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. 1970 Feb;116(3):321–327. doi: 10.1042/bj1160321

Effect of α-p-chlorophenoxyisobutyrate on the metabolism of isoprenoid compounds in the rat

K V Krishnaiah 1, T Ramasarma 1
PMCID: PMC1185368  PMID: 5435680

Abstract

1. Feeding of α-p-chlorophenoxyisobutyrate (CPIB) to rats increased ubiquinone concentration in the liver but not in other tissues. The increase was progressive with the time of feeding and related to the concentration of CPIB in the diet. 2. Incorporation of [1-14C]acetate, but not of [2-14C]mevalonate, into sterols in the liver in vivo or by liver slices in vitro was decreased on feeding the rats with CPIB. However, incorporation of mevalonate into ubiquinone increased. 3. CPIB, when added in low concentrations to liver slices, had no effect on isoprene synthesis from acetate; higher concentrations, however, were inhibitory. 4. No activation of ubiquinone synthesis from mevalonate was observed when CPIB was added to the liver slices synthesizing ubiquinone. 5. The increase in ubiquinone in CPIB-fed animals appears to be due to increased synthesis in the initial stages and to decreased catabolism in the later stages. 6. An inverse relationship was found between the concentration of ubiquinone in the liver and the serum sterol concentration in CPIB-fed rats.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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