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. 1994 May;19(3):222–225.

Effect of mood stabilizing agents on agonist-induced calcium mobilization in human platelets.

I Kusumi 1, T Koyama 1, I Yamashita 1
PMCID: PMC1188593  PMID: 8031747

Abstract

The effect of mood stabilizing agents such as lithium, carbamazepine, valproic acid and clonazepam on serotonin(5-HT)- or thrombin-induced intracellular calcium (Ca) mobilization was studied in the platelets of healthy subjects using the fluorescent Ca indicator fura-2. After incubating platelet-rich plasma with these drugs for one or four hours, there was no significant difference in either basal Ca2+ concentration or 5-HT-stimulated Ca response between each agent treatment and control. 5-HT- or thrombin-induced Ca mobilization was not altered by four weeks of lithium carbonate administration in healthy volunteers. These results indicate that these mood stabilizers fail to affect the agonist-stimulated intracellular Ca mobilizing pathway either in vitro or ex vivo in the platelets of healthy subjects.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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