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. 1968 Aug;109(1):75–78. doi: 10.1042/bj1090075

The fate of 7[14C]-methylguanine after administration to the rat

Valda M Craddock 1, A R Mattocks 1, P N Magee 1,*
PMCID: PMC1186754  PMID: 5669851

Abstract

1. To assess the significance of the methylation of nucleic acids known to be caused by certain carcinogens, the metabolic fate of 7[14C]-methylguanine was studied, with special reference to its possible incorporation into RNA and DNA. 2. The major part (approx. 95%) of the dose was excreted unchanged in the urine. A small amount of N-demethylation took place, as evidenced by the formation of radioactive adenine and guanine, and expiration of 14C-labelled carbon dioxide. No evidence was obtained for the direct incorporation of 7-methylguanine into systems synthesizing nucleic acids, i.e. RNA in liver, DNA in intestine or in the foetus.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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