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. 1969 Sep;114(3):547–556. doi: 10.1042/bj1140547

The interpretation of kinetic data for enzyme-catalysed reactions involving three substrates

K Dalziel 1
PMCID: PMC1184927  PMID: 5820641

Abstract

The analysis and interpretation of initial-rate data for reactions involving three substrates, obtained in suitably designed experiments, are discussed. Possible mechanisms for such reactions are classified, the rate equations are compared and the extent to which they can be distinguished experimentally is considered.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BERG P. Acyl adenylates; an enzymatic mechanism of acetate activation. J Biol Chem. 1956 Oct;222(2):991–1013. [PubMed] [Google Scholar]
  2. CLELAND W. W. The kinetics of enzyme-catalyzed reactions with two or more substrates or products. I. Nomenclature and rate equations. Biochim Biophys Acta. 1963 Jan 8;67:104–137. doi: 10.1016/0006-3002(63)91800-6. [DOI] [PubMed] [Google Scholar]
  3. DALZIEL K. Kinetic studies of liver alcohol dehydrogenase. Biochem J. 1962 Aug;84:244–254. doi: 10.1042/bj0840244. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Dalziel K., Dickinson F. M. The kinetics and mechanism of liver alcohol dehydrogenase with primary and secondary alcohols as substrates. Biochem J. 1966 Jul;100(1):34–46. doi: 10.1042/bj1000034. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. FRIEDEN C. Glutamic dehydrogenase. III. The order of substrate addition in the enzymatic reaction. J Biol Chem. 1959 Nov;234:2891–2896. [PubMed] [Google Scholar]
  6. JAENICKE L., BRODE E. [Research on monocarbon compounds. I. The tetrahydrofolate formylase from pigeon liver. Purification and mechanism]. Biochem Z. 1961;334:108–132. [PubMed] [Google Scholar]
  7. KAUFMAN S. Studies on the mechanism of the reaction catalyzed by the phosphorylating enzyme. J Biol Chem. 1955 Sep;216(1):153–164. [PubMed] [Google Scholar]
  8. KAZIRO Y., OCHOA S. THE METABOLISM OF PROPIONIC ACID. Adv Enzymol Relat Areas Mol Biol. 1964;26:283–378. doi: 10.1002/9780470122716.ch7. [DOI] [PubMed] [Google Scholar]
  9. SILVERSTEIN E., BOYER P. D. EQUILIBRIUM REACTION RATES AND THE MECHANISMS OF LIVER AND YEAST ALCOHOL DEHYDROGENASE. J Biol Chem. 1964 Nov;239:3908–3914. [PubMed] [Google Scholar]

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