Skip to main content
Journal of Psychiatry & Neuroscience : JPN logoLink to Journal of Psychiatry & Neuroscience : JPN
. 1993 Nov;18(5):260–263.

Thyroid functioning during treatment for depression.

M Kusalic 1, F Engelsmann 1, J Bradwejn 1
PMCID: PMC1188546  PMID: 8297924

Abstract

Thirty-nine unipolar depressed patients were treated, after a washout period of seven days in a double blind study with either moclobemide, placebo or amitriptyline, for 42 days. The psychopathological assessment and HRSD were done on seven day intervals and thyroid analysis was done on 14 day intervals. At the end of therapy, the levels of T4 and fT4 decreased significantly in the responders if amitriptyline was used, and non-significantly if placebo or moclobemide were used. The T4 and fT4 values of the non-responders increased non-significantly. The weight change was minimal and non-significant.

Full text

PDF
260

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Brady K. T., Anton R. F. The thyroid axis and desipramine treatment in depression. Biol Psychiatry. 1989 Mar 15;25(6):703–709. doi: 10.1016/0006-3223(89)90241-2. [DOI] [PubMed] [Google Scholar]
  2. Cohen K. L., Swigar M. E. Thyroid function screening in psychiatric patients. JAMA. 1979 Jul 20;242(3):254–257. [PubMed] [Google Scholar]
  3. Fernstrom M. H., Epstein L. H., Spiker D. G., Kupfer D. J. Resting metabolic rate is reduced in patients treated with antidepressants. Biol Psychiatry. 1985 Jun;20(6):692–695. doi: 10.1016/0006-3223(85)90107-6. [DOI] [PubMed] [Google Scholar]
  4. Hamilton M. Development of a rating scale for primary depressive illness. Br J Soc Clin Psychol. 1967 Dec;6(4):278–296. doi: 10.1111/j.2044-8260.1967.tb00530.x. [DOI] [PubMed] [Google Scholar]
  5. Joffe R. T., Singer W. Effect of phenelzine on thyroid function in depressed patients. Biol Psychiatry. 1987 Aug;22(8):1033–1035. doi: 10.1016/0006-3223(87)90014-x. [DOI] [PubMed] [Google Scholar]
  6. Joffe R. T., Singer W. The effect of tricyclic antidepressants on basal thyroid hormone levels in depressed patients. Pharmacopsychiatry. 1990 Mar;23(2):67–69. doi: 10.1055/s-2007-1014485. [DOI] [PubMed] [Google Scholar]
  7. Kirkegaard C., Faber J. Altered serum levels of thyroxine, triiodothyronines and diiodothyronines in endogenous depression. Acta Endocrinol (Copenh) 1981 Feb;96(2):199–207. doi: 10.1530/acta.0.0960199. [DOI] [PubMed] [Google Scholar]
  8. Kolakowska T., Swigar M. E. Thyroid function in depression and alcohol abuse: a retrospective study. Arch Gen Psychiatry. 1977 Aug;34(8):984–988. doi: 10.1001/archpsyc.1977.01770200122018. [DOI] [PubMed] [Google Scholar]
  9. Linnoila M., Gold P., Potter W. Z., Wehr T. A. Tricyclic antidepressants do not alter thyroid hormone levels in patients suffering from a major affective disorder. Psychiatry Res. 1981 Jun;4(3):357–360. doi: 10.1016/0165-1781(81)90037-8. [DOI] [PubMed] [Google Scholar]
  10. Morley J. E., Shafer R. B. Thyroid function screening in new psychiatric admissions. Arch Intern Med. 1982 Mar;142(3):591–593. [PubMed] [Google Scholar]
  11. Müller B., Böning J. Changes in the pituitary-thyroid axis accompanying major affective disorders. Acta Psychiatr Scand. 1988 Feb;77(2):143–150. doi: 10.1111/j.1600-0447.1988.tb05091.x. [DOI] [PubMed] [Google Scholar]
  12. Roca R. P., Blackman M. R., Ackerley M. B., Harman S. M., Gregerman R. I. Thyroid hormone elevations during acute psychiatric illness: relationship to severity and distinction from hyperthyroidism. Endocr Res. 1990;16(4):415–447. doi: 10.1080/07435809009107116. [DOI] [PubMed] [Google Scholar]
  13. Roy-Byrne P. P., Joffe R. T., Uhde T. W., Post R. M. Carbamazepine and thyroid function in affectively ill patients. Clinical and theoretical implications. Arch Gen Psychiatry. 1984 Dec;41(12):1150–1153. doi: 10.1001/archpsyc.1984.01790230036005. [DOI] [PubMed] [Google Scholar]
  14. Rubin R. T., Poland R. E., Lesser I. M., Martin D. J. Neuroendocrine aspects of primary endogenous depression--IV. Pituitary-thyroid axis activity in patients and matched control subjects. Psychoneuroendocrinology. 1987;12(5):333–347. doi: 10.1016/0306-4530(87)90062-x. [DOI] [PubMed] [Google Scholar]
  15. Shelton R. C., Winn S., Ekhatore N., Loosen P. T. The effects of antidepressants on the thyroid axis in depression. Biol Psychiatry. 1993 Jan 15;33(2):120–126. doi: 10.1016/0006-3223(93)90311-z. [DOI] [PubMed] [Google Scholar]
  16. de Montigny C., Blier P. Desensitization of terminal 5-HT autoreceptors by 5-HT reuptake blockers. Arch Gen Psychiatry. 1991 May;48(5):483–484. doi: 10.1001/archpsyc.1991.01810290095019. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Psychiatry and Neuroscience are provided here courtesy of Canadian Medical Association

RESOURCES