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. 1970 Mar;116(5):913–917. doi: 10.1042/bj1160913

Metabolism of a glutathione conjugate of 2-hydroxyoestradiol by rat liver and kidney preparations in vitro

John S Elce 1
PMCID: PMC1185515  PMID: 5441380

Abstract

Adult male rat liver and kidney preparations were incubated with (2-hydroxyoestradiol-1-yl)[35S]glutathione. The glutamic acid and glycine residues were removed by enzymes present in the kidney microsomal fraction; the liver preparations had no effect. The resulting 2-hydroxyoestradiol–cysteine conjugate was acetylated at the α-amino group by both liver and kidney homogenates fortified with acetyl-coenzyme A, but not significantly in the absence of this coenzyme, or by liver or kidney slices. These results suggest that an oestrogen–glutathione conjugate, if formed in vivo, would be converted into the corresponding mercapturic acid before excretion.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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