Abstract
1. The responses of neurones in the anterior pretectal nucleus (APTN) to electrical stimulation of the dorsal columns at twice the threshold for A fibres were studied in the rat anaesthetized with urethane. 2. APTN cells were excited by dorsal column stimulation. Forty-six discharged phasically in response to a single stimulus. Sixteen cells did not respond phasically but slowly increased the discharge rate with repeated stimulation. 3. Electrical stimulation of the contralateral gracile fasciculus caused neurones in the APTN to discharge with a variable latency of 2-22 ms. Stimulations of the ipsilateral gracile and contralateral cuneate fasciculi had weaker effects. 4. Microinjection of DL-homocysteic acid into the contralateral gracile nucleus increased the discharge rate of APTN neurones. Microinjection of gamma-aminobutyric acid into the contralateral gracile nucleus blocked the gracile fasciculus evoked excitation of APTN neurones. 5. On thirteen occasions cells in the gracile nucleus were driven antidromically by electrical stimulation of the APTN. 6. It is concluded that electrical stimulation of the gracile fasciculus activates a monosynaptic excitatory input to the APTN.
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- Angaut-Petit D. The dorsal column system: I. Existence of long ascending postsynaptic fibres in the cat's fasciculus gracilis. Exp Brain Res. 1975 May 22;22(5):457–470. doi: 10.1007/BF00237348. [DOI] [PubMed] [Google Scholar]
- Berkley K. J., Budell R. J., Blomqvist A., Bull M. Output systems of the dorsal column nuclei in the cat. Brain Res. 1986 Sep;396(3):199–225. doi: 10.1016/0165-0173(86)90012-3. [DOI] [PubMed] [Google Scholar]
- Berkley K. J., Mash D. C. Somatic sensory projections to the pretectum in the cat. Brain Res. 1978 Dec 15;158(2):445–449. doi: 10.1016/0006-8993(78)90687-x. [DOI] [PubMed] [Google Scholar]
- Berman N. Connections of the pretectum in the cat. J Comp Neurol. 1977 Jul 15;174(2):227–254. doi: 10.1002/cne.901740204. [DOI] [PubMed] [Google Scholar]
- Foreman R. D., Beall J. E., Coulter J. D., Willis W. D. Effects of dorsal column stimulation on primate spinothalamic tract neurons. J Neurophysiol. 1976 May;39(3):534–546. doi: 10.1152/jn.1976.39.3.534. [DOI] [PubMed] [Google Scholar]
- Foster G. A., Sizer A. R., Rees H., Roberts M. H. Afferent projections to the rostral anterior pretectal nucleus of the rat: a possible role in the processing of noxious stimuli. Neuroscience. 1989;29(3):685–694. doi: 10.1016/0306-4522(89)90141-3. [DOI] [PubMed] [Google Scholar]
- Giesler G. J., Jr, Cliffer K. D. Postsynaptic dorsal column pathway of the rat. II. Evidence against an important role in nociception. Brain Res. 1985 Feb 11;326(2):347–356. doi: 10.1016/0006-8993(85)90044-7. [DOI] [PubMed] [Google Scholar]
- Gregory K. M. The dendritic architecture of the visual pretectal nuclei of the rat: a study with the Golgi-Cox method. J Comp Neurol. 1985 Apr 1;234(1):122–135. doi: 10.1002/cne.902340110. [DOI] [PubMed] [Google Scholar]
- Itoh K., Takada M., Yasui Y., Kudo M., Mizuno N. Direct projections from the anterior pretectal nucleus to the dorsal accessory olive in the cat: an anterograde and retrograde WGA-HRP study. Brain Res. 1983 Aug 8;272(2):350–353. doi: 10.1016/0006-8993(83)90582-6. [DOI] [PubMed] [Google Scholar]
- Lindblom U., Tapper D. N., Wiesenfeld Z. The effect of dorsal column stimulation on the nociceptive response of dorsal horn cells and its relevance for pain suppression. Pain. 1977 Dec;4(2):133–144. doi: 10.1016/0304-3959(77)90127-0. [DOI] [PubMed] [Google Scholar]
- Lu G. W., Bennett G. J., Nishikawa N., Hoffert M. J., Dubner R. Extra- and intracellular recordings from dorsal column postsynaptic spinomedullary neurons in the cat. Exp Neurol. 1983 Nov;82(2):456–477. doi: 10.1016/0014-4886(83)90417-x. [DOI] [PubMed] [Google Scholar]
- Melzack R., Wall P. D. Pain mechanisms: a new theory. Science. 1965 Nov 19;150(3699):971–979. doi: 10.1126/science.150.3699.971. [DOI] [PubMed] [Google Scholar]
- Nashold B. S., Jr, Friedman H. Dorsal column stimulation for control of pain. Preliminary report on 30 patients. J Neurosurg. 1972 May;36(5):590–597. doi: 10.3171/jns.1972.36.5.0590. [DOI] [PubMed] [Google Scholar]
- Noble R., Riddell J. S. Cutaneous excitatory and inhibitory input to neurones of the postsynaptic dorsal column system in the cat. J Physiol. 1988 Feb;396:497–513. doi: 10.1113/jphysiol.1988.sp016974. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Prado W. A., Roberts M. H. An assessment of the antinociceptive and aversive effects of stimulating identified sites in the rat brain. Brain Res. 1985 Aug 12;340(2):219–228. doi: 10.1016/0006-8993(85)90917-5. [DOI] [PubMed] [Google Scholar]
- Rees H., Roberts M. H. Anterior pretectal stimulation alters the responses of spinal dorsal horn neurones to cutaneous stimulation in the rat. J Physiol. 1987 Apr;385:415–436. doi: 10.1113/jphysiol.1987.sp016499. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Roberts M. H., Rees H. The antinociceptive effects of stimulating the pretectal nucleus of the rat. Pain. 1986 Apr;25(1):83–93. doi: 10.1016/0304-3959(86)90011-4. [DOI] [PubMed] [Google Scholar]
- Saadé N. E., Tabet M. S., Banna N. R., Atweh S. F., Jabbur S. J. Inhibition of nociceptive evoked activity in spinal neurons through a dorsal column-brainstem-spinal loop. Brain Res. 1985 Jul 22;339(1):115–118. doi: 10.1016/0006-8993(85)90627-4. [DOI] [PubMed] [Google Scholar]
- Shealy C. N., Mortimer J. T., Reswick J. B. Electrical inhibition of pain by stimulation of the dorsal columns: preliminary clinical report. Anesth Analg. 1967 Jul-Aug;46(4):489–491. [PubMed] [Google Scholar]
- Sweet W. H., Wepsic J. G. Treatment of chronic pain by stimulation of fibers of primary afferent neuron. Trans Am Neurol Assoc. 1968;93:103–107. [PubMed] [Google Scholar]
- Uddenberg N. Functional organization of long, second-order afferents in the dorsal funiculus. Exp Brain Res. 1968;4(4):377–382. doi: 10.1007/BF00235702. [DOI] [PubMed] [Google Scholar]
- Weber J. T., Harting J. K. The efferent projections of the pretectal complex: an autoradiographic and horseradish peroxidase analysis. Brain Res. 1980 Jul 21;194(1):1–28. doi: 10.1016/0006-8993(80)91315-3. [DOI] [PubMed] [Google Scholar]