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. 1969 Apr;112(3):317–323. doi: 10.1042/bj1120317

Effect of actinomycin D and guanidine on the formation of a ribonucleic acid polymerase induced by foot-and-mouth-disease virus and on the replication of virus and viral ribonucleic acid

D N Black 1, F Brown 1
PMCID: PMC1187710  PMID: 4308295

Abstract

The RNA-dependent RNA polymerase induced in baby-hamster kidney cells by infection with foot-and-mouth-disease virus can be detected as early as 60min. after infection, which is 60min. before viral RNA synthesis commences. The time at which the polymerase can first be detected coincides with the latest time at which actinomycin D (50μg./107 cells) or guanidine (1mg./107 cells) inhibits virus replication. However, by increasing the concentration of guanidine, viral replication can be inhibited later in the growth cycle, casting doubt on the validity of the hypothesis that guanidine acts specifically on the formation of the viral RNA polymerase.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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