Abstract
Plasma levels of the active form of vitamin B6 (pyridoxal phosphate) in 19 patients taking phenelzine were found to be reduced on the average to approximately 54% of the value in a control group. There was no correlation of pyridoxal phosphate level with phenelzine daily dosage over the range of 30 mg to 90 mg. No symptoms of vitamin B6 deficiency peripheral neuropathy were found.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bhagavan H. N., Brin M. Drug--vitamin B6 interaction. Curr Concepts Nutr. 1983;12:1–12. [PubMed] [Google Scholar]
- Ebadi M., Gessert C. F., Al-Sayegh A. Drug-pyridoxal phosphate interactions. Q Rev Drug Metab Drug Interact. 1982;4(4):289–331. doi: 10.1515/dmdi.1982.4.4.289. [DOI] [PubMed] [Google Scholar]
- Heller C. A., Friedman P. A. Pyridoxine deficiency and peripheral neuropathy associated with long-term phenelzine therapy. Am J Med. 1983 Nov;75(5):887–888. doi: 10.1016/0002-9343(83)90422-9. [DOI] [PubMed] [Google Scholar]
- Lydiard R. B., Laraia M. T., Howell E. F., Fossey M. D., Reynolds R. D., Ballenger J. C. Phenelzine treatment of panic disorder: lack of effect on pyridoxal phosphate levels. J Clin Psychopharmacol. 1989 Dec;9(6):428–431. [PubMed] [Google Scholar]
- Raskin N. H., Fishman R. A. Pyridoxine-deficiency neuropathy due to hydralazine. N Engl J Med. 1965 Nov 25;273(22):1182–1185. doi: 10.1056/NEJM196511252732203. [DOI] [PubMed] [Google Scholar]
- Stewart J. W., Harrison W., Quitkin F., Liebowitz M. R. Phenelzine-induced pyridoxine deficiency. J Clin Psychopharmacol. 1984 Aug;4(4):225–226. [PubMed] [Google Scholar]
- Yu P. H. Determination of plasma pyridoxal 5'-phosphate by an enzymatic-high-performance liquid chromatographic procedure. Anal Biochem. 1989 Sep;181(2):267–270. doi: 10.1016/0003-2697(89)90241-8. [DOI] [PubMed] [Google Scholar]