macquarie University, ²Macquarie Univeristy

70. Meniere's Disease: The Mechanism of Low-Frequency Hearing Loss Due to Bony Labyrinth Cracks

Yasushi Horii^*1, Karin Ono¹, Shota Toyoda¹, Akari IDE¹

¹ Kansai University

71. Disrupting Perceptual Anchoring to Pure-Tone Sequences in Human Listeners

Kurt Shulver^*1, David McAlpine², Heivet Hernandez-Perez³

¹Australian Hearing Hub, ²Macquarie Univeristy, ³Macquarie University

72. Lipidomics identifies Beta-Oxidation as a Key Process in Noise-Induced Hearing Loss

Gunseli Wallace^*1, Lingchao Ji¹, Maureen Kachman¹, Costas Lyssiotis¹, Charles Burant¹, Gabriel Corfas¹

¹ University of Michigan

73. Molecular Profiles Defining Adult Cochlear and Vestibular Hair Cells

David He^*1, Zhenhang Xu², Amirrasoul Tavakoli Targhi³, Samadhi Kulasooriya⁴, Huizhan Liu⁴, Yi Li⁵, Celia Bloom¹, Jian Zuo⁶, Litao Tao¹, Bechara Kachar⁷

¹Creighton University, ²Xiangya Hospital, Central South University, ³National Institute on Deafness and Other Communication Disorders, ⁴Creighton University School of Medicine, ⁵Beijing Tongren Hospital, ⁶Ting Therapeutics, ⁷National Institute of Deafness and Other Communication Disorders

74. Histone Deacetylase Inhibitor-Induced Phenotypic Transition of Schwann Cells into Repair Types: Implications on Repair and Myelination During Nerve Damage

Ji Eun Choi¹, John Patrick Cuenca^*1, So-Young Chang², Nathaniel Carpena², Haetnim Lim¹, Min Young Lee¹, Jae Yun Jung¹

¹Dankook University, ²Beckman Laser Institute Korea, Dankook University

75. Enhancing Auditory Localization and Speech-In-Noise Comprehension Through Augmented-Reality Auditory Training

Pooseung Koh^*1, Sungyoung Kim¹, Hyo-Jeong Lee², Inyong Choi³, Sungmin Jo⁴

¹Korea Advanced Institute of Science and Technology, ²Hallym University College of Medicine, Chuncheon, South Korea, ³University of Iowa, ⁴Hallym University

76. Dynamic Optical Coherence Tomography as a Tool to Identify Cellular Structures and Assess Changes in the Mouse Organ of Corti

Antonio Franco^*1, Michael Serafino², Clayton B. Walker², Patricia Quiñones², Alberto Recio², Brian Applegate¹, John Oghalai¹

¹University of Southern California, ²Caruso, Keck School of Medicine, University of Southern California

77. SHANK2 Shapes Hair Bundle Architecture Essential for High-Frequency Hearing and Long-Term Maintenance

Han Seul Choi^*1, Hyeyoung Park¹, Hyehyun Min¹, Kwan Soo Kim¹, Soo Min Kim¹, Jinan Li², Chang Liu², Min Goo Lee¹, Lei Song³, Bo Zhao², Jinwoong Bok¹

¹Yonsei University College of Medicine, ²Indiana University School of Medicine, ³Shanghai Jiao Tong University School of Medicine

78. Evaluating Pendrin Correctors in a Mouse Model of Pendred Syndrome and DFNB4

Sieun Yu^*1, Minjin Kang¹, Mi-Hwa Shin¹, Seunghyeon Jang¹, Yeji Song¹

¹ Yonsei University College of Medicine

79. Effects of Contralateral Square-Wave Stimulation on Distortion Product Otoacoustic Emissions

Takuji Koike^*1, Yuta Hara², Sinyoung Lee³

¹University of Electro-Communications, ²The University of Electro-Communications, ³University of Yamanashi

80. Micro-Ct and Histological Analysis of Sheep Cochlea and Tympanic Membrane

Po-Yi Lue^*1, Mark Oliver², Michel Neeff³, Dane Gerneke⁴, Peter Thorne⁵, Haruna Suzuki-Kerr⁵

¹University of Auckland, ²Liggins Institute, the University of Auckland, ³HealthNZ, New Zealand, ⁴Auckland Bioengineering Institute, the University of Auckland, ⁵Department of Physiology, the University of Auckland

81. Physiological Functional Connectivity Changes During Difficult Listening in Older and Younger Adults

Vrishab Commuri^*1, I.M Dushyanthi Karunathilake¹, Stefanie Kuchinsky², Behtash Babadi¹, Jonathan Z. Simon¹

¹University of Maryland, ²Walter Reed National Military Medical Center

82. The Role of Nptn in Stereocilia of Cochlear Hair Cells

Ji ahn Lee^*1, Hyehyun Min², Jinwoong Bok², Chul Hoon Kim²

¹Brain Korea 21 FOUR Project for Medical Science, Yonsei University College of Medicine, ²Yonsei University College of Medicine

83. Enhancement of Inner Ear Organoid Development through Hyperbaric Oxygen Therapy: Implications for Hearing Loss Treatment

Jung-Eun Park^*1, In-sun Yu², Heebin Park³, JungChan Han⁴, Soe-Hyun Choi⁵, Jaemin Jeong⁵, Sung kyun Kim⁶

¹College of Natural Sciences, Seoul Women's University, ²College of Natural Sciences,Seoul Women''s University, ³Graduate School of Biomedical Science and Engineering, Hanyang University, ⁴Graduate School of Biomedical Science and Engineering, Hanyang University , Hanyang Universtiy, ⁵College of Natural Sciences, Seoul Women's University, ⁶Kresge Hearing Research Institute, University of Michigan Medical School

84. Lack of Integrin Alpha-8 Function Increases Hair Cell Sensitivity to Ototoxic Damage

Marisa Zallocchi^*1

¹ Creighton University

85. The Therapeutic Potential of Natural Compounds Against Noise-Induced Hearing Loss

Katya Brunette^*1, Dinesh Gawande¹, Fabiola Alanoca Rugel¹, Vijayprakash Namakkal Manickam¹, Marisa Zallocchi¹, Katyarina Brunette¹

¹ Creighton University

86. Optical Coherence Tomography Imaging of the Posterior and Lateral Semicircular Canal in Mice

Dorothy W. Pan^*1, Wihan Kim², Kevin Biju², Brian E. Applegate², John S. Oghalai²

¹University Southern California, Caruso, ²USC Caruso

87. The Role of CWC27 in Cochlear Development

Norio Yamamoto^*1, Machi Nonomura², Hiroe Ohnishi², Tatsuya Katsuno², Koji Nishimura², Yosuke Tona², Mami Matsunaga², Takayuki Nakagawa², Koichi Omori²

¹Kobe City Medical Center General Hospital, ²Graduate School of Medicine, Kyoto University

88. Comparative Study of Tinnitus Suppression Effect of Cochlear Implant and Bone Conduction Implant in the Patients with Asymmetric Hearing Loss and Single-Sided Deafness

Chan Mi Lee^*1, Jae Sang Han¹, Min-Chae Jeon¹, Minyu Ko¹, So Young Park¹, Shi Nae Park¹

¹ Seoul St. Mary's Hospital, The Catholic University of Korea

89. Evaluating the Consistency of Otoacoustic Emission Measurements With Self-Inserted Probes

Krzysztof Kochanek¹, W. Wiktor Jedrzejczak^*1, Marta Malina², Aleksandra Kowenia², Henryk Skarzynski¹

¹Institute of Physiology and Pathology of Hearing, ²The University of Maria Curie-Sklodowska

90. 3D Characterization of Arteries in the Sheep Cochlea Using Contrast-Enhanced Micro-Computerized Tomography

Haruna Suzuki-Kerr^*1, Suha Lee², Louisa Xie², Dane Gerneke³, Mark Oliver⁴, Joanne Davidson², Peter Thorne²

¹University of Auckland, ²The University of Auckland, ³Auckland Bioengineering Institute, the University of Auckland, ⁴Ngapouri Research Farm Laboratory, the University of Auckland

91. Characterization of SSBP1-Mutation-Associated-Hearing Loss in Patient-Derived Otic Organoids

Nathaniel Carpena^*1, So-Young Chang², Ji-Eun Choi³, Jae Yun Jung³, Sang-Yeon Lee⁴, Min Young Lee³

¹Dankook Institute of Medicine and Optics, Dankook University, ²Beckman Laser Institute Korea, Dankook University, ³Dankook University Hospital, ⁴Seoul National University College of Medicine

92. Exploring Synergistic Effects of Dexamethasone with Alpha Lipoic Acid and Diltiazem in Noise-Induced Hearing Loss Models

Kyusun Park^*1, Ye Lin Kim¹, Min-Chae Jeon¹, Chan Mi Lee¹, Shi Nae Park¹, Jae Sang Han¹

¹ Seoul St. Mary's Hospital, The Catholic University of Korea

93. Interactions Between Objective and Self-Reported Hearing Measures, Ballance and Risk of Falling in Older Adults

Hanna Putter-Katz^*1, Nitza Horev², Erez Yaakobi², Ella Been²

¹Ono Academic College- Oac, ²Ono Academic College

94. Hair Cell-Like Cells Generated in Mature Cochleae by Adenovirus-Mediated Expression of Gfi1, Atoh1, Pou4f3 with or Without Six1

Matthew Averyt¹, Lin Yang¹, Valeria Mas¹, Sunita Singh², Lisa Beyer¹, Diane Prieskorn¹, Andrew Groves², Yehoash Raphael^*1

¹University of Michigan, ²Baylor College of Medicine

95. Ouabain Ototoxicity as a Model for Auditory Neuropathy in Guinea Pigs

Diane Prieskorn¹, Lisa Beyer¹, Rami Skaliter², Dana Hayoun Neeman², Ofer Wiser², Olga Mizrahi², Jennifer Bahr-Davidson², Teresa Jones², Yehoash Raphael^*1

¹University of Michigan, ²Lineage Cell Therapeutics, Inc

96. Chd7 and Sox2 Regulate Mammalian Vestibular Sensory Epithelium Development and Tonotopic Organization of the Cochlea

Jingxia Gao^*1, Derek Bukowski¹, Lisa Beyer², Yehoash Raphael³, Donna Martin¹

¹University of Michigan, ²Kresge Hearing Research Institute, Michigan Medicine, ³Kresge Hearing Research Institute, Michigan Medicine

97. Identification of Biomarkers Associated with Cochlear Synaptic Loss

Andie Zang-Felix^*1, Joseph Pinkl¹, Elinor Sevy¹, Jianxin Bao¹

¹ Duke University

98. GJB2 Gene Therapy-Response of Two Pre-Clinical Mouse Models of the Most Frequent Form of Human deafness, DFNB1

Anne-Valérie Héritier¹, Andrea Lelli¹, Amrit Singh-Estivalet¹, Solène Roux¹, Nawel Mekdad¹, Muriel Sudres¹, Nicolas Michalski¹, Rafik Boudra², Arnaud Giese², Laurent Désiré², Christine Petit^*1

¹Institut de l'Audition/ Institut Pasteur, ²Sensorion

99. GJB2-GT, a Novel Adeno Associated Vector-Based Gene Therapy as a Treatment for the Autosomal Recessive Non-Syndromic Deafness 1A (DFNB1A)

Guillaume Olivier¹, Christophe Tran Van Ba¹, Sandra Pierredon¹, Anne-Valérie Heritier², Charlène Vaux¹, Amrit Singh-Estivalet², Charlène Josephine¹, Andrea Lelli², Lise Barrot¹, Pierre Rambaud¹, Anais Pages¹, Laurène Heriaud¹, Pauline Liaudet¹, Muriel Sudres², Nicolas Michalski², Rafik Boudra¹, Arnaud Giese¹, Christine Petit², Laurent Desire^*1

¹Sensorion, ²Institut de l'Audition/ Institut Pasteur

100. Investigating the Impact of Neural Encoding and Cognition on Time-Compressed Speech Perception

Ebtesam Sajjadi^*1, Kendell Adson¹, Matthew J. Goupell¹, Sandra Gordon-Salant¹, Samira Anderson¹, Ebtesam Sajjadi²

¹University of Maryland, ²University and Maryland

101. Biodegradable Inner Ear Implants for Controlled Release of Glucocorticoids in Combination With Cochlear Implants

Eric Lehner^*1, Arne Liebau¹, Jonas Scheffler¹, Karsten Mäder¹, Stefan Plontke¹

¹ Martin Luther University of Halle-Wittenberg

102. Molecular Targeting of Alzheimer’s Disease-Associated Proteins in the Spiral Ganglion and Cochlear Neural Components by Dysferlin Protein-Protein Interactions

Dennis Drescher^*1, Marian Drescher¹

¹ Wayne State University

103. Therapeutic Potential of ssAAV vs. scAAV in Inner Ear Gene Therapy

Roni Hahn^*1, Shahar Taiber², Eyal Marton³, Olga Shubina-Oleinik⁴, Gwenaëlle S.G. Géléoc⁴, Jeffrey R. Holt⁴, Karen B. Avraham²

¹Medical and Health Sciences Sagol School of Neuroscience, Tel Aviv University, ²Faculty of Medical and Health Sciences and Sagol School of Neuroscience, Tel Aviv University, ³Faculty of Medical and Health Sciences and Sagol School of Neuroscience, Tel Aviv School of Psychological Sciences, Faculty of Social Sciences, Tel Aviv University, ⁴Boston Children's Hospital, Harvard Medical School

104. TNFRSF25: From Genetic Analysis of DNA Methylation in Human to a Mouse Model with Hearing Loss

Marie Valerie Roche¹, Denise Yan², Juan I. Young³, Feng Gong⁴, Katherina Walz³, Xue Liu^*4

¹University of Miami School of Medicine, ²University of Miami School of Medicine, ³University of Miami School of Medicine, John P. Hussman Institute for Human Genomics; John T Macdonald Foundation, ⁴University of Miami School of Medicine

105. Regeneration of Cochlear Synapses Following Intracochlear Delivery of Neurotrophin 3

Renata Knoll^*1, Sina Schwinn¹, Andrea Zhang², Andrew Jung¹, Brooke Wang¹, Judith Kempfle³, David Jung¹

¹Massachusetts Eye and Ear Infirmary, ²Massachusetts Eye and Ear Infirmary / The University of Texas Health Science Center, ³Massachusetts Eye and Ear Infirmary / University of Massachusetts Medical Center

106. Investigating the Role of the Lipid Scramblase XKR8 in Inner Ear Function

Shaikh Emdadur Rahman^*1, Runjia Cui², Katya Krasnopolsky², Talah Wafa², Cheng-Chao Lin³, Jaspal Khillan³, Sergio M. Pontejo³, Tracy Fitzgerald², Angela Ballesteros²

¹National Institute on Deafness and Other Communication Disorders, National Institutes of Health, ²NIDCD, NIH, ³NIAID, NIH

107. Transformation of Object Representation Along the Cortical Auditory Pathways

Kirill Nourski^*1, Mitchell Steinschneider², Ariane Rhone¹, Matthew Howard¹

¹The University of Iowa, ²Albert Einstein College of Medicine, The University of Iowa

108. Vibration Patterns of Outer Hair Cell-Deiters’ Cell Complex

Wei-Ching Lin^*1, Anes Macić¹, Jong-Hoon Nam¹

¹ University of Rochester

109. A Novel Chd7+/CreERT2 Mouse Model to Study Contributions of CHD7 to Inner Ear Development and Function

Jennifer Skidmore^*1, Donna Martin²

¹University of Michigan, ²Department of Pediatrics and Genetics, University of Michigan

110. Prevention of Acute Mouse Model of Aminoglycoside-Induced Outer Hair Cell Loss by Targeting Calcium/Calmodulin Kinases

Fan Wu¹, Shan Xu¹, Shenyu Zou¹, Hongguo Su¹, Khujista Haque¹, Su-Hua Sha^*1

¹ Medical University of South Carolina

111. Comparing and Optimizing Clearing Protocols for Fluorescence Microscopy of the Intact Mouse Cochlea

Franziska Becker¹, Martina Giampetraglia¹, Gina Dunkel¹, Bettina Weigelin¹, Ellen Reisinger¹

¹ University of Tuebingen Medical Center

Ellen Reisinger, University of Tuebingen Medical Center

112. Auditory Object Formation Across Acoustic and Electric Hearing in Cochlear Implants With Electroacoustic Stimulation

Nour Alsabbagh^*1, Phillip Gander², Joel Berger³, Bob McMurray⁴, Timothy Griffiths⁵, Inyong Choi⁶

¹The University of Iowa, ²University of Iowa Hospitals and Clinics, ³University of Iowa Hospitals and Clinics, ⁴University of Iowa, ⁵Biosciences Institute, Newcastle University, ⁶University of Iowa

113. Discrepancies in Serum Composition via Different Blood Collection Routes

Robert Fuentes^*1, Eshita Kashaboina², Esha Kashaboina², Xiaodong Tan², Jing Zheng²

¹Northwestern University, Feinberg School of Medicine, ²Northwestern University, Feinberg School of Medicine, Department of Otolaryngology

114. Treatment With FK506 Attenuates Noise-Induced Hearing Loss via Mediation of Endoplasmic Reticulum Stress

Hongguo Su¹, Khujista Haque¹, Su-Hua Sha^*1

¹ Medical University of South Carolina

115. Age-Related Ultrastructural Changes in the Dorsal Cortex of the Inferior Colliculus in Fischer Brown Norway Rats

Jeffrey Mellott^*1, Dakota Smallridge², Kylee Tenney³, Gillian Barach², Gurveer Singh³, Erin Beskitt², Justine Busby², Syllissa Duncan², Alexa Wawrzyniak², Brenda Vega², Nick Tokar², Andrew Ohl², Jesse Young²

¹Northeast Ohio Medical University, ²NEOMED, ³University of Akron

116. Age-Related Ultrastructural Changes in the Inferior Colliculus of an Alzheimer’s Disease Model

Jeffrey Mellott^*1, Lena Dellaria², Madeline Guy³, Miljan Terzic³, Jesse Young³, Christine Dengler-Crish³

¹Northeast Ohio Medical University, ²Kent State University, ³NEOMED

117. Ultrastructural Evidence for Excitatory and Inhibitory Cholinergic Synapses in the Inferior Colliculus

William A. Noftz¹, Jeffrey G. Mellott¹, Brett Schofield^*1

¹ Northeast Ohio Medical University

118. Cochlear Expression of Orexin Signaling Molecules and Their Role in Hearing

Alka Ghadiyaram^*1, Douglas Vetter², Kathleen Yee³

¹University of Mississippi Medical Center School of Medicine, ²Univ. Mississippi Medical Center, ³University of Mississippi Medical Center

119. Distinguish Patterns and Associated Functions of Cx26 and Cx30 Expressions in the Postnatal Development in the Mouse Cochlea

Yiding Yu^*1, Xiaoling Lu¹, Jin Chen¹, Tianying Zhai¹, Chun Liang¹, hongbo zhao¹

¹ Yale University Medical School

120. Developmental Transformation of the Cochlear Sensory Epithelium Through Local ERK Signaling

Kevin Yu^*1, Trinh Nguyen¹, Travis Babola¹, Patrick Parker¹, Sergi Regot¹, Jonathan Gale², Dwight Bergles¹

¹Johns Hopkins School of Medicine, ²UCL Ear Institute

121. Detecting and Disambiguating “Hidden” Cochlear Pathologies: Inner Hair Cell Injury and Cochlear Synaptopathy

Samantha Hauser^*1, Andrew Sivaprakasam¹, Hari Bharadwaj², Michael Heinz¹

¹Purdue University, ²University of Pittsburgh

122. Investigating the Potential to Reverse Hearing Loss Caused by Myo7a Mutations

Daniel R. Pentland^*1, Lauren Witting¹, Karen P. Steel¹

¹ Wolfson Sensory, Pain and Regeneration Centre, King's College London

123. Diverse Genetic Profiles in Hearing Loss Patients with Enlarged Vestibular Aqueduct: A Small Cohort Study Using a Targeted Exon Sequencing Panel

Gabrielle Merchant^*1, Wesley Tom¹, Jessie Patterson¹, Kristen Janky¹, Elizabeth Kelly¹, M. Rohan Fernando¹

¹ Boys Town National Research Hospital

124. The Role of XIRP2 in Stereocilia F-Actin Repair

Alyssa Luz-Ricca^*1, Elizabeth Wagner¹, Stefano Sala², Patrick Oakes², Jung-Bum Shin¹

¹University of Virginia School of Medicine, ²Loyola University Chicago

125. Phospholipid Flippase ATP8A2 Localization is Impacted by Hair Cell Mechanotransduction and May be Necessary for Synapse Maintenance

Katherine Nimchuk^*1, David Lee¹, Jung-Bum Shin²

¹University of Virginia, ²University of Virginia School of Medicine

126. Exploring Analytical Procedures and Short Channels in Auditory Fnirs Brain Imaging

Yann Lemaire^*1, Jérémie Ginzburg², Olivier Deguine³, Pascal Barone⁴, Anne Caclin²

¹CNRS, CerCo UMR 5549, ²INSERM, Centre de Recherche en Neurosciences de Lyon - Inserm U1028 / CNRS UMR5292, ³Service d'Oto Rhino Laryngologie (ORL), Otoneurologie et ORL Pédiatrique, ⁴CNRS, CerCo UMR5549

127. Myelin Ultrastructure in Mice With Targeted Deletion of Esrrg in the Inner Ear

Rhianna R. Mackenzie^*1, Anwen Bullen², Lisa S. Nolan¹

¹King's College London, ²University College London

128. TRPA1 Deficiency Leads to Reduced Volume of Outer Hair Cell Ribbon Synapses After Noise Exposure

Ava Kruse^*1, Doris Susana Llanes-Coronel¹, A. Catalina Velez-Ortega¹

¹ University of Kentucky

129. Restoration of Cochlear Synapses from Noise-Induce Synaptopathy by Introcochlear Infusion of TrkC Agonist Antibody in Mice.

Ning Hu^*1, Ronald M. Lindsay², Peter S. DiStefano², Steven H. Green¹

¹University of Iowa, ²Zebra Biologics, Inc.

130. Dopamine Receptor Expression in the Mouse Mntb

Sonia Weimann^*1, Meara Plesh-Gill¹, R. Michael Burger¹

¹ Lehigh University

131. Envelope Following Responses Constrained to the Auditory Midbrain Exhibit Evidence of Envelope Hyperresponsivity in Older Adults

Carolyn McClaskey^*1, James Dias¹, Kelly Harris¹

¹ Medical University of South Carolina

132. Hearing Evaluation of Exon-Deleted Mouse Models of Ush2a to Determine Dispensable Exons for Exon Skipping Therapeutic Approaches

Yehree Kim^*1, Yue Dai², Qin Liu², Zheng-Yi Chen²

¹Mass Eye and Ear, ²Mass eye and ear infirmary

133. L-Stellate Cells are Differentially Activated by the Auditory Nerve and T-Stellate Cells Within the Ventral Cochlear Nucleus

Tenzin Ngodup^*1, Laurence O. Trussell¹

¹ Oregon Health and Science University, Oregon Hearing Research Center

134. Optimizing Frequency-Specific Auditory Brainstem Responses to Continuous Speech Using Different Chirp-Phase Profiles

Melissa Polonenko^*1, Samantha Krocak¹

¹ University of Minnesota

135. Cell Type-Specific Assessment of Synaptic Drive onto Principal Neurons of the Mouse Lateral Superior Olive

Hariprakash Haragopal^*1, Mara Voytek¹, Roshen Eapen¹, Bradley Winters¹

¹ Northeast Ohio Medical University

136. Can You Hear Without FIRE: The Impact of Microglia Loss on Cochlear Function

Patrick Atkinson^*1, Aude Chiot², Gisselle Jimenez², Audrey Ching¹, Dillon Brownell², Max Felgner³, Peter Wieghofer⁴, Alan Cheng¹, Bahareh Ajami²

¹Stanford University, ²Oregon Health and Sciences University, ³Universität Leipzig, ⁴University of Augsburg

137. Objective Functional Biomarkers to Find Druggable Targets for Tinnitus and Hyperacusis

Lukas Rüttiger^*1, Elinor Riegger², Stephan Wolpert³, Jakob Wertz², Uwe Klose⁴, Matthias M. Munk⁵, Ernst Dalhoff³, Marlies Knipper²

¹Hearing Research Centre Tübingen, Molecular Physiology of Hearing, University of Tübingen, 2Hearing Research Centre Tübingen, Molecular Physiology of Hearing, University of Tübingen, Elfriede Aulhorn Str. 5, ³University of Tübingen, Germany, ⁴University Hospital Tübingen, ⁵Technical University Darmstadt

138. Loss of tmc1/2 Function Induces Expansion of tmc1/2b+ Cells in the Zebrafish Inner Ear

NA Zhang^*1, Yan Gao², Peng Sun¹, Anna Shipman², Teresa Nicolson²

¹Stanford University School of Medicine, ²Stanford School of Medicine - Otolaryngology

139. Sex-Dependent Galectin-3 Response to Noise-Induced Cochlear Stress in Mice

Mengxiao Ye¹, Guangdi Chen², Bohua Hu^*3

¹Department of Communicative Disorders and Sciences, University at Buffalo, ²University at Buffalo, ³The Department of Communicative Disorders and Sciences

140. Increased Listening Effort and Decreased Speech Discrimination at High Presentation Sound Levels in Older Individuals with Hearing Loss

Chengjie Huang^*1, Natalie Field¹, Samira Anderson¹, Matthew J. Goupell¹

¹ University of Maryland College Park

141. Ptk7 is Required for Hair Cell Planar Polarity in the Utricle

Kira Boyce^*1, Yuqiong Zheng¹, Xiaowei Lu¹

¹ University of Virginia

142. Differential Effects of Tmie Deletion on Canal and Otolith Function in Mice

Zelma Guisela Iriarte¹, Raven Riley¹, Caroline Sit¹, David Huang¹, Jake Harthcock¹, Bryan Rivers², Raymond Huang³, Youguo Xu¹, Ian Mcneill¹, Christopher Spankovich¹, Jeffrey Holt⁴, Gwenaelle Geleoc⁴, Hong Zhu¹, Wu Zhou^*5

¹University of Mississippi Medical Center, ²School of Medicine, University of Mississippi Medical Center, ³University of Virginia, Charlottesville, ⁴Boston Children's Hospital, Harvard Medical School, ⁵University of Mississippi Medical Center

143. Gender Differences in Gene Profiling in the Sexually Immature Murine Cochlea

Rania Sharaf¹, Henry J. Adler¹, Mengxiao Ye¹, Eduardo Cortes Gomez², Jianmin Wang², Bohua Hu^*3

¹Department of Communicative Disorders and Sciences, University at Buffalo, ²Roswell Park Comprehensive Cancer Center, University at Buffalo, ³The Department of Communicative Disorders and Sciences

144. Parvalbumin and Somatostatin in the Songbird Auditory Cortex Suggest Conserved Mechanisms for Inhibition

George Ordiway^*1, Sarah Woolley¹

¹ Zuckerman Institute, Columbia University

145. Translatability of the Larval Zebrafish Lateral Line Neuromast Model as a High-Throughput Screening (HTS) Method for Noise-Induced Hearing Loss Drug Discovery

Dong Xu¹, Jiemin Yuan^*1

¹ Idaho State University

146. Computer Vision Based Audiogram Symbol Detection

Ruoyu Yang^*1, Dana Mae Salvador², Carl Ehrett¹, Peter Dixon²

¹Clemson University, ²Medical University of South Carolina

147. Intermodulation Distortions in a Mouse Cochlea

Cooper Swan¹, Sheiva Hodjati¹, Bernard Slater², Karolina Charaziak^*1

¹USC Keck School of Medicine, ²Gene Therapy Center University of North Carolina Chapel Hill

148. The Role of Strial Macrophages in the Development and Maintenance of the Blood-Labyrinth Barrier

Xin Zhang¹, Yongfang Sha¹, Xu Liu¹, Weiwei He², Alisa Hetrick², Mengzhao Xun¹, Jialin Pang¹, Jianping Liu¹, Hongzhe Li^*2

¹Eye and ENT Hospital, Fudan University, ²VA Loma Linda Healthcare System

149. In Vivo Determination of Gentamicin in Murine Inner Ear Perilymph after Local or Systemic Delivery

Shreshtha Dash^*1, D. David Smith², Bibiana Araujo³, Laura Ben Olivio³, Regina Gendzelevski Kelmann², Rene Vielman Quevedo², Peter S. Steyger²

¹Translational Hearing Center, School of Medicine, Creighton University, ²Translational Hearing Center, School of Medicine, Creighton University, ³Federal University of Rio Grande do Sul

150. Analysis of Phase and Displacement Consistency in Optical Coherence Tomography Vibrometry Measurements from the Guinea Pig Cochlear Apex and a Piezo Driven Model

George Burwood^*1, Tianying Ren¹, Edward Porsov¹, Alfred Nuttall¹, Anders Fridberger²

¹Oregon Health and Science University, ²Department of Biomedical and Clinical Sciences, Linköping University, Sweden

151. Conditional Knockout of mGluR5 in Glutamatergic Pathways Disrupts the Development of Synaptic Excitatory Transmission onto Mouse MNTB Neurons

Huimei Wang^*1, Yong Lu¹

¹ Northeast Ohio Medical University

152. Towards an Artificial Niche for Stem Cells: Investigating the Effects of the Microenvironment on Differentiation of Inner Ear Organoids from Mouse Embryonic Stems

Simona Zingaro¹, Katie E. Smith², Tessa Sanders³, Daniel Jagger¹, Matthew Kelley⁴, Jonathan Gale^*1

¹UCL Ear Institute, ²University College London, ³National Institute on Deafness and Other Communication Disorders, National Institutes of Health, ⁴NIH/NIDCD

153. Organoids to 'Cure' Deafness? A Scoping Review on the Ethics of Using Organoid Technology to Treat Deafness

Esther Fousert^*1, Heiko Locher², Martine de Vries³, Nienke de Graeff³

¹Leiden University Medical Center, The Novo Nordisk Foundation Center for Stem Cell Medicine, reNEW, ²Leiden University Medical Center, Leiden, the Netherlands; The Novo Nordisk Foundation Center for Stem Cell Medicine, reNEW, ³Department of Ethics and Law, Leiden University Medical Center, Leiden, The Netherlands; The Novo Nordisk Foundation Center for Stem Cell Medicine, reNEW

154. Identification of Regulators That Control the Tonotopic Specialization of the Mammalian Auditory Sensory Epithelium

River Huang^*1, Angelika Doetzlhofer²

¹Johns Hopkins University, ²Johns Hopkins University School of Medicine

155. Cross-Sectional Evaluation of Auditory and Vestibular Function in a Mouse Model of Down Syndrome

Regina Gendzelevski Kelmann^*1, Cong Tian¹, Gabrielle R. Merchant², Sarath Vijayakumar¹, Kristen L. Janky², Kelly D. Sullivan³, Joaquin Espinosa³, Peter Steyger¹

¹Creighton University, ²Boys Town National Research Hospital, Omaha, NE, USA, ³Linda Crnic Institute for Down Syndrome, University of Colorado Anschutz Medical Campus, Aurora, CO, USA

156. Identification of Functional Biomarkers Associated with Age-Related Cochlear Synaptopathy

Joseph Pinkl^*1, John Hawks¹, Trung Vu², Jianxin Bao³

¹Gateway Biotechnology Inc., ²University of Illinois, ³Gateway Biotechnology, Inc.

157. Isoform Diversity in the Mouse Cochlea and Utricle

Sarath Vijayakumar^*1, Mi Zhou¹, Guanfang Xie¹, Venkatlaxmi Chettiar¹, Khushboo Patel¹, David He¹, Litao Tao¹

¹ Creighton University

158. Sex Differences in TRPA1-Mediated Changes to the Operating Point of the Organ of Corti After Noise Exposure

Samantha A. Radomski^*1, D. Susana Llanes-Coronel¹, A. Catalina Velez-Ortega¹, Samantha Radomski²

¹University of Kentucky, ²University of Kentucky, College of Medicine

159. Characterization of Let-7 as a Regulator of Supporting Cell Plasticity in the Murine Utricle

Elannah Venhaus^*1, Angelika Doetzlhofer²

¹The Johns Hopkins University School of Medicine, ²Johns Hopkins University School of Medicine

160. Travel Booth to Assess Hearing in Rodents

Jordan Villa^*1, Joaquin Cury¹, Claus-Peter Richter¹

¹ Feinberg School of Medicine, Northwestern University

161. Understanding the Spatial Transcriptome of the Regenerating Zebrafish Inner Ear

Clarke Bagsby^*1, Erin Jimenez¹

¹ Johns Hopkins University

162. The TECTB-C225Y Mutation Causing Autosomal Dominant Deafness in a Nicaraguan Family Enhances Sensitivity to Noise-Induced Hearing Loss in Ageing Mice

Evan Hale^*1, Barbara Vona², Richard J. Goodyear³, Richard T. Osgood⁴, Sami Amr⁵, Karen Mojica⁶, Ricardo Vera-Monroy⁷, Katherine Callahan⁸, Kerry Gudlewski⁷, Rolen Quadros⁹, Cynthia C. Morton¹⁰, Channabasavaiah Gurumurthy⁹, James Saunders⁷, Guy Richardson³, Artur A. Indzhykulian¹¹

¹Speech and Hearing Bioscience and Technology Program, Harvard University, ²Institute for Auditory Neuroscience, ³University of Sussex, ⁴Massachusetts Eye and Ear, Harvard Medical School, ⁵Laboratory for Molecular Medicine, Mass General Brigham, ⁶Vivian Pellas Hospital, Medical Director, Mayflower Medical Outreach, Managua, Nicaragua, ⁷Dartmouth-Hitchcock, Geisel School of Medicine, ⁸University of Vermont Medical Center, ⁹University of Nebraska Medical Center, ¹⁰Brigham and Women's Hospital, ¹¹Massachusetts Eye and Ear Infirmary

163. Evidence for the Auditory Nerve Generating Envelope Following Responses When Measured From Eardrum Electrodes

Skyler Jennings^*1, Jessica Chen¹, Nathan Johansen¹, Shawn Goodman²

¹University of Utah, ²The University of Iowa

164. Perilymph Duration of a Long-Acting Dexamethasone Formulation After Precise Microendoscopic Placement at the Round Window Membrane: A Fluidsim Model Based on Human Serum, Animal Serum, and Animal Perilymph Drug Concentrations

Benson Jung^*1, Jafri Kuthubutheen², Jeffrey Sharon³, Alan Foster⁴, Kathleen Cogan Farinas¹, Hugo Peris¹, Eugene De Juan¹, Charles Limb³, Jeremy Turner⁵, Amanda Henton⁵, Alec Salt⁵

¹Spiral Therapeutics, ²University of Western Australia; WesternENT; Changi General Hospital, Singapore, ³University of California, San Francisco, ⁴Jobral Consulting, ⁵Turner Scientific

165. Therapeutic Advancement of NHPN-1010 for Addressing Chronic Noise-Induced Tinnitus in Rats

Xiaoping Du^*1, Jianzhong Lu¹, Zach Yokell¹, Qunfeng Cai¹, Weihua Cheng¹, Don Nakmali¹, Wei Li¹, Richard Kopke¹, Matthew B. West¹

¹ Hough Ear Institute

166. Intracochlear Insertion Force and Hydrostatic Pressure Measurements During Cochlear Implantation and Coiling in 3D Printed Artificial Cochlea and Mastoid Models

Sita Clark^*1, Iwan Roberts¹, Thomas Hudson², Chloe Swords², Bridget Ryan², Filip Hrncirik¹, Manohar Bance¹

¹The University of Cambridge, ²Cambridge University Hospitals

167. A Multicenter Investigation of Risk Factors Associated with Aminoglycoside-Induced Hearing Loss in Patients with Cystic Fibrosis

Angela Garinis^*1, Ronald Rubenstein², Andrea Kelly³, Peter Camacho³, Lisa Hunter⁴, Peter Steyger⁵, Ashley Deschamp⁶, Alessandra Chesi⁷, Jay Vachhani¹

¹Oregon Health and Science University, ²Washington University in St. Louis, ³Children's Hospital of Philadelphia, ⁴Cincinnati Children's Hospital Medical Center, ⁵Creighton University, ⁶University of Nebraska Medical Center, ⁷University of Pennsylvania

168. Gene Replacement Therapy Rescues Hearing in a Mouse Model With an Mpzl2 Variant

Hyeong Gi Song^*1, Seung Hyun Jang¹, Sun Young Joo¹, Heon Yung Gee¹

¹ Department of Pharmacology, Yonsei University College of Medicine, Seoul, Korea

169. Cross-Cultural Influences of Beating on Music Perception

Josh McDermott^*1, Bryan Medina², Preston Hess³, Malinda McPherson⁴, Eduardo Undurraga⁵, Ricardo Godoy⁶

¹Massachusetts Institute of Technology, ²MIT, ³Massachusetts Institute of Technology, ⁴Purdue University, ⁵Escuela de Gobierno, Pontificia Universidad Católica de Chile, ⁶Brandeis University

170. Restoration of Hearing in a Novel Gjb2^M34T Mouse Model with Gene Addition Therapy

Larisa Antonellis^*1, Kevin T. A. Booth *co-first author¹, Maryna V. Ivanchenko¹, Yaqiao Li¹, Olga Shubina-Oleinik¹, Elijah H. Hochstein¹, David P. Corey¹

¹ Harvard Medical School

171. Optimization Under Ecological Realism Reproduces Signatures of Human Speech Recognition

Annika Magaro^*1, Erica Shook², Alex Kell³, Mark Saddler⁴, Josh McDermott³

¹Massachusetts Institute of Technology, ²Zuckerman Institute, Columbia University, ³MIT, ⁴Technical University of Denmark (DTU)

172. Transient Neurog1 Upregulation and Optogenetic Modulation of Plp1- Positive Schwann Cells in a Mouse Model of Auditory Neuropathy

Judith Kempfle^*1, Victor Adenis², Drew Montigny², Reef Al-Asad², Dunia Abdul-Aziz², Daniel Lee², Albert Edge²

¹Massachusetts Eye and Ear, Harvard Medical School, ²Massachusetts Eye and Ear

173. Spatial Analysis of Inner Ear Pathology in Mice with Audiovestibular Dysfunction Induced by Lassa Virus Infection

Tomoko Makishima^*1, Marina Saito¹, Takeshi Saito¹, Kirsten Littlefield¹, Junki Maruyama¹, Slobodan Paessler¹

¹ University of Texas Medical Branch

174. From Bench to Bedside: Vesicle-Enriched Secretome Fraction as Inner Ear Therapeutic during Cochlear Implantation

Odett Kaiser^*1, Susanne Sasse¹, Jennifer Harre¹, Mario Gimona², Eva Rohde², Hinrich Staecker³, Nils Kristian Prenzler¹, Athanasia Warnecke¹

¹Hannover Medical School, ²Paracelsus Medical University Salzburg, ³Univeristy of Kansas Medical Center

175. Memory Errors Reveal Cross-Cultural Variation in Representations of Environmental Sounds

Bryan Medina^*1, Yue Chen Li², Ricardo Godoy³, Josh McDermott²

¹Massachusetts Institute of Technology, ²MIT, ³Brandeis University

176. Pcp Auto Count: An Imagej Plug-In Developed Using Ai (Actual Intelligence) for Automated Cell Counting and Measurement of Planar Cell Polarity

Kendra Stansak¹, Luke Baum¹, Sumana Ghosh¹, Punam Thapa¹, Brad Walters^*1

¹ University of Mississippi Medical Center

177. EMX2 Generates the Line of Polarity Reversal by Blocking STK32A-Dependent Regulation of GPR156 during Mouse Utricle Development

Michael Deans^*1, Ellison Goodrich², Basile Tarchini³, Shihai Jia²

¹Emory University, ²University of Utah, ³The Jackson Laboratory

178. Does Selective Attention to a Target Speaker Reveal a Cortico-Cochlear Loop?

Sarah Haysley^*1, Skyler Jennings¹, Ehud Ahissar², James Lacker³, Oded Ghitza⁴, Sarah Haysley⁵

¹University of Utah, ²Weizmann Institute, ³Brandeis University, ⁴Boston University, ⁵The University of Utah

179. Unraveling the Role of Mitochondrial Protein ACO2 in Hearing Loss

Lubriel Sambolin-Escobales^*1, Oraya Zinder¹, Laura Reinholdt¹, Basile Tarchini¹

¹ The Jackson Laboratory

180. PROX1 Controls Cellular Patterning and Maturation in the Lateral Compartment of the Mouse Organ of Corti

Shubham Kale^*1, Dimitri Trankner¹, Michael Deans¹

¹ University of Utah

181. Auditory Nerve Response Synchrony of Mutant Mice and Diagnosis of Hearing Loss Pathology

Neil Ingham^*1, Clarisse Panganiban¹, Carolyn McClaskey², Kelly Harris², Karen P. Steel¹

¹Wolfson SPaRC, King's College London, ²Medical University of South Carolina

182. Gene Regulatory Elements Enable Cell-Specific Delivery of GJB2 to Treat a Mouse Model of DFNB1 Deafness

Kevin T. Booth*¹, Maryna V. Ivanchenko*¹, K. Domenica Karavitaki¹, Larisa M. Antonellis¹, Sinisa Hrvatin¹, M. Aurel Nagy¹, Olga Shubina-Oleinik¹, Andrew Ward¹, Yaqiao Li¹, Cole W. Peters¹, Eric C. Griffith¹, David Corey^*1

¹ Harvard Medical School

183. Characterization of Spiral Ganglion Glial Cells Following Selective Ablation of Spiral Ganglion Neurons in Neonatal Mice

Nhi Nguyen^*1, Joshua Lin², Sahiti Vemula³, Seiji B. Shibata¹

¹USC Caruso, ²Caruso, ³Keck School of Medicine of USC

184. Validating a Novel Online Tool for Non-Stationary Fluctuation Analysis of AMPA Receptor Properties

Mona Jawad^*1, Mark Rutherford², Juan Goutman³, James Huettner⁴, Walen Gribaudo³

¹Washington University St. Louis, ²Washington University in St. Louis, ³INGEBI (CONICET), ⁴Washington University School of Medicine

185. Probing for Diplacusis in Individuals with Endolymphatic Hydrops

Samantha Stiepan^*1, Christopher Shera¹, Carolina Abdala¹

¹ University of Southern California

186. Therapeutic Potential of Dexamethasone Palmitate Lipid Nanoparticles in Protecting against Aminoglycoside Ototoxicity

Hyun Su Lee^*1, Yeji Ahn¹, Young Joon Seo¹

¹ Yonsei University Wonju College of Medicine

187. Platelet-rich Plasma as Neuroprotective Therapy Approach for the Inner Ear: In Vitro Study with Isolated Extracellular Vesicles

Jennifer Harre^*1, Odett Kaiser², Anas Arab Oghli³, Susanne Sasse², Hinrich Staecker⁴, Athanasia Warnecke²

¹Hannover Medical School and Cluster of Excellence “Hearing4all”, ²Hannover Medical School and Cluster of Excellence “Hearing4all” - EXC 2177/1, Hanover, Germany, ³Hannover Medical School, ⁴School of Medicine, University of Kansas

188. FOXJ1 Plays a Critical Role in Vestibular Hair Bundle Formation

Lesly Umanzor^*1, Kathleen Gwilliam², Han Dewan³, Beatrice Milon², Ronna Hertzano²

¹National Institute on Deafness and Other Communication Disorders, National Institutes of Health, ²Section on Omics and Translational Science of Hearing, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, ³University of Maryland School of Medicine

189. Characterization of Auditory Function and Histological Changes in a Novel Blast-Tube Model

Megan Barber^*1, Yuan Gao², Federica M. Raciti³, Kayla Minesinger⁴, Curtis King⁵, Nadine Kerr⁶, Suhrud Rajguru⁷

¹University of Miami, ²University of Miami Miller School of Medicine, ³University of Miami Miller School of Medicine, ⁴University of Miami, Biomedical Engineering, ⁵Restor-Ear Devices LLC, ⁶Miami Project to cure paralysis, University of Miami, ⁷University of Miami, Department of Veterans Affairs, Bruce W. Carter Department of Veterans Affairs Medical Center

190. Quantifying Cross-Hearing in Mice following Induction of Unilateral Deafness via Ossiculectomy

Jesus Maldonado^*1, Anthony Ricci², Yuxuan Xu³

¹Stanford School of Medicine, ²Department of Otolaryngology, Stanford University School of Medicine, Stanford University, CA, USA, ³Hamilton College, Clinton, NY, USA

191. The Insm1 Knockout Mouse as a Model for Identifying Morphogen Signaling Pathways Driving Inner Hair Cell Differentiation

Jemma L. Webber^*1, Yingjie Zhou², Jaime Garcia-Anoveros²

¹Creighton University, ²Northwestern University

192. Lysosomal Roles in Delayed Hair Cell Death After Aminoglycoside Uptake

Francisco Barros-Becker^*1, Patricia Wu², Tor Linbo², Ananya Cholkar², David Raible²

¹University of Washington School of Medicine, ²University of Washington

193. Middle Latency Responses Assist Hearing Threshold Detection Using Parallel Abr Stimuli

Isabel Herb^*1, Ross Maddox², Melissa Polonenko¹

¹University of Minnesota, ²University of Michigan

194. Ctcf-Mediated Chromatin Remodeling in Cochlear Development: Implications for Sensory Epithelium Patterning and Hair Cell Maintenance

Jeong-Oh Shin^*1, Jinwoong Bok²

¹Soonchunhyang University College of Medicine, ²Department of Anatomy, Yonsei University College of Medicine

195. Dexamethasone Nanocrystals-Embedded Hydroxypropyl Methylcellulose Hydrogel Increases Cochlear Delivery and Attenuates Hearing Loss Following Intratympanic Injection

Subin Kim^*1, Min Young Jeong², Hye Rim Kim², Jiae Jeon³, Seong su Won⁴, Keum-Jin Yang⁴, Myung Joo Kang², Dong-Kee Kim⁴

¹Soonchunhyang University College of Medicine, Cheonan, Republic of Korea, ²College of Pharmacy, Dankook University, 119 Dandae-ro, Dongnam-gu, Cheonan, 10 Chungnam 31116, Korea, ³Department of Otorhinolaryngology-Head and neck surgery, Soonchunhyang University College of Medicine, ⁴Department of Otolaryngology- Head and Neck Surgery, College of Medicine,The Catholic University of Korea

196. Chronic Trk Receptor Inhibition Increases Noise-Induced Cochlear Synaptopathy in Adult Mice

Luis Cassinotti^*1, Naomi Richelew¹, M. Charles Liberman², Gabriel Corfas¹

¹Kresge Hearing Research Institute University of Michigan Medical School, ²Eaton-Peabody Laboratories, Mass Eye and Ear. Department of Otolaryngology-Head and Neck Surgery, Harvard Medical School. Boston, MA, United States.

197. Roles of D-Serine in Kainate-, and Noise-Induced Cochlear Synaptopathy and Repair

Joseph Vecchi^*1, Anissa Rym SAIDIA², Florence François², Ichiro Furuta², Paul Gratias², Tong Yang², Jérôme Ruel³, Jing Wang²

¹University of Iowa Hospitals and Clinics, ²Institute for Neurosciences of Montpellier- INSERM_U1298. France, ³C2VN, Aix-Marseille Université, INSERM 1263

198. Susceptibility to Noise Trauma in Deaf Otof Knockout Mice

Franke Justin¹, Stalmann Ursula¹, Nicola Strenzke^*1

¹ Göttingen University

199. The Nfi Family of Transcription Factors Instruct Radial Patterning and Cell Type Composition in the Developing Mouse Cochlea

Charles Morgan^*1, Angelika Doetzlhofer¹

¹ Johns Hopkins University School of Medicine

200. Human Umbilical Cord Perivascular Cells Reverse Noise-Induced Damage in the Brain and Cochlea in a Rat Model of Noise-Induced Hearing Loss

Ali Mirzaesmaeili^*1, Ayesha Noman¹, Kajal atel¹, Lianet Lopez¹, Andree Gauthier-Fisher¹, Subhendu Mukherjee², Clifford Librach³, Ali Mirzaesmaeili⁴

¹CReATe Fertility Centre, ²Create Fertility Centre, ³Create Fertility Centre, University of Toronto, ⁴Create fertility center

201. Effects of BDNF-TrkB Activation on Blast-Induced Hearing Loss in a Mouse Model

Sung Kyun Kim^*1, Han-Gyu Bae², Jiwon Park², Se Yeon Jeong³, Jun Hee Kim²

¹Kresge Hearing Research Institute, University of Michigan, ²Kresge Hearing Research Institute, Department of Otolaryngology-Head and Neck Surgery, University of Michigan, ³College of Literature, Science and Arts, University of Michigan

202. The Notch Ligand Jagged1 Plays a Dual Role in Cochlear Hair Cell Regeneration

Angelika Doetzlhofer^*1, Xiao-Jun Li², Charles Morgan¹, Lin Li², Elena Chrysostomou³

¹Johns Hopkins University School of Medicine, ²Xi’an Jiaotong University, ³Salk Institute for Biological Studies

203. Foxo3 Mechanisms in Noise Induced Hearing Loss

Patricia White^*1, Daxiang Na², Holly Beaulac³, Dorota Piekna-Przybylska¹

¹University of Rochester Medical Center, ²University of Rochester, ³Dept. of Neuroscience

204. KCNQ2/3 Potassium Channel Activator Mitigates Noise-Trauma-Induced Hypersensitivity to Sounds in Mice

Jesse Weisbord¹, Laura Marinos^*2, Christopher Cunningham³, Thanos Tzounopoulos³, Manoj Kumar¹

¹Pittsburgh Hearing Research Center, University of Pittsburgh, ²Pittsburgh Hearing Research Center, Center for Neuroscience at the University of Pittsburgh, ³Pittsburgh Hearing Research Center, University of Pittsburgh, Center for Neuroscience at the University of Pittsburgh

205. Cisplatin Induced Hearing Loss through Multi-Cycle Single Low Dose Intravenous Injection

Xiaodong Tan^*1, Robert Fuentes², Chail Koo², Devin Thomas², Claus-Peter Richter³

¹Feinberg School of Medicine, Northwestern University, ²Feinberg School of Medicine, Northwestern University, ³Feinberg School of Medicine, Northwestern University

MP1. Mini-Podium 1: Otitis Media: Imaging, Immunity and Innovative Therapy

3:00 p.m. – 4:00 p.m.

Ocean Ballroom 9–12

A 3D and Explainable Artificial Intelligence Model for Evaluation of Chronic Otitis Media Based on Temporal Bone Computed Tomography: Model Development, Validation, and Clinical Application

Binjun Chen^*1, Fanglu Chi², Yike Li³, Dongdong Ren²

¹Eye and ENT Hospital, Fudan University, ²ENT institute and Department of Otorhinolaryngology Eye and ENT Hospital, Fudan University, ³Vanderbilt University Medical Center

Exploiting Bacterial Nutritional Dependence: A Novel Therapy to Prevent Middle Ear Infections

Brianna Atto^*1, Caitlyn Granland², Jack Pepper², Stephen Tristram³, Robyn Marsh⁴, Ruth Thornton², Lea-Ann Kirkham²

¹School of health Sciences, University of Tasmania, ²Wesfarmers Centre of Vaccines and Infectious Diseases, The Kids Research Institute Australia, Perth, WA, Australia, ³School of health Sciences, University of Tasmania, Tasmania, TAS, Australia, ⁴Child and Maternal Health Division, Menzies School of Health Research, Charles Darwin University

Innate Immune Gene Expression and Regulation by Epithelial Cell Types during Otitis Media

Allen F. Ryan^*1, Arwa Kurabi², Nathan Zemkle²

¹University of California, San Diego, ²University of California San Diego

SS2. Special Session 2: Making History: Celebrating Black Scientists in Otolaryngology

3:00 p.m. – 5:00 p.m.

Ocean Ballroom 1–4

Chair: Jeffrey Cheng, Massachusetts Eye and Ear / Harvard Medical School

Co-chair: Melissa McGovern, University of Pittsburgh School of Medicine

Co-chair: Michele Insanally, University of Pittsburgh School of Medicine

Co-chair: Ilkem Sevgili, Harvard Medical School

Moderator: Juwan Copeland

Making History: Celebrating Black Scientists in Otolaryngology

Melanie Barzik¹, Jeffrey Cheng², Melissa McGovern³, Michele Insanally³, Ilkem Sevgili⁴, Ambroise Wonkam⁵, Brandie Verdone⁶, Nikolas Francis⁷, Andrea McQuate⁸

¹National Institutes of Health, ²Mass. Eye and Ear / Harvard Medical School, ³University of Pittsburgh School of Medicine, ⁴Harvard Medical School, ⁵African Society of Human Genetics, ⁶Johns Hopkins University, ⁷University of Maryland, ⁸University of New Mexico

Making History: Celebrating Black Scientists in Otolaryngology

Tejbeer Kaur¹, Michele Insanally²

¹Rutgers University, Robert Wood Johnson School of Medicine, Rutgers Brain Health Institute, ²University of Pittsburgh School of Medicine

Making History: Celebrating Black Scientists in Otolaryngology

Ilkem Sevgili¹

¹ Harvard Medical School

Visuo-Vestibular Interactions During Gaze Control in Mice: Implications for Successful Navigation

Brandie Verdone^*1

¹ Johns Hopkins University

Investigating the Neurophysiology of Listening

Nikolas Francis^*1

¹ University of Maryland

The Spaghetti and Bean Journey: How I Began Studying Mitochondria in Zebrafish Mechanosensory Hair Cells

Andrea McQuate^*1

¹ University of New Mexico

Africa is the Next Frontier for Hearing Loss Novel Genes Discovery

Ambroise Wonkam^*1

¹ Johns Hopkins University School of Medicine

P6. Podium Session 6: Decoding Speech Perception: Insights from Neural, Behavioral, And Technological Perspectives

3:00 p.m. – 5:00 p.m.

Ocean Ballroom 5–8

Age-Related Dual-Task Cost of Speech Perception in Quiet and Noise While Walking

Yossi Bugannim^*1, Alon Kalron¹, Liat Kishon-Rabin¹

¹ Tel Aviv University

Attentional Dynamics Drive Narrative Lingering Under Effortful Listening Conditions

Ryan Panela^*1, Björn Herrmann², Alexander Barnett³

¹University of Toronto, ²Rotman Research Institute, ³McGill University

The Influence of Semantic Context on the Intelligibility Benefit from Speech Glimpses in Younger and Older Adults

Priya Pandey^*1, Björn Herrmann¹

¹ Rotman Research Institute

Auditory-Motor Entrainment and Listening Experience Shape the Perceptual Learning of Concurrent Speech

Jessica MacLean^*1, Jack Stirn¹, Gavin Bidelman¹

¹ Indiana University

Human-Like Feature Attention Emerges in Task-Optimized Models of the Cocktail Party Problem

Ian Griffith^*1, Preston Hess², Josh McDermott²

¹Harvard University, ²Massachusetts Institute of Technology

Leveraging AI to Improve Speech Perception with Hearing Devices: Multiple Microphones and Speaker Selection Enhance Performance in Realistic Noisy Situations

Tobias Goehring^*1, Iordanis Thoidis², Clement Gaultier³

¹Cambridge Hearing Group, University of Cambridge, ²School of Electrical and Computer Engineering, Aristotle University of Thessaloniki, ³Center for Research and Innovation on Human Audiology, Institut de l’Audition

Uncovering Genetic Comorbidities Related to Speech in Noise Deficits Using Polygenic Risk Score from Two Independent Cohorts

Srividya Grama Bhagavan^*1, Valerie Ingalls¹, Ishan Bhatt¹

¹ The University of Iowa

Cochlear Implant Users Improve Speech-on-Speech Perception With Piano Training

Eleanor Harding^*1, Etienne Gaudrain², Robert Harris³, Barbara Tillmann⁴, Bert Maat⁵, Steven de Rooij⁶, Rolien Free⁵, Deniz Başkent⁵

¹University of Groningen, ²Lyon Neuroscience Research Center, CNRS UMR5292, ³Prince Claus Conservatory, Hanze University of Applied Sciences, ⁴Laboratory for Research on Learning and Development (LEAD), CNRS UMR5022, ⁵University of Groningen, University Medical Center Groningen, ⁶NHL Stenden University of Applied Sciences

MP2. Mini-Podium 2: Etiologies and Novel Treatments of Inner Ear Disorders

4:15 p.m. – 5:15 p.m.

Ocean Ballroom 9–12

AC102, an Innovative Small Molecule Which Shows Strong Efficacy Against Hearing Loss and Tinnitus in Preclinical Models, is Now in Advanced Stage of Phase 2

Christin Galetzka¹, Alena Meis¹, Frieder Holzapfel¹, Jörn Niessing¹, Hans Rommelspacher¹, Reimar Schlingensiepen^*1

¹ AudioCure Pharma GmbH

SPI-1005 Improves Auditory and Vestibular Deficits in Meniere’s Disease in a Multi-Center Phase 3 Randomized Placebo-Controlled Trial (STOPMD-3)

E Emily Harruff¹, Jacqueline Nguyen¹, G Michael Wall¹, Shaun Nguyen², Paul Lambert², Jonathan Kil^*1

¹Sound Pharmaceuticals, Inc., ²MUSC

Machine Learning Model for Predicting Acute Hearing Loss Episodes in Patients with SLC26A4 Variants

Pei-Hsuan Lin^*1, Yu-Jen Wu², Ta-Wei Yang², Yu-Ting Chiang³, Yu-Xhin Lu⁴, Tien-Chen Liu⁴, Chuan-Jen Hsu⁵, Cheng-Fu Chou², Chen-Chi Wu⁶

¹National Taiwan University College of Medicine, ²National Taiwan University, ³Graduate Institute of Medical Genomics and Proteomics, National Taiwan University College of Medicine, Taipei, Taiwan, ⁴National Taiwan University Hospital, Taipei, Taiwan, ⁵National Taiwan University Hospital, Taipei, Taiwan; Taichung Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation; School of Medicine, Tzu Chi University, ⁶National Taiwan University Hospital, Taipei, Taiwan; National Taiwan University Hospital, Taipei, Taiwan; National Taiwan University Hospital Hsin-Chu Branch

Vanadium, Uranium, and Silver Metal Levels Are Associated with Poorer Auditory Test Performance Among Children in a Nicaraguan Mining Community.

Marissa Kachadoorian^*1, Torri Lee¹, Jessica Fitzgerald², Michaela Geffert², Adrian Fuente³, Catherine Rieke², Anastasiya Kobrina², Odile Clavier⁴, Jiang Gui¹, Jie Zhou¹, Siting Li¹, Margaret Karagas¹, Brian Jackson⁵, Karen Mojica⁶, Christopher Niemczak⁷, Jay Buckey⁷, James Saunders⁷

¹Geisel School of Medicine, ²Dartmouth-Hitchcock, ³University of Montreal, ⁴Creare LLC, ⁵Dartmouth College, ⁶Vivian Pellas Hospital, Medical Director, Mayflower Medical Outreach, Managua, Nicaragua, ⁷Dartmouth-Hitchcock, Geisel School of Medicine

Monday, February 24, 2025

S3. Symposium 3: Inner Ear Immunity: Unraveling the Immune Dynamics in Hearing

8:00 a.m. – 10:00 a.m.

Ocean Ballroom 1–4

Chair: Cathy Yea Won Sung, National Institute on Deafness and Other Communication Disorders, National Institutes of Health

Immune Mediated Sensory Hearing Loss in Chronic Suppurative Otitis Media

Peter Santa Maria^*1, Vincent Yuan², Anping Xia², Viktoria Schiel², Ritwija Bhattacharya²

¹Stanford University, ²Otolaryngology, Stanford University

Harnessing Macrophages for the Treatment of Noise-Induced Hidden Hearing Loss

Tejbeer Kaur^*1

¹ Rutgers University, Robert Wood Johnson School of Medicine, Rutgers Brain Health Institute

Single-Cell, Spatial, and Fate-Mapping Analyses Uncover Niche Dependent Diversity of Cochlear Myeloid Cells

Aude Chiot¹, Max Felgner², Dillon Brownell¹, Katherine H. Rott¹, Alina Bogachuk¹, Dennis-Dominik Rosmus³, Patrick J. Atkinson⁴, Alan G. Cheng⁴, Peter Wieghofer³, Bahareh Ajami^*5

¹OHSU, ²Universität Leipzig, ³University of Augsburg, ⁴Stanford University, ⁵Oregon Health and Sciences University

Single-Nucleus RNA Sequencing Reveals Transcriptional Markers of Congenital CMV Infection in the Mouse Cochlea

Daniel Romano^*1, Song-Zhe Li¹, Michael Hoa², Sidharth Puram¹, William Britt³, Keiko Hirose¹

¹Washington University School of Medicine, ²NIDCD, ³University of Alabama at Birmingham

Assessment of AAV-Mediated Innate and Adaptive Immunity in the Mammalian Inner Ear

Yasuko Ishibashi^*1, Jianliang Zhu², Gwladys Gernoux³, Yunkai Yu⁴, Michelle J. Suh², Kevin Isgrig², Mhamed Grati², Rafal Olszewski⁵, Michael Hoa⁶, Liang Cao⁴, Thomas B. Friedman⁷, Oumeya Adjali³, Wade Chien⁸

¹National Institute on Deafness and Other Communication Disorders, National Institutes of Health, ²Inner Ear Gene Therapy Program, National Institute on Deafness and Other Communication Disorders (NIDCD), National Institutes of Health, ³Nantes Université, CHU de Nantes, INSERM, TaRGeT - Translational Research in Gene Therapy, UMR 1089, F-44200 Nantes, ⁴OMICS Technology facility, Genetics Branch, The Center for Cancer Research, National Cancer Institute, National Institute of Health, ⁵Auditory Development and Restoration Program, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, ⁶Auditory Development and Restoration Program, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland, ⁷Laboratory of Molecular Genetics, National Institute on Deafness and Other Communication Disorders (NIDCD), National Institutes of Health, ⁸Inner Ear Gene Therapy Program, National Institute On Deafness and Other Communication Disorders (NIDCD), National Institutes of Health; Johns Hopkins School of Medicine

Role of the Immune System in the Development of Endolymphatic Hydrops and Hearing Instability in Humans

Samuel Adadey^*1, Rafal Olszewski², Shoujun Gu², Dillon Strepay³, Julia Telischi⁴, Alison Benner⁵, Jennifer Chisholm⁶, John Butman⁷, Michael Hoa⁸

¹National Institute on Deafness and Other Communication Disorders, ²Auditory Development and Restoration Program, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, ³Auditory Development and Restoration Program, National Institute on Deafness and Other Communication Disorders, National institutes of Health, ⁴University of Miami Miller School of Medicine, ⁵Auditory Development and Restoration Program, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, ⁶Audiology Unit, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, ⁷National Institutes of Health, ⁸Auditory Development and Restoration Program, National Institute on Deafness and Other Communication Disorders, National Institutes of Health

Organ of Corti Macrophages: A Distinct Group of Cochlear Macrophages With Potential Roles in Cochlear Development and Supporting Cell Degeneration

Mengxiao Ye^*1, Dalian Ding², Celia Zhang³, Guangdi Chen², Henry J. Adler², Rania Sharaf², Bohua Hu⁴

¹University at Buffalo, ²University at Buffalo, ³Hearing and Balance Center, University of the Pacific, ⁴University of Texas at Dallas

P7. Podium Session 7: Cochlear Mechanics: Models, Experiments, And Problems

8:00 a.m. – 10:00 a.m.

Ocean Ballroom 5–8

Inner Ear Fluids Imbalance in Meniere’s Disease Between Blood and Cerebrospinal Fluid

Michael Burcon^*1

¹ Meniere's Disease Research Institute

Broadband Nonlinearity in Vibrations of the Mouse Cochlear Apex

James Dewey^*1

¹ University of Southern California

On the Growth of the Wave Vector of the Cochlear Traveling Waves, and its Dependence on the Relative Phase of Reticular Lamina and Basilar Membrane

Renata Sisto^*1, Arturo Moleti²

¹INAIL Research, ²University of Rome Tor Vergata

3D Finite Element Modeling of Human Cochlear Responses to Air and Bone Conductions for Blast Overpressure and Acoustic Wave Transmission

John Bradshaw¹, Marcus Brown¹, Alexander Bien², Mirembe Mulimba¹, Yijie Jiang^*1, Rong Gan¹

¹University of Oklahoma, ²University of Oklahoma Health Sciences Center

Revisiting Key Hypotheses in Cochlear Micromechanics regarding Traveling Wave Amplification and Longitudinal Vibrations

George Samaras¹, Julien Meaud^*1

¹ Georgia Institute of Technology

Internal Motion of the Organ of Corti in the Absence of Traveling Waves

Francesco Gianoli^*1, Rodrigo Alonso², Brian Fabella¹, A. Jim Hudspeth³

¹The Rockefeller University, ²Rockefeller University, ³HHMI/The Rockefeller University

Determining Parameters for an Active Radial-Slice Model Using Lumped Element Modeling and Simulation-Based Inference

Julius Kraut^*1, Daniel Cardosi², Sunil Puria²

¹Massachusetts Eye and Ear, ²Harvard Medical School

Physiological Role of Camp in the Inner Ear

Sonal Prasad^*1

¹ Linkoping University

P8. Podium Session 8: Hair Cell Regeneration in Fish and Mice

8:00 a.m. – 10:00 a.m.

Ocean Ballroom 9–12

Treatment of Vestibular Dysfunction Through Hair Cell Regeneration by Dual Aav-Mediated Crispr Activation

Chenxi Jin^*1, Zhengyi Chen², Yong Tao³, Hao Wu⁴

¹Shanghai Jiao Tong University, ²Mass Eye and Ear Infirmary/Harvard Medical School, ³Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, ⁴Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine; Ear Institute, Shanghai Jiao Tong University School of Medicine; Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases

Multimodal Analysis of Gene Regulatory Networks Driving Zebrafish Inner Ear Regeneration

Erin Jimenez^*1

¹ Johns Hopkins University

Accessibility of Developmental Enhancers Maintains Competency for Hair Cell Regeneration

Tuo Shi¹, Xizi Wang¹, Yeeun Kim¹, Juan Llamas¹, Gage Crump¹, Ksenia Gnedeva^*2

¹USC Keck School of Medicine, ²University of Southern California, Keck School of Medicine

Exploring Ger-Derived Organoids as a Model for Cochlear Regeneration: Insights from a Single-Cell RNA Sequencing Study

Marie Kubota^*1, Julia M. Abitbol¹, Paul K. Lee¹, Sonia Bustos Barocio¹, Taha A. Jan², Alan G. Cheng¹, Stefan Heller¹

¹Stanford University School of Medicine, ²Vanderbilt University Medical Center

Cell Death; Type Dependent Interactions Between Immune Cells and Sensory Hair Cell Regeneration Programs

Daniela Muench¹, Shiyuan Chen¹, Elizabeth Ellis¹, Nicolas Denans², Mark Lush¹, Tatjana Piotrowski^*1

¹Stowers Institute for Medical Research, ²Janelia Research Campus

Spatial and Transcriptomic Determinants of Regenerated Hair Cell and Supporting Cell Fates

Sara Billings^*1, Lingjun Zhang¹, Roshni Parulekar-Martins1¹, Andrew Groves², Alan G. Cheng³

¹Stanford University, ²Baylor College of Medicine, ³Stanford University

Overexpression of Six1 or Eya1 Promotes Hair Cell Generation and Maturation in the Postnatal Mouse Cochlea

Xiaohui Ma^*1, Jinshu Xu¹, Bengu Tokat¹, Pin-Xian Xu¹

¹ Icahn School of Medicine at Mount Sinai

Reprogramming Supporting Cells with Small Molecules for Cochlear and Vestibular Hair Cell Regeneration

Hanae Lahlou^*1, Hong Zhu², Wu Zhou², Albert S. B. Edge³

¹Harvard Medical School, ²University of Mississippi Medical Center, ³Massachusetts Eye and Ear Infirmary/Harvard Medical School

S4. Symposium 4: Hair-Cell Evolution: Insights from New Model Organisms, Comparative Studies, And Molecular Analyses

10:30 a.m. – 12:30 p.m.

Ocean Ballroom 1–4

Chair: Marcos Sotomayor, University of Chicago

Co-chair: Eduardo Perozo, University of Chicago

Molecular Evolution of Tip-Link Proteins

Marcos Sotomayor¹, Collin Nisler¹, Emily Scheib¹, Yoshie Narui², Deepanshu Choudhary³, Jacob Bowman⁴, Qurat Ashraff¹, Harsha Mandyam Bharathi¹, Vincent Lynch⁴, Emily Scheib^*5

¹University of Chicago, ²Ohio State Center for Electron Microscopy and Analysis, ³The Ohio State University, ⁴University at Buffalo, ⁵NA

Structural Insights into the Evolution of Mammalian Prestin From Anion Transporter to Area Motor

Nicolas Fuentes-Ugarte¹, Tiaren Ruiz-Rojas², Victor Castro-Fernandez³, Raul Araya-Secchi^*4

¹Departamento de Biologia, Facultad de Ciencias, Universidad de Chile, ²Computational Biophysics group. Facultad de Ingenieria, Arquitectura y Diseño. Universidad San Sebastian., ³Departamento de Biologia, Facultad de Ciencias, Universidad de Chile., ⁴Computational Biophysics Group; Facultad de Ingenieria, Arquitectura y Diseño. Universidad San Sebastian

The Nompc Gating Spring

Martin Göpfert^*1, Philip Helhlert², Thomas Effertz², Ruo-Xu Gu², Björn Nadrowski², Bart R. H. Geurten², Dirk Beutner², Bert L. de Groot²

¹University of Göttingen, ²NA

Molecular Characterization of Tunicate Coronal Organ Mechanosensory Cells

Gwynna Fuller^*1, Bita Jadali², Eduardo D. Gigante², Ye-Jin Park¹, Yanyan Qi¹, Christopher J. Johnson², Haley Gidden³, Hongjie Li¹, Alberto Stolfi², Andrew K. Groves¹

¹Baylor College of Medicine, ²Georgia Institute of Technology, ³University of Houston-Clear Lake

Evolutionary Approaches to Cellular and Molecular Mechanotransduction

Eduardo Perozo^*1, Zeeshan Banday², Zhen Tong², Emily Watto², Naileth Gonzalez², Zachary Fournier², Jocelyn Malamy²

¹University of Chicago, ²NA

P9. Podium Session 9: Auditory Cortex: Human and Animal Studies

10:30 a.m. – 12:30 p.m.

Ocean Ballroom 5–8

An Eligibility Trace for Synaptic Plasticity in the Auditory Cortex

Brendan Williams^*1, Tanya Danaphongse², Seth Hays³, Crystal T. Engineer³

¹University of Texas at Dallas, ²Texas Biomedical Device Center, ³The University of Texas at Dallas, Texas Biomedical Device Center

Dynamic Role of Perineuronal Nets in Modulating Auditory Neural Plasticity During Perceptual Learning

Jessica Winne^*1, Rebecca Schrader¹, Melissa Caras¹

¹ University of Maryland

The Impact of Musical Expertise on Disentangled and Contextual Neural Encoding of Music Revealed by Generative Music Models

Yinghao Li^*1, Gavin Mischler¹, Stephan Bickel², Ashesh D. Mehta³, Nima Mesgarani¹

¹Columbia University, ²The Feinstein Institute for Medical Research, ³Hofstra Northwell School of Medicine

Listening to the Room: Disrupting Activity of Dorsolateral Prefrontal Cortex Impairs Learning of Room Acoustics

Heivet Hernandez Perez^*1, Jessica Monaghan², Jason Mikiel-Hunter³, James Traer⁴, Paul Sowman¹, David McAlpine³

¹Macquarie University, ²National Acoustic Laboratories, ³Macquarie University, ⁴The University of Iowa

Instinct Versus Insight: Neural Competition Between Prefrontal and Auditory Cortex Constrains Sound Strategy Learning

Kai Lu^*1, Kelvin Wong², Chengcheng Yang¹, Lin Zhou¹, Yike Shi¹, Maya Costello¹, Robert Liu¹

¹Emory University, ²Emory University

Neural Decoding of Continuous Speech for Different Acoustic Features: Effects of Intelligibility and Spectral Degradation

Alexis D. MacIntyre¹, Robert P. Carlyon¹, Matthew H. Davis¹, Tobias Goehring^*2

¹Cambridge Hearing Group, MRC Cognition and Brain Sciences Unit, University of Cambridge, ²Cambridge Hearing Group, University of Cambridge

Human Auditory Cortex Integrates Information in Speech and Music Using Similar Timescales

Zehua Li^*1, Thomas Wychowski¹, Webster H. Pilcher¹, Samuel Norman-Haignere¹

¹ University of Rochester Medical Center

Large-Scale Recordings of Human Single Neuron Activity During Auditory Working Memory

Joel Berger^*1, Alexander Billig², Phillip Gander³, Sukhbinder Kumar³, Christopher Kovach³, Ariane Rhone³, Christopher GARCIA³, Hiroto Kawasaki³, Matthew Howard³, Timothy Griffiths⁴

¹University of Iowa, ²UCL Ear Institute, ³University of Iowa Hospitals and Clinics, ⁴Biosciences Institute, Newcastle University

P10. Podium Session 10: Binaural Hearing and Sound Localization

10:30 a.m. – 12:30 p.m.

Ocean Ballroom 9–12

Myelination Changes during Development Underlying Auditory Dysfunction in the Auditory Brainstem in Fragile X Syndrome.

Amita Chawla^*1

¹ Oklahoma State University

Sound Localization Accuracy During the First Years of Life in Children Born With Unilateral Sensorineural Hearing Loss

Marlin Johansson^*1, Erik Berninger¹, Filip Asp¹

¹ Karolinska Institutet

Auditory Brainstem Responses in Nine Wild Rodent Species with Different Social Behavior Organizations

Luberson Joseph^*1, Elizabeth McCullagh²

¹Oklahoma State University, ²Oklahoma State University, Department of Integrative Biology

Characterizing Spatial Hearing in Unilateral Hearing Loss: Effects on Spatial Cues and Adaptation

Sara Momtaz Bokharaei^*1, Ryan McCreery¹, Elizabeth Heinrichs-Graham¹, Dawna Lewis¹, G. Christopher Stecker¹

¹ Boys Town National Research Hospital

Age-Related Myelin Deficits in the Auditory Brainstem Contribute to Central Hearing Loss in Gerbils

Ben-Zheng Li^*1, Shani Poleg¹, Matthew Ridenour¹, Daniel Tollin¹, Tim Lei², Achim Klug¹

¹University of Colorado Anschutz Medical Campus, ²University of Colorado Denver

The Influence of Binaural Cues on Auditory Stream Segregation in Younger and Older Normal- Hearing Listeners

Nathan Higgins^*1, Carrie Secor¹, Erol J. Ozmeral¹

¹ University of South Florida

Spatial Hearing with Active Hearables: Evaluation of the Transparency Hearing Mode

Seba Ausili^*1, Nathan Erthal¹, Christopher Bennett¹, Hillary Snapp¹

¹ University of Miami

Auditory Competition or Binaural Decorrelation? A Comparison Between Midbrain Space Maps in the Barn Owl

Roland Ferger^*1, Andrea Bae¹, Jose Luis Pena¹

¹ Albert Einstein College of Medicine

Poster Session III

1:30 p.m. – 3:00 p.m.

Peninsula Ballroom

1. Electrical Modelling of Cochlear Implant Electrodes for Detection of Cell Occupation and Monitoring Stimulation Efficiency

Mit Bhavsar^*1, Merle Sehlmeyer², Stefan Zimmermann², Hannes Maier¹

¹Hannover Medical School, Hannover., ²Institute of Electrical Engineering and Measurement Technology, Leibniz University Hannover

2. Gap Detection Ability Declines with Central Auditory Neurodegeneration Following Age-Related Cochlear Synaptopathy

Takaomi Kurioka^*1, Kunio Mizutari²

¹Kitasato University School of Medicine, ²National Defense Medical College

3. Monocyte-Derived Macrophages, Signaled by TRPV1, Promote Angiogenesis and Wound Healing in the Tympanic Membrane

Xiaorui Shi^*1, Lingling Neng², Kushal Sharma², Allan Kachelmeier², Xiaorui Shi²

¹Oregon Health and Science University, ²Oregon Hearing Research Center, Oregon Health and Science University

4. Unveiling the Genetic Architecture of Hearing Loss in Populations with African Ancestry

Andrea DeFreese^*1, Tanguy du Mérac², Rene Gifford¹, Taha Jan³

¹Vanderbilt University, ²Vanderbilt Genetics institute, Vanderbilt University Medical Center, ³Vanderbilt University Medical Center

5. Serotonergic Modulation of Inhibitory and Excitatory Neurons in the Inferior Colliculus

Karen Galindo^*1, Nicole Hall², Marina Silveira²

¹Univeristy of Texas, San Antonio, ²University of Texas at San Antonio

6. Reduced Level of Kcne1, Kcnj10 and Col4a3 are Sufficient to Maintain Hearing

Darcey. A Kirwin^*1, Elisa Martelletti¹, Daniel R. Pentland¹, Nina Treder¹, Neil Ingham¹, Karen P. Steel¹

¹ Wolfson SPaRC, King's College London

7. Role of Prenatal Stress in Accelerating Age-Related Hearing Loss

Satoshi Hara^*1, Kali Burke¹, Firasat Ali Shah¹, Harumi Saeki², Tomoaki Ito², Hajime Orita², Takashi Anzai², Yusuke Takata², Kazusaku Kamiya², Fumihiko Matsumoto², Amanda Lauer¹, Kathy Gabrielson¹

¹Johns Hopkins University, ²Juntendo University

8. Blindness, Cortical Reorganization, and the Neuroscience of Creativity: A Case Study Investigation of Blind Piano Prodigy Matthew Whitaker

Chetan Giduturi^*1, Karen Barrett², Nicole Jiam², Lucas Hahn², Walker Payne², Stephanie Purnell², Patpong Jiradejvong², Charles Limb²

¹University of Colorado School of Medicine, ²University of California - San Francisco

9. Functional Role of FLRT3 in Mammalian Auditory Hair Cells

Wanying Feng^*1, Xiaofen LI², Pingbo Huang²

¹Hong Kong University of Science and Technology, ²HKUST

10. Computational Loudness Model of an Electrically Stimulated Cochlea

Franklin Alvarez Cardinale^*1, Waldo Nogueira²

¹Hannover Medical School, ²Department of Otolaryngology, Medical University Hannover and Cluster of Excellence “Hearing4all”, Hanover, Germany

11. Origin and Function of Tissue-Resident Macrophages in Postnatal Development of the Eardrum

Xiaorui Shi^*1, Lingling Neng², Kushal Sharma², Allan Kachelmeier³, Xiaorui Shi⁴

¹Oregon Health and Science University, ²Oregon Hearing Research Center, Oregon Health and Science University, ³Oregon Hearing Research Center, Oregon health and Science University, ⁴Oregon hearing Research Center, Oregon Health and Science University

12. Functional in Vivo Characterization of Layer 6 Corticothalamic Neurons in Primary Auditory Cortex

Marina Cardoso de Oliveira^*1, Patrick O. Kanold¹

¹ Johns Hopkins University

13. Effects of Cholesterol Modulation on Cisplatin-Induced Hearing Loss

Megan Guidry^*1, John Lee², Lizhen Wang², Katharine Fernandez², Lisa Cunningham²

¹University of Texas at Austin, ²National Institute on Deafness and Other Communication Disorders

14. Electric Auditory Brainstem Response (EABR) Properties and Histology of a New 32-Channel Cochlear Implant System

Dong-min Kang^*1, Goun Choe², Doo-Hee Kim³, Tae-Soo Noh⁴, Yu-Jung Hwang⁴, Soo-Won Shin³, Gwang-Jin Choi³, Jung-U Lim³, Ho-Seung Lee³, Kyou-Sik Min³, Myung-Whan Suh⁴

¹Seoul National University Hospital, ²Chungnam National University Sejong Hospital, ³TODOC CO. Ltd, ⁴Seoul National University Hospital

15. Deciphering the Role of Rfx1/3 in Cochlear Hair Cell Development and Function

Ningjin Wu^*1, Kathleen Gwilliam¹, Reza Amanipour¹, Wei Song¹, Beatrice Milon¹, Rani Elkon², Ronna Hertzano¹

¹National Institute on Deafness and Other Communication Disorders, National Institutes of Health, ²Sackler School of Medicine, Tel Aviv University

16. Genotype-Phenotype Correlations in DFNA5-Related Hearing Loss

Joseph Chin^*1, William D. Walls², Kai Wang³, Amanda Odell², Diana L. Kolbe², Kevin T. Booth⁴, Hela Azaiez², Richard J.H. Smith²

¹University of Iowa Carver College of Medicine, ²Molecular Otolaryngology and Renal Research Labs, Department of Otolaryngology-Head and Neck Surgery, University of Iowa Carver College of Medicine, Iowa City, ³University of Iowa College of Public Health, ⁴Medical and Molecular Genetics, Indiana School of Medicine

17. FKBP5 Regulates Map Kinase in the Organ of Corti After Noise-Induced Hearing Loss: RNA-Seq Analysis in Mice

Ryotaro Omichi^*1, Yukihide Maeda², Yu-ichiro Tominaga³

¹Okayama University, ²Okayama University, and Saitama Medical University Faculty of Medicine, Otorhinolaryngology, ³Okayama University, and Hiroshima City Hospital

18. 3D Reconstruction of the Inner Ear Membranous Labyrinth Using 7 Tesla Magnetic Resonance Imaging and Advanced Post-Processing Techniques

Syed Ahmad^*1, Joon Soo Kim¹, Diane Jung², Zahra Sayyid¹, Adrian Paez¹, John P. Carey¹, Jun Hua¹, Bryan K. Ward¹

¹Johns Hopkins School of Medicine, ²Miami Miller School of Medicine

19. Differential Use of Auditory Feedback in the Real-Time Control of Speech Movements by Deaf Talkers with Cochlear Implants and Peers With Normal-Hearing

Matthew Masapollo^*1, Susan Nittrouer², Rosalie Gendron¹, Lucie Menard³, David Ostry¹

¹McGill University, ²University of Florida, ³University of Quebec at Montreal

20. Ototoxic Effects of Tobramycin and Lipopolysaccharide: Auditory Impact in Cdh23 Mice

Nicole Rud^*1, Jonathan Fleegel¹, Alyssa Burd¹, Sarath Vijayakumar²

¹Creighton University School of Medicine, ²Translational Hearing Center, School of Medicine, Creighton University

21. Behavioral Validation of Salicylate-Induced Hyperacusis in CBA/CaJ Mice Using An Active Avoidance Paradigm

Jm Rahman^*1, Dimitri Brunelle¹, Collin Park¹, Joseph Walton¹

¹ University of South Florida

22. Effects of Auricular Size and Hardness on Propagation Components of Cartilage Conduction: Comparison Among Auricular-hematoma, Child and Normal-auricle Subjects

Akane Tamura^*1, Sho Otsuka², Hiroko Kotani³, Seiji Nakagawa²

¹Chiba University, ²Center for Frontier Medical Engineering, Chiba University, ³Tokyo Future University

23. Effects of Presbycusis on the Production of Voice and Enjoyment of Amateur Choral Singing

Jessica Edgar^*1, Fernando Nodal¹, Samantha Dieckmann¹, Victoria Bajo¹

¹ University of Oxford

24. Evaluation of Hearing Loss Induced by Blast Exposure of Varying Intensity and Frequency in CBA/J Mice

Yutaka Koizumi^*1, Aaron Remenschneider², Jeffrey Cheng², Christopher J. Smalt³, Kunio Mizutari⁴, Seiji Kakehata⁵

¹Massachusetts Eye and Ear, Harvard Medical School, Yamagata University, ²Mass Eye and Ear, Harvard Medical School, ³MIT Lincoln Laboratory, ⁴Tokyo Women's Medical University Adachi Medical Center, ⁵Yamagata University

25. Gender Differences in the Fbn Rat Model of Aging: Investigation of Abr Waveforms and Ribbon Synapse Changes

Donald Caspary^*1, Lynne Ling¹, Rui Cai¹, Venezia Carmona¹, Debbie Hamilton¹, Josie Long¹, Leeza Zavelsky², Brandon Cox¹

¹Southern Illinois University School of Medicine, ²Goucher College, Baltimore, Maryland

26. Cep250 in Atypical Usher Syndrome

Natalie Rodeman^*1, Aray Adylkhan¹, Xiaowei Lu¹

¹ University of Virginia

27. Healthy Aging Increases the Neural Reliance on Higher-Level Processing in Competing Speech Comprehension

Vivien Barchet^*1, Andrea Bruera¹, Jasmin Wend¹, Johanna Rimmele², Jonas Obleser³, Gesa Hartwigsen¹

¹Max Planck Institute for Human Cognitive and Brain Sciences, ²Max Planck Institute for Empirical Aesthetics, ³University of Lübeck

28. Characterizing Antimicrobial and Ototoxic Properties of Novel Gentamicin Derivative

Jacqueline Yao^*1, Julia Abitbol², Anthony Ricci², Alan Cheng²

¹Stanford University, ²Department of Otolaryngology - Head and Neck Surgery, Stanford University

29. Genomic Foundation of Sensorineural Hearing Loss

Sang-Yeon Lee^*1

¹ Seoul National University College of Medicine

30. Genetic Hearing Loss: Molecular Diagnostic Challenges and Solutions

Lara Kamal^*1, Zippora Brownstein², Inbar Blech², Katherine Domb², Yazeed Zoabi³, Shadi J. Khoury³, Tal Patalon⁴, Asaf Peretz⁴, Juan Fernandez-Recio⁵, Xavier de La Cruz⁶, Fabian Glaser⁷, Noam Shomron³, Karen B. Avraham²

¹Tel Aviv University, ²Faculty of Medical and Health Sciences, Tel Aviv University, ³Faculty of Medical and Health Sciences, Tel Aviv University, ⁴Maccabi Healthcare Services, ⁵Instituto de Ciencias de la Vid y del Vino (ICVV), ⁶Vall d'Hebron Institute of Research (VHIR), ⁷THHI, Technion Human Health Initiative

31. Expression of Aryl Hydrocarbon Receptor in Supporting Cells and Glia: Protective Role in Cochlear Hair Cells

Sujata Pandey^*1, Shelley Tischkau¹, Brandon Cox¹

¹ Southern Illinois University School of Medicine

32. Decoding Auditory Selective Attention in Normal Hearing and Cochlear Implant Listeners

Jusung Ham^*1, Jinhee Kim², Hwan Shim³, Kyogu Lee⁴, Barbara Shinn-Cunningham², Inyong Choi¹

¹University of Iowa, ²Carnegie Mellon University, ³Rochester Institute of Technology, ⁴Seoul National University

33. Identification of Protective Molecules against Cisplatin Induced Ototoxicity

Salimata Kane^*1, Pierre-Bernard Van Lerberghe², Laurent Meijer³, Laurence Delacroix², Brigitte Malgrange²

¹University of Liege, ²GIGA-Neurosciences, University of Liege, C.H.U. Sart Tilman, Liege, Belgium, ³Perha Pharmaceuticals

34. Single-Nucleus RNA-Sequencing Profiling of Mouse Cochlea in Response to Cisplatin

Amanda Bonczkowski^*1, Franz Gareza², Erica Sadler², Katharine Fernandez², Rafal Olszewski², Mark Warchol³, Michael Hoa², Cathy Yea Won Sung², Lisa Cunningham²

¹National Institute on Deafness and Other Communication Disorders, ²National Institute on Deafness and other Communication Disorders, National Institutes of Health, ³Washington University School of Medicine

35. Exploring New Frontiers in Otoprotection: Evaluating the Efficacy of Novel Compounds in an Ex Vivo Cochlear Implant Trauma Model

Nicholas DiStefano^*1, Rahul Mittal², David Elisha³, Jake Langlie², Jeenu Mittal⁴, Adrien A. Eshraghi⁵

¹University of Miami Miller School of Medicine, ²Cochlear Implant and Hearing Research Laboratory, University of Miami Miller School of Medicine, ³Cochlear Implant and Hearing Research Laboratory, University of Miami Miller School of Medicine, ⁴University of Miami Miller School of Medicine, ⁵Cochlear Implant and Hearing Research Laboratory, University of Miami Miller School of Medicine

36. Middle Ear Transfer Functions: High-speed Measurement and Analysis at Moderate to High-Intensity Sound Levels

Jonathan Oliveira Luiz^*1, John Rosowski², Cosme Furlong³, Jeffrey Cheng⁴

¹Massachusetts Eye and Ear, Center for Holographic Studies and Laser micro-mechaTronics, ²Mass Eye and Ear / Harvard Medical School, ³Worcester Polytechnic Institute, ⁴Mass. Eye and Ear Infirmary/Harvard Medical School

37. Auditory Outcomes in Cochlear Implantation for Children with Usher Syndrome

David Elisha^*1, Jake Langlie¹, Rahul Mittal¹, Nicholas DiStefano¹, Maria-Pia Tuset¹, Chrisanda Sanchez¹, Jordan McNair¹, Meredith Holcomb¹, Jeenu Mittal¹, Adrien Eshraghi¹

¹ Cochlear Implant and Hearing Research Laboratory, University of Miami Miller School of Medicine, Miami

38. Hyperosmotic Sisomicin Infusion: A Mouse Model for Hearing Loss

Ayse Maraslioglu Sperber^*1, Fabian Blanc², Stefan Heller¹, Nesrine Benkafadar¹

¹Stanford University School of Medicine, ²Stanford University School of Medicine

39. The Association of Diabetes with the Rate of Hearing Decline in Aging

Lauren Dillard^*1, Kathleen Bainbridge², Lois Matthews³, Judy Dubno³

¹Medical University of South Carolina, College of Medicine, ²National Institute on Deafness and Other Communication Disorders, National Institutes of Health, ³Medical University of South Carolina

40. Remote Auditory Training to Improve Listening Comprehension of Adult Cochlear Implant Users

Naama Tsach^*1, Talma Shpak², Riyad Khnifes³, Karen Banai¹, Rama Novogrodsky¹

¹University of Haifa, ²Otolaryngology- Head and Neck Surgery, Ear and Hearing Program, Bnai-Zion Medical Center. Haifa, ³Otolaryngology- Head and Neck Surgery, Ear and Hearing Program, Bnai-Zion Medical Center, Haifa

41. The Effects of Spatial and Contextual Cues on Listening Effort

Agudemu Borjigin^*1, Nimesha Dantanarayana², Tanvi Thakkar³, Ruth Litovsky⁴

¹University of Wisconsin Madison, ²University of Wisconsin-Madison, ³University of Wisconsin-La Crosse, ⁴University of Wisconsin

42. Hair Cell Survival Following Selective Denervation of the Spiral Ganglion Neurons in Neonatal Mice

Sahiti Vemula^*1, Joshua Lin², Nhi Nguyen³, Seiji Shibata⁴

¹Keck School of Medicine of University of Southern California, ²Keck School of Medicine of USC, ³University of Southern California, ⁴Keck School of Medicine, University of Southern California

43. Effects of Characteristics of Exposed Noise on the Intelligibility of Bone-Conducted Speech with Earplugging

Kazusa Uchida^*1, Sho Otsuka², Seiji Nakagawa²

¹Chiba University, ²Center for Frontier Medical Engineering, Chiba University

44. Intratympanic Dexamethasone Administration Reduces Radiation-Induced Middle Ear Mucosal Damage

Tae Hwan Kim¹, Sheng Jin¹, Soo Jeong Kim¹, Yong-Ho Park¹, Kim Tae Hwan^*1

¹Chungnam National University, ²Brain Research Institute, Chungnam National University

45. Preliminary Evaluations of Speech, Language, and Hearing Functions of Students in Deaf Schools

Yao Chen^*1, Chang Liu², Jingjing Guan³, Ying Hao⁴, Qinfang Xu⁵

¹University of Texas at Austin, ²The University of Texas at Austin, ³Sonova International, ⁴Nanjing Normal University, ⁵Nanjing Normal University of Special Education

46. Adriamycin Nephropathy Causes Sensorineural Hearing Loss via Blood-Labyrinth Barrier Disruption and Hyperpermeability in Balb/c Mice

Sheng Jin¹, Tae Hwan Kim¹, Min Jung Park², Yong-Ho Park¹, Jin Sheng^*1

¹Chungnam National University, ²Brain Research Institute, Chungnam National University

47. Transcriptomic Heterogeneity in Young C57BL/6N Mice Due to the Presence of the Cdh23ahl Allele

Sherylanne Newton^*1, Marisa Flook Pereira², Carlos Aguilar², Michael Bowl²

¹University College London Ear Institute, ²UCL Ear Institute

48. ALFIES Unwrapped: Recording Cortical Responses to Sustained High-Rate Stimulation in Cochlear-Implant Users

Charlotte Garcia^*1, Dorothee Arzounian¹, Francois Guerit², Robert P. Carlyon²

¹University of Cambridge, ²Cambridge Hearing Group, MRC Cognition and Brain Sciences Unit, University of Cambridge

49. Identifying Protector Chemicals of Mechanosensory Hair Cell via Measuring Zebrafish Acoustic Startle Response of Lateral Line

Ling Zheng¹, Qiaosen Shen¹, Tong Zhao¹, Dong Liu¹, Fangyi Chen^*1

¹ Southern University of Science and Technology

50. Stimulus Optimization and Cross-Sectional Analysis of Frequency-Following Responses in Individuals with Sensorineural Hearing Loss

Laura Jacxsens^*1, Lana Biot¹, Tinne Vandenbroeke¹, Emilie Cardon¹, Vincent Van Rompaey¹, Willem De Hertogh², Carles Escera³, Marc J.W. Lammers¹

¹Antwerp University Hospital, ²University of Antwerp, ³University of Barcelona

51. Investigating the Combined Detrimental Effects of Noise Exposure and Electrode Insertion Trauma for Hearing Preservation Outcomes

Kayla Minesinger^*1, Rachele Sangaletti², Maria Camila Salazar², Maria Fernanda Yepes³, Federica M. Raciti⁴, Suhrud Rajguru⁵

¹University of Miami, ²University of Miami, ³University of Miami Miller School of Medicine, ⁴University of Miami Miller School of Medicine, ⁵University of Miami, Department of Veterans Affairs, Bruce W. Carter Department of Veterans Affairs Medical Center

52. Acoustic Stimulation of the Human round Window by Laser-Induced Nonlinear Optoacoustics

Michael Tomanek^*1, Liza Lengert², Mohammad Ghoncheh³, Hinnerk Lohmann², Nils Prenzler³, Stefan Kalies⁴, Sonja Johannsmeier², Tammo Ripken², Alexander Heisterkamp⁴, Hannes Maier³

¹Hannover Medical School, ²Laser Zentrum Hannover e.V., ³Hannover Medical School, ⁴Institute of Quantum Optics

53. Neural Synchrony is a Sensitive Measure of Early Age-Related Auditory Deficits in Mice

Emily Fabrizio-Stover^*1, Shelby Payne¹, Jiaying Wu¹, Kelly Harris¹, Hainan Lang¹

¹ Medical University of South Carolina

54. Investigating the Effect of Head Movements on Front-Back Discrimination and Sound Externalization with Hearing Aids

Tobias Greif^*1, Virginia Best², Elin Roverud², Pinar Ertürk², Robert Baumgartner¹

¹Austrian Academy of Sciences, ²Boston University

55. Mapping Chromatin Interactions in Cochlear Cells Using Micro-C Technology

Tuba Ege^*1, Celia Bloom¹, Khushboo Patel¹, Litao Tao¹

¹ Creighton University

56. The Role of Oncomodulin in HPβCD-Induced Hearing Loss in Mice

Mi-Jung Kim^*1, Robert Fuentes¹, Jing Zheng¹

¹ Northwestern University

57. Cochlear Anatomy Impacts Neural Health and Current Spread at the Electrode-Nerve Interface in Children with Bilateral Cochlear Implants

Carina Sabourin^*1, Stephen Lomber², Jaina Negandhi³, Sharon Cushing⁴, Blake Papsin⁴, Karen Gordon⁴

¹McGill University, ²McGill University Faculty of Medicine, ³Hospital for Sick Children, ⁴University of Toronto, Hospital for Sick Children

58. Promotion of New Connexin Gene Expression in the Cochlea after Deletion of Cx26 (GJB2)

Tianying Zhai^*1, Yi-Ding Yu¹, Chun Liang¹, Yong Kong¹, Hong-Bo Zhao¹

¹ Yale University Medical School

59. Auditory System Development in Genetically Distinct Rat Models of Autism

Manasi Inamdar^*1, Laurel Hart¹, Alexander Cue¹, Daniel Legowski¹, Noelle James¹, Benjamin Auerbach¹

¹ University of Illinois Urbana-Champaign

60. Investigating DNA Damage Response and Apoptosis in Cisplatin-Induced Ototoxicity

Franz Gareza^*1, Cathy Yea Won Sung¹, Amanda Bonczkowski¹, John Lee¹, Lisa Cunningham¹

¹ National Institute on Deafness and Other Communication Disorders, National Institutes of Health

61. Big Brown Bats (Eptesicus fuscus) are Resistant to Age-Related Hearing Loss

Grace Capshaw^*1, Clarice Diebold¹, Danielle Adams², Jack Rayner², Gerald Wilkinson², Cynthia Moss¹, Amanda Lauer¹

¹Johns Hopkins University, ²University of Maryland, College Park

62. Analyzing Mitochondrial Heteroplasmy and DNA Copies in the HEI-OC1 Cell Line Treated with Hydrogen Peroxide and Cochlear Samples of CBA/CaJ Mice

Bo Ding^*1, Xiaoxia Zhu², Parveen Bazard³, Akil Turner³, Justin Gibbons⁴, Freyda Mannering⁵, Minh Tam Nguyen⁶, Robert D. Frisina⁷

¹University of South Florida, ²Medical Engineering Dept., Global Ctr. Hearing and Speech Res., University of South Florida, ³University of South Florida, ⁴Center for Global Health and Infectious Diseases and USF Genomics Program, College of Public Health, University of South Florida,, ⁵University of South Florida, Hearing and Speech Res., University of South Florida, ⁶Computer Science and Engineering, University of South Florida, ⁷Med. Engin., Chem. and Biolog. Engin.,Global Ctr. for Hearing and Speech Res., Univ. of South Florida

63. Cortical Temporal Mismatch Compensation in Bimodal Cochlear Implant Users: A Selective Attention Decoding and Pupillometry Study

Hanna Dolhopiatenko^*1, Waldo Nogueira²

¹Hannover Medical School anCluster of Excellence “Hearing4all”, ²Department of Otolaryngology, Medical University Hannover and Cluster of Excellence “Hearing4all”, Hanover, Germany

64. Characterizing a Multi-Dose Kanamycin Ototoxicity Mouse Model

Yingkun Yang^*1, Sung-Won Choi², Danial Naseem¹, Anthony Ricci¹, Alan Cheng¹

¹Stanford University, ²Pusan National University Hospital

65. Avian Cochlear Nucleus Neurons Exhibit Tonotopic Specializations Across Development

Kristine McLellan^*1, Jason Sanchez¹

¹ Northwestern University

66. Precision Medicine of Hereditary Hearing Loss – the Diagnostic Rate of Whole-Exome Sequencing

Yi-Lu Li^*1, Jessica Peng-Chieh Chen², Jiunn-Liang Wu³

¹National Cheng Kung University Hospital, ²Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan, ³National Cheng Kung University Hospital

67. Association Between Ethnicity/Race and Extended High Frequency Hearing: Implications for Understanding Early Signs of Auditory Aging

Shruthi Ananth^*1, Monica Trevino¹, Srikanta Mishra¹

¹ University of Texas at Austin

68. Refining Convolutional Neural Networks for Temporal Bone Imaging Segmentation Using 3-Dimensional Distance Maps

Andy S. Ding^*1, Manish Sahu², Mathias Unberath², Russell H. Taylor², Francis X. Creighton¹

¹Johns Hopkins School of Medicine, ²Johns Hopkins Whiting School of Engineering

69. Creer Recombination Rate in Murine Intermediate Cells: A Comparison Between Three Different Models

Mahesh Nayak^*1, Justine Renauld², Rene Vielman Quevedo²

¹Creighton University School of Medicine, ²Creighton University

70. The Relationship of Neural Sensitivity and Focused Perceptual Thresholds: An Indicator for Future Cochlear Implant Programming

Dietmar Wohlbauer^*1, Charles Hem², Caylin McCallick³, Faten Awwad³, Julie Arenberg¹

¹Harvard Medical School, Massachusetts Eye and Ear, ²Harvard University, Massachusetts Eye and Ear, ³Massachusetts Eye and Ear

71. Stimulus-Specific Suppression Distinguishes Layer 5 from Layer 6b Extratelencephalic Neurons

Madan Ghimire^*1, Ross Williamson²

¹University of Pittsburgh, ²University of Pittsburgh School of Medicine

72. Revisiting Analog Stimulation in a Guinea Pig Model of Cochlear Implant

Victor Adenis^*1, Ryan Bartholomew², Jae-Ik Lee³, Drew Montigny⁴, M. Christian Brown⁵, Daniel J. Lee⁶, Shelley Fried³, Julie Arenberg⁷

¹Mass Eye and Ear, Harvard Medical School, ²Eaton Peabody Lab, Massachusetts Eye and Ear, ³Massachusetts General Hospital, ⁴Massachusetts Eye and Ear, ⁵Mass. Eye and Ear, Eaton Peabody Lab, ⁶Massachusetts Eye and Ear, ⁷Massachusettes Eye and Ear Infirmary, Eaton Peabody Laboratory

73. Investigating Norrin Expression Patterns Within the Cochlea

Ilkem Sevgili^*1, Yushi Hayashi², Albert Edge¹

¹Harvard Medical School, ²Nippon Medical School

74. The Potential of Natural Therapies to Treat Aminoglycoside-Induced Hearing Loss

Hannah Fleming^*1, Savarimuthu Igacimuthu², Perumal Pandikumar², Marisa Zallocchi³

¹Creighton University School of Medicine, ²Xavier Research Foundation, St Xavier's College, Palayamkottai, Tamil Nadu, ³Creighton University

75. Investigation of the Gene Regulatory Network That Determines the Timing of Cell Cycle Exit and Developmental Patterning in the Organ of Corti

Yeeun Kim^*1, Yun Ji Bertken², John Duc Nguyen¹, Eva Jahanshir¹, Juan Llamas¹, Ksenia Gnedeva¹

¹Keck School of Medicine University of Southern California, Los Angeles, ²UCLA

76. Feasibility of a Handheld Robotic Cochlear Implant Insertion

Nathan Kemper^*1, Marlan Hansen¹, Constantinos Nikou²

¹University of Iowa Health Care, ²iotaMotion, Inc.

77. Osteoprotegerin Deficiency in the Human Otic Capsule as a Potential Driver of Otosclerosis

Zohar Hovev^*1, Sebastian Zwicky², Jennifer O'Malley¹, MengYu Zhu¹, Andreas Eckhard¹

¹Massachusetts Eye and Ear, ²University of Zurich

78. Frequency Resolution and Processing Efficiency in Children with Language-Based Learning Impairments

M. Casper Mayer¹, Hannah R. Rostollan¹, Beverly A. Wright^*1

¹ Northwestern University

79. Within-Subject Standard Deviations in Auditory Masking Tasks Are Higher for Children with Language-Based Learning Impairments Than Controls

Talia A. Rawitz¹, Hannah R. Rostollan¹, Beverly A. Wright^*1

¹ Northwestern University

80. Restoration of Middle Ear Function in Partial Ossicular Discontinuity: A Basic Science and Clinical Correlation

Keelin Fallon^*1, Jeffrey Cheng², Aaron Remenschneider³

¹University of Massachusetts Chan Medical School, ²Massachusetts Eye and Ear Infirmary, ³Boston Children's Hospital; Massachusetts Eye and Ear Infirmary

81. Gating of Hair Cell Ca2+ Channels Governs the Activity of Cochlear Neurons

Nare Karagulyan^*1, Anupriya Thirumalai¹, Susann Michanski¹, Yumeng Qi², Qinghua Fang¹, Haoyu Wang², Nadine Ortner³, Jörg Striessnig³, Nicola Strenzke¹, Carolin Wichmann¹, Yunfeng Hua², Tobias Moser¹

¹Institute for Auditory Neuroscience, University Medical Center Göttingen, ²Shanghai Institute of Precision Medicine, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, ³Center for Molecular Biosciences Innsbruck, University of Innsbruck

82. Genome-Wide Association Study for Age-Related Hearing Loss in CFW Mice

Thomas Zhou^*1, Ely Boussaty¹, Oksana Polesskaya¹, Jennifer Luu¹, Kwang Pak¹, Caroline Ellis¹, Abraham A. Palmer¹, Rick Friedman¹

¹ University of California, San Diego

83. Admittance at the Eardrum Estimated from Canal Measurements

Jonathan Siegel^*1, Susan Voss², Stephen Neely³

¹Northwestern University, ²Smith College, ³Boys Town National Research Hospital

84. Characteristics of Frequency- and Temporal Resolutions, and Speech Perception by Bone-Conducted Stimuli Presented to the Facial Parts

Seiji Nakagawa^*1, Ko Uemura², Sho Otsuka³

¹Center for Frontier Medical Engineering, Chiba University, ²Graduate School of Science and Engineering, Chiba Univ., ³Center for Frontier Medical Engineering, Chiba Univ.

85. Nonlinear Displacement of the Tympanic Membrane in Response to Static Pressure and Low Frequency Tones: A Computational Study

Nastaran Gholami^*1, Hamid Motallebzadeh², Sunil Puria³, Hong Zhu⁴, Wu Zhou⁴, Richard D. Rabbitt⁵

¹University of Utah, ²California State University, Sacramento, ³Harvard Medical School, ⁴University of Mississippi Medical Center, ⁵Otolaryngology, Neuroscience Program, University of Utah

86. Identification of Soluble Factors Affecting Blood-Labyrinth Barrier Permeability During Cisplatin Treatment via Single Nucleus RNA-Sequencing

Cathy Yea Won Sung^*1, Franz Gareza¹, Amanda Bonczkowski², Erica Sadler², Katharine Fernandez², Rafal Olszewski³, Michael Hoa², Mark Warchol⁴, Lisa Cunningham²

¹National Institute on Deafness and Other Communication Disorders, National Institutes of Health, ²NIDCD, ³NIH/NIDCD, ⁴Washington University School of Medicine in St. Louis

87. Reliability of Potential Biomarkers in the Neurodiagnostic Auditory Brainstem Response

Aryn Kamerer^*1, Marlana Petersen¹, Katelyn Chapman¹, Kyler Vugteveen¹, William Allen¹

¹ Utah State University

88. High-Resolution Flat-Panel Ct Analysis of Intrascalar Cochlear Implant Electrode Position

Ana Marija Sola^*1, Nicole Jiam¹, Melanie Gilbert¹, Luke Helpard², Charles Limb¹

¹University of California San Francisco, ²MED-EL

89. Tests of Human Auditory Temporal Resolution: Psychophysical Measurements of Normal Hearing Listeners by Bayesian Estimation

Takashi Morimoto^*1, Yayoi Yamamoto², Chie Obuchi³, Yasuhide Okamoto⁴, Sho Kanzaki⁵, Shuji Mori⁶

¹RION Co., Ltd., ²International University of Health and Welfare, ³University of Tsukuba, ⁴Keio University, ⁵National Hospital Organization Tokyo Medical Center, ⁶Kyushu University

90. In-Silico Framework for Benchmarking Optogenetic Hearing Restoration

Lakshay Khurana^*1, Petr Nejedly², Daniel J. Jagger³, Lukasz Jablonski², Tobias Moser²

¹Institute for Auditory Neuroscience, University Medical Center Göttingen, ²Institute for Auditory Neuroscience, University Medical Center Göttingen, Germany, ³University College London

91. Biomarkers of Alzheimer’s Disease (AD) Expression Levels Increase with Aging in the CBA/CaJ Mouse Auditory System

Xiao Xia Zhu^*1, Bo Ding², Joseph P. Walton³, Robert D. Frisina³

¹University of South Florida, ²Medical Engineering Dept., Global Ctr. Hearing and Speech Res., University of South Florida, ³Med. Engin., Chem. and Biolog. Engin.,Global Ctr. for Hearing and Speech Res.,Univ. of South Florida

92. Gonad-Derived Hormones Mediate Sex Differences in the Maturation of Peripheral Auditory Sensitivity in C57BL/6J Mice from Adolescence to Adulthood

Nicholas Lozier¹, Max Aizenstein¹, Essence Williams¹, Maria Rubio^*2

¹University of Pittsburgh School of Medicine, ²University of Pittsburgh School of MEdicine

93. Characterizing Novel Candidate Molecular Markers of Inferior Colliculus Neuron Types

Elie Huez^*1, Michael Roberts¹

¹ University of Michigan, Kresge Hearing Research Institute

94. Pathology of Fresh Human Cochleae Imaged with OCT and Validated With Histological Assessment

Paul Secchia^*1, Ephraim Oyetunji², Aleksandrs Zosuls³, Anbuselvan Dharmarajan⁴, Jennifer T. O'Malley⁴, MengYu Zhu⁴, Andreas Eckhard⁴, Hideko Nakajima⁴

¹Harvard Medical School, Mass. Eye and Ear Infirmary, ²Harvard Medical School, ³Massachusetts Eye and Ear, ⁴Massachusetts Eye and Ear, Harvard Medical School

95. Efficacy of a Lipid Regulator Fenofibrate Against Agihl in Mice

Vijayprakash Namakkal Manickam^*1, Adrian Draney¹, Lyudmila Batalkina¹, Marisa Zallocchi²

¹Creighton University, ²School of Medicine, Creighton University

96. A Novel Self-Unrolling Branched Cochlear Implant Electrode Design for High-Resolution Electrical Stimulation

Wonil Sohn^*1, Elsa Acosta¹, Pavlo Zolotavin¹, Lan Luan¹, Chong Xie¹

¹ Rice University

97. A Novel Model of Eosinophilic Otitis Media and Exploration of ILC2 in Middle Ear Mucosa

Daisuke Matsushita^*1, Atsushi Matsubara¹, Naomi Kudo¹, Tomoaki Fujita¹, Daisuke Matsushita¹

¹ Hirosaki University Graduate School of Medicine

98. Development of a Novel Pitch Discrimination Test for Cochlear Implant Users

Angeline Truong^*1, Audrey Limb², Patpong Jiradejvong³, Charles Limb³

¹University of California, San Francisco, ²University of California, San Francisco, School of Medicine, ³University of California - San Francisco

99. Neural Mechanisms of Rhythm Perception and Encoding in the Marmoset Auditory Cortex

Chen Li^*1

¹ Shanghai Jiao Tong University School of Medicine

100. ESRP1 and ESRP2 Regulate Hair Cell Function by Affecting mRNA Stability in Zebrafish

Xuebo Yao¹, Yan Zhang¹, Xiaying Hong¹, Zhigang Xu^*1

¹ Shandong University

101. Application of Non-Invasive Electrocochleography in a Clinically Relevant Mouse Model of Hearing Instability

Talah Wafa^*1, Rafal Olszewski², Tracy Fitzgerald³, Michael Hoa⁴

¹National Institute on Deafness and other Communication Disorders, ²Auditory Development and Restoration Program, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, ³NIDCD/NIH, ⁴NIDCD

102. Ultra-High Resolution Models of Neural Activity in the Human Inner Ear

Werner Hemmert^*1, Albert Croner¹, Alissa Breit¹, Johannes Melcher¹, Mahdi Fallahtaherpazir², Martin Dierolf¹, Klaus Achterhold¹, Julia Herzen¹, Franz Pfeiffer¹, Rudolf Glueckert², Anneliese Schrott-Fischer², Siwei Bai¹

¹Technical University of Munich, ²Medical University of Innsbruck

103. POU3F4 is a Critical Factor in Auditory and Vestibular Synaptic Development

Yifan (Paul) Zhou¹, Raymond Huang², Paige Brooks¹, Satish Ghimire¹, Marco Nascone¹, Kevin Rose³, Wei Song³, Bryan Rivers², Ronna Hertzano³, Wu Zhou², Hong Zhu², Thomas Coate^*1

¹Georgetown University, ²University of Mississippi Medical Center, ³Section on omics and translational science of hearing, Neurotology Branch, NIDCD

104. Preferences for Loudness and Pitch Vary Across Cultures

Malinda McPherson^*1, Eduardo Undurraga², Mariana Poblete³, Seleni Rojas⁴, Roberto Zariquiey⁴, Bryan Medina⁵, Josh McDermott⁵

¹Purdue University, ²Escuela de Gobierno, Pontificia Universidad Católica de Chile, ³Universidad de Chile, ⁴Pontifical Catholic University of Peru, ⁵MIT

105. The Diversity of Murine Type II Spiral Ganglion Neurons Biophysical Properties

Nathaniel Nowak^*1, Radha Kalluri¹

¹ University of Southern California

106. Molecular Genetic Testing for Usher Syndrome in a Diverse South Florida Population

Xue Liu^*1, Zachary Cromar², Ryan Chen², Denise Yan³, Susan Blanton⁴, Byron Lam⁵

¹University of Miami School of Medicine, ²University of Miami Miller School of Medicine, ³University of Miami School of Medicine, ⁴University of Miami School of Medicine; John T. Macdonald Foundation; John P. Hussman Institute for Human Genomics, ⁵University of Miami School of Medicine, Bascom Palmer Eye Institute

107. Surgical Planning for Implantable Middle Ear Microphone in Sheep Using Temporal Bone Micro-CT

Isadora Comens^*1, Chaoqun Zhou¹, Emma F. Wawrzynek², John Zhang², D. Bradley Welling³, Jeffrey Lang², Hideko Heidi Nakajima³, Elizabeth Olson¹

¹Columbia University, ²MIT, ³Harvard Medical School, Mass. Eye and Ear Infirmary

108. Effect of ITGA8 Inactivation During Inner Ear Development

Dinesh Gawande^*1, Iman Ezzat¹, Lyudmila Batalkina¹, Marisa Zallocchi²

¹Creighton University, ²School of Medicine, Creighton University

109. Developmental Expression of the Ha Tagged α9 Nachr Subunit in the Mouse Cochlea

Hakim Hiel^*1, Eleftheria Slika¹, Fatima Chakir¹, Paul Fuchs¹

¹ Johns Hopkins University School of Medicine

110. Development and Verifying the Therapeutic Effect of Intra-Tympanic Controlled Nanoparticle Drug Delivery Carrier for Inner Ear Disorders

Tae-Soo Noh^*1, Yu-Jung Hwang¹, Sang-Yeon Lee¹, Moo Kyun Park¹, Jun-Ho Lee¹, Yu-Mi Bae², Ha-Yeon Noh², Jin-Ki kim², Myung-Whan Suh¹

¹Seoul National University Hospital, ²Hanyang University

111. Integration of Functional Human Auditory Neural Circuits Based on a Three-Dimensional Carbon Nanotube System

Yiyun Lou^*1, Jiaoyao Ma¹, Mingyu Xia¹, Wenyan Li², Yiyun Lou²

¹Eye and ENT Hospital, Shanghai Medical College, Fudan University, ²The EENT Hospital of Fudan University

112. PKM2 Controls Cochlear Development through Lactate-Dependent Transcriptional Regulation

Mingxuan Wu¹, Mingyu Xia¹, Huawei Li¹, Wenyan Li^*2

¹Eye and ENT Hospital, Shanghai Medical College, Fudan University, ²The EENT Hospital of Fudan University

113. Evaluation of Variability of Otoacoustic Emissions When Measured by Different Persons

W. Wiktor Jedrzejczak^*1, Krzysztof Kochanek¹, Joanna Krubnik², Henryk Skarzynski¹

¹Institute of Physiology and Pathology of Hearing, Warsaw, Poland, ²The University of Maria Curie-Sklodowska in Lublin

114. Synaptic Variation of Auditory Nerve Inputs Decreases Temporal Precision but Improves Stimulus Reproduction in Globular Bushy Cells

Chunjian Wang^*1, Go Ashida¹, Christian Keine¹, Ivan Milenkovic¹

¹ University of Oldenburg

115. Peritraumatic Near-Infrared Treatment Attenuates the Severity of Permanent Hearing Loss

Max Meuser^*1, Susanne Schwitzer², Parisa Faraji², Arne Ernst³, Dietmar Basta²

¹Unfallkrankenhaus Berlin, ²University of Berlin, Charité Medical School, ³UKB

116. Combining Psychoeducation, Sound Exposure, and Counseling: A New Therapeutic Approach for Hyperacusis

Michel Benard^*1, Sandrien Thieren², Paula van Dommelen³

¹Pento Speech and Hearing Centers, ²Pento Speech and Hearing Centers, Zwolle, the Netherlands, ³The Netherlands Organization for Applied Scientific Research (TNO), Leiden, the Netherlands

117. Atypical ECAP Measures and Auditory Outcomes in Cochlear Implant Users with Vestibular Schwannoma: A Case Series Study

Mahan Azadpour^*1, Taylor Payne¹, Nicole Capach¹, Megan Eitel¹, J. Thomas Roland¹

¹ New York University Grossman School of Medicine

118. Combining Multiple ABR and EFR Stimuli to Predict Cochlear Deafferentation in Individual Humans

Brad Buran^*1, Garnett McMillan², Sarah Verhulst³, Naomi Bramhall²

¹Oregon Health and Science University, ²VA RR and D NCRAR, ³Ghent University

119. Associations Between Physiological Indicators of Cochlear Deafferentation and Listening Effort in Military Veterans with Normal Audiograms

Naomi Bramhall^*1, Brad Buran², Garnett McMillan³

¹VA National Center for Rehabilitative Auditory Research, ²Oregon Health and Science University, ³VA RR and D NCRAR

120. Hearing Impairment in the Fmr1 Knockout Mouse Model for Fragile X Syndrome

Sarah Hunter*¹, Ashton Baxter*¹, Jeffrey Rumschlag¹, Hainan Lang¹, Brent Wilkerson^*1

¹ Medical University of South Carolina

121. The Transcription Factor Helios is Necessary for Both Outer Hair Cell Maturation and Functional Maintenance

Christopher Shults^*1, Hannah Odom², Wei Song², Reza Amanipour², Beatrice Milon², Elena Chrysostomou³, Ran Elkon⁴, Michael Bowl⁵, Ronna Hertzano²

¹National Institute on Deafness and Other Communication Disorders, National Institutes of Health, ²National Institute on Deafness and Other Communication Disorders, National Institutes of Health, ³Salk Institute for Biological Studies, ⁴Department of Human Molecular Genetics and Biochemistry, Faculty of Medicine and Sagol School of Neuroscience, Tel Aviv University, ⁵UCL Ear Institute, University College London

122. Spatial Transcriptomics and Its Application to the Mouse Cochlea

Hannah Odom^*1, Christopher Shults², Wei Song³, Ori Zalzman¹, Ran Elkon⁴, Robert Morell⁵, Ronna Hertzano⁶

¹National Institute on Deafness and Other Communication Disorders, ²National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland, USA, ³National Institute on Deafness and Other Communication Disorders, National Institutes of Health, ⁴Faculty of Medicine and Sagol School of Neuroscience, Tel Aviv University, ⁵Computation Biology and Genomics Core, National Institutes on Deafness and Other Communication Disorders, National Institutes of Health, ⁶Neurotology Branch, National Institute on Deafness and Other Communication Disorders

123. Integrating Physiological and Perceptual Assays to Resolve the Effects of Sensorineural Hearing Loss on Neural Place and Time Cues for Pitch

Andrew Sivaprakasam^*1, Samantha Hauser¹, Michael Heinz¹, Hari Bharadwaj²

¹Purdue University, ²University of Pittsburgh

124. Effect of Piezoelectric Thickness on Dual-Bandwidth Accelerometer Design for Totally Implantable Auditory Prostheses Applications

Panagiota Kitsopoulos^*1, Karl Grosh¹

¹ University of Michigan

125. The Ticking Clock of Hearing: Precision in Gene Expression Timing for Optimal Rescue

Samprita Das^*1, Uri Manor¹

¹ University of California, San Diego

126. Whole-Cochlea Spatial Measurements Using 2-Photon Microscopy

Rene Vielman Quevedo^*1, Kristina Ly¹, Mahesh Nayak², Justine Renauld¹

¹Creighton University, ²Creighton University School of Medicine

127. Requirement of SMOC1, an Extracellular Protein, in Morphogenesis of the Middle and Inner Ear

Kazuya Ono^*1, Takeru Ota¹, Tatsuya Katsuno², Hiroshi Hibino³

¹Osaka University, ²Kyoto University, ³Graduate School of Medicine, Osaka University

128. Immediate Upregulation of Nr4a1 Mrna in Response to Blast-Induced Cochlear Injury in Mice

Shingo Yasutake^*1, Kunio Mizutari², Takaomi Kurioka³

¹National Defense Medical College, ²National Defense Medical College, ³Kitasato University School of Medicine

129. Temporal Changes in Neuronal Innervation During Human Inner Ear Organoid Development

Maria Martinez^*1, Shweta Reddy¹, Eri Hashino¹

¹ Indiana University School of Medicine

130. Ribbon Synapse Assembly and Refinement during Hair Cell Maturation in Human Inner Ear Organoids

Shweta Reddy^*1, Eri Hashino¹, V Shweta Reddy²

¹Indiana University School of Medicine, ²Indiana University

131. Mitochondrial Morphology Differences in the Auditory Brainstem of Fragile X Syndrome Mice Using Electron Microscopy

Naleyshka Colon^*1, Amita Chawla¹, Elizabeth McCullagh¹

¹ Oklahoma State University

132. Mechanisms of Medial Olivocochlear Reflex Enhancement Based on Temporal Prediction - An Investigation by Simultaneous Measurements of Delta-Band Brain Rhythm and Brainstem

Yuki Ishizka^*1, Sho Otsuka², Seiji Nakagawa²

¹Chiba University, ²Chiba university

133. Social Experience Dependent Plasticity in Micro-Organization and Population Coding of Sequences of Mouse Vocalizations in the Mouse Auditory Cortex

Srishti Jain¹, Sohini Gupta^*2, Swapna Agarwalla³, Sharba Bandyopadhyay¹

¹IIT Kharagpur, ²Indian Institute of Technology Kharagpur, ³University of Rochester

134. Noise-Induced Cochlear Synaptopathy in C57BL/6N Mice as a Function of Trauma Strength: Ribbons Are More Vulnerable than Postsynapses

Kerstin Blum¹, Pauline Schepsky¹, Philip Derleder¹, Philipp Schätzle¹, Fahmi Nasri¹, Philipp Fischer¹, Jutta Engel^*1, Simone Kurt¹

¹ Saarland University

135. A Mouse Model of Unilateral Stereotactic Radiosurgery-Induced Hearing Loss

Dimitrios Daskalou^*1, Francis Rousset², Stéphanie Sgroi², Lucie Oberhauser², Nicolas Dupuy³, Jean-Philippe Thiran⁴, Constantin Tuleasca³, Ileana O Jelescu⁵, Marc Levivier³, Pascal Senn²

¹University of Geneva, ²The inner ear and olfaction lab, University of Geneva, Faculty of Medicine, ³Neurosurgery Service and Gamma Knife Center, Centre Hospitalier Universitaire Vaudois (CHUV), Rue du Bugnon 44–46, BH-08, CH-1011, ⁴Laboratory of Signal Processing 5, École Polytechnique Fédérale de Lausanne (EPFL), ⁵Lausanne University Hospital (CHUV)

136. Neural Network Models of Hearing Clarify Factors Limiting Cochlear Implant Outcomes

Annesya Banerjee^*1, Mark Saddler², Josh McDermott³

¹Harvard University, ²Technical University of Denmark (DTU), ³Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology

137. Afferent Connection from Cochlea to Flocculus/Paraflocculus Complex

Max Gattie^*1, Xiaodong Tan¹, Gabriella Sekerková¹, Marco Martina¹, Claus-Peter Richter¹

¹ Northwestern University

138. Raman Spectroscopic Label-Free Microscopy to Detect Biochemical Property Changes in Pluripotent Stem Cells Induced Toward Human Early Otic Lineage

Keshi Chung¹, Elias Estephan¹, Ludivine Rouillon¹, Damien Veret¹, Alban Dussouter¹, Azel Zine^*2

¹LBN, Laboratory of Bioengineering and Nanoscience, University of Montpellier, ²University of Montpellier

139. The Relationship of the Cortilymph Wave to the Traveling Wave, Auditory-Nerve Responses, and Low-Frequency Downward Glides

John Guinan^*1

¹ Mass Eye and Ear, Harvard Medical School

140. Development of Ossicular Palpation Training Simulator Using Haptic Device

Sinyoung Lee^*1, Sho Kanzaki², Takuji Koike³, Yoshiyuki Noda⁴

¹Osaka University, ²National Institute of Sensory Organ, Tokyo Medical Center, ³The University of Electro-Communications, ⁴University of Yamanashi

141. Effects of Cortical Activation on Medial Olivocochlear Reflex

Kandai Uchiyama^*1, Sho Otsuka², Seiji Nakagawa³

¹Graduate school of Chiba University, ²Center for Frontier Medical Engineering, Chiba Univ., ³Center for Frontier Medical Engineering, Chiba University

142. Ebselen-Eluting Silicone Strips Reduce Low Frequency Hearing Loss in a Guinea Pig Model of Cochlear Implantation

Rende Gu¹, Kushal Sharma¹, Annie Jia¹, G. Michael Wall¹, Jonathan Kil^*1

¹ Sound Pharmaceuticals, Inc.

143. Developing a 3D Motor Neuron Organoid and Schwann Cell Co-Culture in a Microfluidic Device for Facial Nerve Injury Model

Ji Eun Choi^*1, Haet Nim Lim¹, Min Young Lee¹, Jae Yun Jung¹

¹ Dankook University

144. Comparison of Long-Term in Vivo Pharmacokinetics Between Fully Loaded and Strip-Coated Electrode Carrier Dummies with Dexamethasone

Arne Liebau^*1, Bernd Kammerer², Sören Schilp³, Kenneth Mugridge³, Susanne Braun³, Stefan K Plontke¹

¹University of Halle (Saale), ²Albert-Ludwigs-University Freiburg, ³MED-EL Headquarters, Innsbruck

145. Serum Level of Mmp-9 and its Genetic Polymorphism as a Biomarkers of Neuroplasticity in Prelingual Deafness Treatment by Cochlear Implantation

Monika Matusiak^*1, Dominika Oziębło², Monika Ołdak¹, Henryk Skarzynski¹, Leszek Kaczmarek³, Emilia Rejmak³

¹Institute of Physiology and Pathology of Hearing, ²Department of Genetics, Institute of Physiology and Pathology of Hearing, ³Nencki Institute of Experimental Biology

146. Psychedelic Drugs Induce the Formation of New Synapses in the Cochlea

Elena Chrysostomou¹, Yuzuru Ninoyu², Sammy Weiser Novak³, Lauren Sullivan¹, Yuning Wang¹, Weronika Matysik¹, Kasie Mays¹, Sungwoo Park¹, Pamela Maher³, Rick Friedman⁴, David Olson⁵, Uri Manor^*1

¹University of California, San Diego, ²Kyoto Prefectural University of Medicine, ³Salk Institute for Biological Studies, ⁴University of California, San Diego Medical Center, ⁵University of California, Davis

147. Modeling Vibrations of the Human Middle Ear in Bone Conduction

Xiying Guan^*1

¹ Wayne State University

148. Longitudinal Multiome Analysis of Sensory Cells in Human Inner Ear Organoids

Yoshitomo Ueda^*1, Mauminah Raina², Manikandan Mayakanan³, Juexin Wang², Eri Hashino³

¹Indiana University School of Medicine, ²Indiana University Indianapolis, Biomedical Engineering and Informatics, ³Indiana University School of Medicine, Otolaryngology and H/N Surgery

149. A Virtual Model of the Rhesus Macaque Inner Ear

Cayman Matson¹, Brett Petersen¹, Nicholas Castle¹, Chenkai Dai^*2

¹University of Oklahoma, ²The University of Oklahoma

150. Assessment of Liraglutide’s Therapeutic Effect on Hearing Function of Chinchillas Exposed to Recurring High-Intensity Blasts

Shangyuan Jiang^*1, Qunfeng Cai¹, Roshan Sharma¹, Yijie Jiang¹, Rong Gan¹

¹ University of Oklahoma

151. Anti-FAM19A5 Antibody Enhances Auditory Function in a Noise-Induced Hearing Loss Mouse Model by Restoring Ribbon Synapses

Hei Yeun Koo^*1, Hyehyun Min², Soon-Gu Kwon³, Han-Byul Kim³, Yosub Park³, Jae Young Seong⁴, Jinwoong Bok²

¹Yonsei University College of Medicine, ²Yonsei University College of Medicine, ³Neuracle Science Co., Ltd, ⁴Graduate School of Medicine, Korea University

152. Introducing Different Spontaneous-Rate Classes of Auditory Nerve Fibers to the CARFAC v3 Cochlear Model

Dick Lyon¹, Jason Mikiel-Hunter^*2, Rob Schonberger¹, Honglin Yu¹

¹Google Australia, ²Macquarie University

153. A Deep Neural Network Trained on Finite-Element Simulation Data as a Surrogate Model of the Middle Ear

Alireza Heidari¹, Mahmoud Ramze Rezaee², Hamid Motallebzadeh^*3, W. Robert J. Funnell¹

¹McGill University, ²Intel Vision Technologies, ³California State University, Sacramento

154. Developing Novel Electrical Stimulation Strategies for Cochlear Implant Users Based on a Model of the Healthy Human Cochlea

Maryam Hosseini^*1, Tim Brochier², Jason Mikiel-Hunter¹, Zachary Smith², Dick Lyon³

¹Macquarie University, ²Cochlear Limited, ³Google Australia

155. An investigation on Mitochondrial Protein Makers in Mouse Cochlear Nucleus Changing During Aging

Meijian Wang^*1, Ruijie Cai¹, Ting Zhao¹, Xintong Li², Sidi Liu¹, Huihui Liu¹, Hao Wu¹

¹Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, ²Shanghai Jiao Tong University School of Medicine

156. Evaluating the Spread of Excitation with Red Light Optogenetic Stimulation of the Auditory Nerve Through Computer Simulations and In-Vivo Electrophysiology

Elisabeth Koert^*1, Jonathan Goetz², Anna Vavakou², Niels Albrecht², Bettina Wolf², Tobias Moser²

¹Institute for Auditory Neurosciences and InnerEarLab, University Medical Center Göttingen, ²Institute for Auditory Neurosciences and InnerEarLab, University Medical Center Göttingen

157. Improvement of Patient Reported Outcomes of Bimodal Ci-Users Compared to Binaural Hearing Aids: a Randomized Controlled Trial

Yeliz Jakobsen¹, Jesper Hvass Schmidt^*2

¹Research Unit for ORL – Head and Neck Surgery and Audiology, Odense University Hospital; University of Southern Denmark, ²Research Unit for ORL – Head and Neck Surgery and Audiology, Odense University Hospital; University of Southern Denmark

158. Quantifying Hidden Hearing Loss through the Efficient Coding Hypothesis

Juan Fuentes^*1, Irene Onorato², Roland Schaette³, Livia De Hoz², David McAlpine⁴

¹Center for Brain and Cognition, Universitat Pompeu Fabra, ²Neuroscience Research Center, Charité, Universitätsmedizin Berlin, ³University College London Ear Institute, ⁴The Hearing Hub, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney

159. Comparative Physiology of Action Potential Generation in Neurons of the Mntb

Laura Console-Meyer¹, Felix Felmy^*2

¹Universtiy of Veterinary Medicine Hannover, ²Universtity for Veterninary Medicine

160. In Vivo Investigation of a Degradable Polymeric Stent for the Eustachian Tube

Stina Winkelmann¹, Kerstin Lebahn², Malena Timm¹, Alexandra Napp¹, Katharina Schmitt¹, Niels Oppel¹, Friederike Pohl¹, Niels Grabow², Thomas Lenarz¹, Gerrit Paasche^*1

¹Hannover Medical School, ²IBMT Rostock University

161. Implantation of a Eustachian Tube Stent in a Model of Eustachian Tube Dysfunction

Katharina Schmitt¹, Malena Timm¹, Philipp Krüger², Niels Oppel¹, Alexandra Napp¹, Friederike Pohl¹, Robert Schuon¹, Marion Bankstahl¹, Thomas Lenarz¹, Tobias Stein², Gerrit Paasche^*1

¹Hannover Medical School, ²bess pro GmbH

162. Evaluation of the Efficacy and Safety of the High Molecular Weight Hyaluronic Acid Vehicle for the Prevention of Ototoxic Hearing Loss

Yu-Jung Hwang^*1, TaeSoo Noh¹, Sang-Yeon Lee², Moo Kyun Park¹, Jun-ho Lee², Myung-Whan Suh¹

¹Seoul National University Hospital, ²Seoul National University College of Medicine

163. Effect of Auditory Attention on Otoacoustic Emission Delay

Yuri Dowaki^*1, Sho Otsuka², Seiji Nakagawa²

¹Chiba University, ²Center for Frontier Medical Engineering, Chiba University

164. Enhancing Round Window Membrane Permeability: Efficacy and Safety of Adjuvants for Intratympanic Dexamethasone Delivery

Ye Lin Kim^*1, Kyusun Park¹, Min-Chae Jeon¹, Chan Mi Lee¹, Shi Nae Park¹, Jae Sang Han¹

¹ Seoul St. Mary's Hospital, The Catholic University of Korea

165. Contralateral Botulinum Toxin Injection Accelerates Recovery in a Animal Model of Facial Nerve Palsy

Min-Chae Jeon^*1, Ye Lin Kim¹, Kyusun Park¹, Chan Mi Lee¹, Jae Sang Han¹, Shi Nae Park¹, Min-Chae Jeon²

¹Seoul St. Mary's Hospital, The Catholic University of Korea, ²Uijeongbu St. Mary’s Hospital, College of Medicine, The Catholic University of Korea

166. Evaluating Underexplored Factors Contributing to Sudden Sensorineural Hearing Loss Recovery

Devin Kennedy^*1, Jacquie Golden¹, Addison Lana¹, Matthew Wiefels¹, Madeline Pyle², Michael Hoffer³, Erin Williams⁴

¹Miller School of Medicine, University of Miami, ²Miller School of Medicine, University of Miami, ³Miller School of Medicine, University of Miami., Miller School of Medicine, University of Medicine., ⁴Miller School of Medicine, University of Miami. University of Miami

167. Diagnostic Methods for Potential Cochlear Synaptopathy in Humans

Lichun Zhang^*1, Florian Herrmann Schmidt¹, Yannik Bastian Rufus Böhlke¹, Karsten Ehrt¹, Wilma Großmann¹, Robert Mlynski¹

¹ Rostock University Medical Center

168. Establishing a Rat Chronic Suppurative Otitis Media Model with Eustachian Tube Blockage Using Gelatin Sponge

Seokhwan Lee¹, Sung-Won Choi^*2

¹Inje University Haeundae Paik Hospital, ²School of Medicine, Pusan National University

169. Computational Model of Human Auditory Evoked Potentials at the Peripheral and Brainstem Levels

Miguel Temboury Gutiérrez^*1, Gerard Encina-Llamas², Torsten Dau¹

¹Technical University of Denmark, ²University of Vic - Central University of Catalonia

170. Perception of Auditory and Visual Emotions in Children with Hearing Aids

Evelien Dirks^*1, Laura Rachman², Michel Benard³, Bert Maat⁴, Rolien Free⁴, Deniz Başkent⁴

¹Dutch Foundation for the Deaf and Hard of Hearing Child (NSDSK), ²Department of Otorhinolaryngology, University Medical Center Groningen, Groningen, the Netherlands; Pento Speech and Hearing Centers, Zwolle, the Netherlands, ³Pento Speech and Hearing Centers, Zwolle, the Netherlands, ⁴Department of Otorhinolaryngology, University Medical Center Groningen, Groningen, the Netherlands

171. A First Look at Human Inner Ear Pathology in POU4F3 Variants: Findings from Three Human Temporal Bone Donors

Diana Correa^*1, Jennifer T O'Malley *¹, Christopher Giardina¹, Alison Brown², Sami Amr³, Alicia Quesnel¹

¹Massachusetts Eye and Ear, Harvard Medical School, ²Biobank Genomics Core, Mass General Brigham Personalized Medicine, ³Brigham and Women’s Hospital, Harvard Medical School, Biobank Genomics Core, Mass General Brigham Personalized Medicine

172. Primary Culture of Inner Ear Schwannoma

Jonas Scheffler^*1, Arne Liebau¹, Eric Lehner¹, Sabine Koitzsch¹, Julia Reiber¹, Stefan Plontke¹

¹ University Medicine Halle (Saale)

173. The Role of Extremely Long-Lived Proteins in Acquired Hearing Loss

Yuvraj Joshi^*1, Jeffrey Savas²

¹Feinberg School of Medicine, Northwestern University, ²Feinberg School of Medicine, Northwestern University

174. Development of Human Inner Ear Organoid Platforms for Human Auditory/Vestibular Disorders

Xue Liu^*1, Michelle DeMarchena¹, John Le¹, Derek Dykxhoorn¹, Zheng Yi Chen², Pei-Ciao Tang³

¹University of Miami School of Medicine, ²Mass Eye and Ear; Harvard Medical School, ³University of Miami School of Medicine, ISCI

175. Cortical Responses in the Primary and Higher-Order Auditory Cortex of Cochlear Implant-Stimulated Unilaterally Deaf Cats

Prasandhya Astagiri Yusuf^*1, Elvina Firdaus¹, Peter Hubka², Jochen Tillein³, Andrej Kral⁴

¹Faculty of Medicine Universitas Indonesia, ²Clinical Research Unit in Audiology, Faculty of Medicine and University Hospital, Comenius University, Slovakia, ³J.W.Goethe University, ⁴Institute of AudioNeuroTechnology, ENT Clinics, Hannover Medical School

176. Multiple Sources of Cholinergic Input to the Nuclei of the Lateral Lemniscus

Dayanara B. Lohr¹, Emily E. Echols¹, Isabella Ackerman², Shreeya Kaur², William A. Noftz¹, Brett Schofield^*1

¹Northeast Ohio Medical University, ²University of Akron

177. Dmso Does Not Aid in Reducing Decalcification Time of Human Temporal Bones

Martin Leyhe¹, Richard Har¹, Nevra Keskin Yilmaz¹, Sebahattin Cureoglu¹, Meredith Adams¹, Rafael da Costa Monsanto^*1

¹ The University of Minnesota

178. Predicting Variability in Pediatric Cochlear Implant Outcomes Through Synchronous Brain Activation Patterns: Insights From fNIRS

Chen-Chi Wu^*1, Hsueh-Ching Tseng², Pei-Hsuan Lin², Chia-Feng Lu³

¹National Taiwan University Hospital, ²National Taiwan University Hospital, Taipei, Taiwan, ³NYCU

179. Developing a Time- And Frequency-Domain Nonlinear Finite Element Model for the Human Middle Ear

Andrew Tubelli^*1, Saddat Nazir², Sunil Puria³, Jeffrey Cheng⁴

¹Massachusetts Eye and Ear, ²Massachusetts General Hospital/Harvard University, ³Harvard Medical School, Mass. Eye and Ear Infirmary, ⁴Massachusetts Eye and Ear / Harvard Medical School

180. Identifying Barriers to Vestibular Rehabilitation Therapy in South Florida

Madison Hawthorne^*1, Luis Rodriguez-Diaz², Devin Kennedy², Michael Hoffer³, Erin Williams⁴

¹Miller School of Medicine, University of Miami, ²University of Miami Miller School of Medicine, ³Miller School of Medicine, University of Miami. Miller School of Medicine, University of Medicine., ⁴Miller School of Medicine, University of Miami. University of Miami, Coral Gables

181. Seasonal Variation in Peripheral Vestibular Disorders Based on Korean Population Data

Junhui Jeong^*1, Tae Mi Youk², Hyun Seung Choi²

¹Bucheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, ²National Health Insurance Service Ilsan Hospital

182. An Open Source Hearing Research Platform

Odile Clavier^*1, Joshua Alexander², Mattheus Ueckermann¹, WIlliam Audette¹, Véronique Archambault-Léger¹, Christopher Brooks¹, Brian Graybill¹, Michael Heinz²

¹Creare LLC, ²Purdue University

183. Automated Classification of Middle- And Inner-Ear Mechanical Pathologies Based on Impedance and Air-Bone Gap

Anna Frazier^*1, Gabrielle R. Merchant², Hideko Heidi Nakajima³, Stephen T. Neely²

¹Harvard University, ²Boys Town National Research Hospital, Omaha, NE, USA, ³Massachusetts Eye and Ear, Harvard Medical School, Boston, USA

184. Effects of Stimulation Parameters on the Phase Locking Value in Postlingually Deafened Adult Cochlear Implant Users

Sydney Chratian¹, Yi Yuan², Christopher Mueller¹, Shuman He^*1

¹The Ohio State University, ²San José State University

185. Measuring the Effective Polarity of Electrical Excitation across the Auditory-Nerve Array to Enhance Spectral Resolution by Cochlear-Implant Listeners

Robert Carlyon^*1, Francois Guerit², John M. Deeks²

¹Cambridge Hearing Group, University of Cambridge, ²Cambridge Hearing Group, MRC Cognition and Brain Sciences Unit, University of Cambridge

186. Influence of Boundary Conditions on Bone Conduction Experiments: A Finite Element Study

Hyun Seong Shin^*1, Namkeun Kim¹

¹ Sogang University

187. Amygdalar Hyperactivity and Non-Discriminate Auditory Threat Evaluation After Noise-Induced Sensorineural Hearing Loss

Bshara Awwad^*1, Jennifer Zhu², Daniel Polley¹

¹Mass Eye and Ear / Harvard Medical School, ²Mass Eye and Ear

188. Mitochondrial Dysfunction and Metabolic Maladaptation in the Stria Vascularis of Alport Syndrome Mice: Insights from Noise-Induced Metabolic Stress Testing

Brendan Smyth^*1, Nathan Yates Nelson², Linda Weisenmiller², Michael Anne Gratton²

¹Sanofi, ²Boys Town National Research Hospital

189. The Effects of Dexamethasone-Eluting Cochlear Implant Arrays on Post-Operative Longitudinal Impedance Measurements and Intracochlear Computed Tomography Changes in Humans

Uzair Khan^*1, Rachel Scheperle², Bruce Gantz², Alexander Claussen², Marlan Hansen²

¹University of Iowa Health Care, ²Department of Otolaryngology - Head and Neck Surgery, University of Iowa Health Care, Iowa City, IA, United States.

190. Effects of Aging and Processing Speed on Temporal Gap Detection in Cochlear Implant Users

Kara Leyzac^*1, Kelly Harris¹

¹ Medical University of South Carolina

191. Clinical Assessments of Functional Auditory Performance Better Expose the Impact of Hearing Loss on Operational Performance Than Audiometry Alone

Heath Jones^*1, Jennifer Noetzel¹, Kyle Hale², Paula Henry³, Kichol Lee², Kevin Andres², JR Stefanson¹

¹U.S. Army Aeromedical Research Laboratory, ²Goldbelt Frontiers, LLC, Alexandria, VA, ³Goldbelt Frontiers, LLC, Alexandria, VAGoldbelt Frontiers, LLC, Alexandria, VA

192. Optical Imaging of Auditory Cortex Responses in the Awake Common Marmoset (Callithrix Jacchus) With Unilateral Cochlear Implants

Sherry Shen^*1, YANG ZHANG², Xiaoqin Wang²

¹Johns Hopkins University School of Medicine, ²Johns Hopkins University

193. Cochlea Implants in Meniere’s Disease – Altered Response Capacity of the Spiral Ganglion Cells and the Influence of Prior Intratympanic Gentamicin and Corticosteroids Therapy on Speech Understanding

Katrin Reimann^*1, Oyuki Brosseit², Frederik Gillhausen², Rainer M. Weiß², Kristina Sinemus², Boris A. Stuck², Jochen Müller-Mazzotta², Kruthika Thangavelu²

¹University Hospital Marburg, Philipps-Universität Marburg, ²Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Marburg, Marburg, Germany

194. Effects of Cochlear Implantation on Proteomic- and miRNA Perilymph Profiles in a Large Animal Model

Matthias Gerlitz¹, Anselm Joseph Gadenstaetter¹, Till Buschhorn¹, Caroline Sesztak¹, Erdem Yildiz¹, Lukas D. Landegger², Clemens Honeder¹, Hinrich Staecker³, Christoph Arnoldner^*1

¹Medical University of Vienna, ²Stanford University School of Medicine, ³University of Kansas Medical Center

195. Moderate Noise Exposure Influences the Cochlear Nucleus Function in a Frequency-Related Pattern

Wenyue Xue^*1, Jason Xie¹, Keziah Hui¹, Jun Yan²

¹Hotchkiss Brain Institute, University of Calgary, ²University of Calgary Cumming School of Medicine

196. Evaluation of Model- and Neural-Network-Based Augmented Hearing Algorithms

Attila Fráter¹, Chuan Wen¹, Marjoleen Wouters¹, Guy Torfs², Iris Arweiler¹, Frederic Acke³, Ingeborg Dhooge³, Sarah Verhulst^*4

¹Hearing Technology @ WAVES, Dept. of Information Technology, Ghent University, ²IDLab, Ghent University, ³Ghent University/Ghent University Hospital, Ghent, Belgium, ⁴Ghent University

197. Auditory Processing Deficits following Exposure to Open-Field Blasts in a Non-Human Animal Model

JoAnn McGee^*1, Xiaohui Lin¹, Catherine Johnson², Edward J. Walsh¹

¹VA Loma Linda Healthcare System, ²Missouri University of Science and Technology

198. Differential Sensitivity of Speech-In-Noise Instruments to Central Auditory Deficits

Lucas Brizolara^*1, Nicole Whittle¹, Kelli Sugai¹, Christian Herrera Ortiz¹, Marjorie R. Leek¹, Caleb Barcenas², Eric Christopherson², Grace Lee², Jonathan Venezia¹, Lucas Brizolara³

¹VA Loma Linda Healthcare System, ²Loma Linda University, ³Department of Veterans Affairs

199. Detection of Bacterial Vs Inflammatory Acute Otitis Media Using Icg-Maltotriose in Short-Wave Infrared (SWIR)

Melissa Chaehyun Lee^*1, Roy Park¹, Mark Nyaeme¹, Anping Xia¹, Mia Hedrick¹, Tulio Valdez¹

¹ Stanford University School of Medicine

S5. Symposium 5: Across Species: The Functional Role of Cochlear Synaptopathy for Speech Coding in The Brain (Cosyspeech)

3:00 p.m. – 5:00 p.m.

Ocean Ballroom 1–4

Chair: Marlies Knipper, University Hospital Tuebingen

Co-chair: Sarah Verhulst, Ghent University

Theoretical and Empirical Approaches to Understanding the Perceptual Consequences of Auditory Synaptopathy

Andrew Oxenham^*1, Magdalena Wojtczak¹

¹ University of Minnesota

Across-Species Speech Coding Processing Models

Deniz Başkent^*1, Etienne Gaudrain²

¹University of Groningen, University Medical Center Groningen, ²Lyon Neuroscience Research Center, CNRS UMR 5292, INSERM UMRS 1028, Université Claude Bernard Lyon 1, Université de Lyon, Lyon, France

Impact of Cochlear Synaptopathy on Vowel Coding in Gerbil Auditory Nerve

Daniil Kiselev^*1, Artem Diuba², Jean-Luc Puel², Jerome Bourien²

¹Institut National de la Santé et de la Recherche Médicale, ²Institute for Neurosciences Montpellier, University of Montpellier, Institut National de la Santé et de la Recherche Médicale, Montpellier

Phoneme Encoding in the Inferior Colliculus of Gerbils, With and Without Noise Induced Cochlear Synaptopathy

Warren Bakay^*1, Ana Belen Lao-Rodríguez¹, Manuel Malmierca¹

¹ Institute of Neuroscience Castilla y Leon, University of Salamanca

Examination of Speech Coding in the Human Auditory Nerve Using Intracranial Recordings

Xavier Dubernard^*1, Arthur Seidermann², Frédéric Venail³, Jean-Charles Kleiber², Jean-Luc Puel⁴, Jerome Bourien⁵

¹University Hospital of Reims, ²University Hospital of Reims, ENT Department, ³INM, Inserm, Otology and Neurotology Unit, Univ Montpellier, CHU Montpellier, ⁴Institute for Neurosciences Montpellier, University of Montpellier, Institut National de la Santé et de la Recherche Médicale, ⁵Institute for Neurosciences Montpellier, University of Montpellier, Institut National de la Santé et de la Recherche Médical

Stimulus Onset Contributions to Speech Comprehension

Marlies Knipper^*1, Jakob Schirmer², Konrad Dapper², Stephan Wolpert³, Marjoleen Wouters⁴, Katharina Bader⁵, Wibke Singer², Deniz Başkent⁶, Etienne Gaudrain⁷, Sarah Verhulst⁸, Christoph Braun⁹, Matthias H. J. Munk¹⁰, Ernst Dalhoff⁵, Lukas Rüttiger²

¹University Hospital Tuebingen, ²University Hospital Tuebingen, ³Molecular Physiology of Hearing, University of Tübingen, Germany, ⁴Ghent University, ⁵Section Physiological Acoustics and Communication, University of Tübingen, Germany, ⁶University of Groningen, University Medical Center Groningen, The Netherlands, ⁷Lyon Neuroscience Research Center, CNRS UMR 5292, INSERM UMRS 1028, Université Claude Bernard Lyon 1, Université de Lyon, ⁸Ghent University, WAVES, ⁹MEG-Center, University of Tübingen, Otfried-Müller-Straße. and Hertie Institute for Clinical Brain Research, Otfried-Müller-Str. Tübingen, Germany, ¹⁰University of Tübingen, Germany

Across-Species Modeling Insights into Hearing-Impaired Speech Coding

Sarah Verhulst^*1, Morgan Thienpont², Marjoleen Wouters², Francois Deloche²

¹Ghent University, ²Hearing Technology @ WAVES, Ghent University

P11. Podium Session 11: Vestibular: Basic Research & Clinical

3:00 p.m. – 5:00 p.m.

Ocean Ballroom 5–8

Characterization of Viral Transfection of Human Vestibular Epithelial Tissues in Vitro

Chisako Tanaka^*1, Sushobhan Biswas¹, Tian Wang², Micheal Freeman¹, Anika Patro¹, Elizabeth Perkins¹, Kareem Tawfik¹, Aaron Moberly¹, Matthew O'Malley¹, Marc Bennett¹, David Haynes¹, Alan G. Chang², Taha A. Jan¹

¹Vanderbilt University Medical Center, ²Stanford University

Blast Exposure, Vestibular Sequelae, and the Role of Therapeutic Hypothermia in Mitigating Blast-induced Vestibular Dysfunction

Pavan Krishnan^*1, Federica M. Raciti², Yuan Gao², Megan Barber³, Rachele Sangaletti³, Suhrud Rajguru³

¹University of Miami/Jackson Health System, ²University of Miami Miller School of Medicine, ³University of Miami

Optimizing Postural Stability Clinical Assessment

Talah Wafa^*1, Christopher Zalewski², Carmen Brewer³, Gayla Poling⁴

¹National Institute on Deafness and other Communication Disorders, ²NIH - NIDCD, ³National Institute on Deafness and Other Communication Disorders/NIH, ⁴National Institute on Deafness and Other Communication Disorders

Increasing Access to Vestibular Rehabilitation Using Machine Vision-Based Automation

Erin Williams^*1, Felipe Echeverri Tribin¹, Luis Rodriguez-Diaz¹, Blaine Ayotte², Christopher McKenna², Odile Clavier², Michael Hoffer¹

¹University of Miami Miller School of Medicine, ²Creare LLC

Bone-Conducted Vibration Reduces Vestibulo-Ocular Reflex Time Constant and Motion Sickness during Step Velocity Testing

Didier Depireux^*1, Daniel Stolzberg¹, Eve Mnatsakanyan², Tin Truong², Samuel Owen¹, Chelsea Nava², Brooke Pearce²

¹OtolithLabs, ²Dizzy and Vertigo Institute of Los Angeles

Sex-Specific Impairment in Spatial and Episodic Memories and Vestibular Function in Aging Shank3 KO Mouse Model of Autism

Nelson Shi¹, Patrick Wu¹, Dylan Arevian¹, Soroush Sadeghi¹, Tara Deemyad^*1

¹ Johns Hopkins University

The Relationship Among Vestibular, Hearing, and Balance Outcomes in Individuals with Down Syndrome

Casey Vandervelde¹, Jessie Patterson², Heather Porter², Gabrielle R. Merchant², Kristen Janky^*2

¹University of Utah, Salt Lake City, ²Boys Town National Research Hospital

Role of Transcription Factor Six2 in the Development of Vestibular Epithelia

Sumana Ghosh^*1, Punam Thapa², Vineel Vanga¹, Kaylee Zettler¹, Steven Gressett¹, Garner Fincher¹, Beth Baker¹, Bradley Walters¹

¹University of Mississippi Medical Center, ²University of Mississippi medical Center

P12. Podium Session 12: OTOF Success and GJB2 Progress

3:00 p.m. – 5:00 p.m.

Ocean Ballroom 9–12

OTOV101 Gene Therapy for Autosomal Recessive Deafness 9: A Multicenter, Open-Label, Single-Arm, Investigator Initiated Intervention Study

Renjie Chai¹, Jieyu Qi^*2, Liyan Zhang³, Ling Lu⁴, Fangzhi Tan³, Cheng Cheng⁵, Wenxiu Dong⁶, Yinyi Zhou², Lulu Jiang⁶, Chang Tan⁶, Shanzhong Zhang⁶, Huaien Song⁷, Maoli Duan⁸, Xia Gao⁵, Dingjun Zha⁹, Yu Sun¹⁰, Lei Xu¹¹, FanGang Zeng¹²

¹Southeast University；Nantong University；Beijing Institute of Technology；Sichuan Provincial People's Hospital, ²Beijing Institute of Technology, ³Southeast University, ⁴Zhongda Hospital ；Southeast University, ⁵Nanjing Drum Tower Hospital, ⁶Otovia Therapeutics Inc, ⁷Fosun Health Capital, ⁸Karolinska University Hospital, ⁹Xijing Hospital, ¹⁰Huazhong University of Science and Technology, Union Hospital, ¹¹Shandong Second Provincial General Hospital, ¹²University of California Irvine

From Cells to Cures: hIPSC-Derived Inner Ear Organoids and RNA Therapy to Resolve Genetic Inner Ear Diseases

Esther Fousert^*1, Winnie van den Boogard², Wouter van der Valk², Amy Lucassen², John de Groot³, Peter Paul van Benthem³, Hannie Kremer⁴, Erik de Vrieze⁵, Erwin van Wijk⁵, Heiko Locher²

¹Leiden University Medical Center, The Novo Nordisk Foundation Center for Stem Cell Medicine, reNEW, ²Leiden University Medical Center, Leiden, the Netherlands; The Novo Nordisk Foundation Center for Stem Cell Medicine, reNEW, ³Leiden University Medical Center, Leiden, the Netherlands, ⁴Radboud University Medical Center, Nijmegen, the Netherlands; Radboud University Medical Center, Nijmegen, the Netherlands, ⁵Radboud University Medical Center, Nijmegen, the Netherlands

Safety and Efficacy of DB-OTO Gene Therapy in Children with Profound Deafness Due to Otoferlin Variants: Data From the Chord Phase 1/2 Open-Label Trial

Jay T Rubenstein^*1, Manohar Bance², Lawrence Lustig³, Akira Ishiyama⁴, Robert Nash⁵, Ruben Polo⁶, Manuel Jesus Manrique⁷, Evie Landry⁸, Margaret A Meredith⁹, Tera Quigley¹⁰, Jason Riggs¹⁰, Eduardo Corrales¹⁰, Jonathon Whitton¹⁰, Jeffery Anderson¹⁰, Vassili Valayannopoulos¹⁰

¹University of Washington, ²Cambridge University, ³Columbia University, ⁴UCLA, ⁵Great Ormond Street Hospital, ⁶Hospital Universitario Ramon y Cajal, ⁷Clinica Universidad de Navarra, ⁸Nemours Children's Health, ⁹Seattle Children's Hospital, ¹⁰Regeneron Pharmaceuticals

Rapid Emergence of Cortical Sound Processing and Auditory Perception Following Otoferlin Gene Transfer Therapy in Young Adult Otof-/- Mice

Kameron Clayton^*1, Korey Sudana¹, Jennifer Zhu¹, Elizabeth Norris¹, Evan Hale¹, Myunghoon Yoo¹, Artur Indzhykulian¹, Daniel Polley¹

¹ Eaton-Peabody Laboratories, Massachusetts Eye and Ear

Development of AAV Gene Therapy Targeting GJB2 Related Hearing Loss by Capsid and Promoter Modification

Kazusaku Kamiya^*1, Daisuke Arai¹, Takao Ukaji¹, Makoto Matsuyama¹, Hidekane Yoshimura², Shin-ya Nishio², Sho Kanzaki¹, Yutaka Takumi², Shin-ichi Usami², Katsuhisa Ikeda¹

¹Juntendo University Faculty of Medicine, ²Shinshu University School of Medicine

Effectiveness of Gene Therapy in Patients with DFNB9: Evidence from Cortex and Development

Jiajia Zhang^*1, Zengzhi Guo², Changjie Pan³, Chunchun Hu⁴, Xinyang Weng⁵, Bing Chen⁵, Zheng-Yi Chen⁶, Shan Sun⁷, Xiu Xu⁴, Huawei Li⁵, Fei Chen³, Yilai Shu⁵

¹Fudan University Eye Ear Nose and Throat Hospital, ²Northeastern University, ³Southern University of Science and Technology, ⁴Children’s Hospital of Fudan University, ⁵Eye and ENT Hospital, Fudan University, ⁶Graduate Program in Speech and Hearing Bioscience and Technology and Program in Neuroscience, Harvard Medical School; Eaton-Peabody Laboratory, Massachusetts Eye and Ear Infirmary, ⁷Eye and ENT Hospital, Fudan University

Preclinical Studies Using a Novel Gene Therapy Show Robust Rescue of Hearing for a Common Hereditary Deafness

Andre Landin Malt¹, Felicia Gilels¹, Ashley Hinton¹, Maryna Ivanchenko², Jason Farnsworth¹, Yaqiao Li², William Neidermyer¹, May Wang¹, Tian Yang¹, Jessica Chiang¹, Marc Johnson¹, Casey Maguire³, David P. Corey², Will McLean¹, Shawn Harriman¹, Jodi Cook¹, K. Domenica Karavitaki^*1

¹Skylark Bio, Inc., ²Harvard Medical School, ³Massachusetts General Hospital, Harvard Medical School

Novel Large Animal Model for Human Inner Ear Gene Therapy: Transgene Expression of Viral Vectors in Pigs

Erdem Yildiz¹, Till Buschhorn^*1, Caroline Sesztak¹, Anselm Joseph Gadenstaetter¹, Matthias Gerlitz¹, Clemens Honeder¹, Hinrich Staecker², Christoph Arnoldner¹, Lukas Landegger¹

¹Medical University of Vienna, ²Univeristy of Kansas Medical Center

Tuesday, February 25, 2025

YIS2. Young Investigator Symposium 2: Bridging the Senses: Lessons Learned at The Intersection of Audition and Vision

8:00 a.m. – 10:00 a.m.

Ocean Ballroom 1–4

Chair: Malinda McPherson, Purdue University

Co-chair: Abigail Noyce, Carnegie Mellon University

“Hearing with the eyes”: Visual Perception for Auditory Scientists

Abigail Noyce^*1

¹ Carnegie Mellon University

Spatiotemporal Neural Dynamics of Cross-Modal Integration in Audiovisual Perception

Yalda Mohsenzadeh^*1, Yu Hu¹

¹ The University of Western Ontario

Salient Sounds Boost Visual-Cortical Processing and Enhance Visual Perception

Viola Stoermer^*1

¹ Dartmouth College

How the Visual Domain Might Elucidate the Fidelity of Auditory Working Memory

Jamal Williams^*1

¹ University of California, San Diego

Memory Performance in Hearing and Vision is Differentially Impacted by Task Structure and Stimulus Similarity

Malinda McPherson^*1

¹ Purdue University

Model-Brain Comparisons in the Visual and Auditory Domains

Jenelle Feather^*1

¹ Flatiron Institute

Automatic Perceptual Segmentation Results in Biased Acuity in Audition and Vision

Linda Garami^*1, Maria Geffen², József Fiser¹

¹Central European University, ²University of Pennsylvania

P13. Podium Session 13: Cochlear-Specific Genomics and Gene Regulation

8:00 a.m. – 10:00 a.m.

Ocean Ballroom 5–8

Cochlear Mesenchyme Consists of Four Cellular Subtypes Regulated by Distinct POU3F4 Related Transcriptional Pathways

Wei Song^*1, Kevin Rose², Beatrice Milon², Yang Song³, Thomas Coate⁴, Ran Elkon⁵, Ronna Hertzano²

¹National Institute on Deafness and other Communication Disorders, National Institutes of Health, ²Neurotology Branch, National Institute on Deafness and other Communication Disorders, National Institutes of Health, ³University of Maryland, Baltimore, ⁴Georgetown University, ⁵Tel Aviv University

Six1 is Essential for the Maturation and Homeostasis of the Auditory Sensory Organ in Adult Mice

Ting Zhang¹, Xiaohui Ma², Jinshu Xu¹, Jun Li¹, Pin-Xian Xu^*1

¹Icahn School of Medicine at Mount Sinai, ²Icahn School of Medicine At Mount Sinai

Big Data to Precision Medicine for Hearing Impairment

Zippora Brownstein^*1, Lara Kamal¹, Inbar Blech¹, Yazeed Zoabi¹, Shadi J. Khoury¹, Tal Patalon², Asaf Peretz², Juan Fernandez-Recio³, Xavier de La Cruz⁴, Fabian Glaser⁵, Noam Shomron¹, Karen B. Avraham¹, Lara Kamal⁶

¹Tel Aviv University, ²Maccabi Healthcare Services, ³Instituto de Ciencias de la Vid y del Vino (ICVV), ⁴Vall d'Hebron Institute of Research (VHIR), ⁵THHI, Technion Human Health Initiative, ⁶Faculty of Medical and Health Sciences, Tel Aviv University

Characterizing Gene Regulatory Networks in Mouse Developing Hair Cells Using Bioinformatic Tools and Omics Integration Strategies

Celia Bloom^*1, Tuba Ege¹, Mi Zhou¹, Guanfang Xie¹, Litao Tao¹

¹ Creighton University

Comparative Maturation and Sensory Hair Cell Regeneration Potential in the Inner Ear

Marcela Lipovsek^*1, Rachel Williams¹, Jimena Perez Lloret¹

¹ University College London

Cross-Species Meta-Analysis Identifies Shared and Unique Gene Expression Differentiating Hair Cells from Supporting Cells

Lisa Goodrich^*1, Mahashweta Basu², Nesrine Benkafadar³, Amanda Ciani Berlingeri⁴, Ivan Cruz⁴, Emilia Luca⁵, Jeremy Sandler⁶, Seth Ament⁷, John Brigande⁷, Alain Dabdoub⁷, Albert Edge⁷, Ksenia Gnedeva⁷, Andrew Groves⁷, Stefan Heller⁷, Ronna Hertzano⁷, Tatjana Piotrowski⁷, David Raible⁷, Yehoash Raphael⁷, Jennifer Stone⁷, Litao Tao⁷, Mark Warchol⁷

¹Harvard Medical School, ²Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, ³Stanford University School of Medicine, ⁴Virginia Merrill Bloedel Hearing Research Center, The University of Washington, ⁵Sunnybrook Research Institute, ⁶Stowers Institute for Medical Research, ⁷Hearing Restoration Project

Ligand Dependent Function of the Retinoic Acid Receptor Alpha Complex During Cochlear Organogenesis

Saikat Chakraborty¹, Shuze Wang¹, Jack Ruhala¹, Jie Liu¹, Joerg Waldhaus^*1

¹ University of Michigan

The Genetic Landscape of Hearing Loss: Insights from a Multiethnic Cohort of Over 7,700 Cases

Hela Azaiez^*1, Amanda Odell², Estella Roster², Diana Kolbe², Donghong Wang², Maria Wong², Carla Nishimura², Kathy Frees², Amanda Taylor², Daniel Walls², Elisabeth A Black-Ziegelbein², Adela Mansilla², Joseph Chin², Kevin T Booth², Miles Klimara², Kiersten Knobbe², Luke Hovey², Erika Renkes², Paige Harlan², Cathy Feng², Jori E. Hendon², Amy E. Weaver², Richard JH Smith²

¹University of Iowa, ²Molecular Otolaryngology and Renal Research Laboratories, University of Iowa Hospitals and Clinics

P14. Podium Session 14: New Advances in Tinnitus: Humans and Animal Models

8:00 a.m. – 10:00 a.m.

Ocean Ballroom 9–12

Hearing Damage Due to Use of Radio Ear-Pieces in the United Kingdom Police

Hannah Guest¹, Christopher Plack^*1

¹ Manchester Centre for Audiology and Deafness, The University of Manchester

Suppressing Distracting Sounds: Neurophysiological and Behavioral Assays to Distinguish Between Benign and Bothersome Tinnitus

David Sorensen^*1, Jenna Sugai², Kenneth Hancock², Daniel Polley²

¹Harvard Medical School, ²Eaton-Peabody Laboratories, Massachusetts Eye and Ear

Ebselen Permanently Reverses Noise-Induced Tinnitus in Young and Older Mice with Age-Related Hearing Loss

Annie Jia¹, Kushal Sharma¹, Rende Gu¹, Ryan Longenecker¹, Jonathan Kil^*1

¹ Sound Pharmaceuticals, Inc.

Hyperexcitability in the Central Auditory System Caused by Chronic Noise Exposure

Fei Xu¹, Guangdi Chen¹, Wei Sun^*1

¹ University at Buffalo

Tinnitus is Associated with Reduced Spontaneous Spiking Activity in Auditory Nerve Fibers

Imme IJsseldijk¹, Amarins Heeringa^*1

¹ Carl Von Ossietzky University

Tinnitus is Associated with Greater GABA(A) Receptor Availability in the Human Primary Auditory Cortex

Pim Van Dijk^*1, Marc Thioux¹, Emile de Kleine¹, Sonja Pyott¹, Antoon Willemsen¹, Erik de Vries¹

¹ University Medical Center Groningen

Effects of Lifetime Occupational Noise Exposure on Tinnitus in Older Adults with Hearing Loss

Sabina Storbjerg Houmøller^*1, Li-Tang Tsai², Sreeram K Narayanan², Carl Pedersen³, Dan Dupont Hougaard⁴, Michael Gaihede⁴, Christian Godballe², Jesper Hvass Schmidt³

¹University of Southern Denmark, ²Research Unit for ORL – Head and Neck Surgery and Audiology, Odense University Hospital and University of Southern Denmark, ³Research Unit for ORL – Head and Neck Surgery and Audiology, Odense University Hospital; University of Southern Denmark, ⁴Aalborg University Hospital

Genetic Architecture of Tinnitus: A Genome-Wide Association Study Among Women

Nan Lin¹, Raji Balasubramanian², Heather A. Eliassen³, Konstantina M. Stankovic⁴, Gary Curhan⁵, Sharon Curhan⁵, Oana Zeleznik^*6

¹Brigham and Women's Hospital and Harvard Medical School, ²University of Massachusetts, Amherst, ³Brigham and Women's Hospital and Harvard T.H. Chan School of Public Health, ⁴Stanford University School of Medicine, ⁵Brigham and Women's Hospital/Harvard Medical School, ⁶Harvard Medical School

S6. Symposium 6: Electric-Acoustic Interactions Within and Across Ears: Animal, Human, And Computational Models from Periphery to Cortex

10:30 a.m. – 12:30 p.m.

Ocean Ballroom 1–4

Chair: Waldo Nogueira, Medical University of Hannover

Co-chair: Lina Reiss, Oregon Health and Science University

Co-chair: Yang-Soo Yoon, Baylor University

Outcomes of Electric-Acoustic Stimulation in the Same Ear: Insights from Electrophysiological Measures in Animal Models and Cochlear Implant Users

Viral Tejani^*1

¹ Case Western Reserve University, University Hospitals

Simulating Intracochlear Electrocochleography with a Combined Model of Acoustic Hearing and Electric Current Spread in the Cochlea

Margriet van Gendt^*1, Aristeidis Choustoulakis², Jeroen Briaire², Johan Frijns²

¹Leiden University Medical Center, the Netherlands, ²Leiden University Medical Center

Psychoacoustic Electric-Acoustic Masking with Round Window Extra-Cochlear Electric Stimulation in Cochlear Implant Users with Residual Hearing

Patrick Hinz^*1, Waldo Nogueira¹

¹ Medical University Hannover and Cluster of Excellence “Hearing4all”

Effects of Residual Hearing in the Non-Implanted Ear on Device Use and Auditory Development in Children with Bimodal Hearing (Including Single Sided Deafness)

Karen Gordon^*1, Hanne Bartels¹, Harrison Gao¹, Robel Alemu¹, Melissa Polonenko¹, Emily Wener¹, Hyo Jeong Lee¹, Jaina Negandhi¹, Blake Papsin¹, Sharon Cushing¹

¹ The Hospital for Sick Children

Binaural Cue Sensitivity and Spatial Hearing in Eas Candidates: Pre- to Post-Implant Performance and Processing in Adults and Children

Rene Gifford^*1, Jonathan Neukam¹, Linjie Shi¹, Linsey Sunderhaus¹

¹ Vanderbilt University Medical Center

Bimodal Neuromodulation for Tinnitus Treatment: Scientific to Real-World Evidence

Hubert Lim^*1

¹ University of Minnesota

P15. Podium Session 15: Genetics Of Hearing Loss: Determining Causation and Function

10:30 a.m. – 12:30 p.m.

Ocean Ballroom 5–8

Single Nuclei RNA-Sequencing Reveals Genetic and Cellular Insights Into Cisplatin-Induced Ototoxicity

Deanne Nixie Miao^*1, Emilia Luca², Janilyn Arsenion³, John Pham¹, Alain Dabdoub⁴, Britt Drogemoller⁵

¹University of Manitoba, ²Sunnybrook Research Institute/ University of Toronto, ³Department of Immunology, University of Manitoba, ⁴Sunnybrook Research Institute/University of Toronto, ⁵Department of Biochemistry and Medical Genetics, University of Manitoba

Functional Outcome in a Rationally Designed Genomically Humanized Mouse Model for Dominantly Inherited Hearing Loss DFNA9

Vincent Van Rompaey^*1, Dorien Verdoodt², Erwin Van Wijk³, Peter Ponsaerts⁴, Fien Aben², Lize Sels², Evi De Backer², Hanne Gommeren², Krystyna Szewczyk², Sanne Broekman⁵, Hanka Venselaar⁶, Guy Van Camp⁷, Erik de Vrieze⁸

¹Universitair Ziekenhuis Antwerpen, ²Resonant Labs Antwerp, Faculty of Medicine and Health Sciences, University of Antwerp, ³Radboud University Nijmegen Medical Center, ⁴Laboratory of Experimental Hematology, University of Antwerp, ⁵Radboud University Medical Center, Nijmegen, ⁶Department of Medical BioSciences, Radboud University Medical Center, Nijmegen, ⁷Centre of Medical Genetics, University of Antwerp, ⁸Dept. of Otorhinolaryngology, Radboud University Medical Center, Nijmegen, The Netherlands

Critical Challenges in Splicing-Related Variant Analysis for Accurate Pathogenicity Assessment

Yu Lu^*1, Bingqian Yang², Linke Li³

¹West China Hospital, Sichuan University, ²Renmin Hospital of Wuhan University, ³West China Hospital, Sichuan University

Functional Results and Implications of the SLC26A5 Genotype R399X/T470N for Genetic Nonsyndromic Hearing Loss DFNB61

Rosemary Kabahuma^*1, Kazuaki Homma², Satoe Takahashi², ZhengYi Chen³, Michael Pepper¹, Xue Liu⁴

¹University of Pretoria, ²Northwestern University, ³Mass Eye and Ear, ⁴University of Miami School of Medicine

Identification of ATP8A2 as a Novel Dfna Gene Associated with Late-Onset Hearing Loss: Insights from Human and Mouse Models

Jing Cheng^*1, Jing Wang¹, Lanchen Wang¹, Wan Hua¹, Libo Liu¹, Yu Huang¹, Guotong Lin², Lei Song², Huijun Yuan¹

¹West China Hospital, ²Shanghai Jiao Tong University School of Medicine

Gene Therapy in a Rabbit Model for USH3A

Diane Prieskorn¹, Lisa Beyer¹, Y Eugene Chen¹, Dongshan Yang¹, Yehoash Raphael^*1

¹ University of Michigan

Beyond the Gene Panel: Methods to Identify Missing Genetic Causes of Pediatric Sensorineural Hearing Loss

Shelby Redfield^*1, Tieqi Sun², Adrian Pastolero¹, Margaret Kenna², Eliot Shearer²

¹Boston Children's Hospital, ²Boston Children’s Hospital; Harvard Medical School

Unraveling the Genetic Basis of Autosomal Dominant Hearing Loss

Dominika Oziębło¹, Marcin L. Leja¹, Nina Gan¹, Natalia Baldyga¹, Henryk Skarzynski², Monika Ołdak^*1

¹ Institute of Physiology and Pathology of Hearing

P16. Podium Session 16: Decoding The Aging Auditory System: Molecular Mechanisms, Functional Decline, And Therapeutic Prospects

10:30 a.m. – 12:30 p.m.

Ocean Ballroom 9–12

Single-Nucleus Profiling of Inner Ear Aging Reveals Cellular Diversity and Hair Cell Degeneration Caused by Inflammation-Induced Aberrant Rna Splicing

Mingyu Xia^*1, Jiaoyao Ma², Yunjie Li², Wenyan Li², Huawei Li²

¹Eye and ENT Hospital, Fudan University, ²ENT institute and Otorhinolaryngology Department of Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University

Unraveling Age-Related Cellular and Molecular Mechanisms Associated with Vestibular Hair Cells and Their Slow pace of Aging Compared to Cochlear Hair Cells

Samadhi Kulasooriya^*1, Huizhan Liu¹, Sarath Vijayakumar¹, Celia Bloom¹, Mi Zhou¹, Litao Tao¹

¹ Creighton University School of Medicine

Physiological and Histological Characterization of a Macaque Model of Presbycusis

Swarat Kulkarni^*1, Amy Stahl¹, David Pitchford¹, Leslie Liberman², M. Charles Liberman², Troy A Hackett³, Ramnarayan Ramachandran⁴

¹Vanderbilt University, ²Eaton-Peabody Laboratories, Mass Eye and Ear, Harvard Medical School. Boston, MA, United States, ³National Institute of Health, ⁴Vanderbilt University, Vanderbilt University Medical Center

Structural Integrity of the Auditory-Language Brain Networks Varies With Cognitive Status and Accounts for Speech-In-Noise Deficits in Older Adults

Gavin Bidelman^*1, Jack Stirn², Connor Shin², Elaina Lewis³, Mengyuan Zhou⁴, Rose Rizzi², Jessica MacLean²

¹Indiana University, ²Indiana University Department of Speech, Language, and Hearing Sciences, ³Indiana University School of Medicine, ⁴Jacobs School of Music, Indiana University

Age-related Mitochondrial Depolarization and Mitophagy Impairment in the Cochlear Biobattery

Tyreek Jenkins^*1, Jiaying Wu¹, Li Li¹, John Lemasters¹, Hainan Lang¹

¹ Medical University of South Carolina

Genetic Contribution to Hearing Loss Progression in Aged Diversity Outbred Mice

Daniel Johnson^*1, Sarah Cancelarich¹, Kara Campos¹, Jacqueline Otto¹, Kevin Bugge¹, Irina Marcovich¹, Meghan Drummond¹

¹ Regeneron Pharmaceuticals

Pou4f3 is Critical for Stereocilia Bundle Maintenance and Hair Cell Survival in Adult Mammalian Cristae

Brad Walters^*1, Kendra Stansak¹, Tianwen Chen¹, Caroline Nall¹, Tierah Macon¹, Wu Zhou¹, Hong Zhu¹, Brandon C. Cox²

¹University of Mississippi Medical Center, ²Southern Illinois University School of Medicine

Noise Induced Hidden Hearing Loss Accelerates Alzheimer’s Disease Development and Progression

Tianying Zhai^*1, Chun Liang¹, Peng Zhe¹, Yong Kong¹, Hong-Bo Zhao¹

¹ Yale University Medical School

Poster Session IV

1:30 p.m. – 3:00 p.m.

Peninsula Ballroom

1. The Cochlear Hook Region Detects Harmonics Beyond the Canonical Hearing Range in Guinea Pigs

Kazuhiro Horii^*1, Bakushi Ogawa¹, Noriko Nagase¹, Iori Morimoto¹, Chikara Abe¹, Takenori Ogawa¹, Samuel Choi², Fumiaki Nin¹

¹Gifu University, ²Niigata University

2. Visualizing how Presynaptic Activity Shapes Ribbon Formation in Zebrafish

Olivia Molano^*1, Saman Hussain², Sophie Lear², Katherine Pinter², Katie Kindt²

¹National Institute on Deafness and Other Communication Disorders, National Institutes of Health, ²NIH/NIDCD

3. Novel Biomarker Identification in Plasma for Hearing Instability Disorders Using Targeted Proteomics Approaches

Samuel Adadey^*1, Shoujun Gu², Rafal Olszewski², Julia Telischi³, Gayla Poling¹, Jennifer Chisholm⁴, Michael Hoa⁵

¹National Institute on Deafness and Other Communication Disorders, ²Auditory Development and Restoration Program, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, ³University of Miami Miller School of Medicine, ⁴Audiology Unit, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, ⁵Auditory Development and Restoration Program, National Institute on Deafness and Other Communication Disorders, National Institutes of Health

4. The Cellular and Molecular Architecture of the Mammalian Vestibular System

Meghna Kolluri^*1, Paula Fontanet¹, Charles Petitpre¹, Csaba Adori¹, Prach Techameena¹, Haohao Wu¹, Shih-Hsin Chang¹, Beatriz Del Blanco², Angel Barco², Saida Hadjab¹, Francois Lallemend¹

¹Karolinska Institutet, ²Universidad Miguel Hernandez

5. Cochlear Extension and Patterning Require Myosin II and Cadherin 1

Elizabeth Driver^*1, Valeria Morales Ciriaco¹, Matthew Kelley¹

¹ National Institute on Deafness and Other Communication Disorders, National Institutes of Health

6. Integrating Mouse Cochlear Proteomics and Single-Cell Transcriptomics to Develop a Comprehensive Database of Inner Ear Tissue Expression

Kenechukwu Charles-Obi^*1, Samuel Adadey², Shoujun Gu², Rafal Olszewski², Michael Hoa²

¹National Institute on Deafness and Other Communication Disorders, National Institutes of Health, ²Auditory Development and Restoration Program, National Institute on Deafness and Other Communication Disorders, National Institutes of Health

7. Long-term Memory for Voices Frees up Cognitive Capacity to Enhance Intelligibility of Masked Speech

Manda Fischer^*1, Ingrid Johnsrude¹

¹ University of Western Ontario

8. The Role of Pitch Variability in Recognition and Intelligibility of Trained Voices

Harriet Smith^*1, Emma Holmes²

¹University College London, ²University College London (UCL)

9. Identifying Key Molecules Involved in the Biogenesis, Transport, and Recycling of Synaptic Vesicles at Ribbon Synapses

Sandeep David^*1, Katherine Pinter², Katie Kindt²

¹National Institute on Deafness and Other Communication Disorders, National Institutes of Health, ²NIH/NIDCD

10. Sound Quality and Music Perception of Custom Passive and Uniform Fit Electronic Musician's Hearing Protection Devices

Conner Jansen^*1, Colleen Le Prell¹

¹ University of Texas at Dallas

11. Investigating cAMP and PKA Signaling in Avian Supporting Cell Proliferation

Carolyn Miranda Portillo^*1, Austin Huang², Stefan Heller², Nesrine Benkafadar²

¹Stanford University School of Medicine, ²Department of Otolaryngology – Head and Neck Surgery, Stanford University School of Medicine

12. Phonological Processing in Cochlear Implant Users: A Functional Near-Infrared Spectroscopy (fNIRS) Study

Yingying Wang^*1, Yi Yuan², Shuman He², Anne Maxwell³, Hongying Dai³

¹University of Nebraska-Lincoln, ²The Ohio State University, ³University of Nebraska Medical Center

13. Hair Cell Apoptosis and Scramblase Activity in Tmc1 Mutations

Robert Fettiplace^*1, Maryline Beurg¹, Dakota Konrad¹

¹ University of Wisconsin-Madison

14. Exploration of Electrocochleography Variability in Patients with Hearing Instability

Jennifer Chisholm^*1, Christopher Zalewski², Talah Wafa², Noelle Allemang², Julie Christensen², Hui Cheng³, Julia Telischi⁴, Gayla Poling², Anna Centeno⁵, Marcia Mulquin⁵, Michael Hoa⁶

¹National Institute on Deafness and Other Communication Disorders, ²Auditory and Vestibular Clinical Research Section, NIDCD, ³Bioinformatics and Biostatistics Collaboration Core, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, ⁴University of Miami Miller School of Medicine, ⁵NIDCD, ⁶Auditory Development and Restoration Program, National Institute on Deafness and Other Communication Disorders, National Institutes of Health

15. Generating and Evaluating a Novel Bioactive Coating for Cochlear Implant Electrodes

Jacqueline Ogier^*1, Lilith Caballero Aguilar¹, Michael Leeming¹, Bryony Nayagam¹

¹ University of Melbourne

16. Cochlear Amplification Modulates Synaptic Transmission at the Endbulb of Held Synapse in the Cochlear Nucleus

Fang Wang^*1, Yige Li¹, Geng-Lin Li¹

¹ Eye and ENT Hospital, Fudan University

17. Evaluation of CRISPR-Based Allele-Specific Editing on Patient Dermal Fibroblasts for a Novel DFNA9-Causing Missense Variant in the LCCL Domain of Cochlin

Keith Abbey^*1, Mhamed Grati², Rabia Faridi³, Sayaka Inagaki³, Cristina Fenollar-Ferrer³, Rafal Olszewski⁴, Zeynep Ozgur², Erich Boger⁵, Isabelle Roux³, Cynthia Morton⁶, Michael Hoa⁴, Robert J. Morell⁵, Thomas B. Friedman³, Wade Chien²

¹National Institute on Deafness and Other Communication Disorders, National Institutes of Health, ²Inner Ear Gene Therapy Program, National Institute on Deafness and Other Communication Disorders (NIDCD), National Institutes of Health (NIH), ³Laboratory of Molecular Genetics, NIDCD, NIH, ⁴Auditory Development and Restoration Program, NIDCD, NIH, ⁵Genomics and Computational Biology Core, NIDCD, NIH, ⁶Harvard Medical School

18. AAV2.7m8 Transduces Inner Hair Cells and Supporting Cells in Adult Non-Human Primate Inner Ears

Mhamed Grati¹, Kevin Isgrig¹, Matthew Starost², Marvin Thomas III², Jessica Plunkard³, Jianliang Zhu¹, Yasuko Ishibashi¹, Greg Salyards⁴, James McGehee⁵, Wade Chien^*6

¹Neurotology Program, National Institute on Deafness and Other Communication Disorders (NIDCD), National Institutes of Health, ²NIH/OD/ORS, ³NIH/NIHAC, ⁴NIH/ORS/ORF, ⁵NIH/NIDCD, ⁶Johns Hopkins School of Medicine

19. The Role of FGFR2b Ligands in Spiral Ganglion Neuron Subgroup Specification and Survival

Tessa Sanders^*1, Daniel Ironson¹, Suzanne Mansour², Matthew Kelley¹

¹National Institute on Deafness and Other Communication Disorders, National Institutes of Health, ²University of Utah Human Genetics

20. Neuromodulation in the Descending Auditory System: Mechanisms Underlying Serotoninergic Excitation of Medial Olivocochlear Efferent Neurons

Kirupa Suthakar^*1, Catherine Weisz²

¹National Institute on Deafness and Other Communication Disorders, National Institutes of Health, ²National Institutes of Health

21. Cochlear Nitrative Stress and Associated Signaling in Noise-Induced Hearing Loss

Pankaj Bhatia^*1, Nicole Doyon-Reale¹, Paul Stemmer¹, Samson Jamesdaniel¹

¹ Wayne State University

22. Geospatial Analysis of Rural-Urban Access of Board-Certified Otolaryngology-Head and Neck Surgeons for Vermonters

Christopher Kruglik^*1, Sara Santagostino¹, Josephine Yalovitser¹, John Rustad¹, Heather Herrington¹, Mirabelle Sajisevi¹

¹ University of Vermont College of Medicine

23. Functional Characterization of Non-Calyceal Inputs in the Medial Nucleus of the Trapezoid Body

Laura Console-Meyer^*1, Florian Jenzen², Nikolaos Kladisios², Felix Felmy²

¹Universtiy of Veterinary Medicine Hannover, ²University of Veterinary Medicine Hannover

24. The Role of Cilia in the Development, Survival, and Regeneration of Hair Cells

Hope Boldizar¹, Amanda Friedman¹, Tess Stanley¹, María Padilla¹, Jennifer Galdieri¹, Arielle Sclar¹, Tamara Stawicki^*1

¹ Lafayette College

25. SGN-Specific Integrin Alpha 8 Knockout Mice Displayed Altered Synaptic Count

Iman Ezzat^*1, Lyudmila Batalkina¹, Marisa Zallocchi¹

¹ Creighton University

26. Using Generative Artificial Intelligence to Automate Speech-Comprehension Scoring of Naturalistic Speech Across Languages

Björn Herrmann^*1

¹ Rotman Research Institute

27. Fkbp5 May Control Glutamatergic Synaptic Transmission and Gabaergic Synaptic Transmission in the Vestibule

Yuichiro Tominaga^*1, Ryotaro Omichi², Yukihide Maeda³

¹Hiroshima city hospital, ²Okayama University Hospital, ³Saitama Medical University Faculty of Medicine, Otorhinolaryngology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

28. The Transcription Factor ZMYM4 is Expressed in Otic Neuronal Precursors and Spiral Ganglion Neurons

Karyn Jourdeuil^*1, Matthew Kelley²

¹National Institute on Deafness and Other Communication Disorders, National Institutes of Health, ²NIH/NIDCD

29. ETV Transcription Factors are Necessary for Organ of Corti Development and Pillar Cell Differentiation

Susumu Sakamoto^*1, Matthew Kelley²

¹NIDCD, ²NIH/NIDCD

30. Identification of Genes that Are Involved in Development of Cochlear Supporting Cells

Sofia Gallino^*1, Matthew Kelley²

¹National Institute on Deafness and Other Communication Disorders, National Institutes of Health, ²NIH/NIDCD

31. Novel Heterozygous USH1C Mutation Impacts Hair Cell Mechanotransduction and Causes Progressive Hearing Loss

Yanyan Jia^*1, Wenyan Li²

¹Eye and ENT Hospital of Fudan University, ²The EENT Hospital of Fudan University

32. The Influence of Stimulus Duration on the Acoustic Change Complex in Normal-Hearing Adults

Lana Biot¹, Laura Jacxsens², Emilie Cardon¹, Huib Versnel³, Annick Gilles², Vincent Van Rompaey², Marc Lammers^*2

¹University of Antwerp, ²Antwerp University Hospital, ³University Medical Center Utrecht

33. The role of PCDH15-CD2 Phosphorylation in Hair Bundle Morphogenesis and Function

Aray Adylkhan^*1, Anna Andreeva², Alison Lim¹, Phillip Wilson¹, Bao-Tich Nguyen¹, Ulrich Mueller³, Xiaowei Lu⁴

¹University of Virginia, ²Nazarbayev University, ³Johns Hopkins University, ⁴University of Virginia School of Medicine

34. A Novel Spurr Epoxy Embedding Method for Human Temporal Bones

Richard Har¹, Martin Leyhe¹, Nevra Keskin Yilmaz¹, Sebahattin Cureoglu¹, Meredith Adams¹, Rafael da Costa Monsanto^*1

¹ The University of Minnesota

35. Innovative Use of Human Amniotic Membrane Allograft for Recurrent Epistaxis: A Case Report

Nicole Rud^*1, Dr. Rahul Varman¹

¹ Creighton University School of Medicine

36. Mind the Gap among Aural Performance, Language Perception and Listening Comprehension of Short Stories in Children Using Cochlear Implants

Rotem Hagay¹, Rama Novogrodsky¹, Karen Banai^*1

¹ University of Haifa

37. Single-Cell Analysis of Adult Mouse Utricles After Targeted Ablation of Hair Cells With Diphtheria Toxin

Jocelyn Taylor^*1, Erin Jimenez¹

¹ Johns Hopkins University

38. The Contribution of Tapering to Cochlear Tonotopy

Alessandro Altoe^*1, Christopher Shera²

¹University of Southern California, Caruso, ²University of Southern California

39. Macrophage Heterogeneity in Cochlea: Implications for Auditory Function in Healthy and Aged Mice

Gisselle Jimenez^*1, Aude Chiot², Dillon Brownell², Patrick Atkinson³, Ivan Lopez⁴, Mia Backman², Cavanagh Gohlich², Alan Cheng³, Bahareh Ajami¹

¹Oregon Health and Sciences University, ²Oregon Health and Science University, ³Stanford University, ⁴David Geffen School of Medicine at UCLA

40. Effects of Lifetime Noise Exposure on Auditory Brainstem Response Morphology

William Allen^*1, Aryn Kamerer¹

¹ Utah State University

41. Modeling Normal and Impaired Hearing with Deep Neural Networks Optimized for Ecological Tasks

Mark Saddler^*1, Torsten Dau², Josh McDermott³

¹Technical University of Denmark, ²Technical University of Denmark (DTU), ³MIT

42. Low Frequency Tuning in the Apical Turn of the Cochlea in Aged Mice

Takeru Ota^*1, Kazuya Ono¹, Hiroki Takeda¹, Hiroshi Hibino¹

¹ Osaka University

43. Single-Cell Multiomics Supports Different Immune Profiles in Migraine, Vestibular Migraine and Menière Disease

Pablo Cruz-Granados^*1, Lidia Frejo¹, Patricia Perez-Carpena², Juan Carlos Amor-Dorado³, Emilio Dominguez-Duran⁴, Maria Jose Fernandez-Nava⁵, Angel Batuecas-Caletrio⁵, Elisheba Haro-Hernandez², Marta Martinez-Martinez², Jose Antonio Lopez-Escamez¹

¹The University of Sydney, ²Universidad de Granada, ³Hospital Can Misses Ibiza, ⁴Hospital Infanta Luisa, ⁵Hospital Universitario Salamanca

44. Spectral and Binaural Cue Reweighting Contributions in Sound Localization in Reverberant Environments

Udbhav Singhal^*1, Maike Klingel², Bernhard Laback², Norbert Kopco³

¹P.J. Safarik University, ²Acoustics Research Institute, Austrian Academy of Sciences, Vienna, ³P.J. Safarik University, Kosice

45. Cortical Processing of Phonemic Contrasts Across Two Languages in Bilingual and Monolingual Speakers

Susan Arzac^*1, Ilse Wambacq¹, Maryrose McInerney¹, Subong Kim¹

¹ Montclair State University

46. Integrative Data Analysis for Characterization of a Novel Auditory Brainstem Response Grading Scale

Anh Le^*1, Christopher Zalewski², Carmen Brewer², Gayla Poling³

¹George Washington University, School of Medicine and Health Sciences, ²Audiology Unit, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, ³National Institute on Deafness and Other Communication Disorders

47. Sox2 Binds to Loci Associated with Hair Cell Regeneration Genes

Theresa Mai^*1, Erin Jimenez¹

¹ Johns Hopkins University

48. Programmable NIR Responsive Nanocomposite Enables Noninvasive Intratympanic Delivery of Dexamethasone to Reverse Cisplatin Induced Hearing Loss

Jiali Wang^*1, Rawand A. Mustafa², Mengzhao Xun³, Jessica M. Rosenholm², Wuqing Wang³, Hongbo Zhang², Yilai Shu³

¹Fudan University, ²Pharmaceutical Sciences Laboratory, Faculty of Science and Engineering, Åbo Akademi University; Turku Bioscience Centre, University of Turku and Åbo Akademi University Turku, ³ENT institute and Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, NHC Key Laboratory of Hearing Medicine, Institutes of Biomedical Sciences, Fudan University, Shanghai, China.

49. Accuracy and Efficiency of a Swept Modulation Depth Stimulus for Cross-Species Neuromeric Physiological Analyses

Afagh Farhadi^*1, Hari Bharadwaj², Michael Heinz¹

¹Purdue University, ²University of Pittsburgh

50. Ecap Simulation of Combined Cochlear and Vestibular Stimulation Employing Realistic Human Inner Ear Anatomy

Björn Vey^*1, Michael Handler², Baumgarten Daniel³

¹Institute of Electrical and Biomedical Engineering, UMIT TIROL, ²Institute of Electrical and Biomedical Engineering, UMIT TIROL, Hall in Tirol, ³Institute of Mechatronics, University of Innsbruck, Innsbruck, Austria; Institute of Electrical and Biomedical Engineering, UMIT TIROL, Hall in Tirol

51. Comparisons in Vowel Confusion Patterns Between Bimodal Users With Greater and Lesser Bimodal Advantages

Amir Majidpour^*1, Yang-Soo Yoon¹

¹ Baylor University

52. Balance Function Analysis in Stat1 Knockout Mice

Michelle Kim^*1, Marina Saito², Rebecca Cook², Bibiana Toro Figueira¹, Tomoko Makishima²

¹University of Texas Medical Branch, ²University of Texas Medical Branch at Galveston

53. Hearing Restoration by in Vivo Base Editing in a Humanized MPZL2 Mouse Model of DFNB111 Deafness

Sohyang Jeong^*1, Shao Wei Hu², Luoying Jiang², Won Hoon Choi³, Yilai Shu², Sang-Yeon Lee⁴

¹Seoul National University, ²ENT Institute, Eye and ENT Hospital, Fudan University, ³Seoul National University Hospital, ⁴Seoul National University College of Medicine

54. AAK1 Regulates Membrane Homeostasis of Cochlear Hair Cells

Yihang Zheng^*1, Qingjun Jiang², Tingting Du², Lei Song², Hao Wu²

¹Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, ²Department of Otolaryngology-Head and Neck Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

55. Transcriptomic Characterization of the Vestibular Otolith Organ During Development and Screening of Key Transcription Factors for Type I Hair Cell Development

Binjun Chen^*1, Fanglu Chi², Dongdong Ren²

¹Eye and ENT Hospital, Fudan University, ²ENT institute and Department of Otorhinolaryngology Eye and ENT Hospital, Fudan University

56. Fractalkine Signaling Regulate the Levels of Several Chemotactic Cytokines After Acoustic Trauma

Sree Varshini Murali^*1, Tejbeer Kaur¹, Astrid Cardona²

¹Rutgers University, School of Medicine, Rutgers Brain Health Institute, Piscataway, ²University of Texas, San Antonio

57. Aging, Hearing Loss, and Cognitive Decline

Sophia Turbyville^*1, Yonghee Oh²

¹University of Louisville, School of Medicine, ²University of Louisville

58. Adenine Base Editor-Based Gene Therapy to Improve Mitochondrial Function in Hereditary Deafness Associated with Mitochondrial DNA Replication

Ju Hyuen Cha^*1, Yejin Yun², Won Hoon Choi², Sung Ho Jung², Sang-Yeon Lee³

¹Seoul National University, ²Seoul National Universtiy hospital, ³Seoul National University College of Medicine

59. Estimation of the Hearing Thresholds for Distantly-Presented Bone-Conducted Ultrasound Using Adhesive-Vibrators

Naoya Takahashi^*1, Sho Otsuka², Seiji Nakagawa²

¹Chiba University, ²Center for Frontier Medical Engineering, Chiba University

60. Real-time Spatial Auditory Attention Decoding from Single-Trial EEG

Akira Takeuchi^*1, Hwan Shim¹, Inyong Choi², Sungyoung Kim³

¹Rochester Institute of Technology, ²University of Iowa, ³Rochester Institute of Technology, Rochester, NY/Graduate School of Culture Technology, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea

61. Cochlear Frequency Selectivity and Extended High Frequency Hearing in Individuals with Normal Audiograms

Sajana Aryal^*1, Akansha Chawla¹, Srikanta Mishra¹

¹ University of Texas at Austin

62. Spike-Rate Adaptation and Facilitation in Biophysical Models of the Electrically Stimulated Human Auditory Nerve

Lukas Driendl^*1, Siwei Bai², Albert Croner², Carmen Castaneda², Werner Hemmert²

¹Technical University of Munich, ²Bio-Inspired Information Processing, Munich Institute of Biomedical Engineering, Technical University of Munich

63. MYO15A Rescues Elongation of Developmentally-Stunted Stereocilia in Adult Hair Cells

Elli Hartig^*1, Benjamin Low¹, Michael Wiles¹, Basile Tarchini¹

¹ The Jackson Laboratory

64. Development of Acoustic Startle Response and Prepulse Inhibition in Fragile X Syndrome Mice

Andrea Gensky^*1, Genesis Alarcon¹, Olivia Emerson¹, Grant Emerson¹

¹ Oklahoma State University

65. How Does Hearing Loss Affect Cognitive Influences on Speech-In-Speech Perception?

Elin Bonyadi^*1, Harriet J. Smith¹, Emma Holmes¹

¹ University College London

66. Inhibitory Interneurons in the Mouse Primary Auditory Cortex Drive Contrast Adaptation

Omer Zeliger^*1, Christopher Angeloni², Valerie Baubet², Erin Michel², Maria Geffen³

¹University of Pennsylvania, ²University of Pennsylvania School of Medicine, ³Perelman School of Medicine University of Pennsylvania

67. Neural Tracking of Hierarchical Linguistic Structures in Second Language Acquisition

Yuqing Zhang^*1, Hayley Krush¹, Zhiying Qian¹, Zilong Xie¹

¹ Florida State University

68. Dual Vector Gene Therapy Strategy Rescues Hearing in Recessive and Dominant Types of Hearing Loss

Tais Castagnola^*1, Petit Chloé², Irina Marcovich², Carl Nist-Lund², Sydney O'Malley², Cristobal Von Muhlenbrock², Nicholas Baer², Jeffrey R Holt²

¹Boston Children's Hospital, ²Harvard Medical School/Boston Children's Hospital

69. Technical Details on Single-Molecule Microscopy of MYO7A Trafficking in Live Hair Cell Stereocilia

Mrudhula Sajeevadathan^*1, Harshad Vishwasrao², Inna Belyantseva³, Yasuko Ishibashi⁴, Samuel Adadey⁵, Narinobu Harada⁶, Hari Shroff², Thomas Friedman⁷, Takushi Miyoshi⁸

¹Southern Illinoise University, ²NIBIB/NIH, ³NIDCD/NIH, ⁴Inner Ear Gene Therapy Program, National Institute on Deafness and Other Communication Disorders (NIDCD), National Institutes of Health; Laboratory of Molecular Genetics, National Institute on Deafness and Other Communication Disorders (NIDCD), National Institutes of Health, ⁵National Institute on Deafness and Other Communication Disorders, ⁶Harada Ear Institute, ⁷NIDCD / NIH, ⁸Southern Illinois University School of Medicine

70. Mouse Facial Grimace Can Be Used to Assess Auditory Pain during Sound Exposure and Requires Cochlear Mechanotransduction

Amelie Valles^*1, Benjamin Seicol¹, Anna Kohler¹, Elisabeth Glowatzki¹, Megan Beers Wood¹

¹ Johns Hopkins University School of Medicine

71. A Subcortical Model with Efferent Gain Control Explains Effects of Hearing Loss on Auditory Enhancement Under Simultaneous and Forward Masking

Swapna Agarwalla^*1, Afagh Farhadi², Laurel H. Carney¹

¹University of Rochester, ²Purdue University

72. Intracochlear Responses following Acoustic Trauma

Ana Gallegos Anchondo^*1, Sebastiaan Meenderink¹, Wei Dong¹

¹ VA Loma Linda Healthcare System

73. Neural Circuitry Mapping of Oxytocin

Genesis Alarcon^*1, Elizabeth McCullagh¹, Tamara Woodley¹

¹ Oklahoma State University

74. Single Cell Transcriptomics Reveals Damage Induced Mitotic Response in the Neonatal Mouse Utricle

Sushobhan Biswas^*1, Ruiqi Zhuo¹, Macey Soltis¹, Sarah Easow¹, Taha Jan¹

¹ Vanderbilt University Medical Center

75. Modulation of Vestibular Perception by Virtual Reality in Sitting and Standing Positions

Octaviano Huron^*1, Wilhelmina Tan², Ana Budimlic³, John Straub², Tomoko Makishima⁴

¹University of Texas Medical Branch, John Sealy School of Medicine, ²University of Texas Medical Branch, John Sealy School of Medicine, ³Rice University, ⁴University of Texas Medical Branch

76. Impact of a Novel HOMER2 Duplication Extension Variant on Auditory Function and Development: Insights from a Zebrafish Model

Eunjung Han¹, Ju Ang Kim^*2, Saemi Park¹, Jin Hee Han³, Min Young Kim³, Ngoc-Trinh Tran³, Yehree Kim³, Bong Jik Kim⁴, June Choi¹, Byung Yoon Choi³

¹Korea University Ansan Hospital, Korea University, College of Medicine, ²Seoul National University College of Medicine, Seoul National University Bundang Hospital, ³Seoul National University Hospital, College of Medicine, Seoul National University, ⁴Chungnam National University Sejong Hospital

77. Robust Regeneration of Hair Cells by Co-Expression of Gfi1, Atoh1 and Pou4f3 in the Adult Mouse Cochlea

Lingjun Zhang^*1, Sara E. Billings¹, Andrew K. Groves², Alan G. Cheng¹

¹Stanford University, ²Baylor College of Medicine

78. Synaptic Transmission at the Endbulb of Held Deteriorates in Mcu Knockout Mice

Guanyu Li^*1, Ruili Xie¹

¹ Ohio State University

79. Effects of Center Frequency Mismatch Between Ha and Ci Ears on Speech Perception in Simulated Bimodal Hearing

Raha Nekoutabar^*1, Yang-Soo Yoon¹

¹ Baylor University

80. Refining Spiral Ganglion Glial Cell Targeting with AAVie-K558R Serotype

Joshua Lin^*1, Sahiti Vemula², Nhi Nguyen³, Ksenia Gnedeva³, Seiji Shibata³

¹University of Southern California, Caruso, ²Keck School of Medicine of USC, ³Caruso

81. JAK2: A Key Modulator of Aminoglycoside-Induced Hearing Loss

Jonathan Fleegel^*1, Sarath Vijayakumar², Iman Izzat¹, Vijayprakash Namakkal Manickam², Marisa Zallocchi²

¹Creighton University School of Medicine, ²Creighton University

82. Peripheral Vestibular System Pathology Secondary to Otitis Media in the Chinchilla Model

Nevra Keskin Yilmaz^*1, Tomotaka Shimura², Rafael da Costa Monsanto³, Meredith Adams⁴, Sebahattin Cureoglu³

¹University of Minnesota, ²University of Minnesota Otopathology Laboratory, Minneapolis, Minnesota; Showa University Fujigaoka Hospital, ³University of Minnesota Otopathology Laboratory, Minneapolis, Minnesota, ⁴University of Minnesota

83. Extended High Frequency Bone Conduction in Adults and Children: Clinical Instrumentation, and Preliminary Results

Keelin Fallon^*1, Jeffrey Cheng², John Rosowski², Barbara Herrmann³, Aaron Remenschneider⁴

¹University of Massachusetts Chan Medical School, ²Massachusetts Eye and Ear Infirmary, ³Massachusettes Eye and Ear Infirmary, ⁴Boston Children's Hospital; Massachusetts Eye and Ear Infirmary

84. Poor Nutrition and Tuberculosis Impair Central Auditory Processing in Children Living With and Without HIV in Dar es Salaam, Tanzania

Abby Kambhampaty^*1, Chris Niemczak¹, Samantha Leigh¹, Jonathan Lichtenstein¹, Monika Adhikari¹, Abigail Fellows¹, Albert Magohe², Jiang Gui¹, Enica Massawe², Jay Buckey¹

¹Dartmouth College, ²Muhimbili University of Health and Allied Sciences

85. Fluid Intelligence and Working Memory Are Differentially Recruited to Support Challenging Speech Perception

Jaimy Hannah^*1, Stephen Van Hedger², Jennifer Rodd³, Ingrid Johnsrude¹

¹University of Western Ontario, ²Huron University, ³University College London

86. Epithelial Hyperplasia, Not Fluid Pressure-Induced Membrane Stretch, in Endolymphatic Hydrops Challenges the Classic View of Meniere’s Disease

Diana Correa^*1, Corey Bryton², David Bächinger³, MengYu Zhu¹, Jennifer T O'Malley¹, Tyler Hickman¹, Steven Rauch¹, Andreas Eckhard¹

¹Massachusetts Eye and Ear, Harvard Medical School, ²Tufts University School of Medicine, ³University Hospital Zurich

87. Distinct Roles of SNR, Speech Intelligibility, and Attentional Effort on Neural Speech Tracking in Noise

Xiaomin He^*1, Vinay Raghavan¹, Nima Mesgarani¹

¹ Columbia University

88. Dissecting the Role of GSK3β and Wnt/β-Catenin Signaling in Supporting Cell Proliferation in the Damaged Neonatal Mouse Utricle

Jun He^*1, Tian Wang¹, Ahmad Mahmoudi¹, Alan G. Cheng¹

¹ Stanford University

89. Uncovering Neuronal and Glial Cell Diversity in the Human Spiral Ganglion to Advance Hearing Loss Therapies

Boaz Ehiogu^*1, Emilia Luca², Ryosuke Yamamoto², Alain Dabdoub³

¹University of Toronto, ²Biological Sciences, Sunnybrook Research Institute, ³Sunnybrook Research Institute/University of Toronto

90. Sex Differences in the Auditory Processing of Musical Sounds as Revealed with the Frequency Following Response

Joseph Luetkehans^*1, Trent Nicol¹, Jennifer Krizman¹, Nina Kraus¹

¹ Northwestern University

91. Post-Developmental Mechanisms May Restrict Mammalian Hair Cell Regeneration

Cole Woulbroun^*1, Erin Jimenez¹

¹ Johns Hopkins University

92. Effects of Binaural Unmasking on Subcortical and Cortical Responses to Continuous Speech

Madeline Johnson^*1, Hayley Krush¹, Zilong Xie¹

¹ Florida State University

93. Comparative Assessment of Imaging Modalities for Cochlear Visualization Through Temporal Bone in an Ex Vivo Porcine Model

Akil Turner^*1, Mikalai Budzevich², Savannah Gladd³, Xiao Xia Zhu⁴, Bo Ding⁵, Robert D. Frisina⁶, Parveen Barzard⁵

¹Univeristy of South Florida, ²H Lee Moffitt Cancer Center, SAIL, ³University of South Florida, ⁴Global Ctr. for Hearing and Speech Res., University of South Florida, ⁵Global Ctr. Hearing and Speech Res., University of South Florida, ⁶Med. Engin., Chem. and Biolog. Engin.,Global Ctr. for Hearing and Speech Res., Univ. of South Florida

94. Neural Modulation of Auditory Attention Across Anatomical Regions and Frequency Bands Using ECoG

Yuesheng Ma^*1, James O'Sullivan², Jose Herrero³, Elliot Smith⁴, Catherine Schevon⁴, Guy McKhann⁴, Sameer Sheth⁴, Ashesh Mehta³, Nima Mesgarani¹

¹Columbia University, ²King's College London, ³The Feinstein Institute for Medical Research, ⁴Columbia University Medical Center

95. Sex Specific Peripheral Vestibular Dysfunction in Two Mouse Models of Autism

Daniel Ballinas^*1, Yvette Shu¹, Nelson Shi², Dyllan Zhou², Tara Deemyad², Soroush Sadeghi²

¹Student, ²Johns Hopkins University

96. AC\BC: Sound Source Localization During the Use of a Bone Conduction Headset

Aoi Hunsaker^*1, Theodore Argo², Andrew Brown¹

¹University of Washington, ²Applied Research Associates, Inc.

97. Evoked Calcium Signals in Intact Vestibular Epithelium and Their Relationship to Electrical Changes in Hair Cells and Afferent Neurons

Marina Kabirova^*1, Christopher Luong¹, Olivia Lutz¹, Ruth Anne Eatock¹

¹ University of Chicago

98. Intraoperative Extracochlear Electrically-Evoked Auditory Brainstem Response for Assessment of Cochlear Nerve Function in Translabyrinthine Vestibular Schwannoma Resection

Alena Pauley^*1, Benjamin Ostrander², Jonathan Dilgen³, Peter Dixon², Marc Schwartz⁴, Rick Friedman², Douglas Bennion²

¹University of California, San Deigo School of Medicine, ²Division of Otolaryngology – Head and Neck Surgery, University of California, San Diego, ³UC San Deigo Hospital, ⁴University of California San Diego

99. The Effects of Voice Onset Time on Dichotic Listening Using Persian Consonant-Vowel Stimuli in Young Adults with Normal Hearing

Mahshid Moheb Aleaba^*1, Amir Majidpour², Maryam Aghamolaei³, Ahmadreza Nazeri²

¹Jundishapur University of Medical Sciences, ²Shahid Beheshti University of Medical Sciences, ³Translational and Clinical Research Institute, Medical Faculty of Newcastle University

100. Decoding Auditory Attention with Time-Invariant Speaker Identity

Sukru Samet Dindar^*1, Xilin Jiang¹, Vishal Choudhari¹, Nima Mesgarani¹

¹ Columbia University

101. Android-Based Mobile Application to Estimate the User’s Audiometric Hearing Thresholds and Auditory Temporal Resolution

Ghazaleh Ghaffari^*1, Fredrik Öhberg¹, Mimmi Wernerd¹, Per Hallberg¹, Amin Saremi¹

¹ Umeå University

102. Time-Course of MHCII Expression in Rat Spiral Ganglion After Hair Cell Loss

Zhenshen Zhang^*1, Muhammad Rahman², Steven Green¹

¹University of Iowa, ²University of Iowa Hospitals and Clinics

103. Comparison of Phonemic Restoration between Young and Middle-Aged Adults

Mai Yuasa^*1, Sho Otsuka², Seiji Nakagawa²

¹Chiba University, ²Center for Frontier Medical Engineering, Chiba University

104. Small Arms Fire-Like Noise Induced Hearing Loss (NIHL) May Possess Distinct Diagnostic Profile from Previously Studied Models of NIHL

Meredith Ziliak^*1, Jax Marrone¹, Andres Navarro¹, Sahil Desai¹, Emily Bell¹, Audrey Harrison¹, Edward Bartlett¹

¹ Purdue University

105. Electric Threshold and ECAP Measures of Neural Health Show Varying Trends in Patients Between Cochlear Implant Surgery and Initial Activation

Jennifer Anyanwu^*1, Holden Sanders², Lina Reiss³

¹Philadelphia College of Osteopathic Medicine, ²Oregon Health and Science University, ³Oregon Health and Science University

106. Attentional Disengagement Through External and Internal Distraction Reduces the Neural Tracking of Speech in Background Noise

Yue Ren^*1, M. Eric Cui¹, Björn Herrmann¹

¹ Rotman Research Institute, Baycrest Academy for Research and Education

107. A Retrospective Study for Binaural Speech Perception Trends in Listeners With Hearing Aids and Cochlear Implants

Yonghee Oh^*1, Chase Sereno², Phillip Friggle¹, Josephine Kinder¹, Caroline Cuthbertson¹, Hannah Borton¹, Ingrid Edwards²

¹University of Louisville, ²Heuser Hearing Institute

108. Relationship Between Natural Head Orientation and Unaided and Aided Spatial Hearing Outcomes

Heesung Park^*1, Nathan Higgins¹, Erol Ozmeral¹

¹ University of South Florida

109. Microplastics and Inner Ear Function

Javeria Zaheer¹, Hosun Lee², Min-Hyun Park^*3, Jin Su Kim¹

¹Division of Applied RI, Korea Institute Radiological and Medical Sciences, ²Seoul National University College of Medicine, ³Seoul National University Boramae Medical Center

110. EDNRB2 is a Novel Marker for the Precursor State and Involved in Differentiation into Hair Cells in the Avian Auditory Epithelium

Marie Takeuchi^*1, Mami Matsunaga², Tomoko Kita², Koichi Omori², Takayuki Nakagawa²

¹Graduate School of Kyoto University, ²Graduate School of Medicine, Kyoto University

111. Aging Impairs Temporal and Binaural Processing, and Spatial Hearing, While Increasing Synaptopathy in the Mongolian Gerbil

Matthew Sergison^*1, John Peacock¹, Nathaniel Greene¹, Daniel Tollin¹

¹ University of Colorado Anschutz Medical Campus

112. Deafness Progressing to CI Eligibility Is Eight Times More Likely in the Hypoplastic Than the Degenerative Endotype of Meniere’s Disease

Catrin Brühlmann¹, Jennifer L. Spiegel², Agnes Mühle³, Adrian Dalbert¹, Vincent Y. Lin², Trung N. Le², Thore Schade-Mann³, Jessica Knoppik⁴, Dorothe Veraguth¹, Christof Röösli¹, Alexander Huber¹, Julia Dlugaiczyk¹, Steven D. Rauch⁵, Hubert Löwenheim³, Joseph M. Chen², Amy F. Juliano⁶, Andreas H. Eckhard⁵, David Bächinger^*7

¹University Hospital Zurich, University of Zurich, ²Faculty of Medicine, University of Toronto, ³University of Tübingen Medical Center, ⁴Diagnostic and Interventional Neuroradiology, University Hospital Tübingen, ⁵Harvard Medical School, ⁶Massachusetts Eye and Ear, Harvard Medical School, ⁷University Hospital Zurich

113. The Effect of Brain-Derived Neurotrophic Factor and neurotrophin-3 on the Auditory Nerve Response to Cochlear Implant Stimulation

David Sly^*1, Matthew Ng², Lisa Zhang², Stephen O'Leary², Ricki Minter², Amy Hampson², Leon Winata², Christofer Bester³, Leon Heffer²

¹Ear Science Institute, ²Department of Surgery (Otolaryngology) University of Melbourne, ³Ear Science Institute Australia

114. Differences between Ovar and Vsep in Assessing Otolith Function

Shijie Xiao^*1, Fangyi Chen¹

¹ Southern University of Science and Technology

115. The Shaker-1 Mutation Highlights the Role of Myosin Viia in Maintaining of the Morphological Integrity of the Shortest Rows of Stereocilia in Cochlear Hair Cells

Anna Underhill¹, Ana Amariutei¹, Samuel Webb², Fiorella Grandi³, Adam Carlton¹, Andrew O’Connors¹, Francesca De Faveri¹, Mauricio Saenz-Roldan⁴, Marie-José Lecomte⁵, Stuart Johnson¹, Saaid Safieddine⁶, Corné J. Kros⁷, Walter Marcotti^*1

¹University of Sheffield, ²Sheffield University, ³Sorbonne Université, ⁴Institut de l'Audition, Institut Pasteur, INSERM, Sorbonne Université, ⁵Institut de l'Audition/Institut Pasteur, ⁶Pasteur Institut, ⁷University of Sussex

116. Dynamics of the Multiple Demand Network Connectivity Under Varied Speech to Noise Ratios

Madison Tutton^*1, Ali Tafakkor¹, Bjorn Herrmann², Aysha Motala³, Ingrid Johnsrude¹

¹University of Western Ontario, ²Rotman Research Insitute; University of Toronto, ³University of Stirling

117. Transcriptomic and Epigenomic Characterization of Adult Mouse Vestibular Hair Cells

Amanda Ciani Berlingeri^*1, Mi Zhou², Sarath Vijayakumar², Neil Segil³, Litao Tao², Jennifer Stone⁴

¹University of Washington, ²Creighton University, ³Keck School of Medicine, University of Southern California, ⁴The University of Washington, Virginia Merrill Bloedel Hearing Resource Center

118. Utricular Sensory Cells Exposed to 4-Hydroxynonenal Exhibit Senescence-Like Phenotypes.

Chisato Fujimoto^*1, Kento Koda², Yui Mizumoto², Teru Kamogashira², Ken Hayashi², Kenji Kondo²

¹University of Tokyo, ²The University of Tokyo, Graduate School of Medicine

119. Local Administration of a Ph-Adjusted Sodium Thiosulfate-Containing Gel for Protection of Cisplatin Ototoxicity

Goran Laurell^*1, Pernilla Videhult Pierre², Anette Fransson²

¹Uppsala University Hospital, ²Karolinska Institutet

120. Effect of Ambiguity of Localization for Virtual Sound Source on Semicircular Canal-Ocular Reflex

Yumiko Kato^*1, Yoshiyuki Sasano¹, Izumi Koizuka¹, Shuichi Sakamoto², Manabu Komori¹

¹St. Marianna University School of Medicine, ²Tohoku University Research Institute of Electrical Communication

121. Personalized Porous Gelatin Methacryloyl Sustained-Release Nicotinamide Protects Against Noise-Induced Hearing Loss

Baoyi Feng^*1, Tingting Dong², Yong Tao¹, Hao Wu³

¹Shanghai Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine, ²Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, ³Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine; Ear Institute, Shanghai Jiao Tong University School of Medicine; Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases

122. The Effect of Nitric Oxide on Peripheral and Central Auditory System

Pelin Kocdor^*1, Narges Shomalizadeh², Fatmanur Akpunar², Feride Demirhan², Begun Erbaba³, Esra Ozkan², Ilke Kara-Tas², Mahmoud Mahmoudi², Yasemin Gursoy-Ozdemir²

¹Baskent University, ²Koc University, ³George Washington University

123. Ototoxicity Profiles of Patients Receiving Low-Dose Versus High-Dose Cisplatin Administrations

Katharine Fernandez^*1, Maura Campbell², Chavri Malhotra³, David Lee⁴, Paul Allen², Saad Khan³, Deborah Mulford², Bandi Page⁵, Candice Ortiz⁶, Nicole Schmitt⁷, Shawn Newlands², Peter Kullar³, Peter Santa Maria⁸, Lisa Cunningham¹

¹NIDCD, ²URMC, ³Stanford University, ⁴WUSTL, ⁵Johns Hopkins, ⁶Capital Institute of Hearing and Balance, ⁷Emory University, ⁸Pittsburg University

124. Age-Related Synaptic Changes in the Vestibular System of an Alzheimer’s Mouse Model

Jarnail Singh^*1, Bradley Walters², Brandon Cox¹

¹Southern Illinois University School of Medicine, ²University of Mississippi Medical Center

125. Development of a Rapid Auditory Brainstem Response Threshold Estimation Algorithm for Human Audiometry: A Simulation Experiment of Suprathreshold Sampling Strategies for Accuracy and Efficiency

Erik Petersen^*1, Sandy Huang¹, Brianna Ralston¹, Yi Shen¹, Rafael Delgado²

¹University of Washington, ²Intelligent Hearing Systems

126. Modeling Continuous Speech Perception Using Artificial Neural Networks

Gasser Elbanna^*1, Josh McDermott²

¹Harvard University, ²MIT

127. Characterizing Medial Olivocochlear (MOC)-Mediated Enhancement and its Dependence on Auditory and Moc Stimulation Parameters

Choongheon Lee^*1, Joseph Holt¹

¹ University of Rochester

128. Circadian Modulation of NLRP3 Inflammasome Activation in Macrophages Exacerbates Noise-Induced Hearing Loss: Insights from Single-Cell RNA Sequencing

Qingping Ma^*1, Qixuan Wang², Zhiwu Huang³

¹Shanghai Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, ²Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, ³Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine

129. Volume Electron Microscopic Mapping of Mitochondria in the Inner Ear

Yunfeng Hua^*1, Yi Jiang¹, Haoyu Wang¹, Fangfang Wang¹

¹ Shanghai Ninth People's Hospital

130. Noise-Induced Hearing Loss Impairs Auditory and Visual Decision-Making Task Learning

Marissa Calvano^*1, Madeline Berns¹, Genesis Nunez¹, Bruce Zhang¹, Justin Yao¹

¹ Rutgers University

131. Interactions Among Merlin, Arkadia, and SKOR2 Mediate NF2-Associated Human Schwann Cell Proliferation

Pei-Ciao Tang^*1, Seyoung Um², Olena Bracho², Christian Del Castillo², Christine Dinh³, Derek M. Dykxhoorn², Xue Liu¹

¹University of Miami School of Medicine, ²University of Miami Miller School of Medicine, ³University of Miami, Miller School of Medicine

132. Human Vestibular Perception on a Curve: What is the Key Factor in Determining Heading Direction?

Miguel Yakouma¹, Eric Anson², Benjamin Crane^*1

¹University of Rochester, ²University of Rochester Medical Center

133. Immune Response in the Spiral Ganglion Following Cochlear Hair Cell Loss

Adrianna Caro^*1, Steven H. Green¹

¹ University of Iowa

134. Viscoelasticity Accounts for Fast Adaptation in Outer-Hair-Cell Bundles

Rayan Chatterjee¹, Daibhid O Maoileidigh^*2

¹Stanford University School of Medicine, ²Stanford University

135. Cochlear Health in Ci Users with DFNA9

Julie Moyaert¹, Dyan Ramekers², Vincent Van Rompaey³, Griet Mertens³, Annick Gilles³, Emilie Cardon¹, Lana Biot¹, Marc Lammers^*3

¹University of Antwerp, ²University Hospital Antwerp, ³Antwerp University Hospital

136. Task Induced Changes in Listening Strategy Modulate Cortical and Subcortical Speech Processing

Rose Rizzi^*1, Elaina Lewis², Gavin Bidelman¹

¹Indiana University, ²Indiana University School of Medicine

137. Effects of Unilateral Vestibular Loss on Roll Posture and Neural Activity

Samantha Davis^*1, David Schoppik²

¹New York University, ²NYU School of Medicine, Neuroscience Institute

138. Influence of Enhancing Fundamental-Frequency Dynamics on Speech-on-Speech Intelligibility in Hearing-Impaired Listeners

Paolo A. Mesiano¹, Hamish Innes-Brown¹, Tobias May², Johannes Zaar^*1

¹Eriksholm Research Centre, ²Technical University of Denmark

139. Exploring the Role of Cochlear Immune Response in Acsl4 and Pex3 Mutant Mice With Age-Related Progressive Hearing Loss

Elisa Martelletti^*1, Aliisa Harju², Fajar Masood², Neil J. Ingham², Karen Steel²

¹King's College London, ²King's College London, Wolfson Sensory, Pain and Regeneration Centre

140. Neural Signatures of Musical and Linguistic Interactions During Natural Song Listening

Giorgia Cantisani^*1, Shihab Shamma², Giovanni Di Liberto³

¹Laboratoire des systémes perceptifs, DEC, ENS, PSL University, CNRS, ²University of Maryland, ³Trinity College Dublin

141. Changes in Speech Perception and Auditory Functions Due to Aging and Noise-Induced Cochlear Pathologies

Amin Saremi^*1, Ghazaleh Ghaffari², Stefan Stenfelt³

¹Umea University, ²Umeå University, of Biomedical Engineering R and D, University Hospital of Umeå, Region Vasterbotten, ³Linköping University

142. Isolating Neural Correlates of the Speech-To-Song Illusion with Electrophysiology

Giorgia Cantisani^*1, Mengting Jiang¹, Daniel Pressnitzer¹

¹ Laboratoire des systémes perceptifs, DEC, ENS, PSL University, CNRS

143. The Effect of L-Ergothioneine on Gap-In-Noise Abr Temporal Coding in Middle-Aged CBA/CAJ Mice

Tram Le^*1, Xiao Xia Zhu², Bo Ding³, Irati De Los Santos², Joseph Walton¹, Robert D. Frisina⁴

¹University of South Florida, ²Global Ctr. for Hearing and Speech Res., University of South Florida, ³Global Ctr. Hearing and Speech Res., Univ. of South Florida, ⁴Med. Engin., Chem. and Biology. Engin., Global Ctr. for Hearing and Speech Res., Univ. of South Florida

144. Stimulus Frequency Otoacoustic Emissions Extracted by Pharmacologic Blocking of Outer Hair Cells Shows that Extraction by High-Level, Near-Frequency Suppressors Reveals Nearly the Entire Sfoae

John Guinan^*1, Daniel Tay², Shawn Goodman³, Jeffery Lichtenhan⁴

¹Mass Eye and Ear, Harvard Medical School, ²University of Iowa, ³The University of Iowa, ⁴University of South Florida Morsani College of Medicine

145. Molecular Profiling of the Fetal Human Utricle: Insights from Single-Nucleus Multiomics

Weisheng Liang^*1, Ryosuke Yamamoto², Emilia Luca², Alain Dabdoub³

¹University of Toronto, ²Biological Sciences, Sunnybrook Research Institute, ³Biological Sciences, Sunnybrook Research Institute, University of Toronto

146. Myosin Xva Isoforms Participate in the Mechanotransduction-Dependent Remodeling of the Actin Cytoskeleton in Auditory Stereocilia

Ana I. Lopez-Porras^*1, Ava M. Kruse¹, Mark T McClendon¹, A. Catalina Velez-Ortega¹

¹ University of Kentucky

147. Emergence of Tonotopically Organized Spontaneous Activity in the Brain After Genetic Disruption of MET Channel Function

Patrick Parker^*1, Riley Bottom², Ulrich Mueller³, Dwight Bergles³

¹Johns Hopkins School of Medicine, ²Johns Hopkins University School of Medicine, ³Johns Hopkins University

148. Comprehensive Profiling and Structural Analysis of Kinocilia in Adult Cochlear and Vestibular Hair Cell

Amirrasoul Tavakoli Targhi^*1, Zhenhong Xu², Huizhan Liu², Samadhi Kulasooriya², Su Tu², Celia Bloom², T. Derek Johnson³, Yi Li², Jian Zuo², Litao Tao², Bechara Kachar³, David He²

¹National Institute on Deafness and Other Communication Disorders, ²Creighton University, ³National Institute of Deafness and Other Communication Disorders

149. Applied Statistical Tool to Fabricate Nanocarrier for Targeted Drug Delivery to Inner Ear

Vibhuti Agrahari^*1, Neeraj Thakur²

¹University of Oklahoma, ²University of Oklahoma Health Sciences Center

150. The Consistency of Spectral Context Effects in Speech Perception by Cochlear Implant Users

Christian Stilp^*1, Matthew Winn²

¹Marquette University, ²University of Minnesota

151. BAIAP2L2 Modulates Actin Protrusion Shape via Espin-1-Dependent Actin Regulation

Shiqiong Hu^*1, Runjia Cui¹, Evan Krystofiak¹, Willy Sun¹, Karyn Jourdeuil¹, Miloslav Sedlacek¹, Bechara Kachar¹

¹ National Institute on Deafness and Other Communication Disorders, National Institutes of Health

152. Older Adults at the Cocktail Party: Is it Better with a Musical Background?

Laura Rachman¹, Anastasios Sarampalis², Deniz Başkent¹, Eleanor Harding^*2

¹University of Groningen, University Medical Center Groningen, ²University of Groningen

153. Transcriptome Analysis of the Mouse Cochlear Nucleus in Response to Auditory Input

Huihui Liu^*1, Meijian Wang², Ruijie Cai², Xiaotong Ma², Hao Wu³

¹Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, ²Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ³Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine; Ear Institute, Shanghai Jiao Tong University School of Medicine; Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases

154. Mapping Genetic Contributors to Vestibular Function: A Gwas Approach with the Hybrid Mouse Diversity Panel

Yuzuru Ninoyu^*1, Calvin Pan², Jennifer Luu³, Sameeha Rashid³, Jadyn Johnston³, Briana Ortega³, Ely Boussaty³, Aldons Lusis², RIck Friedman³

¹Kyoto Prefectural University of Medicine, ²University of California Los Angeles, ³University of California San Diego

155. The Relationship of Between-Ear Attentional Transitions with Otoacoustic Emissions

Madoka Matsuge^*1, Yuki Ishizka¹, Shimpei Yamagishi², Haruna Fujihira³, Sho Otsuka⁴, Shigeto Furukawa⁵, Seiji Nakagawa⁴

¹Chiba University, ²NTT Communication Science Laboratories, ³Kyushu University, ⁴Center for Frontier Medical Engineering, Chiba University, ⁵Shizuoka Graduate University of Public Health

156. Acbd7 is Essential for Maintaining Auditory and Vestibular Functions Associated with Hair Cell Synaptic Transmission

Mingxuan Wu¹, Gaogan Jia¹, Yanyan Jia¹, Mingyu Xia¹, Huawei Li¹, Wenyan Li^*2

¹Eye and ENT Hospital, Shanghai Medical College, Fudan University, ²The EENT Hospital of Fudan University

157. The Clinical Phase 2a Prohear Study - A Randomized,Double-Blind, Placebo-Controlled and Split-Body Trial Testing the Otoprotective Potential of ACOU085 in Cisplatin-Treated TesticularCancer Patients

Sven Becker¹, Jonas Dyhrfjeld-Johnsen², Tim Boelke², PROHEAR Investigator Consortium³, Hubert Löwenheim^*4

¹University of Tübingen, ²Acousia Therapeutics, ³University Medical Centers, ⁴Translational Hearing Research, Head and Neck Surgery, University of Tübingen

158. A Sex-Specific Distribution of Meniere’s Disease in a Murine Model of X-Linked Hypophosphatemia

Arpan Bose^*1, Kimberly Ramirez¹, Eva Liu², Steven Rauch³, Sharon Kujawa³, Andreas Eckhard³, Divya Chari³, Arpan Bose⁴

¹University of Massachusetts Chan Medical School, ²Brigham and Women's Hospital, ³Massachusetts Eye and Ear, ⁴UMass Chan Medical School

159. Paralemmin-3 – an Essential Constituent of the Submembrane Cytoskeleton of Auditory Hair Cells

Victoria Halim^*1, Iman Bahader², Christina Ullrich³, Makoto Kuwabara⁴, Dennis Derstroff⁴, Kathrin Kusch², Nicola Strenzke², Carolin Wichmann⁵, Dominik Oliver⁴, Christian Vogl⁶, Manfred Kilimann⁷

¹Institute of Physiology, Medical University of Innsbruck, ²Institute for Auditory Neuroscience, University Medical Center Goettingen, ³University Medical Center Goettingen, ⁴Institute of Physiology and Pathophysiology, Philipps‐Universität Marburg, ⁵Molecular Architecture of Synapses Group, Institute for Auditory Neuroscience, InnerEarLab and Center for Biostructural Imaging of Neurodegeneration, University Medical Center, ⁶Medical University Innsbruck, Institute of Physiology, ⁷Max Planck Institute for Multidisciplinary Sciences

160. The Effect of TMC1 Deafness Mutations on Cochlear Hair Cell Loss

Runjia Cui^*1, Shaikh Emdadur Rahman², Angela Ballesteros³

¹National Institute on Deafness and Other Communication Disorders, ²NIDCD, NIH, ³NIDCD-NIH

161. Continuous and Concurrent Auditory TRFs Using Both EEG and MEG Reveal Processing Hierarchies During Natural Speech of Competing Speakers

Karl Lerud^*1, Charlie Fisher¹, Vrishab Commuri¹, Samira Anderson¹, Behtash Babadi¹, Stefanie Kuchinsky², Jonathan Simon¹

¹University of Maryland - College Park, ²Walter Reed National Military Medical Center

162. Developing RNA Editing Therapy for DFNA5 Hearing Disorder in hPSC-Derived Inner Ear Organoids

Wenliang Zhu^*1, Arun Prabhu Rameshbabu², Natalie Pelon², Karl Koehler³, Zheng-Yi Chen⁴

¹Mass Eye and Ear Infirmary, ²Eaton-Peabody Lab, Massachusetts Eye and Ear Infirmary, Harvard Medical School, ³Boston Children's Hospital/Harvard Medical School, ⁴Massachusetts Eye and Ear Infirmary

163. Chirped-Speech Reveals Connection Between Brainstem Encoding and Speech-in-Noise Perception

Kelsey Mankel^*1, May Chao², Alise Holloway², Jillian Dodson², Lauren Arnold²

¹University of Memphis, ²The University of Memphis

164. Evaluating the Effects of Levodopa on Vestibulo-Ocular Reflex in Parkinson's Disease: Preliminary Observations

Devin McCaslin^*1, Taylor Brown¹, Jaimie Barr¹, Stiven Roytman¹, Kevin Kerber², Giulia Carli¹, Nicolaas Bohnen¹

¹University of Michigan, ²The Ohio State University

165. Does Stereocilia Separation-To-Height Ratio Accurately Define the Geometric Gain?

Varun Goyal^*1, Karl Grosh¹

¹ University of Michigan

166. The L9’T Point Mutation in Alpha9 Nicotinic Acetylcholine Receptors Mitigates Concussion-Induced Vestibular Deficits in Mice

Raven Riley¹, Zelma Iriarte-Oporto¹, Bryan Rivers¹, Raymond Huang¹, Ian Mcneill¹, David Huang¹, Youguo Xu¹, Douglas E. Vetter¹, Kathleen T. Yee¹, Wu Zhou¹, Hong Zhu^*1

¹ University of Mississippi Medical Center

167. Assessment of Lateral Line Efferent Innervation and Rheotaxis Behavior in chrna9 Mutant Zebrafish

Keziah-Khue Nguyen^*1, Sophie Cohen-Bodenes¹, Kylie Schache¹, Lavinia Sheets¹

¹ Washington University School of Medicine

168. Testing of Auditory Reaction Time to Explore Value of Robotic Stop of Cochlear Implant Insertion

Naina Miranda¹, Jewel Chinnu Peter¹, Parker Reineke², Rachel Scheperle³, Constantinos Nikou^*2, Marlan Hansen³

¹University of Iowa, ²iotaMotion, Inc., ³University of Iowa Health Care

169. Localization of Piezo2 in Vestibular and Auditory End Organs in Mice

Tianwen Chen¹, John Lee², Zelma Guisela Iriarte¹, Caroline Sit¹, Kendra Stansak³, Kathleen T. Yee¹, Douglas E. Vetter¹, Brad Walters¹, Hong Zhu¹, Wu Zhou^*4

¹University of Mississippi Medical Center, Jackson, ²National Institute on Deafness and Other Communication Disorders, National Institutes of Health, ³Graduate Program in Neuroscience, University of Mississippi Medical Center, Jackson, ⁴University of Mississippi Medical Center

170. The Effects of Aging on Gravity Receptor Function in Gerbils

Prashant Pendyala^*1, Anthony Peng²

¹University of Colorado Denver, ²Department of Physiology and Biophysics, University of Colorado Denver

171. The Transfected Efficiency of Different AAVs in the Mouse Cochlea

Hong-Bo Zhao^*1, Xiaoling Lu¹, Yi-Ding Yu¹, Jin Chen¹, Li-Man Liu¹, Tian-Ying Zhai¹, Chun Liang¹

¹ Yale University Medical School

172. The Contribution of Vestibular Head Translation Cues to Postural Control

Kassia Love¹, Adam Goodworth², Dominic Young-Smith³, Faisal Karmali^*4

¹Massachusetts Eye and Ear, ²Westmont College, ³Harvard University, ⁴Harvard Medical School

173. Structure and Function of Cupulae, Accessory Structures of the Lateral Line Neuromasts and Ampullae of the Inner Ear

Emma Kenyon^*1, Ilaria Montano², Richard J. Goodyear², James Bull¹, Corné J. Kros², Guy P. Richardson²

¹Swansea University, ²University of Sussex

174. Unraveling the Paradox of Self-Voice Emotion: A Comparative Analysis

Hidekazu Nagamura^*1, Seita Tomioka¹, Kohta I. Kobayasi¹

¹ Doshisha University

175. Lack of MAP2 Cause Sensorineural Hearing Loss and Vestibular Dysfunction

Kazuki Shin'ya^*1, Tomohiro Miyasaka², Akihiro Harada³, Kobayasi Kohta¹

¹Doshisha University, ²Nihon University, ³Osaka University

176. The Influence of Speaker Facial Features on Audiovisual Speech Perception in Age-Related Hearing Loss

Patricia V. Aguiar^*1, Jennifer Preman¹, Brandon T. Paul¹

¹ Toronto Metropolitan University

177. The Attempt to Measure Vestibular Evoked Myogenic Potentials Using Amplitude-Modulated Sound Stimuli

Mizuho Aomi^*1, Toru Seo¹, Izumi Koizuka², Manabu Komori²

¹St. Marianna University Yokohama Seibu Hospital, ²St. Marianna University School of Medicine

178. Transcriptomic Analysis of Newly Regenerated Avian Auditory Hair Cells

Austin Huang^*1, Stefan Heller¹, Nesrine Benkafadar¹

¹ Stanford University School of Medicine

179. Stiffness Changes and Force Production of Outer Hair Cells During Mechanical Stimulation

Kuni Iwasa^*1

¹ National Institute on Deafness and Other Communication Disorders, National Institutes of Health

180. Sound Degradation Type Differentially Affects Neural Indicators of Cognitive Workload and Speech Tracking

Nathan Gagné^*1, Keelin Greenlaw¹, Emily Coffey¹

¹ Concordia University

181. A 3D Oculography Vor Tester Using Machine Learning

Chenkai Dai^*1, Matthew Smith², Ethan Soemantri², Adam Goldberg²

¹The University of Oklahoma, ²University of Oklahoma

182. Investigation on Inner Hair Cell Stereocilia Stimulation Mechanisms Through 3D Finite Element Model of the Mouse Organ of Corti

Yanli Wang¹, Sunil Puria^*2

¹Harvard Medical School, Massachusetts General Hospital, ²Harvard Medical School

183. Hair Cell Synaptic Dysfunction of Otof p.R1939Q Knock-In Mouse

Kwon Woo Kang^*1, Kyu-Hee Han², Yehree Kim³, JuAng Kim³, Min Young Kim³, Jin Hee Han³, Bong Jik Kim⁴, Byung Yoon Choi³, Eunyoung Yi¹

¹College of Pharmacy and Natural Medicine Research Institute, Mokpo National University, ²National Medical Center, ³Seoul National University Bundang Hospital, ⁴Chungnam National University Sejong Hospital

184. Molecular Identity of a Gating Spring

Thomas Effertz^*1, Philip Hehlert², Dirk Beutner³, Martin Göpfert²

¹University of Goettingen, ²Institute for Zoology and Anthropology, University of Goettingen, Goettingen, Germany, ³InnerEarLab, University of Goettingen

185. Speech-In-Noise Processing Across Age and Cognitive Function: A Preliminary Study

Jeewon Lee^*1, Hyunjun An², Yoonseob Lim¹

¹Korea Institute of Science and Technology, ²Hallym University

186. Auxiliary Subunit LRRC52 Regulates Bk Channel Function and Localization in Outer Hair Cells

Samuel Webb¹, Piece Yen¹, Maolei Xiao², Choongheon Lee³, Kevin K. Ohlemiller⁴, Joseph Holt³, Mark Rutherford², Stuart Johnson^*1

¹University of Sheffield, ²Washington University in St. Louis, ³University of Rochester, ⁴Washington University School of Medicine

187. Do Changes in Resting Mechanotransduction Current Impact the Cytoskeleton Actin Composition Within Stereocilia and Cuticular Plate of Auditory Hair Cells?

Juliana Castro Jimenez^*1, Sara Macias Palacio¹, A. Catalina Velez-Ortega¹, Juliana Castro Jimenez²

¹University of Kentucky, ²University of Kentucky, College of Medicine

188. Spatiotemporal Models to Investigate Population-Level Activity in the Vestibular Inner Ear

Olivia Lutz^*1, Hannah Martin², Christopher Luong², Marina Kabirova², Dana Silvian², Brent Doiron², Ruth Anne Eatock²

¹The University of Chicago, ²University of Chicago

189. Elastic Links Are Required for High Positive Correlations Between Inner-Hair-Cell Stereocilia

Riccardo Marrocchio^*1, Dáibhid Ó Maoiléidigh¹

¹ Stanford University

190. Evaluating the Loss of Esrrg on the Cochlear Ribbon Synapses

Shri Vidhya Seshadri^*1, Stuart L. Johnson², Walter Marcotti², Lisa S. Nolan¹

¹King's College London, ²University of Sheffield

191. Calcium Imaging of Mechanically Evoked Hair Cell and Afferent Population Activities in Mammalian Vestibular Inner Ear

Christopher Luong^*1, Marina Kabirova¹, Olivia Lutz¹, Dana Silvian¹, Ruth Anne Eatock¹

¹ University of Chicago

192. Fast Transmission between Vestibular Type I Hair Cells and Their Calyceal Afferents in Mice

Donatella Contini^*1

¹ University of Illinois at Chicago, School of Medicine. University of Chicago

193. The Role of MYO7A Isoforms in Tuning Hair Cell Function

Sihan Li^*1, Jinho Park², Andrew Mecca³, Giusy Caprara³, Natchanon Sittipongpittaya¹, Gloria Sheynkman¹, Edward Egelman¹, Anthony Peng³, Jonathan Bird², Jung-Bum Shin¹

¹University of Virginia, ²University of Florida, ³University of Colorado Anschutz Medical Campus

194. Auditory and Vestibular Consequences of High-Intensity Noise Exposure After Mild Traumatic Brain Injury

Federica M. Raciti^*1, Nadine Kerr², Suhrud Rajguru¹

¹University of Miami, ²Miami Project to cure paralysis, University of Miami

195. Stereocilia Elongation is Regulated by Formin-Dependent Organization of Ankle Links

Chun-Yu Tung¹, Xiayi Liao², Benjamin Perrin^*2

¹Indiana University Purdue University Indianapolis, ²Indiana University - Purdue University Indianapolis

196. Rapamycin Reduces Noise-Induced Vestibular Loss and Improves Walking Speed in Noise Exposed Rats

Marie Anderson¹, David Bauer¹, Ariane Kanicki¹, W. Michael King¹, Richard Altschuler¹, Courtney Stewart^*2

¹Kresge Hearing Research Institute, University of Michigan, ²VA Ann Arbor Healthcare System

197. Physical Exertion as an Index of Listening Effort in Older Individuals with Hearing Loss

Matthias Keller^*1, Carson Rumble-Tricker², Elizabeth Stewart¹, Kevin Seitz-Paquette¹, Mark Fenske², Gurjit Singh³

¹Sonova US Corporate Services, ²University of Guelph, ³Sonova Canada; University of Toronto; Toronto Metropolitan University

198. Post-Auricular Orientation of Auditory Attention in Sound Field Versus Virtual Sound Space

Melina Markotjohn^*1

¹ Dalhousie University Faculty of Medicine

199. Biomechanical Activation of the Utricle by Sound and Vibration in Mouse, Rat, Guinea pig, Toadfish, Sheep and Human

Richard Rabbitt^*1, Christopher Pastras², Suhrud Rajguru³, Hong Zhu⁴, Wu Zhou⁴

¹University of Utah, ²Macquarie University, ³University of Miami, ⁴University of Mississippi

MP3. Mini-Podium 3: Human Inner Ear Anatomy: Techniques

3:00 p.m. – 4:00 p.m.

Ocean Ballroom 5–8

Characterizing the Human Membranous Labyrinth Position Within the Lateral Semicircular Canal: A Histologic Analysis and Proposal for Pathology-Guided Classification

Koffi Lakpa^*1, Rafael da Costa Monsanto², Maurizio Falcioni³, Sabrina Huang¹, Gisselle Garcia¹, Yazeed Qahadad⁴, Andrew Fishman⁵, Józef Mierzwiński⁶, Arnaldo Rivera⁷, Sebahattin Cureoglu², Michael Puricelli⁴

¹University of Wisconsin School of Medicine and Public Health, ²University of Minnesota Otopathology Laboratory, ³Azienda Ospedaliero-Universitaria di Parma, ⁴Division of Otolaryngology-Head and Neck Surgery, University of Wisconsin School of Medicine and Public Health, Madison, ⁵University of Missouri, Columbia; ACIBADEM BelMedic Clinical Center., ⁶Children's Hospital of Bydgoszcz, Department of Otolaryngology, Audiology and Phoniatrics, Pediatric Auditory Implant Program; Nicolaus Copernicus University, Collegium Medicum. Department of Preventive Nursing., ⁷School of Medicine, Missouri University

Automatic Pre-Operative Scalae Segmentation and Quantification Using Synchrotron Radiation Phase-Contrast Imaging

Ashley Micuda^*1, Daniel Newsted¹, Sumit Agrawal¹, Hanif Ladak¹

¹ Western University

Multiplex Immunofluorescence Staining of Human Inner Ear Celloidin Embedded Sections

Ivan Lopez^*1, Achilles Kanaris², Gail Ishiyama³, Akira Ishiyama³

¹David Geffen School of Medicine at University of California, Los Angeles, ²David Geffen School of Medicine at UCLA, ³UCLA

Machine Learning Pipeline for Human Spiral Ganglion Neuron Quantification, Demonstrated on an Adult and Infant with Consecutive Serial Sections

Christopher Giardina^*1, Jennifer O'Malley², Anbuselvan Dharmarajan², M. Charles Liberman², Julie Arenberg³, Alicia Quesnel⁴

¹Harvard Medical School, ²Eaton-Peabody Laboratories, Mass Eye and Ear, Harvard Medical School, ³Massachusetts Eye and Ear Infirmary, Eaton-Peabody Laboratories, Harvard Medical School, ⁴Massachusetts Eye and Ear Infirmary, Harvard Medical School

MP4. Mini-Podium 4: Auditory Cortex: From Inhibitory Networks and Signal-In-Nose Detection to Categorization and Loudness Perception

3:00 p.m. – 4:00 p.m.

Ocean Ballroom 9–12

Recurrent Inhibitory Networks in Layer 1 of the Mouse Primary Auditory Cortex

Lucas Vattino^*1, Maryse E. Thomas², Cathryn MacGregor³, Christine Junhui Liu⁴, Carolyn G. Sweeney², Anne Takesian²

¹Eaton-Peabody Laboratories, Massachusetts Eye and Ear, Harvard Medical School, ²Eaton-Peabody Laboratories, Massachusetts Eye and Ear, Harvard Medical School, ³Eaton-Peabody Laboratories, Massachusetts Eye and Ear, ⁴Graduate Program in Speech and Hearing Bioscience and Technology, Harvard Medical School; Eaton-Peabody Laboratories, Massachusetts Eye and Ear

Enhancing Signal-In-Noise Detection by Learning-Induced Plasticity Mechanisms in the Auditory Cortex

Nilay Atesyakar^*1, Andrea Shang¹, Kasia Bieszczad¹

¹ Rutgers University

Cortical Determinants of Loudness Perception and Loudness Hyperacusis: Mechanisms to Treatments

Kameron Clayton^*1, Matthew McGill¹, Bshara Awwad¹, Kamryn Stecyk¹, Korey Sudana¹, Caroline Kremer¹, Desislava Skerleva¹, Divya Narayanan¹, Jennifer Zhu¹, Kenneth Hancock¹, Sharon Kujawa¹, Elliott Kozin¹, Daniel Polley¹

¹ Eaton-Peabody Laboratories, Massachusetts Eye and Ear

Neuronal Correlates Underlying Auditory Categorization and Bias in Mice

Anjali Sinha^*1, Jared Collina¹, Gozde Erdil¹, Maria Geffen¹

¹ University of Pennsylvania

SSY1. Special Symposium: Young Investigators from The Cross-Disciplinary Otitis Media Mentoring Network Towards Diversity (Commend): Bridging Gaps In Otitis Media Research

3:00 p.m. – 5:00 p.m.

Ocean Ballroom 1–4

Chair: Regie Lyn Santos-Cortez, University of Colorado Anschutz Medical Campus

Co-chair: Diego Preciado, Children's National Hospital and George Washington University School of Medicine

Co-chair: Allen F. Ryan, University of California, San Diego

The Role of Diet in Tympanostomy Tube Otorrhea

Kavita Dedhia^*1, Alyssa Tindall¹, Jillian Karpink¹, Ashley Williams¹, Terri Giordano¹, Virginia Stallings¹

¹ Children's Hospital of Philadelphia

Hearing Thresholds and Middle Ear Analysis of the A2ml1-Knockout Mouse Model

Matthew Hill^*1

¹ University of Colorado School of Medicine

Otitis Media: Single-Cell Transcriptomics and Microfluidic Disease Modeling

Arwa Kurabi^*1

¹ University of California, San Diego

Type I Interferon Signaling Enhances Streptococcus Pneumoniae Middle Ear Infection

Steven Shaw^*1, Gabriela Heslop¹, Sarah Gitomer¹, Sarah Clark¹

¹ University of Colorado School of Medicine

Role of Muc5b Overexpression in Middle Ear Pathology and Otitis Media Susceptibility

Helen Gomez^*1, David A. Schwartz², Ivana V. Yang¹, Arwa Kurabi³, Allen F. Ryan³, Regie Lyn P. Santos-Cortez¹

¹University of Colorado Anschutz Medical Campus, ²School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, ³Division of Otolaryngology, San Diego School of Medicine and Veterans Affairs Medical Center, University of California, La Jolla

Exploring Bacterial Dark Matter: The Function of Virulence-Associated Accessory Genes in Chronic Haemophilus Influenzae Infections

Mary Marino^*1, Evangeline Williams¹, Jocelyn Hammond¹, Karan Bamb¹, Armoni Mayes¹, Kalisse Horne¹, Bhaswati Sen¹, Danielle Piazza¹, Laura Anastor-Walters¹, Ben Janto¹, Donald Hall¹, Garth Ehrlich¹, Joshua Mell¹

¹ Drexel University College of Medicine

Pan-Transcriptomic Analysis of Diverse Clinical Haemophilus Influenzae Isolates During Biofilm Development

Evangeline Williams^*1, Karan Bamb¹, Ari Gordon¹, Rachel Ehrlich¹, Jocelyn Hammond¹, Bhaswati Sen¹, Azad Ahmed¹, Garth Ehrlich¹, Ravinder Kaur², Michael Pichichero², Joshua Mell¹

¹Drexel University College of Medicine, ²2.Rochester General Hospital Research Institute

Cold Microplasma Exposure as a Novel Therapeutic Treatment for Bacterial Acute Otitis Media Demonstrated in a Small Animal Model

Guillermo Monroy^*1, Zhenglun Wu², Eric J Chaney¹, Darold R Spillman³, Michael B Jamrozy⁴, Kavita Desai Kabelitz², Andrey Mironov⁴, Alexander Ho⁵, Gang Xiao⁶, Edita Aksamitiene¹, Marina Marjanovic⁷, Daniel A Llano⁶, Helen Nguyen⁸, J. Gary Eden⁴, Stephen A Boppart⁹

¹Beckman Institute for Advanced Science and Technology, ²Laboratory for Optical Physics and Engineering, ³Beckman Institute for Advanced Science and Technology, NIH/NIBIB P41 Center for Label-free Imaging and Multiscale Biophotonics (CLIMB), ⁴Laboratory for Optical Physics and Engineering, Dept. Electrical and Computer Engineering, ⁵Beckman Institute for Advanced Science and Technology, Dept. Bioengineering, ⁶Beckman Institute for Advanced Science and Technology, ⁷Beckman Institute for Advanced Science and Technology, NIH/NIBIB P41 Center for Label-free Imaging and Multiscale Biophotonics (CLIMB),, ⁸Dept. Civil and Environmental Engineering, ⁹Beckman Institute for Advanced Science and Technology, NIH/NIBIB P41 Center for Label-free Imaging and Multiscale Biophotonics (CLIMB), Dept. Bioengineering, Carle Illinois College of Medicine

MP5. Mini-Podium 5: Innovative Approaches to Hearing Preservation: From Gene Therapy to Light-Based Therapies

4:15 p.m. – 5:15 p.m.

Ocean Ballroom 5–8

An Antioxidative Gene Therapy for the Prevention of Noise Induced Hearing Loss

Shrivaishnavi Chandrasekar^*1, Damian Gulbin-Murphy¹, Todd Mowery¹

¹ Rutgers University

Maintain Genomic Stability Could Prevent Calcium Imbalance Induced Hair Cell Degeneration

Ruijie Cai^*1, Hongchao Liu², Yunge Gao³, Xiaotong Ma⁴, huihui liu⁵, Hao Wu⁶

¹Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, ²Shanghai Jiaotong University, ³Shanghai Jiao Tong University, School of Medicine, ⁴Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ⁵Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ⁶Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine; Ear Institute, Shanghai Jiao Tong University School of Medicine; Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases

Apparent Recovery Masks Progressive Deterioration of Cochlear Calcium Homeostasis Induced by Loud Low-Frequency Sound

Wajiha Zaidi^*1, Anders Fridberger¹

¹ Linköping University

Photobiomodulation as a Non-Invasive Thermal Therapy for Hearing Preservation

Jeremy Ryan^*1, Fateme Esmailie¹

¹ University of North Texas

MP6. Mini-Podium 6: Auditory Midbrain: Structure and Function

4:15 p.m. – 5:15 p.m.

Ocean Ballroom 9–12

Differences in Short-Term Synaptic Plasticity at Cochlear Nucleus Synapses onto Two Classes of Inferior Colliculus Neurons

Yoani Herrera^*1, Michael Roberts¹

¹ University of Michigan

Neural Cues in the Budgerigar Inferior Colliculus for Behavioral Detection of Transient and Sustained Tones in Noise

Yingxuan Wang^*1, Margaret R. Youngman², Kristina S. Abrams², Kenneth S. Henry²

¹University of Rochester, ²University of Rochester Medical Center

Auditory Feature Discrimination in a Rat Model of Fragile X Syndrome

David Gauthier^*1, Noelle James², Benjamin Auerbach²

¹University of Illinois Urbana-Champaign, ²University of Illinois at Urbana-Champaign

Auditory and Tactile Processing in the Mouse Inferior Colliculus

Blom Kraakman^*1, Aaron Wong²

¹Erasmus Medical Center, ²Erasmus MC, Rotterdam, Netherlands

H1. Honoring The Contributions of Dr. Brenda Lonsbury-Martin to Physiological Measures of Auditory Function

5:15 p.m. – 7:15 p.m.

Ocean Ballroom 1–4

Chair: Laura Dreisbach, San Diego State University

Co-chair: Gayla Poling, National Institute on Deafness and Other Communication Disorders

Co-chair: Jonathan Siegel, Northwestern University

Forty Years of Otoacoustic Emissions Research in the Lonsbury-Martin and Martin Laboratory: From Mysterious Origins to Widespread Adoption to the Implications of Recent Cochlear Mechanics Discoveries

Barden Stagner^*1, Glen Martin², Brenda Lonsbury-Martin²

¹VA Loma Linda Healthcare System, ²VA Loma Linda Healthcare System, Loma Linda University Health

Brenda Lonsbury-Martin: Early Milestones in a Distinguished Career

Hongzhe Li^*1

¹ VA Loma Linda Healthcare System

An Intracochlear Look at the Generation of Low-Frequency Distortion Product Otoacoustic Emissions

Wei Dong^*1, Glen K. Martin¹

¹ VA Loma Linda Healthcare System

Multiple Mechanisms, Distributed Sources, and Wave Interference: Toward an Understanding of What Shapes Distortion-Product Otoacoustic Emissions

James Dewey^*1

¹ University of Southern California

SC1. ARO Short Course: Short Course Focused on the Use of Artificial Intelligence for Otolaryngology Research

5:15 p.m. – 7:15 p.m.

Ocean Ballroom 5–8

Chair: Brandon Cox, Southern Illinois University School of Medicine

Co-chair: Jeffrey Holt, Harvard Medical School / Boston Children\'s Hospital

Deep Dreaming of Hearing Proteins – Everything You Wanted to Know but Were Afraid to Ask about Protein Structure Prediction with Alphafold

Marcos Sotomayor, University of Chicago

Novel Deep Learning-Based Tools for Inner Ear Research

Uri Manor, University of California, San Diego

Novel Deep Learning-Based Tools for Inner Ear Research

Yasmin Kassim, Post-doc

Towards a Clinically Viable Speech Neuroprosthesis

Alexander Silva

Wednesday, February 26, 2025

P17. Podium Session 17: Multisensory Interactions

8:00 a.m. – 10:00 a.m.

Ocean Ballroom 1–4

Subcortical Responses to Continuous Speech under Crossmodal Divided Attention

Zilong Xie^*1

¹ Florida State University

Neural Signatures of Emerging Audio-Motor Mappings

Haiqin Zhang^*1, Giorgia Cantisani¹, Shihab A Shamma²

¹École Normale Supérieure, ²University of Maryland; École Normale Supérieure

Can Audiovisual Integration Training Improve Speech Understanding in Noise for Adults with Cochlear Implants?

Ansley Kunnath^*1, René Gifford², Mark Wallace³

¹Vanderbilt University School of Medicine, ²Vanderbilt University Medical Center, ³Vanderbilt University

Audiovisual Speech-Evoked Oscillatory Dynamics in Younger and Older Adults

James Dias^*1, Carolyn McClaskey¹, Kelly Harris¹

¹ Medical University of South Carolina

Sensory Motor Decoding from Violin Playing

Rupesh Chillale^*1, Seong Jong Yoo², Cornelia Fermüller², Shihab Shamma³

¹Institute for System Research, University of Maryland, ²University of Maryland - College Park, ³Institute for System Research, University of Maryland, College Park

Audiovisual Integration in Cochlear Implant Users: A Functional Near-Infrared Spectroscopy (fNIRS) Study Comparing Visual Cues in Speech Perception

Yi Yuan^*1, Yingying Wang², Bailey Javidi³, Christopher Mueller³, Shuman He³

¹San José State University, ²University of Nebraska-Lincoln, ³The Ohio State University

Do “Intuitive” Auditory Cues Facilitate Performance of a Reaching Task? Investigating Shared Features of Auditory and Motor Dynamics

Bruno Mesquita^*1, Mehrdad Kashefi², Rahul Vij², Ingrid Johnsrude²

¹Western University, ²Brain and Mind, Western University

Multisensory Integration in the Zebrafish Brain: Hearing Loss Affects the Bimodal Audio–Visual Interactions in the Tectum

Peng Sun^*1, Teresa Nicolson¹

¹ Stanford University School of Medicine

P18. Podium Session 18: Emerging Gene Therapies for Hearing and Balance Disorders

8:00 a.m. – 10:00 a.m.

Ocean Ballroom 5–8

PAM-Flexible Adenine Base Editing to Rescue Hearing Loss in a Humanized MPZL2 Mouse Model Harboring East Asian Founder Mutation

Sang-Yeon Lee^*1, Sohyang Jung², Won Hoon Choi², Luoying Jiang³, Shao Wei Hu³, Yilai Shu³

¹Seoul National University College of Medicine, ²Seoul National University Hospital, ³ENT Institute, Eye and ENT Hospital, Fudan University, Shanghai

AAVR Expression is Essential for AAV Vector Transduction in Sensory Hair Cells

Fan Wu^*1, Guisheng Chen², Rui Hu², Yiqing Zheng², Suhua Sha¹

¹Medical University of South Carolina, ²Sun Yat-sen Memorial Hospital

Novel Antisense Therapy to Durably Treat USH2A Patients

Stephanie Mauriac^*1, Yu-Han Huang¹, Jiahe Jin¹, Sydney O'Malley¹, Carl Nist-Lund², Jiyoon Lee³, Jennifer B Phillips⁴, Jeremy Wegner⁴, Monte Westerfield⁴, Karl Koehler³, Timothy Yu¹, Gwenaelle Geleoc¹

¹Boston Children's Hospital, Harvard Medical School, ²Harvard Medical School/Boston Children's Hospital, ³Boston Children's Hospital/Harvard Medical School, ⁴Institute of Neuroscience, University of Oregon

AAV-mediated Yap Inhibition for Treatment of Vestibular Schwannoma

Kevin Biju^*1, Juan Llamas², Yeeun Kim², Dorothy W. Pan³, Seiji B. Shibata³, Joni K. Doherty³, John S. Oghalai³, Ksenia Gnedeva²

¹University of Southern California, Caruso, ²Keck School of Medicine University of Southern California, ³USC Caruso - Head and Neck Surgery

Gene Therapy Versus Cochlear Implantation in Restoring Hearing Function and Speech Perception for Deafness Individuals

Xiaoting Cheng^*1

¹ Eye and ENT Hospital, Fudan University

Neutralizing Anti-AAV Antibodies in Blood and CSF: Lessons Learned for the Inner Ear

Paul Krumpoeck^*1, Kleopatra Rapti², Ellen Wiedtke², Erdem Yildiz¹, Aldine Tu¹, Christian Matula¹, Christoph Arnoldner¹, Dirk Grimm², Lukas Landegger¹

¹Vienna General Hospital, Medical University of Vienna, ²Section Viral Vector Technologies, Medical Faculty, University of Heidelberg, BioQuant

A Base Editor for the Long-Term Restoration of Auditory Function in Mice With Recessive Profound Deafness

Chong Cui^*1, Shengyi Wang¹, Daqi Wang¹, Jingjing Zhao¹, Bowei Huang¹, Biyun Zhu¹, Yuxin Chen¹, Honghai Tang¹, Yu Han¹, Cheng Ye¹, Dan Mu¹, Chengdong Zhang², Yuan Yang², Yihan Bao³, Jun Lv¹, Shuang Han¹, Geng-Lin Li¹, Huawei Li¹, Yilai Shu¹

¹Eye and ENT Hospital of Fudan University, ²State Key Laboratory of Oncogenes and Related Genes, Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of Medicine, ³Huashan Hospital, Fudan University

Lentiviral Gene Therapy Can Effectively Address Recessive Hearing and Balance Disorders

Antonio Bon-Nieves¹, Peixin Huang², Felix Warnecke³, Julianne Schott³, Michael Morgan³, Athanasia Warnecke³, Axel Schambach³, Hinrich Staecker^*2

¹University of Puerto Rico School of Medicine, ²University of Kansas Medical Center, ³Hannover Medical School

P19. Podium Session 19: Psychoacoustics: From Acoustic Startle to Auditory Attention

8:00 a.m. – 10:00 a.m.

Ocean Ballroom 9–12

How Working Memory Capacity and Cognitive Load Influence Spoken Word Processing: Evidence From Eye-Tracking and Pupillometry

Gal Nitsan^*1, Boaz M. Ben-David², Karen Banai¹

¹University of Haifa, ²Reichman University (IDC) Herzliya

Electroacoustic Pitch Matching in Cochlear Implant Users with Single-Sided Deafness

Maya Hatley^*1, Rene Gifford², Artur Lorens³, Jonathan Neukam², Annette Lavender¹, Nicole Capach¹, Elad Sagi¹, Ariel Hight¹, Mahan Azadpour¹, Mario Svirsky¹

¹New York University Grossman School of Medicine, ²Vanderbilt University Medical Center, ³Institute of Physiology and Pathology of Hearing

Auditory Attention Decoding for Selective Hearing: Bridging Metrics and User Experience

Vishal Choudhari^*1, Kiki Van der Heijden², Xiaomin He¹, Nima Mesgarani¹

¹Columbia University, ²Radboud University

Measuring and Modeling Multi-Source Environmental Sound Recognition

Sagarika Alavilli^*1, Josh McDermott²

¹Harvard University, ²MIT

Pupil-linked Arousal Tracks Adaptive Auditory Belief Updating in Spatially and Temporally Dynamic Environments

Roman Fleischmann^*1, David Meijer², Ulrich Pomper³, Michelle Spierings³, Robert Baumgartner²

¹Austrian Academy of Sciences, Acoustics Research Institute, ²Austrian Academy of Sciences, Acoustics Research Institute, Vienna, ³University of Vienna

Hidden in Plain Sight: Facial Signatures of Auditory Cognition and Hearing Disorders

Samuel Smith^*1, Jenna Sugai¹, Daniel Polley¹

¹ Eaton-Peabody Laboratories, Massachusetts Eye and Ear

Development of Gap Detection During Adolescence

Julia Huyck^*1, Lauren Cammenga², Allison Steinbrenner¹, Preston Wise¹, Serena Sereki¹, Jordin Benedict¹

¹Kent State University, ²Northeast Ohio Medical University

Acoustic Startle, TTS, and Tinnitus Decrease Sound Localization and Speech-In-Noise Performance

Nathaniel Greene^*1, Carol Sammeth¹, Nick Brunstad², Greg Rule², Ted Argo²

¹University of Colorado Anschutz Medical Campus, ²Applied Research Associates, Inc.

P20. Podium Session 20: Frontiers In Auditory Prostheses

10:30 a.m. – 12:30 p.m.

Ocean Ballroom 1–4

A Stable and Broad Frequency-Selective Cochlear Nucleus Implant Using Penetrating Ultra-Flexible Electrode Arrays

Hao Wu^*1, Jinxi Pan², Bodi Liu², Zeyu Wang³, Guangyuan Chen³, Chengyao Wang³, Huan Jia², Zhaoyan Wang², Chi Ren³, Zhengtuo Zhao³

¹Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, ²Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine; Ear Institute, Shanghai Jiao Tong University School of Medicine; Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, ³Institute of Neuroscience, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences

A Computational Model of the Electrically or Acoustically Evoked Compound Action Potential and Electrocochleography in Cochlear Implant Users with Residual Hearing

Waldo Nogueira^*1, Yixuan Zhang², Daniel Kipping²

¹Medical University of Hannover, ²Hannover Medical School (MHH)

Audio Recordings with a Fully-Implanted Microphone for Cochlear Implants

Emma Wawrzynek^*1, John Zhang², Ioannis Kymissis³, Elizabeth Olson³, Jeffrey Lang², Hideko Heidi Nakajima⁴

¹Massachusetts Institute of Technology, ²MIT, ³Columbia University, ⁴Harvard Medical School, Mass. Eye and Ear Infirmary

Cochlear Implantation Outcomes in Genotyped Subjects with Sensorineural Hearing Loss

Cris Lanting^*1, Mirthe Fehrman², Wendy Huinck², Emmanuel Mylanus², Helger Yntema², Lonneke Haer-Wigman², Hannie Kremer², Ronald Pennings²

¹Radboud University Medical Center, ²Radboud University Medical Center, Nijmegen, the Netherlands

Four-Dimensional Computed Tomography of Cochlear Implantation: A Synchrotron-Based Feasibility Study

Seyed Alireza Rohani^*1, Franziska Niemann², Ashley Micuda¹, Ning Zhu³, Sergey Gasilov³, Masoud Zoka Assadi², Sumit K. Agrawal¹, Hanif M. Ladak¹

¹Western University, ²MED-EL, ³Canadian Light Source Inc.

“First in Man” Optoacoustic Stimulation of the Peripheral Hearing Organ

Sebastian Langguth¹, Nina-Marie Burmeister¹, Aaron Urschel¹, Larissa Schatteburg¹, Svenja Meurer¹, Mircea Teodorescu¹, Christian Hochbruck¹, Bernhard Schick¹, Gentiana Wenzel^*2

¹Saarland University, ²Saarland University Medical Center

Auditory Nerve Penetrating Electrode Device Stability and Nerve Function following Chronic Implantation

Holly Holman^*1, Joseph Crew², W. Mitchel Thomas³, Richard Gurgel³, Inderbir Sondh⁴, Meredith Adams⁵, Moritz Leber², Florian Solzbacher⁶, Hubert Lim⁷, Loren Rieth⁸, David J. Warren³

¹University of Utah, ²Blackrock Neurotech, ³University of Utah, ⁴University of Minnesota - Biomedical Engineering, ⁵University of Minnesota, ⁶University of Utah, Blackrock Neurotech, ⁷University of Minnesota - Otolaryngology and Biomedical Engineering, ⁸West Virginia University - Mechanical and Aerospace Engineering

Cochlear Implants with Dexamethasone-Eluting Electrode Arrays Reduce Foreign Body Response in a Murine Model of Cochlear Implantation and Human Subjects

Muhammad Rahman^*1, Brian Mostaert², Peter Eckard², Shakila Mahmuda Fatima², Rachel Scheperle², Md Ibrahim Razu², Bryce Hunger², Rafal Olszewski³, Shoujun Gu³, Cristina Garcia², Nashwaan Ali Khan², Douglas M Bennion², Jacob Oleson⁴, Ya Lang Enke⁴, Jonathon Kirk4², Robert Gay4², Robert Morell⁵, Keiko Hirose⁶, Michael Hoa³, Alexander Claussen², Marlan Hansen²

¹The University of Iowa, ²The University of Iowa, ³Auditory Development and Restoration Program, Neurotology Branch, National Institute on Deafness and Other Communication Disorders, ⁴Cochlear Limited, Sydney, ⁵Genomics and Computational Biology Core, National Institutes on Deafness and Other Communication Disorders, ⁶Washington University School of Medicine

P21. Podium Session 21: Transcription, Metabolomic, And Cellular Dynamics in Inner Ear Development: Mice and Human Organoids

10:30 a.m. – 12:30 p.m.

Ocean Ballroom 5–8

Single Cell Profiling of the Developing Utricle Reveals Transcriptional Diversity of Hair Cells

Beatrice Mao^*1, Matthew Kelley²

¹National Institute on Deafness and Other Communication Disorders, National Institute of Health, ²NIH/NIDCD

Coordinated Regulation of Immature and Mature Hair Cell Genes in Thyroid Hormone-Treated Human Cochlear Organoids

Tsubasa Saeki^*1, Yoshitomo Ueda¹, Stephen Moore¹, Eri Hashino¹

¹ Indiana University School of Medicine

Constraint-Based Modelling and Functional Imaging Reveal that Metabolic Reprogramming Drives Tonotopic Development in the Murine Organ of Corti

James O'Sullivan^*1, Claire Scott¹, Daniel J. Jagger², Anwen Bullen², Zoe Mann¹

¹King's College London, ²UCL Ear Institute

Everted Inner Ear Organoids: Generating Surface Hair Cell Sensory Epithelia to Better Investigate Human Development and Disease

Carl Nist-Lund^*1, Camila Perea², Jiahe Jin², Jingyuan Zhang², Qianyi Ma³, Wouter van der Valk⁴, Matthew Steinhart⁵, Jiyoon Lee², Karl Koehler²

¹Boston Children's Hospital, Harvard Medical School, ²Boston Children's Hospital/Harvard Medical School, ³Boston Children's Hospital, ⁴Leiden University Medical Center, ⁵Indiana University

Investigating the Molecular Properties of the Stria Vascularis

Matsya Thulasiram^*1, Ryosuke Yamamoto², Rafal Olszewski³, Shoujun Gu³, Robert Morell⁴, Michael Hoa⁵, Alain Dabdoub⁶

¹University of Toronto, ²Biological Sciences, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, ³Auditory Development and Restoration Program, NIDCD Otolaryngology-Surgeon-Scientist Program, NIDCD, ⁴NIDCD/NIDCR Genomics and Computational Biology Core, National Institutes of Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, ⁵Auditory Development and Restoration Program, NIDCD Otolaryngology-Surgeon-Scientist Program, NIDCD; Georgetown University School of Medicine, ⁶Biological Sciences, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto; Auditory Development and Restoration Program, NIDCD Otolaryngology-Surgeon-Scientist Program, NIDCD; University of Toronto

Vestibular Ganglion Neuron Organization and Peripheral Targeting Are Regulated by Their Birthdates

Zachary Stoner^*1, Doris Wu²

¹National Institute on Deafness and other Communication Disorders, ²NIDCD

Targeted Cell Interconversions Reveal Inner Hair Cell Induction of Supporting Cell Identity and Distribution in the Organ of Corti

Ignacio Garcia-Gomez^*1, Jemma L. Webber², Berta Soria-Izquierdo¹, John C. Clancy¹, Yingjie Zhou¹, Trevor D.M. Harriman¹, Charles P. Murphey¹, Anne Duggan¹, Mary Ann Cheatham¹, Jaime García-Añoveros¹

¹Northwestern University, ²Northwestern University and Creighton University

Progenitor Cell Dynamics in mESC-Derived Inner Ear Organoids: Insights from Single-Cell RNA Sequencing

Jiayi Wu¹, Stefan Heller¹, Maggie Matern^*1

¹ Stanford University School of Medicine

P22. Podium Session 22: Brainstem: Structure and Function

10:30 a.m. – 12:30 p.m.

Ocean Ballroom 9–12

Gene Expression Changes in the Inferior Colliculus after Sound Exposure

Suryaveer Kapoor¹, John Zhou², Marmar Moussa¹, Alice Burghard^*3

¹University of Oklahoma, ²Yale University, ³University of Connecticut Health Center

In Utero Exposure to Valproic Acid Abolishes the MNTB Projection to the Medial Geniculate

Yusra Mansour¹, Randy Kulesza^*2

¹Henry Ford Health System and Lake Erie College of Osteopathic Medicine, ²Lake Erie College of Osteopathic Medicine

Noise-Induced Hearing Loss Enhances Ca2+-Dependent Spontaneous Bursting Activity in Lateral Cochlear Efferents

Hui Hong^*1, Laurence O. Trussell²

¹Oregon Health and Science University, ²Oregon Health and Science University, Oregon Hearing Research Center

Origins of the Auditory Brainstem Response (ABR) in Mice: Source Localization with Multichannel Topographic EEG

Xue Wang¹, Andrej Kral¹, Rüdiger Land^*2

¹Institute of Audioneurotechnology, Hannover Medical Schoo, ²Hannover Medical School

Rapid, Accurate Prediction of Hearing Thresholds Using the Parallel Auditory Brainstem Response (pABR) in Adults with Hearing Loss

Melissa Polonenko^*1, Isabel Herb¹, Ross Maddox²

¹University of Minnesota, ²University of Michigan

SK Channel Dysfunction Underlies Excessive Neurotransmission in Fragile X Syndrome Mouse

Tianhao Wu¹, Tianyi Xiao¹, Youad Darwish¹, Hai Huang^*1

¹ Tulane University

Tonotopically Patterned Expression of HCN Channels Contributes to the Precision of Temporal Encoding in Cochlear Nucleus Neurons

Kwame Owusu-Nyantakyi^*1, Lashaka Hamlette¹, Stefan Oline¹, Sonia Weimann¹, R. Michael Burger¹

¹ Lehigh University

DNLL Neurons Improve on Poor MSO IPD-Tuning at Very Low Frequencies through an Iceberg Effect

Philip Joris^*1, Philip Smith²

¹Katholieke Universiteit Leuven, ²Dept. of Neuroscience