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. 1978 Sep 1;173(3):989–991. doi: 10.1042/bj1730989

Proteins from sciatic-nerve myelin in quaking and jimpy mice.

J M Matthieu
PMCID: PMC1185869  PMID: 708386

Abstract

Myelin from two neurological mutants in mice was isolated from sciatic nerves and its protein composition analysed. In Quaking mice, two intrinsic myelin proteins P1 and P2 were drastically decreased, whereas the major myelin protein P0 was unaffected. A normal protein composition was found in sciatic myelin from Jimpy mice.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Appeldoorn B. J., Chandross R. J., Bear R. S., Hogan E. L. An x-ray diffraction study of central and peripheral myelination in Jimpy and Quaking mice. Brain Res. 1975 Mar 7;85(3):517–521. doi: 10.1016/0006-8993(75)90824-0. [DOI] [PubMed] [Google Scholar]
  2. Brostoff S. W., Eylar E. H. The proposed amino acid sequence of the P1 protein of rabbit sciatic nerve myelin. Arch Biochem Biophys. 1972 Dec;153(2):590–598. doi: 10.1016/0003-9861(72)90377-3. [DOI] [PubMed] [Google Scholar]
  3. Brostoff S. W., Greenfield S., Hogan E. L. The differentiation of synthesis from incorporation of basic protein in Quaking mutant mouse myelin. Brain Res. 1977 Jan 28;120(3):517–520. doi: 10.1016/0006-8993(77)90404-8. [DOI] [PubMed] [Google Scholar]
  4. Brostoff S. W., Sacks H., DiPaola C. The P2 protein of bovine root myelin: partial chemical characterization. J Neurochem. 1975 Feb;24(2):289–294. doi: 10.1111/j.1471-4159.1975.tb11878.x. [DOI] [PubMed] [Google Scholar]
  5. Everly J. L., Brady R. O., Quarles R. H. Evidence that the major protein in rat sciatic nerve myelin is a glycoprotein. J Neurochem. 1973 Aug;21(2):329–334. doi: 10.1111/j.1471-4159.1973.tb04253.x. [DOI] [PubMed] [Google Scholar]
  6. Friedrich V. L., Jr, Hauser G. Biosynthesis of psychosine and levels of cerebrosides in the central and peripheral nervous systems of quaking mice. J Neurochem. 1973 Apr;20(4):1131–1141. doi: 10.1111/j.1471-4159.1973.tb00083.x. [DOI] [PubMed] [Google Scholar]
  7. Greenfield S., Brostoff S., Eylar E. H., Morell P. Protein composition of myelin of the peripheral nervous system. J Neurochem. 1973 Apr;20(4):1207–1216. doi: 10.1111/j.1471-4159.1973.tb00089.x. [DOI] [PubMed] [Google Scholar]
  8. Greenfield S., Norton W. T., Morell P. Quaking mouse: isolation and characterization of myelin protein. J Neurochem. 1971 Nov;18(11):2119–2128. doi: 10.1111/j.1471-4159.1971.tb05070.x. [DOI] [PubMed] [Google Scholar]
  9. Kishimoto Y. Abnormality in sphingolipid fatty acids from sciatic nerve and brain of Quaking mice. J Neurochem. 1971 Jul;18(7):1365–1368. doi: 10.1111/j.1471-4159.1971.tb00240.x. [DOI] [PubMed] [Google Scholar]
  10. LOWRY O. H., ROSEBROUGH N. J., FARR A. L., RANDALL R. J. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951 Nov;193(1):265–275. [PubMed] [Google Scholar]
  11. Matthieu J. M., Koellreutter B., Joyet M. L. Protein and glycoprotein composition of myelin and myelin subfractions from brains of 'quaking' mice. J Neurochem. 1978 Apr;30(4):783–790. doi: 10.1111/j.1471-4159.1978.tb10785.x. [DOI] [PubMed] [Google Scholar]
  12. Norton W. T., Poduslo S. E. Myelination in rat brain: method of myelin isolation. J Neurochem. 1973 Oct;21(4):749–757. doi: 10.1111/j.1471-4159.1973.tb07519.x. [DOI] [PubMed] [Google Scholar]
  13. Samorajski T., Friede R. L., Reimer P. R. Hypomyelination in the quaking mouse. A model for the analysis of disturbed myelin formation. J Neuropathol Exp Neurol. 1970 Oct;29(4):507–523. doi: 10.1097/00005072-197010000-00001. [DOI] [PubMed] [Google Scholar]
  14. Suzuki K., Zagoren J. C. Quaking mouse: an ultrastructural study of the peripheral nerves. J Neurocytol. 1977 Feb;6(1):71–84. doi: 10.1007/BF01175415. [DOI] [PubMed] [Google Scholar]
  15. Suzuki K., Zagoren J. C. Variations of Schmidt-Lanterman incisures in Quaking mouse. Brain Res. 1976 Apr 16;106(1):146–151. doi: 10.1016/0006-8993(76)90079-2. [DOI] [PubMed] [Google Scholar]
  16. Watanabe I., Bingle G. J. Dysmyelination in "quaking" mouse. Electron microscopic study. J Neuropathol Exp Neurol. 1972 Apr;31(2):352–369. doi: 10.1097/00005072-197204000-00010. [DOI] [PubMed] [Google Scholar]
  17. Wiggins R. C., Benjamins J. A., Morell P. Appearance of myelin proteins in rat sciatic nerve during development. Brain Res. 1975 May 16;89(1):99–106. doi: 10.1016/0006-8993(75)90137-7. [DOI] [PubMed] [Google Scholar]
  18. Wood J. G., Dawson R. M. A major myelin glycoprotein of sciatic nerve. J Neurochem. 1973 Sep;21(3):717–719. doi: 10.1111/j.1471-4159.1973.tb06019.x. [DOI] [PubMed] [Google Scholar]

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