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. 1978 Oct 15;176(1):327–330. doi: 10.1042/bj1760327

The mechanism of haem degradation in vitro. Kinetic evidence for the formation of a haem-oxygen complex.

S B Brown, S E Thomas
PMCID: PMC1186231  PMID: 728112

Abstract

The rate of haem degradation in aqueous pyridine shows a saturation dependence on O2 concentration. CO competitively inhibits the reaction. This is evidence for formation of an iron-O2 complex and is consistent with an intramolecular pathway for haem degradation.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Brown S. B., Grundy M. S. The role of iron in haem degradation [proceedings]. Biochem Soc Trans. 1977;5(4):1017–1020. doi: 10.1042/bst0051017. [DOI] [PubMed] [Google Scholar]
  2. Brown S. B., King R. F. 180 studies of haem catabolism. Biochem Soc Trans. 1976;4(2):197–201. doi: 10.1042/bst0040197. [DOI] [PubMed] [Google Scholar]
  3. Brown S. B., King R. F. The mechanism of haem catabolism. Bilirubin formation in living rats by [18O]oxygen labelling. Biochem J. 1978 Feb 15;170(2):297–311. doi: 10.1042/bj1700297. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Brown S. B., King R. F. The structure of haem in pyridine/water mixtures and its implication in studies of haem catabolism. Biochem J. 1976 Feb 1;153(2):479–483. doi: 10.1042/bj1530479. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Brown S. B. Stereospecific haem cleavage. A model for the formation of bile-pigment isomers in vivo and in vitro. Biochem J. 1976 Oct 1;159(1):23–27. doi: 10.1042/bj1590023. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Chaney B. D., Brown S. B. The mechanism of coupled oxidation of octaethylhaem to octaethylbiliverdin [proceedings]. Biochem Soc Trans. 1978;6(2):419–421. doi: 10.1042/bst0060419. [DOI] [PubMed] [Google Scholar]
  7. King R. F., Brown S. B. The mechanism of haem catabolism. A study of haem breakdown in spleen microsomal fraction and in a model system by 18O labelling and metal substitution. Biochem J. 1978 Jul 15;174(1):103–109. doi: 10.1042/bj1740103. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Schmid R., McDonagh A. F. The enzymatic formation of bilirubin. Ann N Y Acad Sci. 1975 Apr 15;244:533–552. doi: 10.1111/j.1749-6632.1975.tb41553.x. [DOI] [PubMed] [Google Scholar]

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