Skip to main content
NCBI home page
Biochemical Journal logoLink to Biochemical Journal
. 1979 Jan 15;178(1):241–244. doi: 10.1042/bj1780241

Ca2+-stimulated ribonuclease. A new marker enzyme of differentiated rat mammary tissues.

D K Liu, D Kulick, G H Williams
PMCID: PMC1186503  PMID: 435282

Abstract

A unique ribonuclease, active only in the presence of Ca2+, was present in lactating mammary gland and milk of the rat. This enzyme was absent from virgin-rat mammary gland and non-mammary tissues of lactating rats. The presence of moderate activity in differentiated mammary tumours, together with an increase in activity in normal tissue parelleling development of mammary function, identify this enzyme as a marker of mammary differentiation in the rat.

Full text

PDF
241

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Barnard E. A. Ribonucleases. Annu Rev Biochem. 1969;38:677–732. doi: 10.1146/annurev.bi.38.070169.003333. [DOI] [PubMed] [Google Scholar]
  2. HILF R., MICHEL I., BELL C., FREEMAN J. J., BORMAN A. BIOCHEMICAL AND MORPHOLOGIC PROPERTIES OF A NEW LACTATING MAMMARY TUMOR LINE IN THE RAT. Cancer Res. 1965 Apr;25:286–299. [PubMed] [Google Scholar]
  3. Jenness R. Proceedings: Biosynthesis and composition of milk. J Invest Dermatol. 1974 Jul;63(1):109–118. doi: 10.1111/1523-1747.ep12678111. [DOI] [PubMed] [Google Scholar]
  4. Liu D. K., Liao W. S., Fritz P. J. Ca2+-stimulated ribonucleases from rat mammary gland and R3230AC mammary adenocarcinoma nuclei. Biochemistry. 1977 Jul 26;16(15):3361–3369. doi: 10.1021/bi00634a012. [DOI] [PubMed] [Google Scholar]
  5. Liu D. K., Matrisian P. E. Regional differences in ribonuclease content of rat and mouse kidney. Biochem J. 1977 May 15;164(2):371–377. doi: 10.1042/bj1640371. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Liu D. K., Williams G. H., Fritz P. J. Alkaline ribonuclease and ribonuclease inhibitor in mammary gland during the lactation cycle and in the R3230AC mammary tumour. Biochem J. 1975 Apr;148(1):67–76. doi: 10.1042/bj1480067. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. McGuire W. L. Hormonal stimulation of lactose synthetase in mammary carcinoma. Science. 1969 Sep 5;165(3897):1013–1014. doi: 10.1126/science.165.3897.1013. [DOI] [PubMed] [Google Scholar]
  8. Nardacci N. J., McGuire W. L. Casein and alpha-lactalbumin messenger RNA in experimental breast cancer. Cancer Res. 1977 Apr;37(4):1186–1190. [PubMed] [Google Scholar]
  9. Nicholls D. M., Ryan M. P., Miall S. H., Cappon I. D. Factors affecting protein synthesis in rat kidney ribosome preparations. Can J Biochem. 1970 Jan;48(1):105–112. doi: 10.1139/o70-017. [DOI] [PubMed] [Google Scholar]
  10. Patton S. Milk secretion at the cellular level: a unique approach to the mechanism of exocytosis. J Dairy Sci. 1978 May;61(5):643–650. doi: 10.3168/jds.S0022-0302(78)94423-5. [DOI] [PubMed] [Google Scholar]
  11. Turkington R. W. Homogeneity of differentiated function in mammary carcinoma cell populations. Cancer Res. 1970 Jun;30(6):1841–1845. [PubMed] [Google Scholar]
  12. Weil P. A., Sidikaro J., Stancel G. M., Blatti S. P. Hormonal control of transcription in the rat uterus. Stimulation of deoxyribonucleic acid-dependent RNA polymerase III by estradiol. J Biol Chem. 1977 Feb 10;252(3):1092–1098. [PubMed] [Google Scholar]

Articles from Biochemical Journal are provided here courtesy of The Biochemical Society

RESOURCES