Skip to main content
Journal of Psychiatry & Neuroscience: JPN logoLink to Journal of Psychiatry & Neuroscience: JPN
. 1999 May;24(3):244–247.

Is atypical depression a moderate severity depression? A 536-case study.

F Benazzi 1
PMCID: PMC1189015  PMID: 10354659

Abstract

OBJECTIVE: To determine if atypical depression is less common among outpatients with severe depression than among those with nonsevere depression. DESIGN: Case series. SETTING: Private practice. PATIENTS: Five hundred and thirty-six consecutive outpatients presenting for treatment of unipolar or bipolar II depression. OUTCOME MEASURES: Prevalence of atypical depression among patients with severe depression (Global Assessment of Functioning Scale [GAF] score of 50 or less) and nonsevere depression. RESULTS: There was no significant difference in the prevalence of atypical depression between patients with severe and nonsevere depression. CONCLUSIONS: Results do not support previous studies that atypical depression is usually of moderate severity. A rating scale like the GAF, which assesses both symptom severity and impairment of functioning, may give a more complete assessment of depression severity than a symptoms rating scale (used in previous studies), which does not cover atypical features and does not assess functioning.

Full text

PDF
244

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Akiskal H. S. The prevalent clinical spectrum of bipolar disorders: beyond DSM-IV. J Clin Psychopharmacol. 1996 Apr;16(2 Suppl 1):4S–14S. doi: 10.1097/00004714-199604001-00002. [DOI] [PubMed] [Google Scholar]
  2. Benazzi F. Atypical depression in private practice depressed outpatients: a 203-case study. Compr Psychiatry. 1999 Jan-Feb;40(1):80–83. doi: 10.1016/s0010-440x(99)90081-0. [DOI] [PubMed] [Google Scholar]
  3. Benazzi F. Prevalence of bipolar II disorder in outpatient depression: a 203-case study in private practice. J Affect Disord. 1997 Apr;43(2):163–166. doi: 10.1016/s0165-0327(96)01421-8. [DOI] [PubMed] [Google Scholar]
  4. Controversies in the diagnosis and treatment of severe depression. J Clin Psychiatry. 1996 Nov;57(11):554–561. doi: 10.4088/jcp.v57n1111. [DOI] [PubMed] [Google Scholar]
  5. Davidson J. R., Miller R. D., Turnbull C. D., Sullivan J. L. Atypical depression. Arch Gen Psychiatry. 1982 May;39(5):527–534. doi: 10.1001/archpsyc.1982.04290050015005. [DOI] [PubMed] [Google Scholar]
  6. Elkin I., Shea M. T., Watkins J. T., Imber S. D., Sotsky S. M., Collins J. F., Glass D. R., Pilkonis P. A., Leber W. R., Docherty J. P. National Institute of Mental Health Treatment of Depression Collaborative Research Program. General effectiveness of treatments. Arch Gen Psychiatry. 1989 Nov;46(11):971–983. doi: 10.1001/archpsyc.1989.01810110013002. [DOI] [PubMed] [Google Scholar]
  7. HAMILTON M. A rating scale for depression. J Neurol Neurosurg Psychiatry. 1960 Feb;23:56–62. doi: 10.1136/jnnp.23.1.56. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Kendler K. S., Eaves L. J., Walters E. E., Neale M. C., Heath A. C., Kessler R. C. The identification and validation of distinct depressive syndromes in a population-based sample of female twins. Arch Gen Psychiatry. 1996 May;53(5):391–399. doi: 10.1001/archpsyc.1996.01830050025004. [DOI] [PubMed] [Google Scholar]
  9. Montgomery S. A., Asberg M. A new depression scale designed to be sensitive to change. Br J Psychiatry. 1979 Apr;134:382–389. doi: 10.1192/bjp.134.4.382. [DOI] [PubMed] [Google Scholar]
  10. Nelson J. C., Docherty J. P., Henschen G. M., Kasper S., Nierenberg A. A., Ward N. G. Algorithms for the treatment of subtypes of unipolar major depression. Psychopharmacol Bull. 1995;31(3):475–482. [PubMed] [Google Scholar]
  11. Perugi G., Akiskal H. S., Lattanzi L., Cecconi D., Mastrocinque C., Patronelli A., Vignoli S., Bemi E. The high prevalence of "soft" bipolar (II) features in atypical depression. Compr Psychiatry. 1998 Mar-Apr;39(2):63–71. doi: 10.1016/s0010-440x(98)90080-3. [DOI] [PubMed] [Google Scholar]
  12. Quitkin F. M., Harrison W., Stewart J. W., McGrath P. J., Tricamo E., Ocepek-Welikson K., Rabkin J. G., Wager S. G., Nunes E., Klein D. F. Response to phenelzine and imipramine in placebo nonresponders with atypical depression. A new application of the crossover design. Arch Gen Psychiatry. 1991 Apr;48(4):319–323. doi: 10.1001/archpsyc.1991.01810280035005. [DOI] [PubMed] [Google Scholar]
  13. Quitkin F. M., McGrath P. J., Stewart J. W., Harrison W., Wager S. G., Nunes E., Rabkin J. G., Tricamo E., Markowitz J., Klein D. F. Phenelzine and imipramine in mood reactive depressives. Further delineation of the syndrome of atypical depression. Arch Gen Psychiatry. 1989 Sep;46(9):787–793. doi: 10.1001/archpsyc.1989.01810090029005. [DOI] [PubMed] [Google Scholar]
  14. Stewart J. W., McGrath P. J., Quitkin F. M., Rabkin J. G., Harrison W., Wager S., Nunes E., Ocepek-Welikson K., Tricamo E. Chronic depression: response to placebo, imipramine, and phenelzine. J Clin Psychopharmacol. 1993 Dec;13(6):391–396. [PubMed] [Google Scholar]
  15. Stewart J. W., Tricamo E., McGrath P. J., Quitkin F. M. Prophylactic efficacy of phenelzine and imipramine in chronic atypical depression: likelihood of recurrence on discontinuation after 6 months' remission. Am J Psychiatry. 1997 Jan;154(1):31–36. doi: 10.1176/ajp.154.1.31. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Psychiatry and Neuroscience are provided here courtesy of Canadian Science Publishing

RESOURCES