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. 1978 Dec 15;176(3):733–737. doi: 10.1042/bj1760733

Sources of ammonia for mammalian urea synthesis.

H A Krebs, R Hems, P Lund, D Halliday, W W Read
PMCID: PMC1186295  PMID: 747649

Abstract

The initial rate of incorporation of [15N]alanine into the 6-amino group of the adenine nucleotides in rat hepatocytes was about one-eighteenth of the rate of incorporation into urea. Thus the purine nucleotide cycle cannot provide most of the ammonia needed in urea synthesis for the carbamoyl phosphate synthase reaction (EC 2.7.2.5). On the other hand, contrary to the view expressed by McGivan & Chappell [(1975) FEBS Lett. 52, 1--7], the experiments support the view that hepatic glutamate dehydrogenase can supply the required ammonia.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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