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. 1997 Apr;72(4):1582–1594. doi: 10.1016/S0006-3495(97)78805-2

Collective binding properties of receptor arrays.

N Agmon 1, A L Edelstein 1
PMCID: PMC1184353  PMID: 9083663

Abstract

Binding kinetics of receptor arrays can differ dramatically from that of the isolated receptor. We simulate synaptic transmission using a microscopically accurate Brownian dynamics routine. We study the factors governing the rise and decay of the activation probability as a function of the number of transmitter molecules released. Using a realistic receptor array geometry, the simulation reproduces the time course of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor-mediated excitatory postsynaptic currents. A consistent interpretation of experimentally observed synaptic currents in terms of rebinding and spatial correlations is discussed.

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Selected References

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