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. 1969 Nov;115(3):597–601. doi: 10.1042/bj1150597

The regulation of l-asparaginase activity in rats and mice. Effects of normal and malignant growth, of sex and of dietary changes

E Bonetti 1, Ada Abbondanza 1, E Della Corte 1, F Stirpe 1
PMCID: PMC1185143  PMID: 4311065

Abstract

1. The activity of l-asparaginase was very low in the liver of newborn rats and mice, and increased within a few days of birth. 2. In rats, but not in mice, the enzyme activity was higher in females than in males, was enhanced by administration of oestradiol, and was decreased by gonadectomy. 3. The enzyme activity decreased in mice starved or fed on a low-protein diet; in rats it was enhanced by starvation, by feeding them on a high-protein diet, or by administration of l-asparagine. 4. The asparaginase activity was decreased in regenerating liver, and was almost absent in the Morris hepatoma 5123.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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