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. 1968 Nov;110(2):201–206. doi: 10.1042/bj1100201

The metabolism of [Me-14C]choline in the brain of the rat in vivo

G B Ansell 1, Sheila Spanner 1
PMCID: PMC1187198  PMID: 5726197

Abstract

[Me-14C]Choline was injected intracerebrally into the adult rat, and its uptake into the lipids and their water-soluble precursors in brain was studied. The radioactivity could be detected only in the choline-containing lipids and was confined to the base choline. The results indicated that initial phosphorylation of the free choline followed by the formation of CDP-choline and the subsequent transfer of the phosphorylcholine to a diglyceride is one of the principal routes by which choline lipids in brain are formed. Further evidence for this was obtained in experiments in which either phosphoryl[Me-14C]choline or [32P]orthophosphate was injected and the radioactivity in the choline-containing water-soluble and lipidbound components studied.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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