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. 1969 Sep;114(2):289–298. doi: 10.1042/bj1140289

A comparative study of the effect of aflatoxin B1 and actinomycin D on HeLa cells

E H Harley 1,2, K R Rees 1,2, A Cohen 1,2
PMCID: PMC1184854  PMID: 4897460

Abstract

1. The cytotoxic effects of aflatoxin B1 on HeLa cells were examined and effects of short exposures of the cells to the toxin were found to be reversible. 2. Aflatoxin B1 inhibited the synthesis of both ribosomal and heterodisperse RNA. It is proposed that the toxin's mechanism of action on ribosomal RNA synthesis is related to its inhibitory effect on the maturation of the 45s-ribosomal-RNA precursor. 3. Protein synthesis is inhibited to a greater extent by aflatoxin B1 than by actinomycin D. In contrast with actinomycin D, aflatoxin B1 was shown to disaggregate polyribosomes directly.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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