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. 1978 Dec 15;176(3):977–981. doi: 10.1042/bj1760977

Conversion between renin and high-molecular-weight renin in the dog.

S Funakawa, Y Funae, K Yamamoto
PMCID: PMC1186323  PMID: 747665

Abstract

Two forms of renin, one of mol.wt. 43,000 and the other 60,000, were found in the dog kidney. Conversion between the two forms of renin was reversible at neutral pH. Though the molecular weight of renin in kidney-cortex homogenate was 43,000, it was completely converted into high-molecular-weight renin in the presence of substances that react with thiol groups. On the contrary, stored renin in the granules was the form of normal size (mol. wt. 43,000) regardless of the absence or presence of such substances. The present experiments indicated that renin is stored in the granules as the form of normal size and might be converted into high-molecular-weight renin when it is released from the granules and attached to some substance in the soluble fraction of renal-cortical tissue.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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