Skip to main content
NCBI home page
Canadian Journal of Veterinary Research logoLink to Canadian Journal of Veterinary Research
. 1998 Jul;62(3):214–217.

Phenylbutazone prevents the endotoxin-induced delay in gastric emptying in horses.

N Valk 1, T J Doherty 1, J T Blackford 1, T W Abraha 1, D L Frazier 1
PMCID: PMC1189478  PMID: 9684051

Abstract

The effect of phenylbutazone on gastric emptying in horses was determined by measuring serum concentrations of acetaminophen. Gastric emptying was determined in normal fasted horses (n = 6), horses given endotoxin intravenously (n = 6), horses given intravenous phenylbutazone (n = 6), and horses given intravenous phenylbutazone plus endotoxin (n = 6). The mean time to reach maximum serum acetaminophen concentration (Tmax), the maximum serum concentration (Cmax), and the area under the serum acetaminophen concentration versus time curve (AUC) were compared among treatment groups. Phenylbutazone did not alter gastric emptying in normal horses. Endotoxin caused a profound delay in gastric emptying, and pretreatment with phenylbutazone abolished this effect.

Full text

PDF
214

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Adams S. B., MacHarg M. A. Neostigmine methylsulfate delays gastric emptying of particulate markers in horses. Am J Vet Res. 1985 Dec;46(12):2498–2499. [PubMed] [Google Scholar]
  2. Baker S. J., Gerring E. L. Gastric emptying of four liquid meals in pony foals. Res Vet Sci. 1994 Mar;56(2):164–169. doi: 10.1016/0034-5288(94)90099-x. [DOI] [PubMed] [Google Scholar]
  3. Breslow M. J., Miller C. F., Parker S. D., Walman A. T., Traystman R. J. Effect of vasopressors on organ blood flow during endotoxin shock in pigs. Am J Physiol. 1987 Feb;252(2 Pt 2):H291–H300. doi: 10.1152/ajpheart.1987.252.2.H291. [DOI] [PubMed] [Google Scholar]
  4. Ciancio M. J., Vitiritti L., Dhar A., Chang E. B. Endotoxin-induced alterations in rat colonic water and electrolyte transport. Gastroenterology. 1992 Nov;103(5):1437–1443. doi: 10.1016/0016-5085(92)91162-w. [DOI] [PubMed] [Google Scholar]
  5. Clements J. A., Heading R. C., Nimmo W. S., Prescott L. F. Kinetics of acetaminophen absorption and gastric emptying in man. Clin Pharmacol Ther. 1978 Oct;24(4):420–431. doi: 10.1002/cpt1978244420. [DOI] [PubMed] [Google Scholar]
  6. Doherty T. J., Andrews F. M., Provenza M. K., Frazier D. L. Acetaminophen as a marker of gastric emptying in ponies. Equine Vet J. 1998 Jul;30(4):349–351. doi: 10.1111/j.2042-3306.1998.tb04109.x. [DOI] [PubMed] [Google Scholar]
  7. Eades S. C., Moore J. N. Blockade of endotoxin-induced cecal hypoperfusion and ileus with an alpha 2 antagonist in horses. Am J Vet Res. 1993 Apr;54(4):586–590. [PubMed] [Google Scholar]
  8. King J. N., Gerring E. L. Antagonism of endotoxin-induced disruption of equine bowel motility by flunixin and phenylbutazone. Equine Vet J Suppl. 1989 Jun;(7):38–42. doi: 10.1111/j.2042-3306.1989.tb05653.x. [DOI] [PubMed] [Google Scholar]
  9. King J. N., Gerring E. L. Detection of endotoxin in cases of equine colic. Vet Rec. 1988 Sep 3;123(10):269–271. doi: 10.1136/vr.123.10.269. [DOI] [PubMed] [Google Scholar]
  10. King J. N., Gerring E. L. The action of low dose endotoxin on equine bowel motility. Equine Vet J. 1991 Jan;23(1):11–17. doi: 10.1111/j.2042-3306.1991.tb02705.x. [DOI] [PubMed] [Google Scholar]
  11. Mizuta H., Kawazoe Y., Haga K., Ogawa K. Effects of meals on gastric emptying and small intestinal transit times of a suspension in the beagle dog assessed using acetaminophen and salicylazosulfapyridine as markers. Chem Pharm Bull (Tokyo) 1990 Aug;38(8):2224–2227. doi: 10.1248/cpb.38.2224. [DOI] [PubMed] [Google Scholar]
  12. Moore J. N., Garner H. E., Shapland J. E., Hatfield D. G. Prevention of endotoxin-induced arterial hypoxaemia and lactic acidosis with flunixin meglumine in the conscious pony. Equine Vet J. 1981 Apr;13(2):95–98. doi: 10.1111/j.2042-3306.1981.tb04122.x. [DOI] [PubMed] [Google Scholar]
  13. Ringger N. C., Lester G. D., Neuwirth L., Merritt A. M., Vetro T., Harrison J. Effect of bethanechol or erythromycin on gastric emptying in horses. Am J Vet Res. 1996 Dec;57(12):1771–1775. [PubMed] [Google Scholar]
  14. Schmidt H., Secchi A., Wellmann R., Bach A., Böhrer H., Gebhard M. M., Martin E. Effect of endotoxemia on intestinal villus microcirculation in rats. J Surg Res. 1996 Mar;61(2):521–526. doi: 10.1006/jsre.1996.0157. [DOI] [PubMed] [Google Scholar]
  15. Valk N., Doherty T. J., Blackford J. T., Abraha T. W., Frazier D. L. Effect of cisapride on gastric emptying in horses following endotoxin treatment. Equine Vet J. 1998 Jul;30(4):344–348. doi: 10.1111/j.2042-3306.1998.tb04108.x. [DOI] [PubMed] [Google Scholar]

Articles from Canadian Journal of Veterinary Research are provided here courtesy of Canadian Veterinary Medical Association

RESOURCES