Abstract
1. Carbaryl is metabolized more rapidly by fat body of the blowfly larva than by gut, muscle, cuticle or haemolymph. 2. Metabolism of carbaryl by the fat body is affected by the age of the larva, the pH of the incubation medium, and the concentration of magnesium chloride in the incubation medium. 3. Chloramphenicol, 2,4-dinitrophenol and 5-dimethylamino-6-nitro-1,3-benzodioxole (a carbaryl synergist) inhibit carbaryl metabolism by the fat body. 4. Subcellular fractionation of the fat body indicates that the pellet sedimenting at 30000g is the most reactive with carbaryl. 5. Probable metabolites of carbaryl formed by the fat body include the 4- and 5-hydroxy derivatives, and, possibly, the N-hydroxymethyl and 5,6-dihydrodihydroxy derivatives.
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Selected References
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- Ku T. Y., Bishop J. L. Penetration, excretion, and metabolism of carbaryl in susceptible and resistant German cockroaches. J Econ Entomol. 1967 Oct;60(5):1328–1332. doi: 10.1093/jee/60.5.1328. [DOI] [PubMed] [Google Scholar]
- Price G. M. The in vitro incorporation of [U-14C] valine into fat body protein of the larva of the blowfly, Calliphora erythrocephala. J Insect Physiol. 1966 Jul;12(7):731–740. doi: 10.1016/0022-1910(66)90025-4. [DOI] [PubMed] [Google Scholar]
- Zayed S. M., Hassan A., Hussein T. M. Metabolism of carbamate drugs. II. Degradation of 1-naphthyl-N-methyl carbamate (Sevin) in adult larva of the cotton leaf worm (Prodenia litura F.). Biochem Pharmacol. 1966 Dec;15(12):2057–2064. doi: 10.1016/0006-2952(66)90234-6. [DOI] [PubMed] [Google Scholar]