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. 1978 Oct 1;175(1):261–270. doi: 10.1042/bj1750261

Isolation of the C-fragment and C'-fragment of lipotropin from pig pituitary and C-fragment from brain.

D G Smyth, C R Snell, D E Massey
PMCID: PMC1186062  PMID: 736896

Abstract

Three novel peptides derived from lipotropin, the C-Fragment (residues 61-91), C'-Fragment (61-87) and N-Fragment (1-38), were isolated from pig pituitary, and the C-Fragment was shown to be present in brain. The experimental procedures developed for their isolation are described. The formation of each of the fragments involves enzymic cleavage of lipotropin at consecutive basic residues, with specificity identical with that involved in the activation of known prohormones. In brain assays C-Fragment exhibits a range of biological activities related to its ability to act as an inhibitory neurotransmitter.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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