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. 1968 Sep;109(3):369–374. doi: 10.1042/bj1090369

The influence of external sodium ions on the sodium pump in erythrocytes

R N Priestland 1, R Whittam 1
PMCID: PMC1186831  PMID: 4234831

Abstract

1. A study has been made of the interaction between Na+ and K+ on the adenosine triphosphatase activity of erythrocyte `ghosts', and on the K+ influx and Na+ efflux of intact erythrocytes. The adenosine triphosphatase activity and the ion movements were greater at a low external K+ concentration in the absence of Na+ than they were in the presence of 150mm-Na+. The inhibition by external Na+ of K+ influx had an inhibitory constant of 5–10mm. 2. Activation by K+ of kidney microsomal adenosine triphosphatase was retarded by Na+, and activation by Na+ was retarded by K+. Fragmented erythrocyte membranes behaved similarly. 3. These observations suggest that there is competition between Na+ and K+ at the K+-sensitive site of the membrane.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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