Skip to main content
Biochemical Journal logoLink to Biochemical Journal
. 1969 Dec;115(4):831–836. doi: 10.1042/bj1150831

Studies on flavonoid metabolism. Metabolism of (+)-[14C]catechin in the rat and guinea pig

N P Das 1,*, L A Griffiths 1
PMCID: PMC1185212  PMID: 5357023

Abstract

1. The fate of (+)-[U-14C]catechin and (+)-[ring A-14C]catechin has been studied in the guinea pig and rat. 2. (+)-[U-14C]Catechin was shown to give rise to labelled phenolic acids, labelled phenyl-γ-valerolactones and 14CO2. 3. (+)-[ring A-14C]-Catechin did not give rise to labelled phenolic acids, but labelled phenyl-γ-valerolactones were detected together with a higher proportion of 14CO2. 4. Administered [14C]δ-(3-hydroxyphenyl)-γ-valerolactone gave rise to labelled m-hydroxyphenylpropionic acid in the rat whereas administered [14C]m-hydroxyphenylpropionic acid gave rise to a compound yielding labelled m-hydroxybenzoic acid on hydrolysis. 5. The distribution of radioactivity in the urine and faeces of (+)-[14C]catechin-fed animals is described; a high proportion of residual radioactivity was found in urine that had been exhaustively extracted with diethyl ether.

Full text

PDF
831

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BOOTH A. N., DEEDS F., JONES F. T., MURRAY C. W. The metabolic fate of rutin and quercetin in the animal body. J Biol Chem. 1956 Nov;223(1):251–257. [PubMed] [Google Scholar]
  2. Das N. P., Griffiths L. A. Studies on flavonoid metabolism. Biosynthesis of (+)-[14C]catechin by the plant Uncaria gambir Roxb. Biochem J. 1967 Oct;105(1):73–77. doi: 10.1042/bj1050073. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Das N. P., Griffiths L. A. Studies on flavonoid metabolism. Metabolism of (+)-catechin in the guinea pig. Biochem J. 1968 Dec;110(3):449–456. doi: 10.1042/bj1100449. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Das N. P., Griffiths L. A. Studies on flavonoid metabolism. Metabolism of flavone in the guinea pig. Biochem J. 1966 Feb;98(2):488–492. doi: 10.1042/bj0980488. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Griffiths L. A. Studies on flavonoid metabolism. Identification of the metabolities of (+)-catechin in rat urine. Biochem J. 1964 Jul;92(1):173–179. doi: 10.1042/bj0920173. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. KALLIANOS A. G., PETRAKIS P. L., SHETLAR M. R., WENDER S. H. Preliminary studies on degradation products of quercetin in the rat's gastrointestinal tract. Arch Biochem Biophys. 1959 Apr;81(2):430–433. doi: 10.1016/0003-9861(59)90222-x. [DOI] [PubMed] [Google Scholar]
  7. MASRI M. S., BOOTH A. N., DE EDS F. The metabolism and acid degradation of quercetin. Arch Biochem Biophys. 1959 Nov;85:284–286. doi: 10.1016/0003-9861(59)90476-x. [DOI] [PubMed] [Google Scholar]
  8. NAKAGAWA Y., SHETLAR M. R., WENDER S. H. URINARY PRODUCTS FROM QUERCETIN IN NEOMYCIN-TREATED RATS. Biochim Biophys Acta. 1965 Feb 15;97:233–241. doi: 10.1016/0304-4165(65)90087-5. [DOI] [PubMed] [Google Scholar]
  9. OLSON J. A., Jr, LINDBERG M., BLOCH K. On the demethylation of lanosterol to cholesterol. J Biol Chem. 1957 Jun;226(2):941–956. [PubMed] [Google Scholar]
  10. Parke D. V., Williams R. T. Studies in detoxication. 30. The metabolism of benzene. (a) The determination of benzene. (b) The elimination of unchanged benzene by rabbits. Biochem J. 1950 Feb;46(2):236–243. doi: 10.1042/bj0460236. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Biochemical Journal are provided here courtesy of The Biochemical Society

RESOURCES