Abstract
Crystalline gallium mycobactin P and chromic mycobactin P have been prepared. The chromic compound, unlike other metallic complexes of mycobactin P, does not detectably exchange its metal with ferric iron; it competitively antagonizes the growth-promoting action of mycobactin P towards Mycobacterium johnei. Mycobactin P, desferrioxamine B and desferrichrysin form coloured 1:1 complexes with ammonium vanadate. The vanadyl complexes of the water-soluble desferrisideramines are formed in aqueous solution. Two distinct forms occur at pH7 and pH3; these are slowly interconvertible when the pH is changed. The complexes show other changes at lower pH values; unlike other metallic desferrisideramine complexes, the vanadyl compounds do not dissociate even in the strongest acids, but dissociate above pH9. Their properties have been studied spectrophotometrically, by electrophoresis and by electrometric titration. The affinity of mycobactin for ferric iron is greater than that of desferrioxamine B under two different conditions of measurement.
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- BICKEL H., GAEUMANN E., KELLER-SCHIERLEIN W., PRELOG V., VISCHER E., WETTSTEIN A., ZAEHNER H. [On iron-containing growth factors, sideramines, and their antagonists, the iron-containing antibiotics, sideromycins]. Experientia. 1960 Apr 15;16:129–133. doi: 10.1007/BF02157712. [DOI] [PubMed] [Google Scholar]
- BURNHAM B. F. Bacterial iron metabolism: investigations on the mechanism of ferrichrome function. Arch Biochem Biophys. 1962 May;97:329–335. doi: 10.1016/0003-9861(62)90085-1. [DOI] [PubMed] [Google Scholar]
- BURNHAN B. F. INVESTIGATIONS ON THE ACTION OF THE IRON-CONTAINING GROWTH FACTORS, SIDERAMINES; AND IRON-CONTAINING ANTIBIOTICS, SIDEROMYCINS. J Gen Microbiol. 1963 Jul;32:117–121. doi: 10.1099/00221287-32-1-117. [DOI] [PubMed] [Google Scholar]
- FRANCIS J., MACTURK H. M., MADINAVEITIA J., SNOW G. A. Mycobactin, a growth factor for Mycobacterium johnei. I. Isolation from Mycobacterium phlei. Biochem J. 1953 Nov;55(4):596–607. doi: 10.1042/bj0550596. [DOI] [PMC free article] [PubMed] [Google Scholar]
- NEILANDS J. B. An assay method for ferrichrome. J Biol Chem. 1953 Dec;205(2):643–646. [PubMed] [Google Scholar]
- NEILANDS J. B. Some aspects of microbial iron metabolism. Bacteriol Rev. 1957 Jun;21(2):101–111. doi: 10.1128/br.21.2.101-111.1957. [DOI] [PMC free article] [PubMed] [Google Scholar]
- SNOW G. A. THE STRUCTURE OF MYCOBACTIN P, A GROWTH FACTOR FOR MYCOBACTERIUM JOHNEI, AND THE SIGNIFICANCE OF ITS IRON COMPLEX. Biochem J. 1965 Jan;94:160–165. doi: 10.1042/bj0940160. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wheather D. W., Snow G. A. Assay of the mycobactins by measurement of the growth of Mycobacterium johnei. Biochem J. 1966 Jul;100(1):47–49. doi: 10.1042/bj1000047. [DOI] [PMC free article] [PubMed] [Google Scholar]
- White A. J., Snow G. A. Isolation of mycobactinss from various mycobacteria. The properties of mycobactin S and H. Biochem J. 1969 Mar;111(5):785–792. doi: 10.1042/bj1110785. [DOI] [PMC free article] [PubMed] [Google Scholar]
- White A. J., Snow G. A. Methods for the separation and identification of mycobactins from various species of mycobacteria. Biochem J. 1968 Jul;108(4):593–597. doi: 10.1042/bj1080593. [DOI] [PMC free article] [PubMed] [Google Scholar]