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. 1970 Jan;116(2):177–180. doi: 10.1042/bj1160177

Inhibition by α-amanitin of ribonucleic acid polymerase solubilized from rat liver nuclei

F Novello 1, L Fiume 1, F Stirpe 1
PMCID: PMC1185343  PMID: 5414093

Abstract

1. α-Amanitin inhibits in vitro the RNA polymerase solubilized from isolated rat liver nuclei. 2. In contrast with previous observations with whole nuclei, the inhibition occurs approximately to the same extent in the presence and in the absence of ammonium sulphate. 3. Evidence is presented that the toxin acts by interacting with the enzyme itself and not with DNA or other components.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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