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. 1969 Apr;112(3):275–283. doi: 10.1042/bj1120275

Studies on the effect of vitamin D on calcium absorption and transport

George Hashim 1,*, Irwin Clark 1
PMCID: PMC1187706  PMID: 5801302

Abstract

1. Mucosal cells of the small intestine obtained from rats deprived of vitamin D or given excessive amounts of the vitamin accumulated significantly more calcium than did cells from control animals. 2. Mucosal cells from vitamin D-deficient rats released less calcium than did cells from normal or hypervitaminotic D animals. 3. Studies in vivo showed that the transfer of 45Ca from the intestine to the blood was delayed in vitamin D deficiency, but was accelerated in hypervitaminosis D. 4. The findings support the thesis that vitamin D is involved in the release of calcium rather than in its uptake by mucosal cells. 5. Further evidence is presented suggesting that uptake of calcium by intestinal mucosal cells at 0° is primarily passive, whereas at 38° uptake and release are effected by an active process that depends on energy derived from glycolytic activity.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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